Acute antipsychotic treatments induce distinct c-Fos expression patterns in appetite-related neuronal structures of the rat brain

Brain Research

Volumn 1508, Issue , 2013, Pages 34-43

  Rajkumar, Ramamoorthy ^a,b   See, Lionel Kee Yon ^a,b   Dawe, Gavin Stewart ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antipsychotics; c Fos; Chlorpromazine; Clozapine; Fluphenazine; Hypothalamic structures

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; FLUPHENAZINE; PROTEIN C FOS; RELAXIN 3;

ANIMAL CELL; ANIMAL EXPERIMENT; APPETITE; ARCUATE NUCLEUS; ARTICLE; BRAIN REGION; CELL STRUCTURE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; NUCLEUS INCERTUS; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; APPETITE; ARCUATE NUCLEUS; BRAIN; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GENES, FOS; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; NERVE TISSUE PROTEINS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN;

RATTUS; RODENTIA;

EID: 84876125011     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.02.050     Document Type: Article

References (89)

1. D. Allison, J. Mentore, M. Heo, L. Chandler, J. Cappelleri, M. Infante, and P. Weiden Antipsychotic-induced weight gain: a comprehensive research synthesis Am. J. Psychiatry 156 1999 1686 1696 (Pubitemid 29517559)
2. M. Angeles-Castellanos, J. Mendoza, and C. Escobar Restricted feeding schedules phase shift daily rhythms of c-Fos and protein Per1 immunoreactivity in corticolimbic regions in rats Neuroscience 144 2007 344 355 (Pubitemid 44848385)
3. S.M. Antelman, C.A. Black, and N.E. Rowland Clozapine induces hyperhagia in undeprived rats Life Sci. 21 1977 1747 1749 (Pubitemid 8268313)
4. B.A. Baldo, R.A. Daniel, C.W. Berridge, and A.E. Kelley Overlapping distributions of orexin/hypocretin- and dopamine-beta-hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress J. Comp. Neurol. 464 2003 220 237 (Pubitemid 36976049)
5. T. Baptista, N.M. Kin, S. Beaulieu, and E.A. de Baptista Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives Pharmacopsychiatry 35 2002 205 219 (Pubitemid 36061310)
6. T. Baptista, M. Parada, and L. Hernandez Long term administration of some antipsychotic drugs increases body weight and feeding in rats. Are D2 dopamine receptors involved? Pharmacol. Biochem. Behav. 27 1987 399 405 (Pubitemid 17107006)
7. D.G. Baskin, R.J. Seeley, J.L. Kuijper, S. Lok, D.S. Weigle, J.C. Erickson, R.D. Palmiter, and M.W. Schwartz Increased expression of mRNA for the long form of the leptin receptor in the hypothalamus is associated with leptin hypersensitivity and fasting Diabetes 47 1998 538 543 (Pubitemid 28160442)
8. R.A. Bathgate, C.S. Samuel, T.C. Burazin, A.L. Gundlach, and G.W. Tregear Relaxin: new peptides, receptors and novel actions Trends Endocrinol. Metab. 14 2003 207 213 (Pubitemid 36841478)
9. R.A. Bathgate, C.S. Samuel, T.C. Burazin, S. Layfield, A.A. Claasz, I.G. Reytomas, N.F. Dawson, C. Zhao, C. Bond, R.J. Summers, L.J. Parry, J.D. Wade, and G.W. Tregear Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family J. Biol. Chem. 277 2002 1148 1157 (Pubitemid 34968862)
10. M.L. Berk, and J.A. Finkelstein Afferent projections to the preoptic area and hypothalamic regions in the rat brain Neuroscience 6 1981 1601 1624 (Pubitemid 11043031)
