메뉴 건너뛰기




Volumn 9, Issue 3, 2013, Pages

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in Caenorhabditis elegans

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE; PROTEIN WDR 23; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 84875999410     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003354     Document Type: Article
Times cited : (60)

References (63)
  • 1
    • 77953012548 scopus 로고    scopus 로고
    • Stress-activated cap'n'collar transcription factors in aging and human disease
    • Sykiotis GP, Bohmann D, (2010) Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal 3: re3.
    • (2010) Sci Signal , vol.3
    • Sykiotis, G.P.1    Bohmann, D.2
  • 2
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: where are we now?
    • Halliwell B, (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97: 1634-1658.
    • (2006) J Neurochem , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 3
    • 37749024370 scopus 로고    scopus 로고
    • Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila
    • Sykiotis GP, Bohmann D, (2008) Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. Dev Cell 14: 76-85.
    • (2008) Dev Cell , vol.14 , pp. 76-85
    • Sykiotis, G.P.1    Bohmann, D.2
  • 4
    • 0042626242 scopus 로고    scopus 로고
    • SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    • An JH, Blackwell TK, (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17: 1882-1893.
    • (2003) Genes Dev , vol.17 , pp. 1882-1893
    • An, J.H.1    Blackwell, T.K.2
  • 5
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi M, Yamamoto M, (2006) Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46: 113-140.
    • (2006) Adv Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 6
    • 0037996661 scopus 로고    scopus 로고
    • Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress
    • Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, et al. (2003) Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. J Neurosci 23: 3394-3406.
    • (2003) J Neurosci , vol.23 , pp. 3394-3406
    • Shih, A.Y.1    Johnson, D.A.2    Wong, G.3    Kraft, A.D.4    Jiang, L.5
  • 7
    • 70350625466 scopus 로고    scopus 로고
    • Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf
    • Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, et al. (2009) Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8: 524-541.
    • (2009) Aging Cell , vol.8 , pp. 524-541
    • Oliveira, R.P.1    Porter Abate, J.2    Dilks, K.3    Landis, J.4    Ashraf, J.5
  • 8
    • 0141621061 scopus 로고    scopus 로고
    • NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons
    • Lee JM, Shih AY, Murphy TH, Johnson JA, (2003) NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. J Biol Chem 278: 37948-37956.
    • (2003) J Biol Chem , vol.278 , pp. 37948-37956
    • Lee, J.M.1    Shih, A.Y.2    Murphy, T.H.3    Johnson, J.A.4
  • 9
    • 0038146898 scopus 로고    scopus 로고
    • Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
    • Lee JM, Calkins MJ, Chan K, Kan YW, Johnson JA, (2003) Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. J Biol Chem 278: 12029-12038.
    • (2003) J Biol Chem , vol.278 , pp. 12029-12038
    • Lee, J.M.1    Calkins, M.J.2    Chan, K.3    Kan, Y.W.4    Johnson, J.A.5
  • 10
    • 79956329138 scopus 로고    scopus 로고
    • Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression
    • Escartin C, Won SJ, Malgorn C, Auregan G, Berman AE, et al. (2011) Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression. J Neurosci 31: 7392-7401.
    • (2011) J Neurosci , vol.31 , pp. 7392-7401
    • Escartin, C.1    Won, S.J.2    Malgorn, C.3    Auregan, G.4    Berman, A.E.5
  • 11
    • 0842304134 scopus 로고    scopus 로고
    • Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    • Kraft AD, Johnson DA, Johnson JA, (2004) Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. J Neurosci 24: 1101-1112.
    • (2004) J Neurosci , vol.24 , pp. 1101-1112
    • Kraft, A.D.1    Johnson, D.A.2    Johnson, J.A.3
  • 12
    • 0032536783 scopus 로고    scopus 로고
    • Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice
    • Chan JY, Kwong M, Lu R, Chang J, Wang B, et al. (1998) Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J 17: 1779-1787.
