Chronic high-dose haloperidol has qualitatively similar effects to risperidone and clozapine on immediate-early gene and tyrosine hydroxylase expression in the rat locus coeruleus but not medial prefrontal cortex

Neuroscience Research

Volumn 57, Issue 1, 2007, Pages 17-28

  Verma, Vivek ^a   Lim, Ee Peng ^a   Han, Siew Ping ^a   Nagarajah, Rajini ^a   Dawe, Gavin S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antipsychotic agents; Genes; Immediate early; Locus coeruleus; Prefrontal cortex; Tyrosine 3 monooxygenase

Indexed keywords

CLOZAPINE; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; HALOPERIDOL; NEUROLEPTIC AGENT; PROPRANOLOL; PROTEIN C FOS; RISPERIDONE; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; IMMUNOREACTIVITY; LOCUS CERULEUS; MALE; NEGATIVE SYNDROME; NONHUMAN; ONCOGENE C FOS; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT DURATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; CELL COUNT; CLOZAPINE; GENE EXPRESSION; GENES, IMMEDIATE-EARLY; HALOPERIDOL; IMMEDIATE-EARLY PROTEINS; IMMUNOHISTOCHEMISTRY; LOCUS COERULEUS; MALE; NEURONS; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RISPERIDONE; TYROSINE 3-MONOOXYGENASE;

EID: 33846074470     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2006.09.002     Document Type: Article

References (58)

