Recombinant PTD-Cu/Zn SOD attenuates hypoxia-reoxygenation injury in cardiomyocytes

Free Radical Research

Volumn 47, Issue 5, 2013, Pages 386-393

  Liu, J ^a,b   Hou, J ^a   Xia, Z Y ^a   Zeng, W ^b   Wang, X ^b   Li, R ^b   Ke, C ^b   Xu, J ^a   Lei, S ^a   Xia, Z ^c,d  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Cardiomyocyte; Copper zinc superoxide dismutase; Hypoxia reoxygenation injury; Protein transduction domain

Indexed keywords

ANTIOXIDANT; HYDROGEN PEROXIDE; PLASMID VECTOR; RECOMBINANT PROTEIN TRANSDUCTION DOMAIN COPPER ZINC SUPEROXIDE DISMUTASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DAMAGE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; FLOW CYTOMETRY; HEART MUSCLE CELL; HYPOXIA; HYPOXIA REOXYGENATION INJURY; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; NONHUMAN; PROTEIN EXPRESSION; RAT; REOXYGENATION; WESTERN BLOTTING;

ANIMALS; ANOXIA; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; RECOMBINANT FUSION PROTEINS; SUPEROXIDE DISMUTASE; SUPEROXIDES;

PROKARYOTA; RATTUS;

EID: 84876205743     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2013.780286     Document Type: Article

References (55)

