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Volumn 8, Issue 4, 2013, Pages

Rac2-Deficiency Leads to Exacerbated and Protracted Colitis in Response to Citrobacter rodentium Infection

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; RAC2 PROTEIN; REACTIVE OXYGEN METABOLITE;

EID: 84876191369     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061629     Document Type: Article
Times cited : (20)

References (42)
  • 1
    • 79955561083 scopus 로고    scopus 로고
    • Epidemiology and natural history of inflammatory bowel diseases
    • Cosnes J, Gower-Rousseau C, Seksik P, Cortot A, (2011) Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 140: 1785-1794.
    • (2011) Gastroenterology , vol.140 , pp. 1785-1794
    • Cosnes, J.1    Gower-Rousseau, C.2    Seksik, P.3    Cortot, A.4
  • 2
    • 85027955735 scopus 로고    scopus 로고
    • Inflammatory bowel disease and colitis: new concepts from the bench and the clinic
    • Vermeire S, Van Assche G, Rutgeerts P, (2011) Inflammatory bowel disease and colitis: new concepts from the bench and the clinic. Curr Opin Gastroenterol 27: 32-37.
    • (2011) Curr Opin Gastroenterol , vol.27 , pp. 32-37
    • Vermeire, S.1    Van Assche, G.2    Rutgeerts, P.3
  • 3
    • 79955566359 scopus 로고    scopus 로고
    • Recent insights into the genetics of inflammatory bowel disease
    • Cho JH, Brant SR, (2011) Recent insights into the genetics of inflammatory bowel disease. Gastroenterology 140: 1704-1712.
    • (2011) Gastroenterology , vol.140 , pp. 1704-1712
    • Cho, J.H.1    Brant, S.R.2
  • 4
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, et al. (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 42: 1118-1125.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5
  • 5
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, et al. (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43: 246-252.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3    Franke, A.4    D'Amato, M.5
  • 6
    • 84861575218 scopus 로고    scopus 로고
    • NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2
    • Muise AM, Xu W, Guo CH, Walters TD, Wolters VM, et al. (2011) NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut.
    • (2011) Gut
    • Muise, A.M.1    Xu, W.2    Guo, C.H.3    Walters, T.D.4    Wolters, V.M.5
  • 7
    • 0028925752 scopus 로고
    • Regulation of the phagocyte respiratory burst by small GTP-binding proteins
    • Bokoch GM, (1995) Regulation of the phagocyte respiratory burst by small GTP-binding proteins. Trends Cell Biol 5: 109-113.
    • (1995) Trends Cell Biol , vol.5 , pp. 109-113
    • Bokoch, G.M.1
  • 8
    • 0026335622 scopus 로고
    • Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2
    • Knaus UG, Heyworth PG, Evans T, Curnutte JT, Bokoch GM, (1991) Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science 254: 1512-1515.
    • (1991) Science , vol.254 , pp. 1512-1515
    • Knaus, U.G.1    Heyworth, P.G.2    Evans, T.3    Curnutte, J.T.4    Bokoch, G.M.5
  • 9
    • 3242799065 scopus 로고    scopus 로고
    • Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils
    • Filippi MD, Harris CE, Meller J, Gu Y, Zheng Y, et al. (2004) Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. Nat Immunol 5: 744-751.
    • (2004) Nat Immunol , vol.5 , pp. 744-751
    • Filippi, M.D.1    Harris, C.E.2    Meller, J.3    Gu, Y.4    Zheng, Y.5
  • 10
    • 0142084736 scopus 로고    scopus 로고
    • Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
    • Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, et al. (2003) Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science 302: 445-449.
    • (2003) Science , vol.302 , pp. 445-449
    • Gu, Y.1    Filippi, M.D.2    Cancelas, J.A.3    Siefring, J.E.4    Williams, E.P.5
  • 11
    • 27744557516 scopus 로고    scopus 로고
    • The role of Rac1 and Rac2 in bacterial killing
    • Koh AL, Sun CX, Zhu F, Glogauer M, (2005) The role of Rac1 and Rac2 in bacterial killing. Cell Immunol 235: 92-97.