    • (1998) EMBO J , vol.17 , pp. 1779-1787
    • Chan, J.Y.1    Kwong, M.2    Lu, R.3    Chang, J.4    Wang, B.5
  • 13
    • 34249891333 scopus 로고    scopus 로고
    • Two neurons mediate diet-restriction-induced longevity in C. elegans
    • Bishop NA, Guarente L, (2007) Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447: 545-549.
    • (2007) Nature , vol.447 , pp. 545-549
    • Bishop, N.A.1    Guarente, L.2
  • 14
    • 76149095203 scopus 로고    scopus 로고
    • Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans
    • Park SK, Link CD, Johnson TE, (2010) Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans. FASEB J 24: 383-392.
    • (2010) FASEB J , vol.24 , pp. 383-392
    • Park, S.K.1    Link, C.D.2    Johnson, T.E.3
  • 15
    • 37349034239 scopus 로고    scopus 로고
    • Mitochondrial dysfunction, oxidative stress, regulation of exocytosis and their relevance to neurodegenerative diseases
    • Keating DJ, (2008) Mitochondrial dysfunction, oxidative stress, regulation of exocytosis and their relevance to neurodegenerative diseases. J Neurochem 104: 298-305.
    • (2008) J Neurochem , vol.104 , pp. 298-305
    • Keating, D.J.1
  • 16
    • 84866522881 scopus 로고    scopus 로고
    • The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury
    • Saykally JN, Rachmany L, Hatic H, Shaer A, Rubovitch V, et al. (2012) The nuclear factor erythroid 2-like 2 activator, tert-butylhydroquinone, improves cognitive performance in mice after mild traumatic brain injury. Neuroscience.
    • (2012) Neuroscience
    • Saykally, J.N.1    Rachmany, L.2    Hatic, H.3    Shaer, A.4    Rubovitch, V.5
  • 17
    • 66149175591 scopus 로고    scopus 로고
    • Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1
    • Park SK, Tedesco PM, Johnson TE, (2009) Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 8: 258-269.
    • (2009) Aging Cell , vol.8 , pp. 258-269
    • Park, S.K.1    Tedesco, P.M.2    Johnson, T.E.3
  • 18
    • 2442719045 scopus 로고    scopus 로고
    • Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster
    • Landis GN, Abdueva D, Skvortsov D, Yang J, Rabin BE, et al. (2004) Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci U S A 101: 7663-7668.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7663-7668
    • Landis, G.N.1    Abdueva, D.2    Skvortsov, D.3    Yang, J.4    Rabin, B.E.5
  • 19
    • 66349105688 scopus 로고    scopus 로고
    • The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans
    • Choe KP, Przybysz AJ, Strange K, (2009) The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol 29: 2704-2715.
    • (2009) Mol Cell Biol , vol.29 , pp. 2704-2715
    • Choe, K.P.1    Przybysz, A.J.2    Strange, K.3
  • 20
    • 77955297540 scopus 로고    scopus 로고
    • Genetic and cellular characterization of Caenorhabditis elegans mutants abnormal in the regulation of many phase II enzymes
    • Hasegawa K, Miwa J, (2010) Genetic and cellular characterization of Caenorhabditis elegans mutants abnormal in the regulation of many phase II enzymes. PLoS One 5: e11194.
    • (2010) PLoS One , vol.5
    • Hasegawa, K.1    Miwa, J.2
  • 21
    • 33749535905 scopus 로고    scopus 로고
    • Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery
    • Angers S, Li T, Yi X, MacCoss MJ, Moon RT, et al. (2006) Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 443: 590-593.
    • (2006) Nature , vol.443 , pp. 590-593
    • Angers, S.1    Li, T.2    Yi, X.3    MacCoss, M.J.4    Moon, R.T.5
  • 22
    • 33751112293 scopus 로고    scopus 로고
    • DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases
    • He YJ, McCall CM, Hu J, Zeng Y, Xiong Y, (2006) DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev 20: 2949-2954.
