Humanin binds MPP8: Mapping interaction sites of the peptide and protein

Journal of Peptide Science

Volumn 19, Issue 5, 2013, Pages 301-307

  Maximov, Vadim V ^a   Martynenko, Alina V ^a   Arman, Inga P ^a   Tarantul, Vyacheslav Z ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

HN; Humanin; M phase phosphoprotein 8; MPP8; Protein protein interaction

Indexed keywords

HUMANIN; M PHASE PHOSPHOPROTEIN 8; NUCLEIC ACID BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL MOTILITY; CONTROLLED STUDY; FETUS; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMINO ACIDS; BINDING SITES; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; GENE LIBRARY; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; ONCOGENE PROTEINS; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN INTERACTION MAPS;

EID: 84876411142     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.2500     Document Type: Article

References (59)

1. Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A 2001; 98(11): 6336-6341.
2. Hashimoto Y, Ito Y, Niikura T, Shao Z, Hata M, Oyama F, Nishimoto I. Mechanisms of neuroprotection by a novel rescue factor humanin from Swedish mutant amyloid precursor protein. Biochem. Biophys. Res. Commun. 2001; 283(2): 460-468.
3. Kariya S, Takahashi N, Ooba N, Kawahara M, Nakayama H, Ueno S. Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport 2002; 13(6): 903-907.
4. Jung SS, Van Nostrand WE. Humanin rescues human cerebrovascular smooth muscle cells from Abeta-induced toxicity. J. Neurochem. 2003; 84(2): 266-272.
5. Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait AC, Reed JC. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 2003; 423(6938): 456-461.
6. Ikonen M, Liu B, Hashimoto Y, Ma L, Lee KW, Niikura T, Nishimoto I, Cohen P. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A 2003; 100(22): 13042-13047.
7. Kariya S, Takahashi N, Hirano M, Ueno S. Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes. Mol. Cell. Biochem. 2003; 254(1-2): 83-89.
8. Sponne I, Fifre A, Koziel V, Kriem B, Oster T, Pillot T. Humanin rescues cortical neurons from prion-peptide-induced apoptosis. Mol. Cell. Neurosci. 2004; 25(1): 95-102.
9. Luciano F, Zhai D, Zhu X, Bailly-Maitre B, Ricci JE, Satterthwait AC, Reed JC. Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. J. Biol. Chem. 2005; 280(16): 15825-15835.
10. Zhai D, Luciano F, Zhu X, Guo B, Satterthwait AC, Reed JC. Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak. J. Biol. Chem. 2005; 280(16): 15815-15824.
11. Wang D, Li H, Yuan H, Zheng M, Bai C, Chen L, Pei X. Humanin delays apoptosis in K562 cells by downregulation of P38 MAP kinase. Apoptosis 2005; 10(5): 963-971.
12. Colu{cyrillic}n E, Strand ML, Carlsson-Skwirut C, Wahlgren A, Svechnikov KV, Cohen P, Sts{cyrillic}der O. Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis. J. Cell. Physiol. 2006; 208(2): 373-385.
13. Yang Z, Zhang Q, Ge J, Tan Z. Protective effects of tetramethylpyrazine on rat retinal cell cultures. Neurochem. Int. 2008; 52(6): 1176-1187.
14. Hoang PT, Park P, Cobb LJ, Paharkova-Vatchkova V, Hakimi M, Cohen P, Lee KW. The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism 2010; 59(3): 343-349.
15. Jin H, Liu T, Wang WX, Xu JH, Yang PB, Lu HX, Sun QR, Hu HT. Protective effects of [Gly14]-Humanin on beta-amyloid-induced PC12 cell death by preventing mitochondrial dysfunction. Neurochem. Int. 2010; 56(3): 417-423.
16. Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C. Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology 2010; 151(1): 350-357.
17. Li LM, Zhang Y, Qiao JT, Zhang C. Humanin protects neurons against apoptosis induced by Abeta31-35 through suppression of intrinsic pathway. Sheng Li Xue Bao 2010; 62(2): 93-100.
18. Xu X, Chua KW, Chua CC, Liu CF, Hamdy RC, Chua BH. Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury. Brain Res. 2010; 1355: 189-194.