11. S. Bhatnagar, and M.F. Dallman The paraventricular nucleus of the thalamus alters rhythms in core temperature and energy balance in a state-dependent manner Brain Res. 851 1999 66 75 (Pubitemid 30038130)
12. J.C. Bittencourt, and P.E. Sawchenko Do centrally administered neuropeptides access cognate receptors?: an analysis in the central corticotropin-releasing factor system J. Neurosci. 20 2000 1142 1156 (Pubitemid 30220471)
13. J.P. Boisvert, T.J. Boschuetz, J.M. Resch, C.R. Mueller, and S. Choi Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei Neurosci. Lett. 498 2011 213 217
14. T. Brömel, W.F. Blum, A. Ziegler, E. Schulz, M. Bender, C. Fleischhaker, H. Remschmidt, J.C. Krieg, and J. Hebebrand Serum leptin levels increase rapidly after initiation of clozapine therapy Mol. Psychiatry 3 1998 76 80 (Pubitemid 28045189)
15. D.E. Casey, and S.H. Zorn The pharmacology of weight gain with antipsychotics J. Clin. Psychiatry 62 Suppl 7 2001 4 10 (Pubitemid 32402180)
16. D.L. Choi, J.F. Davis, M.E. Fitzgerald, and S.C. Benoit The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats Neuroscience 167 2010 11 20
17. D.L. Choi, J.F. Davis, I.J. Magrisso, M.E. Fitzgerald, J.W. Lipton, and S.C. Benoit Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat Neuroscience 210 2012 243 248
18. B.M. Cohen, S. Cherkerzian, J. Ma, N. Ye, C. Wager, and N. Lange Cells in midline thalamus, central amygdala, and nucleus accumbens responding specifically to antipsychotic drugs Psychopharmacology (Berl) 167 2003 403 410 (Pubitemid 36754242)
19. B.M. Cohen, W. Wan, M.P. Froimowitz, D.J. Ennulat, S. Cherkerzian, and H. Konieczna Activation of midline thalamic nuclei by antipsychotic drugs Psychopharmacology (Berl) 135 1998 37 43 (Pubitemid 28055448)
20. A. Deutch, M. Lee, and M. Iadarola Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: the nucleus accumbens shell as a locus of antipsychotic action Mol. Cell Neurosci. 3 1992 332 341
21. A.Y. Deutch, and R.S. Duman The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization Neuroscience 70 1996 377 389 (Pubitemid 126755251)
22. J.K Elmquist, E. Maratos-Flier, C.B. Saper, and J.S. Flier Unraveling the central nervous system pathways underlying responses to leptin Nat. Neurosci. 1 1998 445 450
23. J.K. Elmquist, C.F. Elias, and C.B. Saper From lesions to leptin: hypothalamic control of food intake and body weight Neuron 22 1999 221 232 (Pubitemid 29109657)
24. J. Fadel, M. Bubser, and A.Y. Deutch Differential activation of orexin neurons by antipsychotic drugs associated with weight gain J. Neurosci. 22 2002 6742 6746 (Pubitemid 35386430)
25. A. Fink-Jensen, and P. Kristensen Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain Neurosci. Lett. 182 1994 115 118 (Pubitemid 24362036)
26. B. Ford, C.J. Holmes, L. Mainville, and B.E. Jones GABAergic neurons in therat pontomesencephalic tegmentum: codistribution with cholinergic and other tegmentalneurons projecting to the posterior lateral hypothalamus J. Comp. Neurol. 363 1995 177 196
27. R. Ganguli Weight gain associated with antipsychotic drugs J. Clin. Psychiatry 60 Suppl 21 1999 20 24 (Pubitemid 29523629)