    • (2005) Cell Immunol , vol.235 , pp. 92-97
    • Koh, A.L.1    Sun, C.X.2    Zhu, F.3    Glogauer, M.4
  • 12
    • 0036839579 scopus 로고    scopus 로고
    • Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions
    • Li S, Yamauchi A, Marchal CC, Molitoris JK, Quilliam LA, et al. (2002) Chemoattractant-stimulated Rac activation in wild-type and Rac2-deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions. J Immunol 169: 5043-5051.
    • (2002) J Immunol , vol.169 , pp. 5043-5051
    • Li, S.1    Yamauchi, A.2    Marchal, C.C.3    Molitoris, J.K.4    Quilliam, L.A.5
  • 13
    • 0033082165 scopus 로고    scopus 로고
    • Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
    • Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, et al. (1999) Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 10: 183-196.
    • (1999) Immunity , vol.10 , pp. 183-196
    • Roberts, A.W.1    Kim, C.2    Zhen, L.3    Lowe, J.B.4    Kapur, R.5
  • 14
    • 9444238519 scopus 로고    scopus 로고
    • Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass
    • Sun CX, Downey GP, Zhu F, Koh AL, Thang H, et al. (2004) Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass. Blood 104: 3758-3765.
    • (2004) Blood , vol.104 , pp. 3758-3765
    • Sun, C.X.1    Downey, G.P.2    Zhu, F.3    Koh, A.L.4    Thang, H.5
  • 15
    • 12544259676 scopus 로고    scopus 로고
    • Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain
    • Yamauchi A, Marchal CC, Molitoris J, Pech N, Knaus U, et al. (2005) Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem 280: 953-964.
    • (2005) J Biol Chem , vol.280 , pp. 953-964
    • Yamauchi, A.1    Marchal, C.C.2    Molitoris, J.3    Pech, N.4    Knaus, U.5
  • 16
    • 70149115733 scopus 로고    scopus 로고
    • Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2
    • Zhang H, Sun C, Glogauer M, Bokoch GM, (2009) Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol 183: 2718-2728.
    • (2009) J Immunol , vol.183 , pp. 2718-2728
    • Zhang, H.1    Sun, C.2    Glogauer, M.3    Bokoch, G.M.4
  • 17
    • 33746638278 scopus 로고    scopus 로고
    • Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
    • Wheeler AP, Wells CM, Smith SD, Vega FM, Henderson RB, et al. (2006) Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. J Cell Sci 119: 2749-2757.
    • (2006) J Cell Sci , vol.119 , pp. 2749-2757
    • Wheeler, A.P.1    Wells, C.M.2    Smith, S.D.3    Vega, F.M.4    Henderson, R.B.5
  • 18
    • 8444239999 scopus 로고    scopus 로고
    • Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles
    • Yamauchi A, Kim C, Li S, Marchal CC, Towe J, et al. (2004) Rac2-deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles. J Immunol 173: 5971-5979.
    • (2004) J Immunol , vol.173 , pp. 5971-5979
    • Yamauchi, A.1    Kim, C.2    Li, S.3    Marchal, C.C.4    Towe, J.5
  • 19
    • 0142116231 scopus 로고    scopus 로고
    • Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
    • Walmsley MJ, Ooi SK, Reynolds LF, Smith SH, Ruf S, et al. (2003) Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 302: 459-462.
    • (2003) Science , vol.302 , pp. 459-462
    • Walmsley, M.J.1    Ooi, S.K.2    Reynolds, L.F.3    Smith, S.H.4    Ruf, S.5
  • 20
    • 0036533662 scopus 로고    scopus 로고
    • The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes
    • Croker BA, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, et al. (2002) The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol 168: 3376-3386.
    • (2002) J Immunol , vol.168 , pp. 3376-3386
    • Croker, B.A.1    Tarlinton, D.M.2    Cluse, L.A.3    Tuxen, A.J.4    Light, A.5
  • 21
    • 0035989343 scopus 로고    scopus 로고
    • Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses
    • Croker BA, Handman E, Hayball JD, Baldwin TM, Voigt V, et al. (2002) Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol 80: 231-240.
