Analysis of the CYP1a1 mRNA dose-response in human keratinocytes indicates that relative potencies of dioxins, furans, and PCBs are species and congener specific

Toxicological Sciences

Volumn 118, Issue 2, 2010, Pages 704-715

  Sutter, Carrie H ^a   Bodreddigari, Sridevi ^a   Sutter, Thomas R ^a   Carlson, Erik A ^b   Silkworth, Jay B ^b  

^a University of Memphis   (United States)

^b GENERAL ELECTRIC COMPANY   (United States)

Author keywords

Chloracne; Human; Human health risk assessment; Keratinocyte; PCB; TCDD; Threshold; Toxic equivalency factor

Indexed keywords

1,2,3,6,7,8 HEXACHLORODIBENZO 4 DIOXIN; 1,2,3,6,7,8 HEXACHLORODIBENZOFURAN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLORODIBENZOFURAN; 3,3',4,4',5 PENTACHLOROBIPHENYL; CYTOCHROME P450 1A1; DIOXIN; FURAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHLORACNE; DONOR; HUMAN; HUMAN CELL; KERATINOCYTE; RISK FACTOR;

ANIMALS; BENZOFURANS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; DIOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KERATINOCYTES; POLYCHLORINATED BIPHENYLS; RATS; RISK ASSESSMENT; RNA, MESSENGER; SPECIES SPECIFICITY;

RODENTIA;

EID: 78549243767     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq262     Document Type: Article

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