D-fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent fos expression in enkephalin and neurotensin neurons of the amygdala

Neuroscience

Volumn 90, Issue 3, 1999, Pages 851-858

  Javed, A ^a   Kamradt, M C ^a   Van De Kar, L D ^a   Gray, T S ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

5 HT; CRF; Enkephalin; Neurotensin; Oxytocin; Vasopressin

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; DEXFENFLURAMINE; ENKEPHALIN; FLUOXETINE; NEUROTENSIN; OXYTOCIN; PROTIRELIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; SOMATOSTATIN; TYROSINE 3 MONOOXYGENASE; VASOPRESSIN;

AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ONCOGENE C FOS; PEPTIDERGIC NERVOUS SYSTEM; PRIORITY JOURNAL; RAT; STRIA TERMINALIS; SUPRAOPTIC NUCLEUS; THALAMUS MIDLINE NUCLEUS;

AMYGDALA; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; ENKEPHALINS; FENFLURAMINE; HYPOTHALAMUS; MALE; NEURONS; NEUROTENSIN; NEUROTRANSMITTER AGENTS; OXYTOCIN; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGENTS;

EID: 0032893155     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00523-5     Document Type: Article

References (58)

1. Abel K. M., O'Keane V., Murray R. M. Enhancement of the prolactin response to D-fenfluramine in drug-naive schizophrenic patients. Br. J. Psychiat. 168:1996;57-60.
2. Bancroft J., Cook A. The neuroendocrine response to D-fenfluramine in women with premenstrual depression. J. affect. Disord. 36:1995;57-64.
3. Beasley C. M., Masica D. N., Potvin J. H. Fluoxetine: a review of receptor and functional effects and their clinical implications. Psychopharmacology. 107:1992;1-10.
4. Beck C. H. M. Acute treatment with antidepressant drugs selectively increases the expression of c-fos in the rat brain. J. Psychiat. Neurosci. 20:1995;25-32.
5. Blundell J. E. Serotonin and appetite. Neuropharmacology. 23:1984;1537-1551.
6. Borroni E., Ceci A., Garattini S., Mennini T. Differences between D-fenfluramine and D-norfenfluramine in serotonin presynaptic mechanisms. J. Neurochem. 40:1983;891-893.
7. Caccia S., Cappi M., Fracasso C., Garattini S. Influence of dose and route administration on the kinetics of fluoxetine and its metabolite norfluoxetine in the rat. Psychopharmacology. 100:1990;509-514.
8. Ceccatelli S., Villar M. J., Goldstein M., Hökfelt T. Expression of c-fos immunoreactivity in transmitter-characterized neurons after stress. Proc. natn. Acad. Sci. U.S.A. 86:1989;9569-9573.
9. Cleare A. J., Bond A. J. Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects. Psychiat. Res. 69:1997;89-95.
10. Cleare A. J., Murray R. M., O'Keane V. Reduced prolactin and cortisol responses to D-fenfluramine in depressed compared to healthy matched control subjects. Neuropsychopharmacology. 14:1996;349-354.
11. Davis T. P., Porreca F., Burks T. F., Dray A. The proenkephalin A fragment, peptide E: central processing and CNS activity in vivo. Eur. J. Pharmac. 111:1985;177-183.
12. De Simoni M. G., Juraszczyk Z., Fodritto F. Different effects of fenfluramine isomers and metabolites on extracellular 5-HIAA in nucleus accumbens and hippocampus of freely moving rats. Eur. J. Pharmac. 153:1988;295-299.
13. Dreifuss J. J., Raggenbass M., Charpak S., Dubois-Dauphin M., Tribollet E. A role of central oxytocin in autonomic functions: its actions in the motor nucleus of the vagus nerve. Brain Res. Bull. 20:1988;765-770.
14. Fuller R. W., Snoddy H. D., Robertson D. W. Mechanisms of effects of D-fenfluramine on brain serotonin metabolism in rats: uptake inhibition versus release. Pharmac. Biochem. Behav. 30:1988;715-721.
15. Garattini S., Bizzi A., Caccia S., Mennini T., Samanin R. Progress in assessing the role of serotonin in the control of food intake. Clin. Neuropharmac. 11(Suppl. 1):1988;S8-S32.
16. Garattini S., Mennini T., Samanin R. From fenfluramine racemate to D-fenfluramine: specificity and potency of the effects on the serotonergic system and food intake. Ann. N. Y. Acad. Sci. 499:1987;156-166.
