Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 15, 2013, Pages 6103-6108

  Yeh, Elizabeth S ^a,b   Belka, George K ^a,b   Vernon, Ann E ^a,b   Chen, Chien Chung ^a,b   Jung, Jason J ^a,b   Chodosh, Lewis A ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Breast cancer; Protein kinase B

Indexed keywords

ADENYLATE KINASE; CASPASE 3; CYTOKERATIN 8; DACTINOMYCIN; HORMONALLY UP REGULATED NEU ASSOCIATED KINASE; MESSENGER RNA; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CARCINOGENESIS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; MAMMARY GLAND; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

ANIMALS; APOPTOSIS; CELL SURVIVAL; GENE DELETION; MAMMARY NEOPLASMS, ANIMAL; MICE; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MYC; PTEN PHOSPHOHYDROLASE; TRANSCRIPTION, GENETIC; UP-REGULATION;

MUS;

EID: 84876048679     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1217415110     Document Type: Article

References (26)

1. Bright NJ, Thornton C, Carling D (2009) The regulation and function of mammalian AMPK-related kinases. Acta Physiol (Oxf) 196(1):15-26.
2. Wertheim GB, et al. (2009) The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci USA 106(37):15855-15860.
3. Yeh ES, et al. (2011) Hunk is required for HER2/neu-induced mammary tumorigenesis. J Clin Invest 121(3):866-879.
4. Korobko IV, et al. (2010) Pro-survival activity of the MAK-V protein kinase in PC12 cells. Cell Cycle 9(20):4248-4249.
5. Komurov K, et al. (2010) Comprehensive mapping of the human kinome to epidermal growth factor receptor signaling. J Biol Chem 285(27):21134-21142.
6. Baselga J (2011) Targeting the phosphoinositide-3(PI3) kinase pathway in breast cancer. Oncologist 16 (Suppl 1):12-19.
7. Hollander MC, Blumenthal GM, Dennis PA (2011) PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat Rev Cancer 11(4):289-301.
8. Pelengaris S, Khan M, Evan G (2002) c-MYC: More than just a matter of life and death. Nat Rev Cancer 2(10):764-776.
9. Evan GI, et al. (1992) Induction of apoptosis in fibroblasts by c-myc protein. Cell 69(1):119-128.
10. Clegg NJ, et al. (2011) MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors. PLoS ONE 6(3):e17449.
11. Chan JC, et al. (2011) AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer. Sci Signal 4(188):ra56.
12. Gunther EJ, et al. (2002) A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology. FASEB J 16(3):283-292.
13. Blakely CM, et al. (2005) Developmental stage determines the effects of MYC in the mammary epithelium. Development 132(5):1147-1160.
14. Sutherland KD, et al. (2006) c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3. EMBO J 25(24):5805-5815.
15. Wang X, et al. (2011) Phosphorylation regulates c-Myc' s oncogenic activity in the mammary gland. Cancer Res 71(3):925-936.
16. Strange R, Li F, Saurer S, Burkhardt A, Friis RR (1992) Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development 115(1):49-58.
17. Galaktionov K, Chen X, Beach D (1996) Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382(6591):511-517.
18. Maroulakou IG, et al. (2008) Distinct roles of the three Akt isoforms in lactogenic differentiation and involution. J Cell Physiol 217(2):468-477.
19. Schwertfeger KL, Richert MM, Anderson SM (2001) Mammary gland involution is delayed by activated Akt in transgenic mice. Mol Endocrinol 15(6):867-881.
20. Sekulic A, et al. (2000) A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res 60(13):3504-3513.
21. Wickenden JA, Watson CJ (2010) Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: A play in 3 Akts. Breast Cancer Res 12(2):202.
22. Li G, et al. (2002) Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 129(17):4159-4170.
23. Quintela-Fandino M, et al. (2010) HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. Proc Natl Acad Sci USA 107(6):2622-2627.
24. Plas DR, Thompson CB (2005) Akt-dependent transformation: There is more to growth than just surviving. Oncogene 24(50):7435-7442.
25. Shaw RJ, et al. (2004) The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6(1):91-99.
26. Morrison BW, Leder P (1994) neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene 9(12):3417-3426.