1. Ananth J., Burgoyne K.S., Gadasalli R., and Aquino S. How do the atypical antipsychotics work?. J. Psychiatry Neurosci. 26 (2001) 385-394
2. Berridge C.W., and Waterhouse B.D. The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes. Brain Res. Brain Res. Rev. 42 (2003) 33-84
3. Bing G., Chen S., Zhang Y., Hillman D., and Stone E.A. Noradrenergic-induced expression of c-fos in rat cortex: neuronal localization. Neurosci. Lett. 140 (1992) 260-264
4. Bing G., Stone E.A., Zhang Y., and Filer D. Immunohistochemical studies of noradrenergic-induced expression of c-fos in the rat CNS. Brain Res. 592 (1992) 57-62
5. Bing G.Y., Filer D., Miller J.C., and Stone E.A. Noradrenergic activation of immediate early genes in rat cerebral cortex. Brain Res. Mol. Brain Res. 11 (1991) 43-46
6. Cedarbaum J.M., and Aghajanian G.K. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Res. 112 (1976) 413-419
7. Dawe G.S., Huff K.D., Vandergriff J.L., Sharp T., O'Neill M.J., and Rasmussen K. Olanzapine activates the rat locus coeruleus: in vivo electrophysiology and c-Fos immunoreactivity. Biol. Psychiatry 50 (2001) 510-520
8. Deutch A.Y., and Duman R.S. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization. Neuroscience 70 (1996) 377-389
9. Devoto P., Flore G., Saba P., Fa M., and Gessa G.L. Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus. BMC Neurosci. 6 (2005) 31
10. Devoto P., Flore G., Saba P., Fa M., and Gessa G.L. Stimulation of the locus coeruleus elicits noradrenaline and dopamine release in the medial prefrontal and parietal cortex. J Neurochem. 92 (2005) 368-374
11. Dinan T.G., and Aston-Jones G. Acute haloperidol increases impulse activity of brain noradrenergic neurons. Brain Res. 307 (1984) 359-362
12. Dinan T.G., and Aston-Jones G. Chronic haloperidol inactivates brain noradrenergic neurons. Brain Res. 325 (1985) 385-388
13. Dragunow M., and Faull R. The use of c-fos as a metabolic marker in neuronal pathway tracing. J. Neurosci. Methods 29 (1989) 261-265
14. Fink-Jensen A., and Kristensen P. Effects of typical and atypical neuroleptics on Fos protein expression in the rat forebrain. Neurosci. Lett. 182 (1994) 115-118
15. Freedman J.E., and Aghajanian G.K. Idazoxan (RX 781094) selectively antagonizes alpha 2-adrenoceptors on rat central neurons. Eur. J. Pharmacol. 105 (1984) 265-272
16. Herry C., and Mons N. Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdala. Eur. J. Neurosci. 20 (2004) 781-790
17. Kapur S., VanderSpek S.C., Brownlee B.A., and Nobrega J.N. Antipsychotic dosing in preclinical models is often unrepresentative of the clinical condition: a suggested solution based on in vivo occupancy. J. Pharmacol. Exp. Ther. 305 (2003) 625-631
18. Kasper S., and Resinger E. Cognitive effects and antipsychotic treatment. Psychoneuroendocrinology 28 Suppl. 1 (2003) 27-38
19. Kawahara H., Kawahara Y., and Westerink B.H. The noradrenaline-dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis. Eur. J. Pharmacol. 418 (2001) 177-186
20. King D.J. Drug treatment of the negative symptoms of schizophrenia. Eur. Neuropsychopharmacol. 8 (1998) 33-42
21. Kvetnansky R., and Sabban E.L. Stress and molecular biology of neurotransmitter-related enzymes. Ann. N.Y. Acad. Sci. 851 (1998) 342-356
22. Li X.M., Perry K.W., Wong D.T., and Bymaster F.P. Olanzapine increases in vivo dopamine and norepinephrine release in rat prefrontal cortex, nucleus accumbens and striatum. Psychopharmacology (Berl) 136 (1998) 153-161
23. Marcus M.M., Malmerfelt A., Nyberg S., and Svensson T.H. Biochemical effects in brain of low doses of haloperidol are qualitatively similar to those of high doses. Eur. Neuropsychopharmacol. 12 (2002) 379-386
24. Markowitz J.S., Brown C.S., and Moore T.R. Atypical antipsychotics. Part I: pharmacology, pharmacokinetics, and efficacy. Ann. Pharmacother. 33 (1999) 73-85
25. Meltzer H.Y., and McGurk S.R. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia. Schizophr. Bull. 25 (1999) 233-255
26. Mitchell S.N., Smith K.M., Joseph M.H., and Gray J.A. Increases in tyrosine hydroxylase messenger RNA in the locus coeruleus after a single dose of nicotine are followed by time-dependent increases in enzyme activity and noradrenaline release. Neuroscience 56 (1993) 989-997
27. Mize R.R. Quantitative image analysis for immunocytochemistry and in situ hybridization. J. Neurosci. Methods 54 (1994) 219-237
28. Nagy J.I., Price M.L., Staines W.A., Lynn B.D., and Granholm A.C. The hyaluronan receptor RHAMM in noradrenergic fibers contributes to axon growth capacity of locus coeruleus neurons in an intraocular transplant model. Neuroscience 86 (1998) 241-255
29. Nakashima A., Ota A., and Sabban E.L. Interactions between Egr1 and AP1 factors in regulation of tyrosine hydroxylase transcription. Brain Res. Mol. Brain Res. 112 (2003) 61-69
30. Nasif F.J., Cuadra G.R., and Ramirez O.A. Effects of chronic risperidone on central noradrenergic transmission. Eur. J. Pharmacol. 394 (2000) 67-73
