The cyclooxygenase system participates in functional mdr1b overexpression in primary rat hepatocyte cultures

Hepatology

Volumn 35, Issue 3, 2002, Pages 579-588

  Ziemann, Christina ^a   Schäfer, Dirk ^b   Rüdell, Gudrun ^a   Kahl, Georg F ^a   Hirsch Ernst, Karen I ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR; GLYCOPROTEIN P; INDOMETACIN; MELOXICAM; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; RHODAMINE 123;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE CONTROL; GENE OVEREXPRESSION; LIVER CELL CARCINOMA; LIVER CELL CULTURE; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; RECEPTOR UPREGULATION; TIME;

EID: 0036186458     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2002.31778     Document Type: Article

References (50)

1. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
2. Biochemistry of multidrug resistance mediated by the multidrug transporter
3. Multiple physiological functions for multidrug transporter P-glycoprotein?
4. Hepatic canalicular membrane 4: Expression of the multidrug resistance genes in the liver
5. P-glycoprotein expression during tumor progression in the rat liver
6. Overexpression of the MDR1 gene and P-glycoprotein in human hepatocellular carcinoma
7. Induction of multidrug resistance gene expression during cholestasis in rats and nonhuman primates
8. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver
9. Regulation of the multidrug resistance gene in regenerating rat liver
10. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation
11. Cyclooxygenase-2 expression in hepatocellular carcinoma
12. Overexpression of P-glycoprotein in adenomatous hyperplasia of human liver with cirrhosis
13. Inverse relationship between P-glycoprotein expression and its proliferative activity in hepatocellular carcinoma
14. Molecular pathology of cyclooxygenase-2 in neoplasia
15. Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition
16. Regulation of the proliferation of primary rat hepatocytes by eicosanoids
17. Stimulation of liver regeneration by prostacyclin
18. Transforming growth factor-alpha-induced DNA synthesis and c-myc expression in primary rat hepatocyte cultures is modulated by indomethacin
19. Prostaglandin E2 and rat liver regeneration
20. Modulation of P-glycoprotein and mdr1b mRNA expression by growth factors in primary rat hepatocyte culture
21. Overexpression of the class II P-glycoprotein gene in primary rat hepatocyte culture: Evidence for increased mRNA stability
22. Induction of mdr1b mRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte cultures
23. Reactive oxygen species participate in mdr1b mRNA and P-glycoprotein overexpression in primary rat hepatocyte cultures
24. IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in Caco-2 human colon carcinoma cells
25. Oxidative damage of cardiomyocytes is limited by extracellular regulated kinases 1/2-mediated induction of cyclooxygenase-2
26. Divergent regulation of the class II P-glycoprotein gene in primary cultures ofhepatocytes versus H35 hepatoma by glucocorticoids
27. Proliferation of fetal rat hepatocytes in response to growth factors and hormones in primary culture
28. Effect of prostaglandin E2 on eicosanoid release by human bronchial biopsy specimens from normal and inflamed mucosa
29. Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein
30. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2 activity in vitro)
31. Enhancement of prostaglandin E2 production by epidermal growth factor requires the coordinate activation of cytosolic phospholipase A2 and cyclooxygenase 2 in human squamous carcinoma A431 cells
32. Rapid and transient induction of cyclooxygenase 2 by epidermal growth factor in human amnion-derived Wish cells
33. Physiological oxygen tensions modulate expression of the mdr1b multidrug-resistance gene in primary rat hepatocyte cultures
34. Enhanced expression of the human multidrug resistance 1 gene in response to UV light irradiation
35. Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes
36. Prostanoid receptors and their biological actions
37. Redox regulation of P-glycoprotein-mediated multidrug resistance in multicellular prostate tumor spheroids
38. Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-κB signaling
39. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis
40. 2-Acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway
41. Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin
42. Characterization of the basal and carcinogen regulatory elements of the rat mdr1b promoter
43. Sp1 and Egr-1 have opposing effects on the regulation of the rat Pgp2/mdr1b gene
44. Analysis of a porcine EP3-receptor: Cloning, expression and signal transduction
45. Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen
46. Celecoxib loses its anti-inflammatory efficacy at high doses through activation of NF-kappaB
47. Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators
48. Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs
49. Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: Possible c-Src-mediated pathway
50. Regulation of cyclooxygenase 2 expression in hepatocytes by CCAAT/enhancer-binding proteins