28. S. Gebhardt, M. Haberhausen, J.C. Krieg, H. Remschmidt, M. Heinzel-Gutenbrunner, J. Hebebrand, and F.M. Theisen Clozapine/olanzapine- induced recurrence or deterioration of binge eating-related eating disorders J. Neural. Transm. 114 2007 1091 1095 (Pubitemid 47106444)
29. M.A. García-Cabezas, P. Martínez-Sánchez, M.A. Sánchez-González, M. Garzón, and C. Cavada Dopamine innervation in the thalamus: monkey versus rat Cereb. Cortex 19 2009 424 434
30. M. Goto, L.W. Swanson, and N.S. Canteras Connections of the nucleus incertus J. Comp. Neurol. 438 2001 86 122 (Pubitemid 32730352)
31. J.M. Gray, S. Schrock, and M. Bishop Estrogens and antiestrogens: actions and interactions with fluphenazine on food intake and body weight in rats Am. J. Physiol. 264 1993 R1214 1218
32. M. Han, C. Deng, T.H. Burne, K.A. Newell, and X.F. Huang Short- and long-term effects of antipsychotic drug treatment on weight gain and H1 receptor expression Psychoneuroendocrinology 33 2008 569 580
33. A.W. Hartfield, N.A. Moore, and P.G. Clifton Effects of clozapine, olanzapine and haloperidol on the microstructure of ingestive behaviour in the rat Psychopharmacology (Berl) 167 2003 115 122 (Pubitemid 36628151)
34. K. Herrick-Davis, E. Grinde, and M. Teitler Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors J. Pharmacol. Exp. Ther. 295 2000 226 232
35. T. Hida, E. Takahashi, K. Shikata, T. Hirohashi, T. Sawai, T. Seiki, H. Tanaka, T. Kawai, O. Ito, T. Arai, A. Yokoi, T. Hirakawa, H. Ogura, T. Nagasu, N. Miyamoto, and J. Kuromitsu Chronic intracerebroventricular administration of relaxin-3 increases body weight in rats J. Recept. Signal. Transduct. Res. 26 2006 147 158
36. M. Hummer, G. Kemmler, M. Kurz, I. Kurzthaler, H. Oberbauer, and W.W. Fleischhacker Weight gain induced by clozapine Eur. Neuropsychopharmacol. 5 1995 437 440
37. A. Javed, M.C. Kamradt, L.D. Van de Kar, and T.S. Gray d-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala Neuroscience 90 1999 851 858 (Pubitemid 29156750)
38. L.E. Johnstone, T.M. Fong, and G. Leng Neuronal activation in the hypothalamus and brainstem during feeding in rats Cell Metab. 4 2006 313 321 (Pubitemid 44430912)
39. S. Kapur, S.C. VanderSpek, B.A. Brownlee, and J.N. Nobrega Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy J. Pharmacol. Exp. Ther. 305 2003 625 631 (Pubitemid 36459179)
40. G. Kaur, and S,K. Kulkarni Studies on modulation of feeding behavior by atypical antipsychotics in female mice Prog. Neuropsychopharmacol. Biol. Psychiatry 26 2002 277 285 (Pubitemid 34038054)
41. S.L. Kirk, J.C. Neill, D.N. Jones, and G.P. Reynolds Ziprasidone suppresses olanzapine-induced increases in ingestive behaviour in the rat Eur. J. Pharmacol. 505 2004 253 254 (Pubitemid 39535699)
42. K. Komossa, C. Rummel-Kluge, H. Hunger, S. Schwarz, P.S. Bhoopathi, W. Kissling, and S. Leucht Ziprasidone versus other atypical antipsychotics for schizophrenia Cochrane Database Syst. Rev. 4 2009 CD006627
43. W.K. Kroeze, S.J. Hufeisen, B.A. Popadak, S.M. Renock, S. Steinberg, P. Ernsberger, K. Jayathilake, H.Y. Meltzer, and B.L. Roth H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs Neuropsychopharmacology 28 2003 519 526
44. C. Kuei, S. Sutton, P. Bonaventure, C. Pudiak, J. Shelton, J. Zhu, D. Nepomuceno, J. Wu, J. Chen, F. Kamme, M. Seierstad, M.D. Hack, R.A. Bathgate, M.A. Hossain, J.D. Wade, J. Atack, T.W. Lovenberg, and C. Liu R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization J. Biol. Chem. 282 2007 25425 25435 (Pubitemid 47372825)
