The new use of an ancient remedy: A double-blinded randomized study on the treatment of rheumatoid arthritis

American Journal of Chinese Medicine

Volumn 41, Issue 2, 2013, Pages 263-280

  Chen, Letian ^a   Qi, Haiyu ^a   Jiang, Dezhen ^a   Wang, Renshuo ^a   Chen, Aidong ^a   Yan, Zhixiang ^b   Xiao, Jun ^c,d  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b University of Macau   (Macao)

^c UNIVERSITY OF MINNESOTA   (United States)

^d Macrohard Institute of Health   (United States)

Author keywords

Cervus and Cucumis Polypeptide Injection; Disease Modifying Antirheumatic Drugs; Peoniflorin; Rheumatoid Arthritis

Indexed keywords

CERVUS CUCUMIS POLYPEPTIDE; HERBACEOUS AGENT; LEFLUNOMIDE; METHOTREXATE; PAEONIFLORIN; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALOPECIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHINESE MEDICINE; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; DYSPEPSIA; FATIGUE; FEMALE; GLUCOSE BLOOD LEVEL; HEADACHE; HUMAN; HYPERTENSION; INSOMNIA; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MOUTH ULCER; NAUSEA; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RASH; RESPIRATORY TRACT INFECTION; RHEUMATOID ARTHRITIS; RHINITIS; SIDE EFFECT; SINUSITIS; TREATMENT RESPONSE; URINARY TRACT INFECTION; VOMITING;

ADULT; AGED; ARTHRITIS, RHEUMATOID; DRUG THERAPY, COMBINATION; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; MALE; MIDDLE AGED; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84876266381     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500195     Document Type: Article

References (50)