17. Giovannelli L., Shiromani P. J., Jirikowski G. F., Bloom F. E. Expression of c-fos protein by immunohistochemically identified oxytocin neurons in the rat hypothalamus upon osmotic stimulation. Brain Res. 588:1992;41-48.
18. Gray T. S. (1990) The organization and possible function of amygdaloid corticotropin-releasing factor pathways. In Corticotropin-releasing Factor: Basic and Clinical Studies of a Neuropeptide (eds De Souza E. B. and Nemeroff C. B.), pp. 53-68. CRC, Boca Raton, FL.
19. 178-199, a corticotropin release inhibiting factor, in the brain of the rat. Soc. Neurosci. Abstr. 23:1997;56.4.
20. Hökfelt T., Elde R., Johansson O., Terenius L., Stein L. The distribution of enkephalin-immunoreactive cell bodies in the rat central nervous system. Neurosci. Lett. 5:1977;25-31.
21. Hökfelt T., Martensson R., Björklund A., Kleinau S. and Goldstein M. (1984) Distribution maps of tyrosine-hydroxylase-immunoreactive neurons in the rat brain. In Handbook of Chemical Neuroanatomy (eds Björklund A. and Hökfelt T.), Vol. 2, pp. 277-379. Elsevier Science, Amsterdam.
22. Honkaniemi J. Colocalization of peptide- and tyrosine hydroxylase-like immunoreactivities with Fos-immunoreactive neurons in rat central amygdaloid nucleus after immobilization stress. Brain Res. 598:1992;107-113.
23. Javed A., Van de Kar L. D., Gray T. S. p-Chlorophenylalanine and fluoxetine inhibit D-fenfluramine-induced Fos expression in the paraventricular nucleus, cingulate cortex and frontal cortex but not in other forebrain and brainstem regions. Brain Res. 774:1997;94-105.
24. Jennes L., Stumpf W. E., Kalivas P. W. Neurotensin: topographical distribution in rat brain by immunocytochemistry. J. comp. Neurol. 210:1982;211-224.
25. Johansson O., Hökfelt T., Elde R. P. Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat. Neuroscience. 13:1984;265-339.
26. Kamegai J., Minami S., Sugihara H., Higuchi H., Wakabayashi I. Growth hormone induces expression of the c-fos gene on hypothalamic neuropeptide-Y and somatostatin neurons in hypophysectomized rats. Endocrinology. 135:1994;2765-2771.
27. Kawano H., Daikoku S., Saito S. Immunohistochemical studies of intrahypothalamic somatostatin-containing neurons in rats. Brain Res. 242:1982;227-232.
28. Khan D., Abrams G. M., Zimmerman E. A., Carraway R., Leeman S. E. Neurotensin neurons in the rat hypothalamus: an immunocytochemical study. Endocrinology. 107:1980;47-54.
29. Knapp S., Mandell A. J. Coincidence of blockade of synaptosomal 5-hydroxytryptamine uptake and decrease in tryptophan hydroxylase activity: effects of fenfluramine. J. Pharmac. exp. Ther. 198:1976;123-132.
30. Koibuchi N., Gibbs R. B., Suzuki M., Pfaff D. W. Thyroidectomy induces Fos-like immunoreactivity within thyrotropin-releasing hormone-expressing neurons located in the paraventricular nucleus of the adult rat hypothalamus. Endocrinology. 129:1991;3208-3216.
31. Laflamme N., Bovetto S., Richard D., Rivest S. Effect of dexfenfluramine on the transcriptional activation of CRF and its type 1 receptor within the paraventricular nucleus of the rat hypothalamus. Br. J. Pharmac. 117:1996;1021-1034.
32. Lechan R. M., Jackson I. M. D. Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary. Endocrinology. 111:1982;55-65.
33. Leibowitz S. F., Weiss G. F., Suh J. S. Medial hypothalamic nuclei mediate serotonin's inhibitory effect on feeding behavior. Pharmac. Biochem. Behav. 37:1990;735-742.
34. 1A agonist, 8-OH-DPAT. Neuropharmacology. 33:1994;335-342.
35. Li B., Rowland N. E. Dexfenfluramine induces fos-like immunoreactivity in discrete brain regions in rats. Brain Res. Bull. 31:1993;43-48.
36. Li B., Rowland N. E. Effect of chronic dexfenfluramine on Fos in rat brain. Brain Res. 728:1996;188-192.
37. McCann M. J., Rogers R. C. Oxytocin excites gastric-related neurons in rat dorsal vagal complex. J. Physiol. 428:1990;95-108.
38. McTavish D., Heel R. C. Dexfenfluramine: a review of its pharmacological properties and therapeutic potential in obesity. Drugs. 43:1992;713-733.