45. R. Leadbetter, M. Shutty, D. Pavalonis, V. Vieweg, P. Higgins, and M. Downs Clozapine induced weight gain: prevalence and clinical relevance Am. J. Psychiatry 149 1992 68 72
46. M.D. Lee, and P.G. Clifton Meal patterns of free feeding rats treated with clozapine, olanzapine, or haloperidol Pharmacol. Biochem. Behav. 71 2002 147 154 (Pubitemid 34102473)
47. B.H. Li, B. Xu, N.E. Rowland, and S.P. Kalra c-fos expression in the rat brain following central administration of neuropeptide Y and effects of food consumption Brain Res. 665 1994 277 284 (Pubitemid 24356731)
48. J.A. Lieberman, T.S. Stroup, J.P. McEvoy, M.S. Swartz, R.A. Rosenheck, D.O. Perkins, R.S. Keefe, S.M. Davis, C.E. Davis, B.D. Lebowitz, J. Severe, and J.K. Hsiao Clinical antipsychotic trials of intervention effectiveness (CATIE) Investigators. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia N. Engl. J. Med. 353 2005 1209 1223
49. C. Liu, and T.W. Lovenberg Relaxin-3, INSL5, and their receptors Results Probl. Cell Differ. 46 2008 213 237
50. C. Liu, E. Eriste, S. Sutton, J. Chen, B. Roland, C. Kuei, N. Farmer, H. Jörnvall, R. Sillard, and T.W. Lovenberg Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135 J. Biol. Chem. 278 2003 50754 50764 (Pubitemid 37548924)
51. S. Ma, P. Bonaventure, T. Ferraro, P.J. Shen, T.C. Burazin, R.A. Bathgate, C. Liu, G.W. Tregear, S.W. Sutton, and A.L. Gundlach Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via Gprotein- coupled receptor-135 in the rat Neuroscience 144 2007 165 190 (Pubitemid 44839028)
52. B.M. McGowan, S.A. Stanley, K.L. Smith, J.S. Minnion, J. Donovan, E.L. Thompson, M. Patterson, M.M. Connolly, C.R. Abbott, C.J. Small, J.V. Gardiner, M.A. Ghatei, and S.R. Bloom Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats Regul. Pept. 136 2006 72 77 (Pubitemid 44255823)
53. B.M McGowan, S. Stanley, K. Smith, N. White, M. Connolly, E. Thompson, J. Gardiner, K. Murphy, M. Ghatei, and S. Bloom Central relaxin-3 administration causes hyperphagia in male Wistar rats Endocrinology 146 2005 3295 3300 (Pubitemid 41058100)
54. B.M. McGowan, S.A. Stanley, N.E. White, A. Spangeus, M. Patterson, E.L. Thompson, K.L. Smith, J. Donovan, J.V. Gardiner, M.A. Ghatei, and S.R. Bloom Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats Am. J. Physiol. Endocrinol. Metab. 292 2007 E913 919
55. J. Mendoza, M. Angeles-Castellanos, and C. Escobar Entrainment by a palatable meal induces food-anticipatory activity and c-Fos expression in reward-related areas of the brain Neuroscience 133 2005 293 303 (Pubitemid 40694178)
56. J. Minet-Ringuet, P.C. Even, M. Lacroix, D. Tomé, and R. de Beaurepaire A model for antipsychotic-induced obesity in the male rat Psychopharmacology (Berl) 187 2006 447 454 (Pubitemid 44200516)
57. T.M. Mizuno, H. Makimura, J. Silverstein, J.L. Roberts, T. Lopingco, and C.V. Mobbs Fasting regulates hypothalamic neuropeptide Y, agouti-related peptide, and proopiomelanocortin in diabetic mice independent of changes in leptin or insulin Endocrinology 140 1999 4551 4557 (Pubitemid 30666120)
58. M. Murashita, I. Kusumi, H. Hosoda, K. Kangawa, and T. Koyama Acute administration of clozapine concurrently increases blood glucose and circulating plasma ghrelin levels in rats Psychoneuroendocrinology 32 2007 777 784 (Pubitemid 47187574)
