A Randomized, Double-Blind, Parallel, Single-Site Pilot Trial to Compare Two Different Starting Doses of Methotrexate in Methotrexate-Naïve Adult Patients with Rheumatoid Arthritis

Clinical Therapeutics

Volumn 34, Issue 5, 2012, Pages 1195-1203

  Hobl, Eva Luise ^a   Mader, Robert M ^a   Jilma, Bernd ^a   Duhm, Bernhard ^b   Mustak, Monika ^b   Bröll, Hans ^c   Högger, Petra ^d   Erlacher, Ludwig ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b KAISER FRANZ JOSEF HOSPITAL   (Austria)

^c Ludwig Boltzmann Cluster for Rheumatology   (Austria)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Clinical response; Methotrexate; Pharmacokinetics; Rheumatoid arthritis; Starting dosage

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATININE; METHOTREXATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE ACTIVITY; DISEASE ACTIVITY SCORE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG TOLERABILITY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; GASTROINTESTINAL DISEASE; HEADACHE; HEALTH ASSESSMENT QUESTIONNAIRE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYPERTRANSAMINASEMIA; INFLAMMATION; JOINT SWELLING; MALE; NAUSEA; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; STOMATITIS; TREATMENT RESPONSE; VERTIGO; XEROSTOMIA;

ADULT; AGED; ANTIRHEUMATIC AGENTS; AREA UNDER CURVE; ARTHRITIS, RHEUMATOID; BLOOD SEDIMENTATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; METHOTREXATE; MIDDLE AGED; PILOT PROJECTS; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX; TIME FACTORS; TREATMENT OUTCOME;

EID: 84860736264     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2012.03.059     Document Type: Article

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