1. Arnett, F.C., S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, H.S. Luthra, T.A. Medsger, D.M. Mitchell, D.H. Neustadt, R.S. Pinals,J.G. Schaller, J.T. Sharp, R.L. Wilder and G.G. Hunder. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31: 315-324, 1988
2. Bathon, J.M., R.W. Martin, R.M. Fleischmann, J.R. Tesser, M.H. Schiff, E.C. Keystone, M.C. Genovese, M.C. Wasko, L.W. Moreland, A.L. Weaver, J. Markenson and B.K. Finck. A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N. Engl. J. Med. 343: 1586-1593, 2000
3. Calandra, T. and T. Roger. Mactophage migration inhibitory factor: A regulator of innate immunity. Nat. Rev. Immunol. 3: 791-800, 2003
4. Chang, Y., L. Zhang, C. Wang, X.Y. Jia and W. Wei. Paeoniflorin inhibits function of synoviocytes pretreated by rIL-1- and regulates EP4 receptor expression. J. Ethnopharmacol. 137: 1275-1282, 2011
5. Elenkov, I.J. and G.P. Chrousos. Stress hormones, proinflammatory and anti-inflammatory cytokines,and autoimmunity. Ann. N. Y. Acad. Sci. 966: 290-303, 2002
6. Felson, D.T., J.J. Anderson, M. Boers, C. Bombardier, D. Furst, C. Goldsmith, L.M. Katz, R. Jr. Lightfoot, H. Paulus, V. Strand, P. Tugwell, M. Weinblatt, H.J. Williams, F. Wolfe and S. Kieszak. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 38: 727-735, 1995
7. Fox, D.A. The role of T cells in the immunopathogenesis of rheumatoid arthritis. Arthritis. Rheum. 40: 598-609, 1997
8. Guo, S.Y., L.J. Lin, H. Chu, C. Yang, D.D. Gong, J. Tian and H.X. Fu. Efficacy of Lugua polypeptide injection on active rheumatoid arthritis. Chin. J. Orthop. Trauma 21: 610-612, 2008
9. Herman, S., N. Zurgil, S. Machlav, A. Shinberg, P. Langevitz, M. Ehrenfeld and M. Deutsch. Distinct effects of anti-tumor necrosis factor combined therapy on TH1/TH2 balance in rheumatoid arthritis patients. Clin. Vaccine Immunol. 7: 1077-1082, 2011
10. Hobl, E.L., R.M. Mader, B. Jilma, B. Duhm, M. Mustak, H. Bröll, P. Högger and L. Erlacher. A randomized, double-blind, parallel, single-site pilot trial to compare two different starting doses of methotrexate in methotrexate-naïve adult patients with rheumatoid arthritis. Clin. Ther. 34: 1195-1203, 2012
11. Hurlimann, D., A. Forster, G. Noll, F. Enseleit, R. Chenevard and O. Distler. Anti-tumor necrosis factor- treatment improves endothelial function in patients with rheumatoid arthritis. Circulation 106: 2184-2187, 2002
12. Joosten, L.A.B., M.M.A. Helsen, T. Saxne, F.A.J. van De Loo, D. Heinegard and W.B. van Den Berg. IL-1-b blockade prevents cartilage and bone destruction in murine type II collageninduced arthritis, whereas TNF- blockade only ameliorates joint inflammation. J. Immunol. 163: 5049-5055, 1999
13. Ju, D., H. Jia, H. Wu, C. Xiao, J. Zhou, H. Zhao, J. Teng and J. Pan. Effect of Lugua polypeptide injection on blood serum activity of TNF-, IL-6 and C II antibody in rats with immune arthritis induced by type II collagen. Chin. J. Basic Med. Tradit. Chin. Med. 9: 817-820,2003
14. Ju, D., C. Zhang, H. Wu, H. Jia, H. Zhao, C. Xiao, M. Liu and Y. Li. Effect of Lugua polypeptide injection on MMP3 and TIMP-1 mRNA Expression in synovium in rats with immune arthritis induced by type II collagen. Chin. J. Basic. Med. Tradit. Chin. Med. 11: 27-31, 2005
15. Katsuyama, M., R. Ikeqama, H. Karahashi, F. Amano, Y. Sugimoto and A. Ichikawa. Characterization of the LPS-stimulated expression of EP2 and EP4 prostaglandin E receptors in mouse macrophage-like cell line, J774.1. Biochem. Biophys. Res. Commun. 251: 727-731, 1998
16. Kim, H.R., M.K. Park, M.L. Cho, C.H. Yoon, S.H. Lee, S.H. Park, L. Leng, R. Bucala, I. Kang,J. Choe and H.Y. Kim. Macrophage migration inhibitory factor upregulates angiogenic factors and correlates with clinical measures in rheumatoid arthritis. J. Rheumatol. 34: 927-936, 2007
17. Kinne, R.W., B. Stuhlmuller, E. Palombo-Kinne and G.R. Burmester. The role of macrophages in rheumatoid arthritis. In G.S. Firestein, G.S. Panayi and F.A. Wollheim (eds.), Rheumatoid Arthritis. Oxford University Press, New York, 2006, pp. 55-75
18. Kremer, J., M. Genovese, G.W. Cannon, J. Caldwell, J. Cush, D.E. Furst, M. Luggen, E. Keystone,J. Bathon, A. Kavanaugh, E. Ruderman, P. Coleman, D. Curtis, E. Kopp, S. Kantor,M. Weisman, J. Waltuck, H.B. Lindsley, J. Markenson, B. Crawford, I. Fernando, K. Simpson and V. Strand. Combination leflunomide and methotrexate (MTX) therapy for patients with active rheumatoid arthritis failing MTX monotherapy: open-label extension of a randomized,double-blind, placebo controlled trial. J. Rheumatol. 31: 1521-1531, 2004
19. Kremer, J.M., G.S. Alarcon, R.W. Jr. Lightfoot, R.F. Willkens, D.E. Furst, H.J. Williams, P.B. Dent,and M.E. Weinblatt. Methotrexate for rheumatoid arthritis. Suggested guidelines for monitoring liver toxicity. American College of Rheumatology. Arthritis Rheum. 3: 316-328, 1994
20. Li, Q., J. Liu and Y. Duan. Influence of cervus and cucumis polypeptide injection on expression of BMP2 in cancellous bone, and its bone mineral density and biomechanical properties in ovariectomized rats. Chin. J. Osteoporos. 12: 602-606, 2006
21. Luo, X. (ed.). Compendium of Materia Medica for Emergencies (Jingshi Zhenglei Jibei Bencao). Chinese Medical Science and Technology Press, Beijing, 1993
22. Mor, A., S.B. Abramson and M.H. Pillinger. The fibroblast-like synovial cell in rheumatoid arthritis: A key player in inflammation and joint destruction. Clin. Immunol. 115: 118-128, 2005
