The protective effect of Egr-1 antisense oligodeoxyribonucleotide on myocardial injury induced by ischemia-reperfusion and hypoxia-reoxygenation

Cellular Physiology and Biochemistry

Volumn 22, Issue 5-6, 2008, Pages 645-652

  Zhang, Yanmei ^a   Shi, Ganggang ^a,b   Zheng, Jinhong ^b   Lv, Yanqiu ^a   Gao, Ping ^a   Huang, Zhanqin ^a   Gao, Fenfei ^a   Zhou, Yanqiong ^a  

^a First Affiliated Hospital

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Antisense oligodeoxyribonucleotide; Early growth response 1; Hypoxia reoxygenation; Ischemia reperfusion; Myocardial

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; EARLY GROWTH RESPONSE FACTOR 1; MYELOPEROXIDASE; TROPONIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; GENETIC TRANSFECTION; HEART; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART PROTECTION; HEMODYNAMICS; HYPOXIA; IN VITRO STUDY; INFLAMMATION; ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

RATTUS;

EID: 57649200101     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000185548     Document Type: Article

References (29)

1. Yan SF, Pinsky DJ, Mackman N, Stern DM: Egr-1: is it always immediate and early? J Clin Invest 2000;105:553-534.
2. Yan SF, Fujita T, Lu J, Okada K, Shan Zou Y, Mackman N, Pinsky DJ, Stern DM: Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 2000;6:1355-1361.
3. Okada M, Fujita T, Sakaguchi T, Olson KE, Collins T, Stern DM, Yan SF, Pinsky DJ: Extinguishing Egr-1-dependent inflammatory and thrombotic cascades after lung transplantation. FASEB J 2001;15:2757-2759.
4. Okada M, Yan SF, Pinsky DJ: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. FASEB J 2002;16:1861-1868.
5. Pritchard MT, Nagy LE: Ethanol-induced liver injury: potential roles for egr-1. Alcohol Clin Exp Res 2005;29:146S-150S.
6. Hoffman JW Jr, Gilbert TB, Poston RS, Silldorff EP: Myocardial reperfusion injury: etiology, mechanisms, and therapies. J Extra Corpor Technol 2004;36:391-411.
7. Kong L, Andrassy M, Chang JS, Huang C, Asai T, Szabolcs MJ, Homma S, Liu R, Zou YS, Leitges M, Yan SD, Ramasamy R, Schmidt AM, Yan SF: PKCbeta modulates ischemia-reperfusion injury in the heart. Am J Physiol Heart Circ Physiol 2008;294:H1862-70.
8. Brand T, Sharma HS, Fleischmann KE, Duncker DJ, McFalls EO, Verdouw PD, Schaper W: Proto-oncogene expression in porcine myocardium subjected to ischemia and reperfusion. Circ Res 1992;71:1351-1360.
9. Aebert H, Cornelius T, Ehr T, Holmer SR, Birnbaum DE, Riegger GA, Schunkert H: Expression of immediate early genes after cardioplegic arrest and reperfusion. Ann Thorac Surg 1997;63:1669-1675.
10. Fujita T, Asai T, Andrassy M, Stern DM, Pinsky DJ, Zou YS, Okada M, Naka Y, Schmidt AM, Yan SF: PKC beta regulates ischemia/reperfusion injury in the lung. J Clin Invest 2004;113:1615-1623.
11. Chen Y, Lui VC, Rooijen NV, Tam PK: Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. Gut 2004;53:1772-1780.
12. Bonventre JV, Sukhatme VP, Bamberger M, Ouellette AJ, Brown D: Localization of the protein product of the immediate early growth response gene, Egr-1, in the kidney after ischemia and reperfusion. Cell Regul 1991;2:251-260.
13. Zhang YM, Shi GG, Zheng J, Tang Z, Gao P, Lv Y, Guo F, Jia Q: The protective effects of N-n-butyl haloperidol iodide on myocardial ischemia-reperfusion injury in rats by inhibiting Egr-1 expression. Cell Physiol Biochem 2007;20:639-648.
14. Kacimi R, Chentoufi J, Honbo N, Long CS, Karliner JS: Hypoxia differentially regulates stress proteins in cultured cardiomyocytes: role of the p38 stress-activated kinase signaling cascade, and relation to cytoprotection. Cardiovasc Res 2000;46:139-150.
15. Jonassen AK, Brar BK, Mjos OD, Sack MN, Latchman DS, Yellon DM: Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. J Mol Cell Cardiol. 2000;32:757-764.
16. Coleman DL, Bartiss AH, Sukhatme VP, Liu J, Rupprecht HD: Lipopolysaccharide induces Egr-1 mRNA and protein in murine peritoneal macrophages. J Immunol 1992;149:3045-3051.
17. Kaufmann K, Thiel G: Epidermal growth factor and thrombin induced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J Cell Biochem 2002;85:381-391
18. Kaufmann K, Thiel G: Epidermal growth factor and platelet-derived growth factor induce expression of Egr-1, a zinc finger transcription factor, in human malignant glioma cells. J Neurol-Sci 2001;189:83-91
19. Man K, Ng KT, Lee TK, Lo CM, Sun CK, Li XL, Zhao Y, Ho JW, Fan ST: FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. Am J Transplant 2005;5:40-49.
20. Man K, Lee TK, Liang TB, Lo CM, Fung PC, Tsui SH, Li XL, Ng KT, Fan ST: FK 409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway. Ann Surg 2004;240:159-168.
21. Zhang YM, Shi GG, Tang Z, Zheng JH, Li WQ, Guo FX, Jia QY: Effects of N-n-butyl haloperidol iodide on myocardial ischemia/reperfusion injury and Egr-1 expression in rat. Acta Biochim Biophys Sin (Shanghai) 2006;38:435-441.
22. Bhindi R, Khachigian LM,Lowe HC: DNAzymes targeting the transcription factor Egr-1 reduce myocardial infarct size following ischemia-reperfusion in rats. J Thromb Haemost 2006;4:1479-1483.
23. Parekh N, Venkatesh B, Cross D, Leditschke A, Atherton J, Miles W, Winning A, Clague A, Rickard C: Cardiac troponin I predicts myocardial dysfunction in aneurysmal subarachnoid hemorrhage. J Am Coll Cardiol 2000;36:1328-1335.
24. Sorsa T, Pollesello P, Solaro RJ: The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c. Mol Cell Biochem 2004;266:87-107.
25. Bek MJ, Reinhardt HC, Fischer KG, Hirsch JR, Hupfer C, Dayal E, Pavenstadt H: Up-regulation of early growth response gene-1 via the CXCR3 receptor induces reactive oxygen species and inhibits Na+/K+-ATPase activity in an immortalized human proximal tubule cell line. J Immunol 2003;170:931-940.
26. Minc E, de Coppet P, Masson P, Thiery L, Dutertre S, Amor-Guéret M, Jaulin C: The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. J Biol Chem 1999;274:503-509.
27. Porntadavity S, Xu Y, Kiningham K, Rangnekar VM, Prachayasitikul V, St Clair DK: TPA-activated transcription of the human MnSOD gene: role of transcription factors Sp-1 and Egr-1. DNA Cell Biol 2001;20:473-481.
28. Maehara K, Uekawa N, Isobe K: Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene. Biochem Biophys Res Commun 2002;295:187-92.
29. Meldrum, DR, Meng X, Dinarello CA, Ayala A, Cain BS, Shames BD, Ao L, Banerjee A, Harken AH: Human myocardial tissue TNFalpha expression following acute global ischemia in vivo. J Mol Cell Cardiol 1998;30:1683-1689.