Reversal of P-glycoprotein-mediated multidrug resistance is induced by mollugin in MCF-7/adriamycin cells

Phytomedicine

Volumn 20, Issue 7, 2013, Pages 622-631

  Tran, Thu Phuong ^a   Kim, Hyung Gyun ^a   Choi, Jae Ho ^a   Na, Min Kyun ^a   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

Author keywords

AMP activated protein kinase; Cyclic AMP responsive element; MDR1; Mollugin; NF B

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; I KAPPA B; MOLLUGIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PLANT EXTRACT; PROTEIN KINASE; RHODAMINE 123; RUBICA CORDIFOLIA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CANCER RESISTANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE REPRESSION; HUMAN; MEDICINAL PLANT; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RUBICA CORDIFOLIA; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOOXYGENASE 2; DOWN-REGULATION; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLUORESCENT DYES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; NF-KAPPA B; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS C-AKT; PYRANS; RHODAMINE 123;

EID: 84876417062     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2013.01.014     Document Type: Article

References (26)

1. T. Aoki, M. Nishimura, T. Matsuoka, K. Yamamoto, T. Furuyashiki, H. Kataoka, S. Kitaoka, R. Ishibashi, A. Ishibazawa, and S. Miyamoto PGE(2)-EP(2) signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-kappaB Bristish Journal of Pharmacology 163 2011 1237 1249
2. D. Carling, P.R. Clarke, V.A. Zammit, and D.G. Hardie Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities European Journal of Biochemistry 186 1989 129 136
3. L. Deng, Y.C. Lin-Lee, F.X. Claret, and M.T. Kuo 2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway Journal of Biological Chemistry 276 2001 413 420
4. M.M. Gottesman, T. Fojo, and S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nature Reviews Cancer 2 2002 48 58
5. N. Horike, H. Sakoda, A. Kushiyama, H. Ono, M. Fujishiro, H. Kamata, K. Nishiyama, Y. Uchijima, Y. Kurihara, H. Kurihara, and T. Asano AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver Journal of Biological Chemistry 283 2008 33902 33910
6. N.L. Huang, S.H. Chiang, C.H. Hsueh, Y.J. Liang, Y.J. Chen, and L.P. Lai Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation International journal of cardiology 134 2009 169 175
7. R.W. Johnstone, A.A. Ruefli, K.M. Tainton, and M.J. Smyth A role for P-glycoprotein in regulating cell death Leukemia and Lymphoma 38 2000 1 11
8. Y. Jun do, C.R. Han, M.S. Choi, M.A. Bae, M.H. Woo, and Y.H. Kim Effect of mollugin on apoptosis and adipogenesis of 3T3-L1 preadipocytes Phytotherapy Research 25 2011 724 731
9. H.G. Kim, T.T. Hien, E.H. Han, Y.P. Hwang, J.H. Choi, K.W. Kang, K.I. Kwon, B.H. Kim, S.K. Kim, G.Y. Song, T.C. Jeong, and H.G. Jeong Metformin inhibits P-glycoprotein expression via the NF-kappaB pathway and CRE transcriptional activity through AMPK activation Bristish Journal of Pharmacology 162 2010 1096 1108
10. K.J. Kim, J.S. Lee, M.K. Kwak, H.G. Choi, C.S. Yong, J.A. Kim, Y.R. Lee, W.S. Lyoo, and Y.J. Park Anti-inflammatory action of mollugin and its synthetic derivatives in HT-29 human colonic epithelial cells is mediated through inhibition of NF-kappaB activation European Journal of Pharmacology 622 2009 52 57
11. S.M. Kim, H.S. Park, D.Y. Jun, H.J. Woo, M.H. Woo, C.H. Yang, and Y.H. Kim Mollugin induces apoptosis in human Jurkat T cells through endoplasmic reticulum stress-mediated activation of JNK and caspase-12 and subsequent activation of mitochondria-dependent caspase cascade regulated by Bcl-xL Toxicology and Applied Pharmacology 241 2009 210 220
12. D.B. Longley, and P.G. Johnston Molecular mechanisms of drug resistance The Journal of Pathology 205 2005 275 292
13. Y. Lu, R. Liu, C. Sun, and Y. Pan An effective high-speed countercurrent chromatographic method for preparative isolation and purification of mollugin directly from the ethanol extract of the Chinese medicinal plant Rubia cordifolia Journal of Separation Science 30 2007 1313 1317
14. B. Mayr, and M. Montminy Transcriptional regulation by the phosphorylation-dependent factor CREB Nature Reviews Molecular Cell Biology 2 2001 599 609
15. R.P. Nishanth, B.S. Ramakrishna, R.G. Jyotsna, K.R. Roy, G.V. Reddy, P.K. Reddy, and P. Reddanna C-Phycocyanin inhibits MDR1 through reactive oxygen species and cyclooxygenase-2 mediated pathways in human hepatocellular carcinoma cell line European Journal of Pharmacology. 649 2010 74 83
16. N. Ouchi, H. Kobayashi, S. Kihara, M. Kumada, K. Sato, T. Inoue, T. Funahashi, and K. Walsh Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells The Journal of Biological Chemistry 279 2004 1304 1309
17. V.A. Patel, M.J. Dunn, and A. Sorokin Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2 The Journal of Biological Chemistry 277 2002 38915 38920
18. B.I. Sikic Modulation of multidrug resistance: at the threshold Journal of Clinical Oncology 11 1993 1629 1635
19. A. Sorokin Cyclooxygenase-2: potential role in regulation of drug efflux and multidrug resistance phenotype Current Pharmaceutical Design. 10 2004 647 657
20. P. Surowiak, V. Materna, C. Denkert, I. Kaplenko, M. Spaczynski, M. Dietel, M. Zabel, and H. Lage Significance of cyclooxygenase 2 and MDR1/P-glycoprotein coexpression in ovarian cancers Cancer Letters 235 2006 272 280
21. A.M. van der Bliek, P.M. Kooiman, C. Schneider, and P. Borst Sequence of mdr3 cDNA encoding a human P-glycoprotein Gene 71 1988 401 411
22. M. Zang, A. Zuccollo, X. Hou, D. Nagata, K. Walsh, H. Herscovitz, P. Brecher, N.B. Ruderman, and R.A. Cohen AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells The Journal of Biological Chemistry 279 2004 47898 47905
23. M.C. Zatelli, A. Luchin, F. Tagliati, S. Leoni, D. Piccin, M. Bondanelli, R. Rossi, and E.C. degli Uberti Cyclooxygenase-2 inhibitors prevent the development of chemoresistance phenotype in a breast cancer cell line by inhibiting glycoprotein p-170 expression Endocrine Related Cancer 14 2007 1029 1038
24. G. Zhou, R. Myers, Y. Li, Y. Chen, X. Shen, J. Fenyk-Melody, M. Wu, J. Ventre, T. Doebber, N. Fujii, N. Musi, M.F. Hirshman, L.J. Goodyear, and D.E. Moller Role of AMP-activated protein kinase in mechanism of metformin action Journal of Clinical Investigation 108 2001 1167 1174
25. C. Ziemann, D. Schafer, G. Rudell, G.F. Kahl, and K.I. Hirsch-Ernst The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures Hepatology 35 2002 579 588
26. A. Zyad, J. Benard, T. Tursz, R. Clarke, and S. Chouaib Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: relationship to MDR1, MnSOD, and TNF gene expression Cancer Research 54 1994 825 831