Serotonin mediated changes in corticotropin releasing factor mRNA expression and feeding behavior isolated to the hypothalamic paraventricular nuclei

Neuroscience Letters

Volumn 498, Issue 3, 2011, Pages 213-217

  Boisvert, Joanne P ^a   Boschuetz, Tyler J ^a   Resch, Jon M ^a   Mueller, Christopher R ^a   Choi, SuJean ^a  

^a MARQUETTE UNIVERSITY   (United States)

Author keywords

Appetite; Corticotropin releasing factor; Hypothalamus; MRNA; Serotonin

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; FENFLURAMINE; MESSENGER RNA; METERGOLINE; NEUROPEPTIDE Y; SEROTONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; FEEDING BEHAVIOR; FOOD INTAKE; HYPOPHAGIA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME;

ANIMALS; APPETITE REGULATION; ARCUATE NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; DRUG INTERACTIONS; FEEDING BEHAVIOR; FENFLURAMINE; MALE; METERGOLINE; MICROINJECTIONS; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEROTONIN;

EID: 79959298804     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.05.011     Document Type: Article

References (36)

1. Arase K., Shargill N.S., Bray G.A. Effects of corticotropin releasing factor on genetically obese (fatty) rats. Physiol. Behav. 1989, 45:565-570.
2. Blevins J.E., Eakin T.J., Murphy J.A., Schwartz M.W., Baskin D.G. Oxytocin innervation of caudal brainstem nuclei activated by cholecystokinin. Brain Res. 2003, 993:30-41.
3. Bray G.A. A concise review on the therapeutics of obesity. Nutrition 2000, 16:953-960.
4. Choi S., Blake V., Cole S., Fernstrom J.D. Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression. Brain Res. 2006, 1087:83-86.
5. Choi S., Jonak E.M., Simpson L., Patil V., Fernstrom J.D. Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions. Brain Res. 2002, 928:30-39.
6. 2C receptor protein in the rat CNS. Neuropharmacology 2000, 39:123-132.
7. Connolly H.M., Crary J.L., McGoon M.D., Hensrud D.D., Edwards B.S., Edwards W.D., Schaff H.V. Valvular heart disease associated with fenfluramine-phentermine. N. Engl. J. Med. 1997, 337:581-588.
8. 2A receptor in the central nervous system of adult rat. J. Comp. Neurol. 1999, 409:187-209.
9. Dallman M.F. Viewing the ventromedial hypothalamus from the adrenal gland. Am. J. Physiol. 1984, 246:R1-R11.
10. Garattini S., Caccia S., Mennini T., Samanin R., Consolo S., Ladinsky H. Biochemical pharmacology of the anorectic drug fenfluramine: a review. Curr. Med. Res. Opin. 1979, 6:15-27.
11. 1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y. Eur. J. Pharmacol. 1995, 274:221-224.
12. Grinker J.A., Drewnowski A., Enns M., Kissileff H. Effects of d-amphetamine and fenfluramine on feeding patterns and activity of obese and lean Zucker rats. Pharmacol. Biochem. Behav. 1980, 12:265-275.
13. Hayashi A., Suzuki M., Sasamata M., Miyata K. Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats. Psychopharmacology (Berl) 2005, 178:241-249.
14. Heisler L.K., Cowley M.A., Tecott L.H., Fan W., Low M.J., Smart J.L., Rubinstein M., Tatro J.B., Marcus J.N., Holstege H., Lee C.E., Cone R.D., Elmquist J.K. Activation of central melanocortin pathways by fenfluramine. Science 2002, 297:609-611.
15. Heisler L.K., Pronchuk N., Nonogaki K., Zhou L., Raber J., Tung L., Yeo G.S., O'Rahilly S., Colmers W.F., Elmquist J.K., Tecott L.H. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. J. Neurosci. 2007, 27:6956-6964.
16. Humphrey P.P., Hartig P., Hoyer D. A proposed new nomenclature for 5-HT receptors. Trends Pharmacol. Sci. 1993, 14:233-236.
17. Javed A., Kamradt M.C., Van de Kar L.D., Gray T.S. d-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala. Neuroscience 1999, 90:851-858.
18. Laflamme N, Bovetto S., Richard D., Rivest S. Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus. Br. J. Pharmacol. 1996, 117:1021-1034.
19. Le Feuvre R.A., Aisenthal L., Rothwell N.J. Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds. Brain Res. 1991, 555:245-250.
20. Liposits Z., Phelix C., Paull W.K. Synaptic interaction of serotonergic axons and corticotropin releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study. Histochemistry 1987, 86:541-549.
21. Luiten P.G.M., Ter Horst G.J., Steffens A.B. The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog. Neurobiol. 1987, 28:1-54.
22. Makarenko I.G., Meguid M.M., Ugrumov M.V. Distribution of serotonin 5-hydroxytriptamine 1B (5-HT(1B)) receptors in the normal rat hypothalamus. Neurosci. Lett. 2002, 328:155-159.
23. Max J.P., Thystere P., Chapleur-Chateau M., Burlet A., Nicolas J.P., Burlet C. Hypothalamic neuropeptides could mediate the anorectic effects of fenfluramine. Neuroreport 1994, 5:1925-1928.
24. McGuirk J., Goodall E., Silverstone T., Willner P. Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour. Behav. Pharmacol. 1991, 2:113-119.
25. 1 receptors. Psychopharmacology (Berl) 1989, 97:213-218.
26. O'Shea R.D., Gundlach A.L. Lack of direct action of d-fenfluramine on arcuate preproNPY mRNA levels in the rat. Neuroreport 1994, 5:2113-2116.
27. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2007, Elsevier Academic Press, Amsterdam, Boston.
28. Ramos E.J., Meguid M.M., Campos A.C., Coelho J.C. Neuropeptide Y, alpha-melanocyte-stimulating hormone, and monoamines in food intake regulation. Nutrition 2005, 21:269-279.
29. Sawchenko P.E, Swanson L.W., Steinbusch H.W., Verhofstad A.A. The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res. 1983, 277:355-360.
30. Schwartz M.W., Woods S.C., Porte D., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature 2000, 404:661-671.
31. Simansky K.J. Serotonergic control of the organization of feeding and satiety. Behav. Brain Res. 1996, 73:37-42.
32. Steinbusch H.W. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 1981, 6:557-618.
33. Stengel A., Goebel M., Million M., Stenzel-Poore M.P., Kobelt P., Monnikes H., Tache Y., Wang L. Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting. Endocrinology 2009, 150:153-160.
34. 2C receptors. Neuropharmacology 2001, 41:200-209.
35. Weiss G.F., Papadakos P., Knudson K., Leibowitz S.F. Medial hypothalamic serotonin: effects on deprivation and norepinephrine-induced eating. Pharmacol. Biochem. Behav. 1986, 25:1223-1230.
36. Weiss G.F., Rogacki N., Fueg A., Buchen D., Leibowitz S.F. Impact of hypothalamic d-norfenfluramine and peripheral d-fenfluramine injection on macronutrient intake in the rat. Brain Res. Bull. 1990, 25:849-859.