Akt1 inhibits homologous recombination in Brca1-deficient cells by blocking the Chk1-Rad51 pathway

Oncogene

Volumn 32, Issue 15, 2013, Pages 1943-1949

  Jia, Y ^a,b   Song, W ^a   Zhang, F ^a   Yan, J ^a,c   Yang, Q ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

Author keywords

Brca1; Chk1; HR; PKB Akt; Rad51

Indexed keywords

BRCA1 PROTEIN; CHECKPOINT KINASE 1; PROTEIN KINASE B; PROTEIN P53; RAD51 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CHROMOSOMAL INSTABILITY; CHROMOSOME REARRANGEMENT; CONTROLLED STUDY; DNA STRAND BREAKAGE; FEMALE; HOMOLOGOUS RECOMBINATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; CHROMOSOMAL INSTABILITY; DNA BREAKS; DNA REPAIR; FEMALE; HOMOLOGOUS RECOMBINATION; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RAD51 RECOMBINASE;

MUS;

EID: 84876102787     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.211     Document Type: Article

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