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Volumn 151, Issue 1-2, 2013, Pages 54-60

Protective role of synthetic oligodeoxynucleotides expressing immunosuppressive TTAGGG motifs in concanavalin A-induced hepatitis

Author keywords

Concanavalin A; IFN ; IL 4; Liver; Suppressive ODNs; Th1

Indexed keywords

ANTIINFLAMMATORY AGENT; CONCANAVALIN A; GAMMA INTERFERON; INTERLEUKIN 4; OLIGODEOXYNUCLEOTIDE; OLIGODEOXYNUCLEOTIDE A151; STAT1 PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

EID: 84876311791     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2013.02.004     Document Type: Article
Times cited : (6)

References (37)
  • 1
    • 2942549527 scopus 로고    scopus 로고
    • Use of CpG oligodeoxynucleotides as immune adjuvants
    • Klinman D.M., Currie D., Gursel I., Verthelyi D. Use of CpG oligodeoxynucleotides as immune adjuvants. Immunol Rev 2004, 199:201-216.
    • (2004) Immunol Rev , vol.199 , pp. 201-216
    • Klinman, D.M.1    Currie, D.2    Gursel, I.3    Verthelyi, D.4
  • 2
    • 0033980073 scopus 로고    scopus 로고
    • The role of CpG motifs in innate immunity
    • Krieg A.M. The role of CpG motifs in innate immunity. Curr Opin Immunol 2000, 12:35-43.
    • (2000) Curr Opin Immunol , vol.12 , pp. 35-43
    • Krieg, A.M.1
  • 3
    • 0033525558 scopus 로고    scopus 로고
    • Longevity, stress response, and cancer in aging telomerase-deficient mice
    • Rudolph K.L., Chang S., Lee H.W., Blasco M., Gottlieb G.J., Greider C., et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1996, 96:701-712.
    • (1996) Cell , vol.96 , pp. 701-712
    • Rudolph, K.L.1    Chang, S.2    Lee, H.W.3    Blasco, M.4    Gottlieb, G.J.5    Greider, C.6
  • 4
    • 0030931491 scopus 로고    scopus 로고
    • Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
    • Blasco M.A., Lee H.W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 1997, 91:25-34.
    • (1997) Cell , vol.91 , pp. 25-34
    • Blasco, M.A.1    Lee, H.W.2    Hande, M.P.3    Samper, E.4    Lansdorp, P.M.5    DePinho, R.A.6
  • 5
    • 0042346153 scopus 로고    scopus 로고
    • Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation
    • Gursel I., Gursel M., Yamada H., Ishii K.J., Takeshita F., Klinman D.M. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J Immunol 2003, 171:1393-1400.
    • (2003) J Immunol , vol.171 , pp. 1393-1400
    • Gursel, I.1    Gursel, M.2    Yamada, H.3    Ishii, K.J.4    Takeshita, F.5    Klinman, D.M.6
  • 6
    • 6344262317 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling
    • Shirota H., Gursel M., Klinman D.M. Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-gamma- and IL-12-mediated signaling. J Immunol 2004, 173:5002-5007.
    • (2004) J Immunol , vol.173 , pp. 5002-5007
    • Shirota, H.1    Gursel, M.2    Klinman, D.M.3
  • 7
    • 2342491490 scopus 로고    scopus 로고
    • Suppressive oligonucleotides protect against collagen-induced arthritis in mice
    • Dong L., Ito S., Ishii K.J., Klinman D.M. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 2004, 50:1686-1689.
    • (2004) Arthritis Rheum , vol.50 , pp. 1686-1689
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 8
    • 17044423406 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock
    • Shirota H., Gursel I., Gursel M., Klinman D.M. Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock. J Immunol 2005, 174:4579-4583.
    • (2005) J Immunol , vol.174 , pp. 4579-4583
    • Shirota, H.1    Gursel, I.2    Gursel, M.3    Klinman, D.M.4
  • 9
    • 47249095737 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
    • Sato T., Shimosato T., Alvord W.G., Klinman D.M. Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation. J Immunol 2008, 180:7648-7654.
    • (2008) J Immunol , vol.180 , pp. 7648-7654
    • Sato, T.1    Shimosato, T.2    Alvord, W.G.3    Klinman, D.M.4
  • 10
    • 13444302229 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB×NZW mice
    • Dong L., Ito S., Ishii K.J., Klinman D.M. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB×NZW mice. Arthritis Rheum 2005, 52:651-658.
    • (2005) Arthritis Rheum , vol.52 , pp. 651-658
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 11
    • 48849106640 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE(-/-) mice through modulation of Th1/Th2 balance
    • Cheng X., Chen Y., Xie J.J., Yao R., Yu X., Liao M.Y., et al. Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE(-/-) mice through modulation of Th1/Th2 balance. J Mol Cell Cardiol 2008, 45:168-175.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 168-175
    • Cheng, X.1    Chen, Y.2    Xie, J.J.3    Yao, R.4    Yu, X.5    Liao, M.Y.6