    • (2006) Genes Dev , vol.20 , pp. 2949-2954
    • He, Y.J.1    McCall, C.M.2    Hu, J.3    Zeng, Y.4    Xiong, Y.5
  • 23
    • 33750509178 scopus 로고    scopus 로고
    • CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
    • Higa LA, Wu M, Ye T, Kobayashi R, Sun H, et al. (2006) CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol 8: 1277-1283.
    • (2006) Nat Cell Biol , vol.8 , pp. 1277-1283
    • Higa, L.A.1    Wu, M.2    Ye, T.3    Kobayashi, R.4    Sun, H.5
  • 24
    • 23144441321 scopus 로고    scopus 로고
    • Systematic analysis of genes required for synapse structure and function
    • Sieburth D, Ch'ng Q, Dybbs M, Tavazoie M, Kennedy S, et al. (2005) Systematic analysis of genes required for synapse structure and function. Nature 436: 510-517.
    • (2005) Nature , vol.436 , pp. 510-517
    • Sieburth, D.1    Ch'ng, Q.2    Dybbs, M.3    Tavazoie, M.4    Kennedy, S.5
  • 26
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132: 1025-1038.
    • (2008) Cell , vol.132 , pp. 1025-1038
    • Tullet, J.M.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5
  • 28
    • 77649311383 scopus 로고    scopus 로고
    • Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
    • Onken B, Driscoll M, (2010) Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One 5: e8758.
    • (2010) PLoS One , vol.5
    • Onken, B.1    Driscoll, M.2
  • 29
    • 79959823394 scopus 로고    scopus 로고
    • Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity
    • Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, et al. (2011) Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity. PLoS Genet 7: e1002119.
    • (2011) PLoS Genet , vol.7
    • Li, X.1    Matilainen, O.2    Jin, C.3    Glover-Cutter, K.M.4    Holmberg, C.I.5
  • 30
    • 25844490465 scopus 로고    scopus 로고
    • The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
    • Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev 19: 2278-2283.
    • (2005) Genes Dev , vol.19 , pp. 2278-2283
    • Inoue, H.1    Hisamoto, N.2    An, J.H.3    Oliveira, R.P.4    Nishida, E.5
  • 31
    • 77952379111 scopus 로고    scopus 로고
    • Caenorhabditis elegans bicarbonate transporter ABTS-1 is involved in arsenite toxicity and cholinergic signaling
    • Liao VH, Liu JT, Li WH, Yu CW, Hsieh YC, (2010) Caenorhabditis elegans bicarbonate transporter ABTS-1 is involved in arsenite toxicity and cholinergic signaling. Chem Res Toxicol 23: 926-932.
    • (2010) Chem Res Toxicol , vol.23 , pp. 926-932
    • Liao, V.H.1    Liu, J.T.2    Li, W.H.3    Yu, C.W.4    Hsieh, Y.C.5
  • 32
    • 73949099851 scopus 로고    scopus 로고
    • A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans
    • Jospin M, Qi YB, Stawicki TM, Boulin T, Schuske KR, et al. (2009) A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biol 7: e1000265.
    • (2009) PLoS Biol , vol.7
    • Jospin, M.1    Qi, Y.B.2    Stawicki, T.M.3    Boulin, T.4    Schuske, K.R.5
  • 33
    • 57149117136 scopus 로고    scopus 로고
    • Profiling synaptic proteins identifies regulators of insulin secretion and lifespan
    • Ch'ng Q, Sieburth D, Kaplan JM, (2008) Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet 4: e1000283.
