Activation of midline thalamic nuclei by antipsychotic drugs

Psychopharmacology

Volumn 135, Issue 1, 1998, Pages 37-43

  Cohen, Bruce M ^a   Wan, Weihua ^a   Froimowitz, Michael P ^a   Ennulat, David J ^a   Cherkerzian, Sara ^a   Konieczna, Hanna ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

Antipsychotic drugs; Fos immunohistochemistry; Neuroleptics; Rat; Thalamus

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; DOPAMINE RECEPTOR BLOCKING AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; RACLOPRIDE; RISPERIDONE;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SCHIZOPHRENIA; SYMPTOM; THALAMUS NUCLEUS;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN; HALOPERIDOL; MALE; PROTO-ONCOGENE PROTEINS C-FOS; RACLOPRIDE; RATS; RATS, SPRAGUE-DAWLEY; RISPERIDONE; SALICYLAMIDES; THALAMIC NUCLEI; THIORIDAZINE;

EID: 0031984327     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050483     Document Type: Article

References (63)

1. Andreasen NC (1995) Symptoms, signs, and diagnosis of schizophrenia. Lancet 346:477-481
2. Andreasen NC, Arndt S, Swayze V II, Cizadlo T, Flaum M, O'Leary D, Ehrhardt JC, Yuh WTC (1994) Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging. Science 266:294-298
3. Bartletl FJ, Wolkin A, Brodie JD, Laska EM, Wolf AP, Sanfilipo M (1991) Importance of pharmacologic control in PET studies: effects of thioridazine and haloperidol on cerebral glucose utilization in chronic schizophrenia. Psychiatry Res Neuroimaging 40:115-124
4. Bogerts B (1993) Recent advances in the neuropathology of schizophrenia. Schizophr Bull 431-445
5. Buchsbaum MS, Potkin SG, Marshall JF, Lottenberg S, Teng C, Heh CW, Tafalla R, Reynolds C, Abel L, Plon L, Bunney WE (1992a) Effects of clozapine and thiothixene on glucose metabolic rate in shizophrenia. Neuropsychopharmacology 6: 155-163
6. Buchsbaum MS, Potkin SG, Siegel BV, Lohr J, Katz M, Gottschalk LA, Gulasekaram B, Marshall JF, Lottenberg S, Teng CY, Abel F, Plon F, Bunney WE (1992b) Striatal metabolic rate and clinical response to neuroleptics in schizophrenia. Arch Gen Psychiatry 49:966-974
7. Buchsbaum MS, Someya T, Teng CY, Abel F, Chin S, Najafi A, Haier RJ, Wu J, Bunney WE (1996) PET and MRI of the thalamus in never-medicated patients with schizophrenia. Am J Psychiatry 153:191-199
8. Carlsson M, Carlsson A (1990) Schizophrenia: a subcortical neurotransmitter imbalance syndrome? Schizophr Bull 16:425-432
9. Chastrette N, Pfaff DW, Gibbs RB (1991) Effects of daytime and nighttime stress on Fos-like immunoreactivity in the paraventricular nucleus of the hypothalamus, the habenula, and the posterior paraventricular nucleus of the thalamus. Brain Res 563:339-344
10. Cleghorn JM, Szechtman H, Garnett ES, Brown GM, Nahmias C, Szechtman B, Kaplan R, Franco S (1991) Neuroleptic effects on regional brain metabolism in first episode schizophrenics. Schizophr Res 5:208-209
11. Cohen BM, Wan W (1996) The thalamus as a site of action of antipsychotic drugs. Am J Psychiatry 153:104-106
12. Corey-Bloom J, Jernigan T, Archibald S, Harris MJ, Jeste DV (1995) Quantitative magnetic resonance imaging of the brain in late-life schizophrenia. Am J Psychiatry 152:447-449
13. Crosson B, Hughes CW (1987) Role of the thalamus in language: is it related to schizophrenic thought disorder? Schizophr Bull 13:605-621
14. Cullinan WE, Herman JP, Battaglia DF, Akil H, Watson SJ (1994) Pattern and time course of immediate early gene expression in rat brain following acute stress. Neuroscience 64:477-505
15. Deutch AY, Lee MC, Iadarola M (1992) Regionally specific effects of atypical antipsychotic drugs on striatal Fos expression: the nucleus accumbens shell as a locus of antipsychotic action. Mol Gen Neurosci 3:332-341