39. Mennini T., Garattini S., Caccia S. Anorectic effect of fenfluramine isomers and metabolites: relationship between brain levels and in vitro potencies on serotonergic mechanisms. Psychopharmacology. 85:1985;111-114.
40. Morley J. E. and Levine A. S. (1990) Corticotropin-releasing factor and ingestive behaviors. In Corticotropin-releasing Factor: Basic and Clinical Studies of a Neuropeptide (eds De Souza E. B. and Nemeroff C. B.), pp. 267-274. CRC, Boca Raton, FL.
41. Nathan C. (1985) Dexfenfluramine and body weight in overweight patients. In Metabolic Complications of Human Obesities (ed. Vague J. E.), pp. 229-237. Elsevier Science, Amsterdam.
42. Olschowka J. A., O'Donohue T. L., Mueller G. P., Jacobowitz D. M. The distribution of corticotropin-releasing factor-like immunoreactive neurons in rat brain. Peptides. 3:1982;995.
43. Park S. B., Williamson D. J., Cowen P. J. 5-HT neuroendocrine function in major depression: prolactin and cortisol responses to D-fenfluramine. Psychol. Med. 26:1996;1191-1196.
44. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates, 2nd edn. Academic, San Diego.
45. Richard D. (1993) Involvement of corticotropin-releasing factor in the control of food intake and energy expenditure. In Corticotropin-releasing Factor and Cytokines: Role in the Stress Response (eds Tache Y. and Rivier C.), pp. 155-172. New York Academy of Sciences, New York.
46. Richelson E., Pfenning M. Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. Eur. J. Pharmac. 104:1984;277-286.
47. Rogers R. C., Hermann G. E. Oxytocin, oxytocin antagonist, TRH and hypothalamic paraventricular nucleus stimulation effects on gastric motility. Peptides. 8:1987;505-513.
48. Sagar S. M., Price K. J., Kasting N. W., Sharp F. R. Anatomic patterns of Fos immunostaining in rat brain following systemic endotoxin administration. Brain Res. Bull. 36:1995;381-392.
49. Sawchenko P. E., Swanson L. W. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to medulla or to the spinal cord in the rat. J. comp. Neurol. 205:1982;260-272.
50. Sawchenko P. E. and Swanson L. W. (1990) Organization of CRF immunoreactive cells and fibers in the rat brain: immunohistochemical studies. In Corticotropin-releasing Factor: Basic and Clinical Studies of a Neuropeptide (eds De Souza E. B. and Nemeroff C. B.), pp. 29-52. CRC, Boca Raton, FL.
51. Schuldiner S., Steiner-mordoch S., Yelin R., Wall S. C., Rudnick G. Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Molec. Pharmac. 44:1993;1227-1231.
52. Sofroniew M. V., Schrell U. Evidence for a direct projection from oxytocin and vasopressin neurons in the hypothalamic paraventricular nucleus to the medulla oblongata: immunohistochemical localization of both the horseradish peroxidase transported and the peptide produced by the same neuron. Neurosci. Lett. 22:1981;211-217.
53. Swanson L. W., Sawchenko P. E. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. A. Rev. Neurosci. 6:1983;275-325.
54. Thakore J. H., O'Keane V., Dinan T. G. D-Fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity. Am. J. Psychiat. 153:1996;1460-1463.
55. Van de Kar L. D., Rittenhouse P. A., Li Q., Levy A. D., Brownfield M. S. Hypothalamic paraventricular, but not supraoptic neurons, mediate the serotonergic stimulation of oxytocin secretion. Brain Res. Bull. 36:1994;45-50.
56. Wamsley J. K., Young W. S. III, Kuhar M. J. Immunohistochemical localization of enkephalin in rat forebrain. Brain Res. 190:1980;153-174.
57. Weiss G. F., Rogacki N., Fueg A., Buchen D., Leibowitz S. F. Impact of hypothalamic D-norfenfluramine and peripheral D-fenfluramine injection on macronutrient intake in the rat. Brain Res. Bull. 25:1990;849-859.
58. Xiong J. J., Hatton G. I. Differential responses of oxytocin and vasopressin neurons to the osmotic and stressful components of hypertonic saline injections: a Fos protein double labeling study. Brain Res. 719:1996;143-153.