    • (2002) Immunol Cell Biol , vol.80 , pp. 231-240
    • Croker, B.A.1    Handman, E.2    Hayball, J.D.3    Baldwin, T.M.4    Voigt, V.5
  • 22
    • 0035477599 scopus 로고    scopus 로고
    • Deficiency of small GTPase Rac2 affects T cell activation
    • Yu H, Leitenberg D, Li B, Flavell RA, (2001) Deficiency of small GTPase Rac2 affects T cell activation. J Exp Med 194: 915-926.
    • (2001) J Exp Med , vol.194 , pp. 915-926
    • Yu, H.1    Leitenberg, D.2    Li, B.3    Flavell, R.A.4
  • 23
    • 65449180370 scopus 로고    scopus 로고
    • Rac GTPases play critical roles in early T-cell development
    • Dumont C, Corsoni-Tadrzak A, Ruf S, de Boer J, Williams A, et al. (2009) Rac GTPases play critical roles in early T-cell development. Blood 113: 3990-3998.
    • (2009) Blood , vol.113 , pp. 3990-3998
    • Dumont, C.1    Corsoni-Tadrzak, A.2    Ruf, S.3    de Boer, J.4    Williams, A.5
  • 24
    • 0034705628 scopus 로고    scopus 로고
    • Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation
    • Li B, Yu H, Zheng W, Voll R, Na S, et al. (2000) Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 288: 2219-2222.
    • (2000) Science , vol.288 , pp. 2219-2222
    • Li, B.1    Yu, H.2    Zheng, W.3    Voll, R.4    Na, S.5
  • 26
    • 0034283717 scopus 로고    scopus 로고
    • Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency
    • Williams DA, Tao W, Yang F, Kim C, Gu Y, et al. (2000) Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. Blood 96: 1646-1654.
    • (2000) Blood , vol.96 , pp. 1646-1654
    • Williams, D.A.1    Tao, W.2    Yang, F.3    Kim, C.4    Gu, Y.5
  • 29
    • 34447306637 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase sigma is associated with ulcerative colitis
    • Muise AM, Walters T, Wine E, Griffiths AM, Turner D, et al. (2007) Protein-tyrosine phosphatase sigma is associated with ulcerative colitis. Curr Biol 17: 1212-1218.
    • (2007) Curr Biol , vol.17 , pp. 1212-1218
    • Muise, A.M.1    Walters, T.2    Wine, E.3    Griffiths, A.M.4    Turner, D.5
  • 30
    • 79952017640 scopus 로고    scopus 로고
    • Examining ubiquitinated protein aggregates in tissue sections
    • Kaniuk NA, Brumell JH, (2010) Examining ubiquitinated protein aggregates in tissue sections. Methods Mol Biol 648: 175-182.
    • (2010) Methods Mol Biol , vol.648 , pp. 175-182
    • Kaniuk, N.A.1    Brumell, J.H.2
  • 31
    • 45949095703 scopus 로고    scopus 로고
    • Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells
    • Unit 3 19
    • Lefrancois L, Lycke N (2001) Isolation of mouse small intestinal intraepithelial lymphocytes, Peyer's patch, and lamina propria cells. Curr Protoc Immunol Chapter 3: Unit 3 19.
    • (2001) Curr Protoc Immunol Chapter , vol.3
    • Lefrancois, L.1    Lycke, N.2
  • 32
    • 14744299030 scopus 로고    scopus 로고
    • Regulation of innate immunity by Rho GTPases
    • Bokoch GM, (2005) Regulation of innate immunity by Rho GTPases. Trends Cell Biol 15: 163-171.
    • (2005) Trends Cell Biol , vol.15 , pp. 163-171
    • Bokoch, G.M.1
  • 33
    • 0027520431 scopus 로고
    • Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components
    • Quinn MT, Evans T, Loetterle LR, Jesaitis AJ, Bokoch GM, (1993) Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem 268: 20983-20987.
    • (1993) J Biol Chem , vol.268 , pp. 20983-20987
    • Quinn, M.T.1    Evans, T.2    Loetterle, L.R.3    Jesaitis, A.J.4    Bokoch, G.M.5
  • 34
    • 0028151013 scopus 로고
    • Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558
    • Heyworth PG, Bohl BP, Bokoch GM, Curnutte JT, (1994) Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem 269: 30749-30752.
