MiRNA-30a-5p-mediated silencing of Beta2/NeuroD expression is an important initial event of glucotoxicity-induced beta cell dysfunction in rodent models

Diabetologia

Volumn 56, Issue 4, 2013, Pages 847-855

  Kim, J W ^a   You, Y H ^a   Jung, S ^b   Suh Kim, H ^b   Lee, I K ^c   Cho, J H ^a   Yoon, K H ^a  

^a The Catholic University of Korea   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c Kyungpook National University   (South Korea)

Author keywords

Beta cell dysfunction; Beta2 NeuroD; Glucotoxicity; MicroRNA

Indexed keywords

GLUCOSE; INSULIN; MICRORNA; MICRORNA 30A 5P; NEUROGENIC DIFFERENTIATION FACTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BETA2 GENE; BINDING SITE; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; EXPOSURE; GENE SILENCING; GENETIC TRANSFECTION; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOTOXICITY INDUCED BETA CELL DYSFUNCTION; IN VITRO STUDY; INSULIN RELEASE; NEUROD GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NORTHERN BLOTTING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BINDING; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; CELL LINE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GENE SILENCING; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN-SECRETING CELLS; MICE; MICRORNAS; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84876484626     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2812-x     Document Type: Article

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