1. Serviddio G, Di Venosa N, Federici A, D ' Agostino D, Rollo T, Prigigallo F, et al . Brief hypoxia before normoxic reperfusion (postconditioning) protects the heart against ischemia-reperfusion injury by preventing mitochondria peroxyde production and glutathione depletion . FASEB J 2005; 19 : 354-361.
2. Luo X, Cai H, Ni J, Bhindi R, Lowe HC, Chesterman CN, Khachigian LM . c-Jun DNAzymes inhibit myocardial inflammation, ROS generation, infarct size, and improve cardiac function after ischemia-reperfusion injury . Arterioscler Thromb Vasc Biol 2009; 29 : 1836-1842.
3. Loor G, Kondapalli J, Schriewer JM, Chandel NS, Vanden Hoek TL, Schumacker PT . Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis . Free Radic Biol Med 2010; 49 : 1925-1936.
4. Liu J, Simon LM, Phillips JR, Robin ED . Superoxide dismutase (SOD) activity in hypoxic mammalian systems . J Appl Physiol 1977; 42 : 107-110.
5. Watanabe N, Inoue M, Morino Y . Inhibition of postischemic reperfusion arrhythmias by an SOD derivative that circulates bound to albumin with prolonged in vivo half-life . Biochem Pharmacol 1989; 38 : 3477-3483.
6. Reddi AR, Jensen LT, Naranuntarat A, Rosenfeld L, Leung E, Shah R, Culotta VC . The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection . Free Radic Biol Med 2009; 46 : 154-162.
7. Goldhaber JI, Weiss JN . Oxygen free radicals and cardiac reperfusion abnormalities . Hypertension 1992; 20 : 118-127.
8. Hwang IK, Eum WS, Yoo KY, Cho JH, Kim DW, Choi SH, et al . Copper chaperone for Cu,Zn-SOD supplement potentiates the Cu,Zn-SOD function of neuroprotective eff ects against ischemic neuronal damage in the gerbil hippocampus . Free Radic Biol Med 2005; 39: 392- 402.
9. Francis JW, Ren J, Warren L, Brown RH Jr, Finklestein SP . Postischemic infusion of Cu/Zn superoxide dismutase or SOD:Tet451 reduces cerebral infarction following focal ischemia/reperfusion in rats. Exp Neurol 1997; 146: 435-443.
10. Yoshida T, Maulik N, Engelman RM, Ho YS, Das DK . Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury . Circ Res 2000; 86 : 264-269.
11. Maczewski M, Duda M, Pawlak W, Beresewicz A . Endothelial protection from reperfusion injury by ischemic preconditioning and diazoxide involves a SOD-like anti-O2- mechanism . J Physiol Pharmacol 2004; 55 : 537-550.
12. Sarvazyan N, Askari A, Klevay LM, Askari A, Huang WH . Role of intracellular SOD in oxidant-induced injury to normal and copper-defi cient cardiac myocytes . Am J Physiol 1995; 268 : H1115-1121.
13. Kaipel M, Wagner A, Wassermann E, Vorauer-Uhl K, Kellner R, Redl H, et al . Increased biological half-life of aerosolized liposomal recombinant human Cu/Zn superoxide dismutase in pigs . J Aerosol Med Pulm Drug Deliv 2008; 21 : 281-290.
14. Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ . Crystal structures of holo and Cu-defi cient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis . Proteins 2010; 78 : 1999-2004.
15. Tan SX, Teo M, Lam YT, Dawes IW, Perrone GG . Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae . Mol Biol Cell 2009; 20 : 1493-1508.
16. Yang Q, Larsen SK, Mi Z, Robbins PD, Basse PH . PTD-mediated loading of tumor-seeking lymphocytes with prodrugactivating enzymes . AAPS J 2008; 10 : 614-621.
17. Yan X, Walayat S, Shi Q, Zheng J, Wang Y . Development of a soluble PTD-HPV18E7 fusion protein and its functional characterization in eukaryotic cells . Acta Biochim Biophys Sin (Shanghai) 2009; 41 : 900-909.
18. Huang C, Du R, Zhang P, Meng H, Jia H, Song Y, et al. Expression, purifi cation, and functional characterization of recombinant PTD-SARA . Acta Biochim Biophys Sin (Shanghai) 2011; 43 : 110-117.
19. Kwon YM, Li YT, Liang JF, Park YJ, Chang LC, Yang VC . PTD-modifi ed ATTEMPTS system for enhanced asparaginase therapy: A proof-of-concept investigation . J Control Release 2008; 130 : 252-258.
20. Benov LT, Beyer WJ, Stevens RD, Fridovich I . Purifi cation and characterization of the Cu,Zn SOD from Escherichia coli . Free Radic Biol Med 1996; 21: 117- 121.
21. Palm-Apergi C, Eguchi A, Dowdy SF . PTD-DRBD siRNA delivery . Methods Mol Biol 2011; 683 : 339-347.
22. Batinic-Haberle I, Rajic Z, Tovmasyan A, Reboucas JS, Ye X, Leong KW, et al . Diverse functions of cationic Mn(III) Nsubstituted pyridylporphyrins, recognized as SOD mimics . Free Radic Biol Med 2011; 51: 1035- 1053.
23. Popiel HA, Nagai Y, Fujikake N, Toda T . Protein transduction domain-mediated delivery of QBP1 suppresses polyglutamineinduced neurodegeneration in vivo. Mol Ther 2007; 15: 303- 309.
24. Zhang YE, Wang JN, Tang JM, Guo LY, Yang JY, Huang YZ, et al . In vivo protein transduction: Delivery of PEP-1-SOD1 fusion protein into myocardium effi ciently protects against ischemic insult . Mol Cells 2009; 27 : 159-166.
25. Bodor C, Matolcsy A, Bernath M . Elevated expression of Cu, Zn-SOD and Mn-SOD mRNA in inflamed dental pulp tissue . Int Endod J 2007; 40 : 128-132.
26. Yu Z, He X, Fu D, Zhang Y . Two superoxide dismutase (SOD) with diff erent subcellular localizations involved in innate immunity in Crassostrea hongkongensis . Fish Shellfi sh Immunol 2011; 31 : 533-539.
27. Park SJ, Lee JH, Kim HY, Choi YH, Park JS, Suh YH, et al. Astrocytes, but not microglia, rapidly sense H(2)O(2)via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release. J Immunol 2012; 188: 5132- 5141.