    • (1994) J Biol Chem , vol.269 , pp. 30749-30752
    • Heyworth, P.G.1    Bohl, B.P.2    Bokoch, G.M.3    Curnutte, J.T.4
  • 35
    • 70349238797 scopus 로고    scopus 로고
    • CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen
    • Spehlmann ME, Dann SM, Hruz P, Hanson E, McCole DF, et al. (2009) CXCR2-dependent mucosal neutrophil influx protects against colitis-associated diarrhea caused by an attaching/effacing lesion-forming bacterial pathogen. J Immunol 183: 3332-3343.
    • (2009) J Immunol , vol.183 , pp. 3332-3343
    • Spehlmann, M.E.1    Dann, S.M.2    Hruz, P.3    Hanson, E.4    McCole, D.F.5
  • 36
    • 34250814435 scopus 로고    scopus 로고
    • TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium
    • Lebeis SL, Bommarius B, Parkos CA, Sherman MA, Kalman D, (2007) TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. J Immunol 179: 566-577.
    • (2007) J Immunol , vol.179 , pp. 566-577
    • Lebeis, S.L.1    Bommarius, B.2    Parkos, C.A.3    Sherman, M.A.4    Kalman, D.5
  • 37
    • 38449115712 scopus 로고    scopus 로고
    • Cutting edge: Rac GTPases sensitize activated T cells to die via Fas
    • Ramaswamy M, Dumont C, Cruz AC, Muppidi JR, Gomez TS, et al. (2007) Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. J Immunol 179: 6384-6388.
    • (2007) J Immunol , vol.179 , pp. 6384-6388
    • Ramaswamy, M.1    Dumont, C.2    Cruz, A.C.3    Muppidi, J.R.4    Gomez, T.S.5
  • 38
    • 0030772153 scopus 로고    scopus 로고
    • Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase
    • Lores P, Morin L, Luna R, Gacon G, (1997) Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase. Oncogene 15: 601-605.
    • (1997) Oncogene , vol.15 , pp. 601-605
    • Lores, P.1    Morin, L.2    Luna, R.3    Gacon, G.4
  • 39
    • 77953740033 scopus 로고    scopus 로고
    • The power and the promise of restimulation-induced cell death in human immune diseases
    • Snow AL, Pandiyan P, Zheng L, Krummey SM, Lenardo MJ, (2010) The power and the promise of restimulation-induced cell death in human immune diseases. Immunol Rev 236: 68-82.
    • (2010) Immunol Rev , vol.236 , pp. 68-82
    • Snow, A.L.1    Pandiyan, P.2    Zheng, L.3    Krummey, S.M.4    Lenardo, M.J.5
  • 40
    • 0035158627 scopus 로고    scopus 로고
    • Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide
    • Krieglstein CF, Cerwinka WH, Laroux FS, Salter JW, Russell JM, et al. (2001) Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med 194: 1207-1218.
    • (2001) J Exp Med , vol.194 , pp. 1207-1218
    • Krieglstein, C.F.1    Cerwinka, W.H.2    Laroux, F.S.3    Salter, J.W.4    Russell, J.M.5
  • 41
    • 80855128740 scopus 로고    scopus 로고
    • Gp91(phox) contributes to the development of experimental inflammatory bowel disease
    • Bao S, Carr ED, Xu YH, Hunt NH, (2011) Gp91(phox) contributes to the development of experimental inflammatory bowel disease. Immunol Cell Biol 89: 853-860.
    • (2011) Immunol Cell Biol , vol.89 , pp. 853-860
    • Bao, S.1    Carr, E.D.2    Xu, Y.H.3    Hunt, N.H.4
  • 42
    • 84866545697 scopus 로고    scopus 로고
    • p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation
    • Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, et al. (2012) p40phox Expression Regulates Neutrophil Recruitment and Function during the Resolution Phase of Intestinal Inflammation. J Immunol 189: 3631-3640.
    • (2012) J Immunol , vol.189 , pp. 3631-3640
    • Conway, K.L.1    Goel, G.2    Sokol, H.3    Manocha, M.4    Mizoguchi, E.5


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