The Hedgehog Receptor Patched1 in T Cells Is Dispensable for Adaptive Immunity in Mice

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Michel, Kai D ^a   Uhmann, Anja ^a   Dressel, Ralf ^a   van den Brandt, Jens ^a,b   Hahn, Heidi ^a   Reichardt, Holger M ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b Medical University of Greifswald   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLUCOCORTICOID; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2;

ADAPTIVE IMMUNITY; ADOPTIVE TRANSFER; ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LINEAGE; CONTROLLED STUDY; DISEASE COURSE; GAMMA IRRADIATION; GENOTYPE; GRAFT VERSUS HOST REACTION; IMMUNE SYSTEM; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MELANOMA CELL; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE;

ADAPTIVE IMMUNITY; ANIMALS; CELL LINEAGE; FEMALE; GENE DELETION; HEDGEHOG PROTEINS; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

ERINACEIDAE; MUS;

EID: 84876006432     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0061034     Document Type: Article

References (30)

1. Jiang J, Hui CC, (2008) Hedgehog signaling in development and cancer. Dev Cell 15: 801-812.
2. Scales SJ, de Sauvage FJ, (2009) Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci 30: 303-312.
3. Chan VS, Chau SY, Tian L, Chen Y, Kwong SK, et al. (2006) Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes. Int Immunol 18: 1627-1636.
4. Lowrey JA, Stewart GA, Lindey S, Hoyne GF, Dallman MJ, et al. (2002) Sonic hedgehog promotes cell cycle progression in activated peripheral CD4(+) T lymphocytes. J Immunol 169: 1869-1875.
5. Outram SV, Varas A, Pepicelli CV, Crompton T, (2000) Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 13: 187-197.
6. Shah DK, Hager-Theodorides AL, Outram SV, Ross SE, Varas A, et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol 172: 2296-2306.
7. El Andaloussi A, Graves S, Meng F, Mandal M, Mashayekhi M, et al. (2006) Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol 7: 418-426.
8. Rowbotham NJ, Hager-Theodorides AL, Cebecauer M, Shah DK, Drakopoulou E, et al. (2007) Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation. Blood 109: 3757-3766.
9. Hager-Theodorides AL, Furmanski AL, Ross SE, Outram SV, Rowbotham NJ, et al. (2009) The Gli3 transcription factor expressed in the thymus stroma controls thymocyte negative selection via Hedgehog-dependent and-independent mechanisms. J Immunol 183: 3023-3032.
10. Siggins SL, Nguyen NY, McCormack MP, Vasudevan S, Villani R, et al. (2009) The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms. Blood 114: 995-1004.
11. Uhmann A, Dittmann K, Nitzki F, Dressel R, Koleva M, et al. (2007) The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood 110: 1814-1823.
12. Uhmann A, van den Brandt J, Dittmann K, Hess I, Dressel R, et al. (2011) T cell development critically depends on prethymic stromal patched expression. J Immunol 186: 3383-3391.
13. Stewart GA, Lowrey JA, Wakelin SJ, Fitch PM, Lindey S, et al. (2002) Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells. J Immunol 169: 5451-5457.
14. Rowbotham NJ, Furmanski AL, Hager-Theodorides AL, Ross SE, Drakopoulou E, et al. (2008) Repression of hedgehog signal transduction in T-lineage cells increases TCR-induced activation and proliferation. Cell Cycle 7: 904-908.
15. Wolfer A, Bakker T, Wilson A, Nicolas M, Ioannidis V, et al. (2001) Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol 2: 235-241.
16. Wüst S, van den Brandt J, Tischner D, Kleiman A, Tuckermann JP, et al. (2008) Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis. J Immunol 180: 8434-8443.
17. Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, et al. (2011) Acid Sphingomyelinase Is Required for Protection of Effector Memory T Cells against Glucocorticoid-Induced Cell Death. J Immunol 187: 4509-4516.
18. Sbiera S, Dexneit T, Reichardt SD, Michel KD, van den Brandt J, et al. (2011) Influence of short-term glucocorticoid therapy on regulatory T cells in vivo. PLoS ONE 6: e24345.
19. Dressel R, Elsner L, Quentin T, Walter L, Günther E, (2000) Heat shock protein 70 is able to prevent heat shock-induced resistance of target cells to CTL. J Immunol 164: 2362-2371.
20. Voigt H, Schrama D, Eggert AO, Vetter CS, Müller-Blech K, et al. (2006) CD28-mediated costimulation impacts on the differentiation of DC vaccination-induced T cell responses. Clin Exp Immunol 143: 93-102.
21. Hwang PH, Yi HK, Kim DS, Nam SY, Kim JS, et al. (2001) Suppression of tumorigenicity and metastasis in B16F10 cells by PTEN/MMAC1/TEP1 gene. Cancer Lett 172: 83-91.
22. Drakopoulou E, Outram SV, Rowbotham NJ, Ross SE, Furmanski AL, et al. (2010) Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development. Cell Cycle 9: 4144-4152.
23. Furmanski AL, Saldana JI, Rowbotham NJ, Ross SE, Crompton T, (2012) Role of Hedgehog signalling at the transition from double-positive to single-positive thymocyte. Eur J Immunol 42: 489-499.
24. Rowbotham NJ, Hager-Theodorides AL, Furmanski AL, Crompton T, (2007) A novel role for Hedgehog in T-cell receptor signaling: implications for development and immunity. Cell Cycle 6: 2138-2142.
25. Erlacher M, Michalak EM, Kelly PN, Labi V, Niederegger H, et al. (2005) BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo. Blood 106: 4131-4138.
26. Pazour GJ, Witman GB, (2003) The vertebrate primary cilium is a sensory organelle. Curr Opin Cell Biol 15: 105-110.
27. Eggenschwiler JT, Anderson KV, (2007) Cilia and developmental signaling. Annu Rev Cell Dev Biol 23: 345-373.
28. Goetz SC, Anderson KV, (2010) The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet 11: 331-344.
29. Rahnama F, Toftgard R, Zaphiropoulos PG, (2004) Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J 378: 325-334.
30. Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, et al. (2008) Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J Cell Biol 180: 897-904.