59. T. Oka, T. Hamamura, Y. Lee, S. Miyata, T. Habara, S. Endo, H. Taoka, and S. Kuroda Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain Life Sci. 76 2004 225 237 (Pubitemid 39425227)
60. F.E. Olucha-Bordonau, V. Teruel, J. Barcia-Gonzalez, A. Ruiz-Torner, A.A. Valverde- Navarro, and F. Martinez-Soriano Cytoarchitecture and efferent projections of the nucleus incertus of the rat J. Comp. Neurol. 464 2003 62 97 (Pubitemid 36899037)
61. B. Parsons, D.B. Allison, A. Loebel, K. Williams, E. Giller, S. Romano, and C. Siu Weight effects associated with antipsychotics: a comprehensive database analysis Schizophr. Res. 110 2009 103 110
62. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates fourth ed. 2007 Elsevier Massachusetts
63. A.M. Poulin, and E. Timofeeva The dynamics of neuronal activation during food anticipation and feeding in the brain of food-entrained rats Brain Res. 1227 2008 128 141
64. E. Potter, S. Sutton, C. Donaldson, R. Chen, M. Perrin, K. Lewis, P.E. Sawchenko, and W. Vale Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary Proc. Natl. Acad. Sci. USA 91 1994 8777 8781
65. G.S. Robertson, and H.C. Fibiger Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine Neuroscience 46 1992 315 328
66. G.S. Robertson, H. Matsumura, and H.C. Fibiger Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity J. Pharmacol. Exp. Ther. 271 1994 1058 1066 (Pubitemid 24377799)
67. R.G. Robinson, P.R. McHugh, and F.E. Bloom Chlorpromazine induced hyperphagia in the rat Psychopharmacol. Commun. 1 1975 37 50
68. P.J. Ryan, S. Ma, F.E. Olucha-Bordonau, and A.L. Gundlach Nucleus incertus-an emerging modulatory role in arousal, stress and memory Neurosci. Biobehav. Rev. 35 2011 1326 1341
69. N. Satoh, Y. Ogawa, G. Katsuura, M. Hayase, T. Tsuji, K. Imagawa, Y. Yoshimasa, S. Nishi, K. Hosoda, and K. Nakao The arcuate nucleus as a primary site of satiety effect of leptin in rats Neurosci. Lett. 224 1997 149 152 (Pubitemid 27140403)
70. M.W. Schwartz, S.C. Woods, D. Porte Jr., R.J. Seeley, and D.G. Baskin Central nervous system control of food intake Nature 404 2000 661 667
71. J.B. Sebens, T. Koch, G.J. Ter Horst, and J. Korf Differential Fos-protein induction in rat forebrain regions after acute and long-term haloperidol and clozapine treatment Eur. J. Pharmacol. 273 1995 175 182
72. J. Semba, M.W. Sakai, T. Suhara, and N. Akanuma Differential effects of acute and chronic treatment with typical and atypical neuroleptics on c-fos mRNA expression in rat forebrain regions using non-radioactive in situ hybridization Neurochem. Int. 34 1999 269 277 (Pubitemid 29307792)
73. M. Shobo, H. Yamada, T. Mihara, Y. Kondo, M. Irie, K. Harada, K. Ni, N. Matsuoka, and Y. Kayama Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone Behav. Brain Res. 216 2011 561 568
74. T. Silverstone, G. Smith, and E. Goodall Prevalence of obesity in patients receiving depot antipsychotics Br. J. Psychiatry 153 1988 214 217
75. C.M. Smith, P.J. Ryan, I.T. Hosken, S. Ma, and A.L. Gundlach Relaxin-3 systems in the brain - the first 10 years J. Chem. Neuroanat. 42 2011 262 275