19. Men J, Zhang X, Yang Y, Gao D. An AD-related neuroprotector rescues transformed rat retinal ganglion cells from CoCl-induced apoptosis. J. Mol. Neurosci. 2012; 47(1): 144-149.
20. Kariya S, Hirano M, Furiya Y, Ueno S. Effect of humanin on decreased ATP levels of human lymphocytes harboring A3243G mutant mitochondrial DNA. Neuropeptides 2005; 39(2): 97-101.
21. Kariya S, Hirano M, Furiya Y, Sugie K, Ueno S. Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent. Acta Neuropathol. 2005; 109(4): 367-372.
22. Ying G, Iribarren P, Zhou Y, Gong W, Zhang N, Yu ZX, Le Y, Cui Y, Wang JM. Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor. J. Immunol. 2004; 172(11): 7078-7085.
23. Harada M, Habata Y, Hosoya M, Nishi K, Fujii R, Kobayashi M, Hinuma S. N-Formylated humanin activates both formyl peptide receptor-like 1 and 2. Biochem. Biophys. Res. Commun. 2004; 324(1): 255-261.
24. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: a novel central regulator of peripheral insulin action. PLoS One 2009; 4(7): e6334.
25. Xu X, Chua CC, Gao J, Hamdy RC, Chua BH. Humanin is a novel neuroprotective agent against stroke. Stroke 2006; 37(10): 2613-2619.
26. Xu X, Chua CC, Gao J, Chua KW, Wang H, Hamdy RC, Chua BH. Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway. Brain Res. 2008; 1227: 12-18.
27. Muzumdar RH, Huffman DM, Calvert JW, Jha S, Weinberg Y, Cui L, Nemkal A, Atzmon G, Klein L, Gundewar S, Ji SY, Lavu M, Predmore BL, Lefer DJ. Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice. Arterioscler. Thromb. Vasc. Biol. 2010; 30(10): 1940-1948.
28. Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Mol. Psychiatry 2009; 14(2): 206-222.
29. Niikura T, Sidahmed E, Hirata-Fukae C, Aisen PS, Matsuoka Y. A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One 2011; 6(1): e16259.
30. Zhang W, Zhang W, Li Z, Hao J, Zhang Z, Liu L, Mao N, Miao J, Zhang L. S14G-humanin improves cognitive deficits and reduces amyloid pathology in the middle-aged APPswe/PS1dE9 mice. Pharmacol. Biochem. Behav. 2012; 100(3): 361-369.
31. Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I. A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice. J. Neurosci. Res. 2005; 79(5): 714-723.
32. Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M. Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo. J. Neurosci. 2005; 25(44): 10252-10261.
33. Miao J, Zhang W, Yin R, Liu R, Su C, Lei G, Li Z. S14G-Humanin ameliorates Abeta25-35-induced behavioral deficits by reducing neuroinflammatory responses and apoptosis in mice. Neuropeptides 2008; 42(5-6): 557-567.
34. Mamiya T, Ukai M. [Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo. Br. J. Pharmacol. 2001; 134(8): 1597-1599.
35. Krejcova G, Patocka J, Slaninova J. Effect of humanin analogues on experimentally induced impairment of spatial memory in rats. J. Pept. Sci. 2004; 10(10): 636-639.
36. Kunesov G, Hlavb{cyrillic}cek J, Patocka J, Evangelou A, Zikos C, Benaki D, Paravatou-Petsotas M, Pelecanou M, Livaniou E, Slaninova J. The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues. Peptides 2008; 29(11): 1982-1987.
37. Oh YK, Bachar AR, Zacharias DG, Kim SG, Wan J, Cobb LJ, Lerman LO, Cohen P, Lerman A. Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis 2011; 219(1): 65-73.
38. Zhang X, Urbieta-Caceres VH, Eirin A, Bell CC, Crane JA, Tang H, Jordan KL, Oh YK, Zhu XY, Korsmo MJ, Bachar AR, Cohen P, Lerman A, Lerman LO. Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Life Sci. 2012; 91(5-6): 199-206.
39. Zacharias DG, Kim SG, Massat AE, Bachar AR, Oh YK, Herrmann J, Rodriguez-Porcel M, Cohen P, Lerman LO, Lerman A. Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic plaques in humans. PLoS One 2012; 7(2): e31065.
40. Maximov V, Martynenko A, Hunsmann G, Tarantul V. Mitochondrial 16S rRNA gene encodes a functional peptide, a potential drug for Alzheimer's disease and target for cancer therapy. Med. Hypotheses 2002; 59(6): 670-673.