23. Mulherin, D., O. Fitzgerald and B. Bresnihan. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 39: 115-124, 1996
24. Omote, K., T. Kawamata, Y. Nakayama, H. Yamamoto, M. Kawamata and A. Namiki. Effects of a novel selective agonist for prostaglandin receptor subtype EP4 on hyperalgesia and inflammation in monoarthritic model. Anesthesiology 97: 170-176, 2002
25. Population Reference Bureau. 2011 World Population Data Sheet. http://www.prb.org/pdf11/ 2011population-data-sheet eng.pdf. Accessed on April 1, 2012
26. Shang, Z.J. (ed.). Kai Bao Materia Medica (Kaibao Bencao). Anhui Science and Technology Press,Hefei, 1998
27. Sokka, T., H. Kautiainen, T. Möttönen and P. Hannonen. Work disability in rheumatoid arthritis 10 years after the diagnosis. J. Rheumatol. 26: 1681-1685, 1999
28. Sokka, T. Work disability in early rheumatoid arthritis. Clin. Exp. Rheumatol. 21(5 Suppl 31): S71-74,2003
29. Su, J. (ed.). Newly Revised Canon of Materia Medica (Xinxiu Bencao). Anhui Science and Technology Press, Hefei, 2004
30. Sun, X.Y. (ed.). Shen Nong's Herbal Classic (Shennong Bencao Jing). People's Medical Publishing House, Beijing, 1963
31. Sun, H., X. Yu, S. Qu, H. Xu and D. Su. Study on therapeutic effects of Lugua Polypeptide Solution (LGPS) on adjuvant arthritis in rats and its mechanism. Chin. Pharm. J. 143: 502-506, 2008
32. Sun, Y., Y. Dong, H.J. Jiang, T.T. Cai, L. Chen, X. Zhou, T. Chen and Q. Xu. Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice, Life Sci. 84: 337-344, 2009
33. Tanaka, M., A. Sakai, S. Uchida, S. Tanaka, M. Nagashima, T. Katayama, K. Yamaguchi and T. Nakamura. Prostaglandin E2 receptor (EP4) selective agonist (ONO-4819.CD) accelerates bone repair of femoral cortex after drill-hole injury associated with local up regulation of bone turnover in mature rats. Bone 34: 940-948, 2004
34. Tao, Q., Y. Xu, D. Jin, P. Lu, J. Wang, W. Luo, W. Kong and X. Yan. Clinical effect and safety of Lugua Polypeptide injection in the treatment of rheumatoid arthritis. J. Clin. Orthop. 14: 336-338, 2011
35. Tran, C.N., S.K. Lundy and D.A. Fox. Synovial biology and T cells in rheumatoid arthritis. Pathophysiology 12: 183-189, 2005
36. Tsuboi, H., K. Hossain, A.A. Akhand, K. Takeda, J. Du, M. Rifa'i, Y. Dai, A. Hayakawa, H. Suzuki and I. Nakashima. Paeoniflorin induces apoptosis of lymphocytes through a redoxlinked mechanism. J. Cell. Biochem. 93: 162-172, 2004
37. Wakabayashi, K., K. Otsuka, M. Sato, R. Takahashi, T. Odai, T. Isozaki, N. Yajima, Y. Miwa and T. Kasama. Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity. Mod. Rheumatol. 22: 59-65, 2012
38. Wu, X.Z. (ed.). Classic Classified Materia Medica for Emergencies (Jingshi Zhenglei Jibei Bencao). Chinese Medical Science and Technology Press, Beijing, 1993
39. Wu, H., W. Wei, L.H. Song, L. Zhang, Y. Chen and X. Hu. Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. Int. Immunopharmacol. 7: 662-673, 2007
40. Xu, X., F. Li, K. Li and H. Wu. The effect of cervus and cucumls polypeptide injection on proliferation and osteogenic differentiation of rat osteoblasts (article in Chinese with English abstract). Chin. J. Tradit. Med. Traum. Orthop. 19: 6-8, 2011
41. Yamahara, J., T. Yamada, H. Kimura, T. Sawada and H. Fujimura. Biologically active principles of crude drugs. II. Anti-allergic principles in "Shoseiryu-To" anti-inflammatory properties of paeoniflorin and its derivatives. J. Pharmacobiodyn. 5: 921-929, 1982
42. Yamane, H., Y. Sugimoto, S. Tanaka and A. Ichikawa. Prostaglandin E(2) receptors EP2 and EP4,differentially modulate TNF-alpha and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils. Biochem. Biophys. Res. Commun. 278: 224-228, 2000
43. Zhang, L.L., W. Wei, N.P. Wang, Q.T. Wang, J.Y. Chen, Y. Chen, H. Wu and X.Y. Hu. Paeoniflorin suppresses inflammatory mediator production and regulates G protein-coupled signaling in fibroblast-like synoviocytes of collagen induced arthritic rats. Inflamm. Res. 57: 388-395, 2008
44. Zhao, G.Y., Q.S. Zhu and C.S. Lu. Clinical observation of cervus and cucumis polypeptide for injection used in limbs backbone fracture, Chin. J. Bone Joint Injury 20: 537-538, 2005
45. Zhao, Z.X., Y. Hao and X.L. Ru. Efficacy of cervus and cucumis polypeptide for injection used in treating primary osteoporosis, Chin. J. Bone Joint Injury 21: 500-501, 2006
46. Zheng, Y.Q., W. Wei, L. Zhu and J.X. Liu. Effects and mechanisms of paeoniflorin, a bioactive glucoside from paeony root, on adjuvant arthritis in rats. Inflamm. Res. 56: 182-188, 2007
47. Zhu, L., W. Wei, Y.Q. Zheng and X.Y. Jia. Effects and mechanisms of total glucosides of paeony on joint damage in rat collageninduced arthritis. Inflamm. Res. 54: 211-220, 2005
48. Zhu, L., W. Wei and Y.Q. Zheng. Effect and mechanism of action of total glucosides of paeony on synoviocytes fromrats with collagen-induced arthritis. Acta. Pharmacol. Sin. 41: 166-170, 2006
49. Zhu, Y., W. Lin, F. Yang, X. Cao, C. Chen and X. Cai. Lugua polypeptide injection in the treatment of rheumatoid arthritis. J. Clin. Orthop. 14: 334-336, 2011
50. Zou, R., B. Feng, Y. Qiu and Y. Chen. Influence of cervus and cucumis polypeptide on the bone mineral density (BMD) biomechanical properties in ovariectomized rats. J. Pract. Orthop. 16: 825-828, 2010