The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms

Blood

Volumn 114, Issue 5, 2009, Pages 995-1004

  Siggins, Sarah L ^a   Nguyen, Nhu Y N ^a   McCormack, Matthew P ^a,b   Vasudevan, Sumitha ^a   Villani, Rehan ^c   Jane, Stephen M ^a,b   Wainwright, Brandon J ^c   Curtis, David J ^a,b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; THYMIC STROMAL LYMPHOPOIETIN; CELL SURFACE RECEPTOR; CYTOKINE; G PROTEIN COUPLED RECEPTOR; KRUPPEL LIKE FACTOR; PATCHED RECEPTORS; SMO PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B LYMPHOCYTE; BONE MARROW CELL; CELL COUNT; CELL CYCLE; CELL LOSS; CONTROLLED STUDY; EPITHELIUM CELL; GENE DELETION; HEMATOPOIESIS; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; OSTEOBLAST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; BLOOD; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CELL LINEAGE; CONGENIC STRAIN; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; LYMPHOCYTE; LYMPHOPOIESIS; MALE; METABOLISM; MYELOPOIESIS; PHYSIOLOGY; RADIATION CHIMERA; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL LINEAGE; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; LYMPHOCYTES; LYMPHOPOIESIS; MALE; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID CELLS; MYELOPOIESIS; OSTEOBLASTS; RADIATION CHIMERA; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 70349229823     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-03-208330     Document Type: Article

References (41)

1. Wang Y, McMahon AP, Allen BL. Shifting paradigms in Hedgehog signaling. Curr Opin Cell Biol. 2007;19:159-165.
2. Gering M, Patient R. Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryos. Dev Cell. 2005;8:389-400. (Pubitemid 40309809)
3. Mandal L, Martinez-Agosto JA, Evans CJ, Hartenstein V, Banerjee U. A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors. Nature. 2007; 446:320-324. (Pubitemid 46426149)
4. Dierks C, Beigi R, Guo GR, et al. Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell. 2008;14:238-249.
5. El Andaloussi A, Graves S, Meng F, Mandal M, Mashayekhi M, Aifantis I. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol. 2006; 7:418-426.
6. Outram SV, Varas A, Pepicelli CV, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000;13:187-197. (Pubitemid 30951885)
7. Adolphe C, Narang M, Ellis T, Wicking C, Kaur P, Wainwright B. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development. 2004;131: 5009-5019. (Pubitemid 39485358)
8. Yang ZJ, Ellis T, Markant SL, et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell. 2008;14:135-145.
9. Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol. 2007;17:438-447.
10. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2:172-180. (Pubitemid 33707938)
11. -/- repopulating cells. Blood. 2004;104: 1002-1009.
12. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997;277: 1109-1113. (Pubitemid 27371635)
13. Trowbridge JJ, Scott MP, Bhatia M. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A. 2006;103:14134-14139. (Pubitemid 44452992)
14. Uhmann A, Dittmann K, Nitzki F, et al. The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood. 2007;110:1814-1823. (Pubitemid 47443892)
15. Ellis T, Smyth I, Riley E, et al. Patched 1 conditional null allele in mice. Genesis. 2003;36:158-161. (Pubitemid 36959347)
16. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269: 1427-1429.
17. Gothert JR, Gustin SE, Hall MA, et al. In vivo fatetracing studies using the Scl stem cell enhancer: embryonic hematopoietic stem cells significantly contribute to adult hematopoiesis. Blood. 2005; 105:2724-2732.
18. Rickert RC, Roes J, Rajewsky K. B lymphocytespecific, Cre-mediated mutagenesis in mice. Nucleic Acids Res. 1997;25:1317-1318.
19. Orban PC, Chui D, Marth JD. Tissue- and sitespecific DNA recombination in transgenic mice. Proc Natl Acad Sci U S A. 1992;89:6861-6865.
20. Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A. Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001;29:418-425. (Pubitemid 34326692)
21. Curtis DJ, Hall MA, Van Stekelenburg LJ, Robb L, Jane SM, Begley CG. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood. 2004;103:3342-3348. (Pubitemid 38525662)
22. Metcalf D. Haemopoietic Colony-stimulating Factors. Amsterdam: Elsevier; 1984.
23. Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development. 2004;131:217-228.
24. Schneider A, Zhang Y, Guan Y, Davis LS, Breyer MD. Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera ofMx1Cre mice. Am J Physiol Renal Physiol. 2003;284:F411-417. (Pubitemid 36114704)
25. Calvi LM, Adams GB, Weibrecht KW, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425:841-846. (Pubitemid 37351468)
26. Zhu J, Garrett R, Jung Y, et al. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007; 109:3706-3712. (Pubitemid 46641719)
27. Kollet O, Dar A, Shivtiel S, et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med. 2006;12:657-664. (Pubitemid 43865234)
28. Walkley CR, Shea JM, Sims NA, Purton LE, Orkin SH. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell. 2007;129:1081-1095. (Pubitemid 46908695)
29. Zhang J, Niu C, Ye L, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425:836-841. (Pubitemid 37351467)
30. Kuraguchi M, Wang XP, Bronson RT, et al. Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. PLoS Genet. 2006;2:e146. (Pubitemid 44504788)
31. Osborn MJ, Ryan PL, Kirchhof N, Panoskaltsis- Mortari A, Mortari F, Tudor KS. Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis. Blood. 2004;103:843-851. (Pubitemid 38129541)
32. Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol. 2005;78:325-337. (Pubitemid 41061305)
33. Mak KK, Bi Y, Wan C, et al. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev Cell. 2008;14:674-688. (Pubitemid 351622607)
34. Ohba S, Kawaguchi H, Kugimiya F, et al. Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity. Dev Cell. 2008;14:689-699. (Pubitemid 351622616)
35. Kopp HG, Avecilla ST, Hooper AT, Rafii S. The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiology (Bethesda). 2005;20:349-356. (Pubitemid 41457400)
36. Kiel MJ, Radice GL, Morrison SJ. Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell. 2007;1:204-217.
37. Plaisant M, Fontaine C, Cousin W, Rochet N, Dani C, Peraldi P. Activation of Hedgehog signaling inhibits osteoblast differentiation of human mesenchymal stem cells. Stem Cells. 2009;3: 703-713.
38. Ishikawa F, Yoshida S, Saito Y, et al. Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol. 2007;25:1315-1321. (Pubitemid 350076512)
39. Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001;15:3059-3087. (Pubitemid 33115673)
40. Yauch RL, Gould SE, Scales SJ, et al. A paracrine requirement for hedgehog signalling in cancer. Nature. 2008;455:406-410.
41. Carpenter D, Stone DM, Brush J, et al. Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A. 1998;95:13630-13634. (Pubitemid 28523023)