76. B.E. Sumner, L.A. Cruise, D.A. Slattery, D.R. Hill, M. Shahid, and B. Henry Testing the validity of c-fos expression profiling to aid the therapeutic classification of psychoactive drugs Psychopharmacology (Berl) 171 2004 306 321 (Pubitemid 38200069)
77. S.W. Sutton, P. Bonaventure, C. Kuei, B. Roland, J. Chen, D. Nepomuceno, T.W. Lovenberg, and C. Liu Distribution of G-protein-coupled receptor (GPCR)135 binding sites and receptor mRNA in the rat brain suggests a role for relaxin-3 in neuroendocrine and sensory processing Neuroendocrinology 80 2004 298 307 (Pubitemid 40470238)
78. M. Takada, K.J. Campbell, T. Moriizumi, and T. Hattori On the origin of the dopaminergic innervation of the paraventricular thalamic nucleus Neurosci. Lett. 115 1990 33 36 (Pubitemid 20231588)
79. H. Takagi, S. Shiosaka, M. Tohyama, E. Senba, and M. Sakanaka Ascending components of the medial forebrain bundle from the lower brain stem in the rat, with special reference to raphe and catecholamine cell groups. A study by the HRP method Brain Res. 193 1980 315 337 (Pubitemid 10123944)
80. B.G. Taksande, N.R. Kotagale, K.T. Nakhate, P.D. Mali, D.M. Kokare, K. Hirani, N.K. Subhedar, C.T. Chopde, and R.R. Ugale Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y Br. J. Pharmacol. 164 2b 2011 704 718
81. M. Tanaka, N. Iijima, Y. Miyamoto, S. Fukusumi, Y. Itoh, H. Ozawa, and Y. Ibata Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress Eur. J. Neurosci. 21 2005 1659 1670 (Pubitemid 40646611)
82. M. Tang-Christensen, J.J. Holst, B. Hartmann, and N. Vrang The arcuate nucleus is pivotal in mediating the anorectic effects of centrally administered leptin Neuroreport 10 1999 1183 1187 (Pubitemid 29403691)
83. F.M. Theisen, A. Linden, I.R. König, M. Martin, H. Remschmidt, and J. Hebebrand Spectrum of binge eating symptomatology in patients treated with clozapine and olanzapine J. Neural Transm. 110 2003 111 121 (Pubitemid 36135558)
84. E. Valassi, M. Scacchi, and F. Cavagnini Neuroendocrine control of food intake Nutr. Metab. Cardiovasc. Dis. 18 2008 158 168 (Pubitemid 351282471)
85. V. Verma, E.P. Lim, S.P. Han, R. Nagarajah, and G.S. Dawe Chronic high-dose haloperidol has qualitatively similar effects to risperidone and clozapine on immediate-early gene and tyrosine hydroxylase expression in the rat locus coeruleus but not medial prefrontal cortex Neurosci. Res. 57 2007 17 28 (Pubitemid 46073244)
86. V. Verma, K. Rasmussen, and G.S. Dawe Effects of short-term and chronic olanzapine treatment on immediate early gene protein and tyrosine hydroxylase immunoreactivity in the rat locus coeruleus and medial prefrontal cortex Neuroscience 143 2006 573 585 (Pubitemid 44716600)
87. N. Vrang, M. Tang-Christensen, P.J. Larsen, and P. Kristensen Recombinant CART peptide induces c-Fos expression in central areas involved in control of feeding behaviour Brain Res. 818 1999 499 509 (Pubitemid 29229965)
88. L. Wang, D.H. Saint-Pierre, and Y. Taché Peripheral ghrelin selectively increases Fos expression in neuropeptide Y - synthesizing neurons in mouse hypothalamic arcuate nucleus Neurosci. Lett. 325 2002 47 51 (Pubitemid 34521976)
89. D.A. Wirshing, W.C. Wirshing, L. Kysar, M.A. Berisford, D. Goldstein, J. Pashdag, J. Mintz, and S.R. Marder Novel antipsychotics: comparison of weight gain liabilities J. Clin. Psychiatry 60 1999 358 363 (Pubitemid 29289721)