31. Nilsson L.K., Schwieler L., Engberg G., Linderholm K.R., and Erhardt S. Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms. Int. J. Neuropsychopharmacol. 8 (2005) 329-339
32. Nisell M., Nomikos G.G., Chergui K., Grillner P., and Svensson T.H. Chronic nicotine enhances basal and nicotine-induced Fos immunoreactivity preferentially in the medial prefrontal cortex of the rat. Neuropsychopharmacology 17 (1997) 151-161
33. Nutt D.J., Lalies M.D., Lione L.A., and Hudson A.L. Noradrenergic mechanisms in the prefrontal cortex. J. Psychopharmacol. 11 (1997) 163-168
34. Ohashi K., Hamamura T., Lee Y., Fujiwara Y., and Kuroda S. Propranolol attenuates haloperidol-induced Fos expression in discrete regions of rat brain: possible brain regions responsible for akathisia. Brain Res. 802 (1998) 134-140
35. Ohashi K., Hamamura T., Lee Y., Fujiwara Y., Suzuki H., and Kuroda S. Clozapine- and olanzapine-induced Fos expression in the rat medial prefrontal cortex is mediated by beta-adrenoceptors. Neuropsychopharmacology 23 (2000) 162-169
36. Ordway G.A., and Szebeni K. Effect of repeated treatment with olanzapine or olanzapine plus fluoxetine on tyrosine hydroxylase in the rat locus coeruleus. Int. J. Neuropsychopharmacol. 7 (2004) 321-327
37. Papanikolaou N.A., and Sabban E.L. Sp1/Egr1 motif: a new candidate in the regulation of rat tyrosine hydroxylase gene transcription by immobilization stress. J. Neurochem. 73 (1999) 433-436
38. Papanikolaou N.A., and Sabban E.L. Ability of Egr1 to activate tyrosine hydroxylase transcription in PC12 cells. Cross-talk with AP-1 factors. J. Biol. Chem. 275 (2000) 26683-26689
39. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. third ed. (1997), Academic Press
40. Ramirez O.A., and Wang R.Y. Locus coeruleus norepinephrine-containing neurons: effects produced by acute and subchronic treatment with antipsychotic drugs and amphetamine. Brain Res. 362 (1986) 165-170
41. Robertson G.S., and Fibiger H.C. Neuroleptics increase c-fos expression in the forebrain: contrasting effects of haloperidol and clozapine. Neuroscience 46 (1992) 315-328
42. Robertson G.S., and Fibiger H.C. Effects of olanzapine on regional c-Fos expression in rat forebrain. Neuropsychopharmacology 14 (1996) 105-110
43. Robertson G.S., Matsumura H., and Fibiger H.C. Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity. J. Pharmacol. Exp. Ther. 271 (1994) 1058-1066
44. Sabban E.L., Hebert M.A., Liu X., Nankova B., and Serova L. Differential effects of stress on gene transcription factors in catecholaminergic systems. Ann. N.Y. Acad. Sci. 1032 (2004) 130-140
45. Sagar S.M., Sharp F.R., and Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 240 (1988) 1328-1331
46. Sahoo P.K., Soltani S., Wong K.C., and Chen Y.C. A survey of thresholding techniques. Comput. Vision Graph. Image Process. 41 (1988) 233-260
47. Schotte A., Janssen P.F., Megens A.A., and Leysen J.E. Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography. Brain Res. 631 (1993) 191-202
48. Sebens J.B., Koch T., Ter Horst G.J., and Korf J. Olanzapine-induced Fos expression in the rat forebrain; cross-tolerance with haloperidol and clozapine. Eur. J. Pharmacol. 353 (1998) 13-21
49. Serova L.I., Nankova B.B., Feng Z., Hong J.S., Hutt M., and Sabban E.L. Heightened transcription for enzymes involved in norepinephrine biosynthesis in the rat locus coeruleus by immobilization stress. Biol. Psychiatry 45 (1999) 853-862
50. Smith K.M., Mitchell S.N., and Joseph M.H. Effects of chronic and subchronic nicotine on tyrosine hydroxylase activity in noradrenergic and dopaminergic neurones in the rat brain. J. Neurochem. 57 (1991) 1750-1756
51. Souto M., Monti J.M., and Altier H. Effects of clozapine on the activity of central dopaminergic and noradrenergic neurons. Pharmacol. Biochem. Behav. 10 (1979) 5-9
52. Stahl S.M. Essential Psychopharmacology: The Prescriber's Guide (2005), Cambridge University Press
53. Staiger J.F., Bisler S., Schleicher A., Gass P., Stehle J.H., and Zilles K. Exploration of a novel environment leads to the expression of inducible transcription factors in barrel-related columns. Neuroscience 99 (2000) 7-16
54. Stone E.A., and Zhang Y. Adrenoceptor antagonists block c-fos response to stress in the mouse brain. Brain Res. 694 (1995) 279-286
55. Stone E.A., Zhang Y., and Carr K.D. Massive activation of c-fos in forebrain after mechanical stimulation of the locus coeruleus. Brain Res. Bull. 36 (1995) 77-80
56. Stone E.A., Zhang Y., John S.M., and Bing G. c-Fos response to administration of catecholamines into brain by microdialysis. Neurosci. Lett. 133 (1991) 33-35
57. Westerink B.H., de B.P., de Vries J.B., Kruse C.G., and Long S.K. Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain. Eur. J. Pharmacol. 361 (1998) 27-33
58. Zigmond R.E., Schon F., and Iversen L.L. Increased tyrosine hydroxylase activity in the locus coeruleus of rat brain stem after reserpine treatment and cold stress. Brain Res. 70 (1974) 547-552