Digoxin downregulates NDRG1 and VEGF through the inhibition of HIF-1α under hypoxic conditions in human lung adenocarcinoma A549 cells

International Journal of Molecular Sciences

Volumn 14, Issue 4, 2013, Pages 7273-7285

  Wei, Dong ^a   Peng, Jing Jing ^a   Gao, Hui ^a   Li, Hua ^a   Li, Dong ^a   Tan, Yong ^a   Zhang, Tao ^a  

^a Oncology Medicine Centre General Hospital of Chinese PLA Chengdu Command   (China)

Author keywords

A549 cells; Digoxin (DGX); HIF 1 ; Hypoxia; NDRG1; VEGF

Indexed keywords

DIGOXIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; N MYC DOWNREGULATED GENE 1 PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; CELL CYCLE PROTEIN; DNA; N-MYC DOWNSTREAM-REGULATED GENE 1 PROTEIN; SIGNAL PEPTIDE; VASCULOTROPIN A;

ARTICLE; CANCER INHIBITION; CELL HYPOXIA; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA INDUCIBLE FACTOR 1ALPHA GENE; LUNG ADENOCARCINOMA; N MYC DOWNREGULATED GENE 1; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; VASCULOTROPIN GENE; WESTERN BLOTTING; ADENOCARCINOMA; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; CELL CYCLE PROTEINS; CELL HYPOXIA; CELL LINE, TUMOR; CELL SURVIVAL; DIGOXIN; DNA, NEOPLASM; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG NEOPLASMS; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84876012356     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms14047273     Document Type: Article

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