28. Zhang Y, Shi G, Zheng J, Lv Y, Gao P, Huang Z, et al . The protective eff ect of Egr-1 antisense oligodeoxyribonucleotide on myocardial injury induced by ischemia-reperfusion and hypoxiareoxygenation. Cell Physiol Biochem 2008; 22: 645- 652.
29. Martou G, O ' Blenes CA, Huang N, McAllister SE, Neligan PC, Ashrafpour H, et al . Development of an in vitro model for study of the effi cacy of ischemic preconditioning in human skeletal muscle against ischemia-reperfusion injury . J Appl Physiol 2006; 101 : 1335-1342.
30. D ' Agostino DP, Putnam RW, Dean JB . Superoxide (.*O2-) production in CA1 neurons of rat hippocampal slices exposed to graded levels of oxygen. J Neurophysiol 2007; 98: 1030- 1041.
31. Padmini E, Usha RM . Mitochondrial membrane potential is a suitable candidate for assessing pollution toxicity in fi sh . Sci Total Environ 2011; 409 : 3687-3700.
32. Perry SW, Norman JP, Barbieri J, Brown EB, Gelbard HA . Mitochondrial membrane potential probes and the proton gradient: A practical usage guide. Biotechniques 2011; 50: 98- 115.
33. Walter D, Matter A, Fahrenkrog B . Bre1p-mediated histone H2B ubiquitylation regulates apoptosis in Saccharomyces cerevisiae . J Cell Sci 2010; 123 : 1931-1939.
34. Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D, et al . H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells . J Cell Sci 1998; 111 : 3209-3220.
35. Simkova V, Baumgart K, Vogt J, Wachter U, Weber S, Gr ö ger M, et al . The eff ect of superoxide dismutase overexpression on hepatic gluconeogenesis and whole-body glucose oxidation during resuscitated normotensive murine septic shock . Shock 2008; 30 : 578-584.
36. Ulker S, McMaster D, McKeown PP, Bayraktutan U . Impaired activities of antioxidant enzymes elicit endothelial dysfunction in spontaneous hypertensive rats despite enhanced vascular nitric oxide generation. Cardiovasc Res 2003; 59: 488- 500.
37. Hellman LM, Zhao C, Melikishvili M, Tao X, Hopper JE, Whiteheart SW, Fried MG . Histidine-tag-directed chromophores for tracer analyses in the analytical ultracentrifuge . Methods 2011; 54 : 31-38.
38. Aksenov MY, Aksenova MV, Markesbery WR, Butterfi eld DA . Amyloid beta-peptide (1- 40)-mediated oxidative stress in cultured hippocampal neurons . Protein carbonyl formation, CK BB expression, and the level of Cu, Zn, and Mn SOD mRNA. J Mol Neurosci 1998; 10: 181- 192.
39. Rui T, Kvietys PR . NFkappaB and AP-1 diff erentially contribute to the induction of Mn-SOD and eNOS during the development of oxidant tolerance. FASEB J 2005; 19: 1908- 1910.
40. Xu XM, Lin H, Maple J, Bj ö rkblom B, Alves G, Larsen JP, Møller SG . The Arabidopsis DJ-1a protein confers stress protection through cytosolic SOD activation . J Cell Sci 2010; 123 : 1644-1651.
41. Halestrap AP, Kerr PM, Javadov S, Woodfi eld KY . Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart . Biochim Biophys Acta 1998; 1366 : 79-94.
42. Zoratti M, Szabo I . The mitochondrial permeability transition . Biochim Biophys Acta 1995; 1241 : 139-176.
43. Salvioli S, Ardizzoni A, Franceschi C, Cossarizza A . JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fl uorescent probe to assess delta psi changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis . FEBS Lett 1997; 411 : 77-82.
44. Suzuki K, Kostin S, Person V, Els ä sser A, Schaper J . Time course of the apoptotic cascade and eff ects of caspase inhibitors in adult rat ventricular cardiomyocytes . J Mol Cell Cardiol 2001; 33 : 983-994.
45. Khaidakov M, Szwedo J, Mitra S, Ayyadevara S, Dobretsov M, Lu J, Mehta JL . Antiangiogenic and antimitotic eff ects of aspirin in hypoxia-reoxygenation modulation of the LOX-1- NADPH oxidase axis as a potential mechanism . J Cardiovasc Pharmacol 2010; 56 : 635-641.
46. Green M, Loewenstein PM . Autonomous functional domains of chemically synthesized human immunodefi ciency virus tat trans-activator protein. Cell 1988; 55: 1179- 1188.
47. Frankel AD, Pabo CO . Cellular uptake of the tat protein from human immunodefi ciency virus . Cell 1988; 55 : 1189-1193.
48. Ho A, Schwarze SR, Mermelstein SJ, Waksman G, Dowdy SF . Synthetic protein transduction domains: Enhanced transduction potential in vitro and in vivo . Cancer Res 2001; 61 : 474-477.
49. Flynn CR, Cheung-Flynn J, Smoke CC, Lowry D, Roberson R, Sheller MR, Brophy CM . Internalization and intracellular traffi cking of a PTD-conjugated anti-fi brotic peptide, AZX100, in human dermal keloid fi broblasts . J Pharm Sci 2010; 99 : 3100-3121.
50. Derossi D, Joliot AH, Chassaing G, Prochiantz A . The third helix of the Antennapedia homeodomain translocates through biological membranes . J Biol Chem 1994; 269 : 10444-10450.
51. Vives E, Brodin P, Lebleu B. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus . J Biol Chem 1997; 272 : 16010-16017.
52. Yoon JS, Jung YT, Hong SK, Kim SH, Shin MC, Lee DG, et al . Characteristics of HIV-Tat protein transduction domain . J Microbiol 2004; 42 : 328-335.
53. Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ . Identifi cation of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofi laments . J Biol Chem 2007; 282 : 183-193.
54. Hu J, Mukhopadhyay A, Truesdell P, Chander H, Mukhopadhyay UK, Mak AS, Craig AW . Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis . J Cell Sci 2011; 124 : 1739-1751.
55. Yu C, Wang P, Li S, Wang X, Yu Z, Wang Z . The protective eff ect of Cu/Zn-SOD against oxidative stress after PTEN deletion . Cancer Invest 2011; 29 : 253-256.