  • 13
    • 27144453293 scopus 로고    scopus 로고
    • A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease
    • Ho P.P., Fontoura P., Platten M., Sobel R.A., DeVoss J.J., Lee L.Y., et al. A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. J Immunol 2005, 175:6226-6234.
    • (2005) J Immunol , vol.175 , pp. 6226-6234
    • Ho, P.P.1    Fontoura, P.2    Platten, M.3    Sobel, R.A.4    DeVoss, J.J.5    Lee, L.Y.6
  • 14
    • 79953183018 scopus 로고    scopus 로고
    • Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function
    • Yamashita J., Iwamura C., Sasaki T., Mitsumori K., Ohshima K., Hada K., et al. Apolipoprotein A-II suppressed concanavalin A-induced hepatitis via the inhibition of CD4 T cell function. J Immunol 2011, 186:3410-3420.
    • (2011) J Immunol , vol.186 , pp. 3410-3420
    • Yamashita, J.1    Iwamura, C.2    Sasaki, T.3    Mitsumori, K.4    Ohshima, K.5    Hada, K.6
  • 15
    • 0034661995 scopus 로고    scopus 로고
    • Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen
    • Ohta A., Sekimoto M., Sato M., Koda T., Nishimura S., Iwakura Y., et al. Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. J Immunol 2000, 165:956-961.
    • (2000) J Immunol , vol.165 , pp. 956-961
    • Ohta, A.1    Sekimoto, M.2    Sato, M.3    Koda, T.4    Nishimura, S.5    Iwakura, Y.6
  • 16
    • 73149094279 scopus 로고    scopus 로고
    • CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice
    • Zhang H., Gong Q., Li J.H., Kong X.L., Tian L., Duan L.H., et al. CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice. Int Immunopharmacol 2010, 10:79-85.
    • (2010) Int Immunopharmacol , vol.10 , pp. 79-85
    • Zhang, H.1    Gong, Q.2    Li, J.H.3    Kong, X.L.4    Tian, L.5    Duan, L.H.6
  • 18
    • 0036854891 scopus 로고    scopus 로고
    • Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS
    • Hong F., Jaruga B., Kim W.H., Radaeva S., El-Assal O.N., Tian Z., et al. Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS. J Clin Invest 2002, 110:1503-1513.
    • (2002) J Clin Invest , vol.110 , pp. 1503-1513
    • Hong, F.1    Jaruga, B.2    Kim, W.H.3    Radaeva, S.4    El-Assal, O.N.5    Tian, Z.6
  • 19
    • 33845627683 scopus 로고    scopus 로고
    • Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA
    • González-Périz A., Planagumà A., Gronert K., Miquel R., López-Parra M., Titos E., et al. Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. FASEB J 2006, 20:2537-2539.
    • (2006) FASEB J , vol.20 , pp. 2537-2539
    • González-Périz, A.1    Planagumà, A.2    Gronert, K.3    Miquel, R.4    López-Parra, M.5    Titos, E.6
  • 20
    • 33751189598 scopus 로고    scopus 로고
    • Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice
    • Bea F., Kreuzer J., Preusch M., Schaab S., Isermann B., Rosenfeld M.E., et al. Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2006, 26:2787-2792.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2787-2792
    • Bea, F.1    Kreuzer, J.2    Preusch, M.3    Schaab, S.4    Isermann, B.5    Rosenfeld, M.E.6
  • 21
    • 70350605493 scopus 로고    scopus 로고
    • Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice
    • Fushimi S., Ogino T., Hara J., Takahata T., Wakabayashi H., Watanabe H., et al. Forced expression of suppressor of cytokine signaling 3 in T cells protects the development of concanavalin A-induced hepatitis in mice. Clin Immunol 2009, 133:437-446.
    • (2009) Clin Immunol , vol.133 , pp. 437-446
    • Fushimi, S.1    Ogino, T.2    Hara, J.3    Takahata, T.4    Wakabayashi, H.5    Watanabe, H.6
  • 22
    • 0030017301 scopus 로고    scopus 로고
    • Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A
    • Küsters S., Gantner F., Künstle G., Tiegs G. Interferon gamma plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 1996, 111:462-471.
    • (1996) Gastroenterology , vol.111 , pp. 462-471
    • Küsters, S.1    Gantner, F.2    Künstle, G.3    Tiegs, G.4
  • 23
    • 0028795171 scopus 로고
    • Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor
    • Gantner F., Leist M., Lohse A.W., Germann P.G., Tiegs G. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 1995, 21:190-198.
    • (1995) Hepatology , vol.21 , pp. 190-198
    • Gantner, F.1    Leist, M.2    Lohse, A.W.3    Germann, P.G.4    Tiegs, G.5
  • 24
    • 0028349904 scopus 로고
    • Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
    • Shuai K., Horvath C.M., Huang L.H., Qureshi S.A., Cowburn D., Darnell J.E. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 1994, 76:821-828.
    • (1994) Cell , vol.76 , pp. 821-828
    • Shuai, K.1    Horvath, C.M.2    Huang, L.H.3    Qureshi, S.A.4    Cowburn, D.5    Darnell, J.E.6