16. Deutch AY, Ongur D, Duman RS (1995) Antipsychotic drugs induce FOS protein in the thalamic paraventricular nucleus: a novel locus of antipsychotic drug action. Neuroscience 66: 337-346
17. 2 dopamine receptor antagonist induce Fos and related proteins in rat striatal neurons. Neuroscience 37: 287-294
18. Early TS, Reiman EM, Raichle ME, Spitznagel EL (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proc Natl Acad Sci USA 84:561-563
19. 99mTc-Exametazime in unmedicated schizophrenic patients. Biol Psychiatry 33:487-495
20. Fink-Jensen A, Kristensen P (1994) Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain. Neurosci Lett 182:115-118
21. Frazier JA, Giedd JBN, Hamburger SD, Albus KE, Kaysen D, Vaituzis AC, Rajapakse JC, Lenane MC, McKenna K, Jacobsen LK, Gordan CT, Breier A, Rapoport JL (1996) Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia. Arch Gen Psychiatry 53:617-624
22. Groenwegen HJ (1988) Organization of the afferent connections of the mediodorsal thalamic nucleus in the rat, related to the mediodorsal-prefrontal topography. Neuroscience 24: 379-431
23. Gur RE, Mozley PD, Resnick SM, Mozley LH, Shlasel DL, Gallacher F, Arnold SE, Karp JS, Alavi A, Reivich M, Gur RC (1995) Resting cerebral glucose metabolism in first-episode and previously treated patients with schizophrenia relates to clinical features. Arch Gen Psychiatry 52:657-667
24. Holcomb HH, Cascella NG, Thaker GK, Medoff DR, Dannals RF, Tamminga CA (1996) Functional sites of neuroleptic drug action in the human brain: PET/FDG studies with and without haloperidol. Am J Psychiatry 153:41-49
25. 1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci USA 89:11988-11992
26. 2 receptors: distribution, pharmacological characterization and region-specific regulation by clozapine. J Pharmacol Exp Ther 261: 1282-1290
27. Kling AS, Metter EJ, Riege WH, Kuhl DE (1986) Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 143:175-180
28. Lesch A, Bogerts B (1984) The diencephalon in schizophrenia: evidence for reduced thickness of the periventricular grey matter. Eur Arch Psychiatry 234:212-219
29. 99mTc-HMPAO single-photon emission imaging in chronic schizophrenia. Psychol Med 22:27-35
30. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak SJ (1992) Patterns of cerebral blood flow in schizophrenia. Br J Psychiatry 160:179-186
31. MacGibbon GA, Lawlor PA, Bravo R, Dragunow M (1994) Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja. Mol Brain Res 23:21-32
32. Mansour A, Watson SJ Jr (1995) Dopamine receptor expression in the central nervous system. In: Bloom FE, Kupfer DJ (eds) Psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 207-219
33. McCulloch J, Savaki HE, Sokoloff L (1982) Distribution of effects of haloperidol on energy metabolism in the rat brain. Brain Res 243:81-90
34. Miller J (1990) Induction of c-fos mRNA expression in rat striaturn by neuroleptic drugs. J Neurochem 54:1453-1455
35. Morgan JI, Curran T (1991) Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes. Annu Rev Neurosci 14:431-451
36. 4 receptors in GABAergic neurons of the primate brain. Nature 381:245-248
37. Nguyen TV, Kosofsky BE, Birnbaum R, Cohen BM, Hyman SE (1992) Differential expression of c-fos and zif 268 in rat striatum after haloperidol, clozapine, and amphetamine. Proc Natl Acad Sci USA 89:4270-4274
38. Pakkenberg B (1990) Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenia. Arch Gen Psychiatry 47:1023-1028
39. Pakkenberg B (1992) Stereological quantitation of human brains from normal and schizophrenic individuals. Acta Neurol Scand 137:20-33
40. Paxinos G, Watson C (1986) The rat brain in sterotaxic coordinates, 2nd edn. Academic Press, New York
41. Pizzolato G, Soncrant TT, Rapoport SI (1984) Haloperidol and cerebral metabolism in the conscious rat: relation to pharmacokinetics. J Neurochem 43:724-732
