Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes

Journal of Biomedical Science

Volumn 20, Issue 1, 2013, Pages

  Nakashima, Akio ^a   Kawanishi, Ippei ^a,b   Eguchi, Sumiko ^a   Yu, Eugene Hsin ^a,c   Eguchi, Satoshi ^a,d   Oshiro, Noriko ^a,e   Yoshino, Ken Ichi ^a   Kikkawa, Ushio ^a   Yonezawa, Kazuyoshi ^a  

^a KOBE UNIVERSITY   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c Current Address: Yu's Endocrine and Diabetes Clinic   (Taiwan)

^d AKITA UNIVERSITY   (Japan)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Amino acids; CAD; mLST8; mTOR; Pyrimidine synthesis

Indexed keywords

AMINO ACID; CASPASE ACTIVATED DEOXYRIBONUCLEASE; MAMMALIAN TARGET OF RAPAMYCIN; MLST8 PROTEIN; UNCLASSIFIED DRUG; ASPARTATE CARBAMOYLTRANSFERASE; CAD TRIFUNCTIONAL ENZYME; CARBAMOYL PHOSPHATE SYNTHASE (GLUTAMINE HYDROLYSING); DIHYDROOROTASE; MLST8 PROTEIN, HUMAN; MTORC1 COMPLEX, HUMAN; PYRIMIDINE; PYRIMIDINE DERIVATIVE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL STRAIN HEK293; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING; MOLECULAR RECOGNITION; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PYRIMIDINE SYNTHESIS; SERUM; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACIDS; ASPARTATE CARBAMOYLTRANSFERASE; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); DIHYDROOROTASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; PHOSPHORYLATION; PROTEIN BINDING; PYRIMIDINES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84876190107     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-20-24     Document Type: Article

References (23)

1. TOR signaling in growth and metabolism. Wullschleger S, Loewith R, Hall MN, Cell 2006 124 471 484 10.1016/j.cell.2006.01.016 16469695
2. Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor. Avruch J, Long X, Lin Y, Ortiz-Vega S, Rapley J, Papageorgiou A, Oshiro N, Kikkawa U, Biochem Soc Trans 2009 37 223 226 10.1042/BST0370223 19143636
3. mTOR: from growth signal integration to cancer, diabetes and ageing. Zoncu R, Efeyan A, Sabatini DM, Nat Rev Mol Cell Biol 2011 12 21 35 10.1038/nrm3025 21157483
4. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN, Nat Cell Biol 2004 6 1122 1128 10.1038/ncb1183 15467718
5. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM, Curr Biol 2004 14 1296 1302 10.1016/j.cub.2004.06.054 15268862
6. GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM, Mol Cell 2003 11 895 904 10.1016/S1097-2765(03)00114-X 12718876
7. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC alpha but not S6K1. Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM, Dev Cell 2006 11 859 871 10.1016/j.devcel.2006.10. 007 17141160
8. De novo synthesis of pyrimidine nucleotides; emerging interfaces with signal transduction pathways. Huang M, Graves LM, Cell Mol Life Sci 2003 60 321 336 10.1007/s000180300027 12678497
9. Mammalian pyrimidine biosynthesis: fresh insights into an ancient pathway. Evans DR, Guy HI, J Biol Chem 2004 279 33035 33038 10.1074/jbc. R400007200 15096496
10. Regulation of carbamoyl phosphate synthetase by MAP kinase. Graves LM, Guy HI, Kozlowski P, Huang M, Lazarowski E, Pope RM, Collins MA, Dahlstrand EN, Earp HS III, Evans DR, Nature 2000 403 328 332 10.1038/35002111 10659854
11. Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades. Sigoillot FD, Evans DR, Guy HI, J Biol Chem 2002 277 15745 15751 10.1074/jbc.M201112200 11872754
12. Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase. Sigoillot FD, Kotsis DH, Masko EM, Bame M, Evans DR, Evans HI, Front Biosci 2007 12 3892 3898 10.2741/2358 17485345
13. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Robitaille AM, Robitaille S, Shimobayashi M, Cornu M, Fava LL, Moe S, Prescianotto-Baschong C, Sauer U, Jenoe P, Hall MN, Science 2013 339 1320 1323 10.1126/science.1228771 23429704
14. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Ben-Sahra I, Howell JJ, Asara JM, Manning BD, Science 2013 339 1323 1328 10.1126/science.1228792 23429703
15. Regulation of eIF-4E BP1 phosphorylation by mTOR. Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, Weng QP, Kasuga M, Nishimoto I, Avruch J, J Biol Chem 1997 272 26457 26463 10.1074/jbc.272.42.26457 9334222
16. Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function. Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K, Genes Cells 2004 9 359 366 10.1111/j.1356-9597. 2004.00727.x 15066126
17. The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. Oshiro N, Takahashi R, Yoshino K, Tanimura K, Nakashima A, Eguchi S, Miyamoto T, Hara K, Takehana K, Avruch J, Kikkawa U, Yonezawa K, J Biol Chem 2007 282 20329 20339 10.1074/jbc.M702636200 17517883
18. Control of pyrimidine biosynthesis in mammalian tissues. I. Partial purification and characterization of glutamine-utilizing carbamyl phosphate synthetase of mouse spleen and its tissue distribution. Tatibana M, Ito K, J Biol Chem 1969 244 5403 5413 5344144
19. The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD. Lindsey-Boltz LA, Wauson EM, Graves LM, Sancar A, Nucleic Acids Res 2004 32 4524 4530 10.1093/nar/gkh789 15326225
20. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J, J Biol Chem 1998 27 14484 14494
21. The WD repeat: a common architecture for diverse functions. Smith TF, Gaitatzes C, Saxena K, Neer EJ, Trends Biochem Sci 1999 24 181 185 10.1016/S0968-0004(99)01384-5 10322433
22. Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade. Kotsis DH, Masko EM, Sigoillot FD, Gregorio RD, Guy-Evans HI, Evans DR, Mol Cell Biochem 2007 301 69 81 10.1007/s11010-006-9398-x 17206380
23. Identification of CAD as an androgen receptor interactant and an early marker of prostate tumor recurrence. Morin A, Fritsch L, Mathieu JR, Gilbert C, Guarmit B, Firlej V, Gallou-Kabani C, Vieillefond A, Delongchamps NB, Cabon F, FASEB J 2012 26 460 467 10.1096/fj.11-191296 21982950