41. Mukai H, Hokari Y, Seki T, Takao T, Kubota M, Matsuo Y, Tsukagoshi H, Kato M, Kimura H, Shimonishi Y, Kiso Y, Nishi Y, Wakamatsu K, Munekata E. Discovery of mitocryptide-1, a neutrophil-activating cryptide from healthy porcine heart. J. Biol. Chem. 2008; 283(45): 30596-30605.
42. Mukai H, Seki T, Nakano H, Hokari Y, Takao T, Kawanami M, Tsukagoshi H, Kimura H, Kiso Y, Shimonishi Y, Nishi Y, Munekata E. Mitocryptide-2: purification, identification, and characterization of a novel cryptide that activates neutrophils. J. Immunol. 2009; 182(8): 5072-5080.
43. Seki T, Fukamizu A, Kiso Y, Mukai H. Mitocryptide-2, a neutrophil-activating cryptide, is a specific endogenous agonist for formyl-peptide receptor-like 1. Biochem. Biophys. Res. Commun. 2011; 404(1): 482-487.
44. Hokari Y, Seki T, Nakano H, Matsuo Y, Fukamizu A, Munekata E, Kiso Y, Mukai H. Isolation and identification of novel neutrophil-activating cryptides hidden in mitochondrial cytochrome C. Protein Pept. Lett. 2012; 19(6): 680-687.
45. Tarantul V, Nikolaev A, Hannig H, Kalmyrzaev B, Muchoyan I, Maximov V, Nenasheva V, Dubovaya V, Hunsmann G, Bodemer W. Detection of abundantly transcribed genes and gene translocation in human immunodeficiency virus-associated non-Hodgkin's lymphoma. Neoplasia 2001; 3(2): 132-142.
46. Hartmann TB, Mattern E, Wiedemann N, van Doorn R, Willemze R, Niikura T, Hildenbrand R, Schadendorf D, Eichmuller SB. Identification of selectively expressed genes and antigens in CTCL. Exp. Dermatol. 2008; 17(4): 324-334.
47. Maximov VV, Arman IP, Tarantul VZ. Identification of the proteins interacting with neuroprotective peptide Humanin in a yeast two-hybrid system. Russian Journal of Genetics. 2006; 42(2): 208-211.
48. Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM. Identification of novel M phase phosphoproteins by expression cloning. Mol. Biol. Cell 1996; 7(9): 1455-1469.
49. Bua1 DJ, Kuo1 AJ, Cheung1 P, Liu CL, Migliori V, Espejo A, Casadio F, Bassi C, Amati B, Bedford MT, Guccione E, Gozani O. Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One 2009; 4(8): e6789.
50. Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res. 2010; 38(2): e11.
51. Kokura K, Sun L, Bedford MT, Fang J. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J. 2010; 29(21): 3673-3687.
52. Bork P. Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally? Proteins 1993; 17(4): 363-374.
53. Niikura T, Hashimoto Y, Tajima H, Ishizaka M, Yamagishi Y, Kawasumi M, Nawa M, Terashita K, Aiso S, Nishimoto I. A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Eur. J. Neurosci. 2003; 17(6): 1150-1158.
54. Kigawa A, Wakui H, Maki N, Okuyama S, Masai R, Ohtani H, Komatsuda A, Suzuki D, Toyoda M, Kobayashi R, Sawada K. Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide. Clin. Exp. Nephrol. 2004; 8(4): 331-338.
55. Hashimoto Y, Kurita M, Aiso S, Nishimoto I, Matsuoka M. Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Mol. Biol. Cell 2009; 20(12): 2864-2873.
56. Rossini L, Hashimoto Y, Suzuki H, Kurita M, Gianfriddo M, Scali C, Roncarati R, Franceschini D, Pollio G, Trabalzini L, Terstappen GC, Matsuoka M, Caricasole A. VSTM2L is a novel secreted antagonist of the neuroprotective peptide Humanin. FASEB J. 2011; 25(6): 1983-2000.
57. Hashimoto Y, Niikura T, Ito Y, Sudo H, Hata M, Arakawa E, Abe Y, Kita Y, Nishimoto I. Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insults. J. Neurosci. 2001; 21(23): 9235-9245.
58. Moretti E, Giannerini V, Rossini L, Matsuoka M, Trabalzini L, Collodel G. Immunolocalization of humanin in human sperm and testis. Fertil. Steril. 2010; 94(7): 2888-2890.
59. Ijiri K, Tsuruga H, Sakakima H, Tomita K, Taniguchi N, Shimoonoda K, Komiya S, Goldring MB, Majima HJ, Matsuyama T. Increased expression of humanin peptide in diffuse-type pigmented villonodular synovitis: implication of its mitochondrial abnormality. Ann. Rheum. Dis. 2005; 64(6): 816-823.