Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain

Molecular Pain

Volumn 6, Issue , 2010, Pages

  Serrano, Alexandre ^a   Paré, Michel ^a   McIntosh, Fraser ^a   Elmes, Steven J R ^a   Martino, Giovanni ^a   Jomphe, Claudia ^b   Lessard, Etienne ^a   Lembo, Paola M C ^a   Vaillancourt, François ^a   Perkins, Martin N ^a   Cao, Chang Q ^a  

^a ASTRAZENECA   (United Kingdom)

^b Pharsighta Certaratrade Company   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AZ 889; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; UNCLASSIFIED DRUG; PIPERAZINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG MEGADOSE; HUMAN; HUMAN CELL; HYPERALGESIA; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NERVE CELL STIMULATION; NERVE POTENTIAL; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL ANESTHESIA; SPINAL GANGLION; TIME TO MAXIMUM PLASMA CONCENTRATION; WITHDRAWAL REFLEX; ANIMAL; CALCIUM SIGNALING; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; NEURALGIA; PATHOLOGY; PHYSIOLOGY; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALS; CALCIUM SIGNALING; DRUG DELIVERY SYSTEMS; GANGLIA, SPINAL; HYPERALGESIA; NEURALGIA; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CCR2; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 78650847856     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-6-90     Document Type: Article

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