  • 25
    • 0032103969 scopus 로고    scopus 로고
    • Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma
    • Miner K.T., Croft M. Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma. J Immunol 1998, 160:5280-5287.
    • (1998) J Immunol , vol.160 , pp. 5280-5287
    • Miner, K.T.1    Croft, M.2
  • 26
    • 0031569126 scopus 로고    scopus 로고
    • Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type1 and 2 phenotype
    • Nakamura T., Lee R.K., Nam S.Y., Podack E.R., Bottomly K., Flavell R.A. Roles of IL-4 and IFN-gamma in stabilizing the T helper cell type1 and 2 phenotype. J Immunol 1997, 158:2648-2653.
    • (1997) J Immunol , vol.158 , pp. 2648-2653
    • Nakamura, T.1    Lee, R.K.2    Nam, S.Y.3    Podack, E.R.4    Bottomly, K.5    Flavell, R.A.6
  • 27
    • 48849089879 scopus 로고    scopus 로고
    • Synthetic oligonucleotides as modulators of inflammation. Synthetic oligonucleotides as modulators of inflammation
    • Klinman D., Shirota H., Tross D., Sato T., Klaschik S. Synthetic oligonucleotides as modulators of inflammation. Synthetic oligonucleotides as modulators of inflammation. J Leukoc Biol 2008, 84:958-964.
    • (2008) J Leukoc Biol , vol.84 , pp. 958-964
    • Klinman, D.1    Shirota, H.2    Tross, D.3    Sato, T.4    Klaschik, S.5
  • 29
    • 0031201023 scopus 로고    scopus 로고
    • Suppression of concanavalin A-induced hepatitis in IFN-gamma (-/-) mice, but not in TNF-alpha (-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes
    • Tagawa Y., Sekikawa K., Iwakura Y. Suppression of concanavalin A-induced hepatitis in IFN-gamma (-/-) mice, but not in TNF-alpha (-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes. J Immunol 1997, 159:1418-1428.
    • (1997) J Immunol , vol.159 , pp. 1418-1428
    • Tagawa, Y.1    Sekikawa, K.2    Iwakura, Y.3
  • 30
    • 0033590929 scopus 로고    scopus 로고
    • IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes
    • Kano A., Haruyama T., Akaike T., Watanabe Y. IRF-1 is an essential mediator in IFN-gamma-induced cell cycle arrest and apoptosis of primary cultured hepatocytes. Biochem Biophys Res Commun 1999, 257:672-677.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 672-677
    • Kano, A.1    Haruyama, T.2    Akaike, T.3    Watanabe, Y.4
  • 31
    • 0042834253 scopus 로고    scopus 로고
    • Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes
    • Jaruga B., Hong F., Sun R., Radaeva S., Gao B. Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes. J Immunol 2003, 171:3233-3244.
    • (2003) J Immunol , vol.171 , pp. 3233-3244
    • Jaruga, B.1    Hong, F.2    Sun, R.3    Radaeva, S.4    Gao, B.5
  • 33
    • 33745310159 scopus 로고    scopus 로고
    • Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs
    • Klinman D.M., Gursel I., Klaschik S., Dong L., Currie D., Shirota H. Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs. Ann NY Acad Sci 2005, 1058:87-95.
    • (2005) Ann NY Acad Sci , vol.1058 , pp. 87-95
    • Klinman, D.M.1    Gursel, I.2    Klaschik, S.3    Dong, L.4    Currie, D.5    Shirota, H.6
  • 34
    • 33745699554 scopus 로고    scopus 로고
    • The T-box transcription factor T-bet in immunity and autoimmunity
    • Peng S.L. The T-box transcription factor T-bet in immunity and autoimmunity. Cell Mol Immunol 2006, 3:87-95.
    • (2006) Cell Mol Immunol , vol.3 , pp. 87-95
    • Peng, S.L.1
  • 35
    • 0036139684 scopus 로고    scopus 로고
    • Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages
    • Rosen H.R., Miner C., Sasaki A.W., Lewinsohn D.M., Conrad A.J., Bakke A., et al. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology 2002, 35:190-198.
    • (2002) Hepatology , vol.35 , pp. 190-198
    • Rosen, H.R.1    Miner, C.2    Sasaki, A.W.3    Lewinsohn, D.M.4    Conrad, A.J.5    Bakke, A.6
  • 36
    • 0035053878 scopus 로고    scopus 로고
    • The lymphoid liver: considerations on pathways to autoimmune injury
    • Kita H., Mackay I.R., Van De Water J., Gershwin M.E. The lymphoid liver: considerations on pathways to autoimmune injury. Gastroenterology 2001, 120:1485-1501.
    • (2001) Gastroenterology , vol.120 , pp. 1485-1501
    • Kita, H.1    Mackay, I.R.2    Van De Water, J.3    Gershwin, M.E.4
  • 37
    • 4444352518 scopus 로고    scopus 로고
    • Immunologic mechanisms of alcoholic liver injury
    • Thiele G.M., Freeman T.L., Klassen L.W. Immunologic mechanisms of alcoholic liver injury. Semin Liver Dis 2004, 24:273-287.
    • (2004) Semin Liver Dis , vol.24 , pp. 273-287
    • Thiele, G.M.1    Freeman, T.L.2    Klassen, L.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.