42. Pizzolato G, Soncrant TT, Larson DM, Rapoport SI (1987) Stimulatory effect of the D: antagonist sulpiride on glucose utilization in dopaminergic regions of rat brain. J Neurochem 49:631-638
43. Resnick SM, Gur RE, Alavi A, Gur RC, Reivich M (1988) Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatr Res 24:1-11
44. Robertson GS, Fibiger HC (1992) Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine. Neuroscience 46:315-328
45. Sedvall G, Farde L (1995) Chemical brain anatomy in schizophrenia. Lancet 346:743-749
46. Shapiro RM (1993) Regional neuropathology in schizophrenia: where are we? Where are we going? Schizophr Res 10:187-239
47. Siegel BV, Buchsbaum MS, Bunney WE Jr, Gottschalk LA, Haier RJ, Lohr JB, Lottenberg S, Najafi A, Nuechterlein KH, Potkin SG, Wu JC (1993) Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. Am J Psychiatry 150:1325-1336
48. Silbersweig DA, Stern E, Frith C, Cahill C, Holmes A, Grootoonk S, Seaward J, McKenna P, Chua SE, Schnorr L, Jones T, Frackowiak RSJ (1995) A functional neuroanatomy of hallucinations in schizophrenia. Nature 378:176-179
49. Stevens JR (1973) An anatomy of schizophrenia. Arch Gen Psychiatry 29:177-189
50. Su H-S, Bentivoglio M (1990) Thalamic midline cell populations projecting to the nucleus accumbens, amygdala, and hippocampus in the rat. J Comp Neurol 297:582-593
51. Swerdlow NR, Koob GF (1987) Dopamine, schizophrenia, mania and depression: toward a unified hypothesis of cortico-striatopallido-thalamic function. Behav Brain Sci 10:97-245
52. Szechtman H, Nahmias C, Garnett ES, Firnau G, Brown GM, Kaplan RD, Cleghorn JM (1988) Effect of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch Gen Psychiatry 45:523-532
53. Tamminga CA, Thaker GK, Buchanan R, Kirkpatrick B, Alphs LD, Chase TN, Carpenter WT (1992) Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch Gen Psychiarty 49:522-530
54. Tarazi F, Osamu Shirakawa, Tamminga CA (1992) Low dose raclopride spares the extrapyramidal system in rat brain from metabolic effects. Eur J Pharmacol 232:71-77
55. Vita A, Bressi S, Perani D, Inverizzi G, Giobbio GM, Dicci M, Garbarini M, Sole AD, Fazio F (1995) High-resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenia patients. Am J Psychiatry 152: 876-882
56. Vogt BA, Sikes RW, Vogt LJ (1993) Anterior cingulate cortex and the medial pain system. In: Vogt BA, Gabriel M (eds) Neurobiology of cingulate cortex and limbic thalamus: a comprehensive handbook. Birkhauser, Boston, pp 314-344
57. Volkow ND, Brodie JD, Wolf A, Angrist B, Russell J, Cancro (1986) Brain metabolism in patients with schizophrenia before and after acute neuroleptic administration. J Neurol Neurosurg Psychiatry 49:1199-1202
58. Wan W, Ennulat DJ, Cohen BM (1995) Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain. Brain Res 688: 95-104
59. Wiesel FA, Wik G, Sjogren I, Blomqvist G, Greitz T, Stone-Elander S (1987) Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr Scand 76:628-641
60. Wik G, Wiesel F-A (1991) Regional brain glucose metabolism: correlations to biochemical measures and anxiety in patients with schizophrenia. Psychiatry Res Neuroimaging 40:101-114
61. Wik G, Wiesel F-A, Sjogren I, Blomqvist G, Greitz T, Stone-Elander S (1989) Effects of sulpiride and chlorpromazine on regional cerebral glucose metabolism in schizophrenic patients as determined by positron emission tomography. Psychopharmacology 97:309-318
62. Wolkin A, Sanfilipo M, Duncan E, Angrist B, Wolf AP, Cooper TB, Brodie JD, Laska E, Rotrosen JP (1996) Blunted change in cerebral glucose utilization after haloperidol treatment in schizophrenic patients with prominent negative symtoms. Am J Psychiatry 153:346-354
63. 2 receptors and dopamine levels in the thalamus of the rat. Life Sci 48:1845-1852