    • (2008) PLoS Genet , vol.4
    • Ch'ng, Q.1    Sieburth, D.2    Kaplan, J.M.3
  • 34
    • 33746627569 scopus 로고    scopus 로고
    • Factors regulating the abundance and localization of synaptobrevin in the plasma membrane
    • Dittman JS, Kaplan JM, (2006) Factors regulating the abundance and localization of synaptobrevin in the plasma membrane. Proc Natl Acad Sci U S A 103: 11399-11404.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11399-11404
    • Dittman, J.S.1    Kaplan, J.M.2
  • 36
    • 55249084960 scopus 로고    scopus 로고
    • Neuropeptides
    • Li C, Kim K, (2008) Neuropeptides. Worm Book pp. 1-36.
    • (2008) Worm Book , pp. 1-36
    • Li, C.1    Kim, K.2
  • 37
    • 0027510550 scopus 로고
    • Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination
    • Perry MD, Li W, Trent C, Robertson B, Fire A, et al. (1993) Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination. Genes Dev 7: 216-228.
    • (1993) Genes Dev , vol.7 , pp. 216-228
    • Perry, M.D.1    Li, W.2    Trent, C.3    Robertson, B.4    Fire, A.5
  • 38
    • 0033198944 scopus 로고    scopus 로고
    • RNA-triggered gene silencing
    • Fire A, (1999) RNA-triggered gene silencing. Trends Genet 15: 358-363.
    • (1999) Trends Genet , vol.15 , pp. 358-363
    • Fire, A.1
  • 39
    • 33846503468 scopus 로고    scopus 로고
    • Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126)
    • Schmitz C, Kinge P, Hutter H, (2007) Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126). Proc Natl Acad Sci U S A 104: 834-839.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 834-839
    • Schmitz, C.1    Kinge, P.2    Hutter, H.3
  • 40
    • 0037192490 scopus 로고    scopus 로고
    • Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1
    • Winston WM, Molodowitch C, Hunter CP, (2002) Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1. Science 295: 2456-2459.
    • (2002) Science , vol.295 , pp. 2456-2459
    • Winston, W.M.1    Molodowitch, C.2    Hunter, C.P.3
  • 41
    • 78650944949 scopus 로고    scopus 로고
    • The cell-non-autonomous nature of electron transport chain-mediated longevity
    • Durieux J, Wolff S, Dillin A, (2011) The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 144: 79-91.
    • (2011) Cell , vol.144 , pp. 79-91
    • Durieux, J.1    Wolff, S.2    Dillin, A.3
  • 42
    • 79956101953 scopus 로고    scopus 로고
    • Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle
    • Meissner B, Rogalski T, Viveiros R, Warner A, Plastino L, et al. (2011) Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. PLoS One 6: e19937.
    • (2011) PLoS One , vol.6
    • Meissner, B.1    Rogalski, T.2    Viveiros, R.3    Warner, A.4    Plastino, L.5
  • 43
    • 0033231549 scopus 로고    scopus 로고
    • C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane
    • Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM, (1999) C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 4: 815-826.
    • (1999) Mol Cell , vol.4 , pp. 815-826
    • Labrousse, A.M.1    Zappaterra, M.D.2    Rube, D.A.3    van der Bliek, A.M.4
  • 45
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, et al. (2010) Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 28: 511-515.
    • (2010) Nat Biotechnol , vol.28 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3    Mortazavi, A.4    Kwan, G.5
  • 46
  • 47
    • 67349276677 scopus 로고    scopus 로고
    • Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone
    • Przybysz AJ, Choe KP, Roberts LJ, Strange K, (2009) Increased age reduces DAF-16 and SKN-1 signaling and the hormetic response of Caenorhabditis elegans to the xenobiotic juglone. Mech Ageing Dev 130: 357-369.
    • (2009) Mech Ageing Dev , vol.130 , pp. 357-369
    • Przybysz, A.J.1    Choe, K.P.2    Roberts, L.J.3    Strange, K.4
  • 49
    • 0028104274 scopus 로고
    • Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements
    • Blackwell TK, Bowerman B, Priess JR, Weintraub H, (1994) Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements. Science 266: 621-628.
    • (1994) Science , vol.266 , pp. 621-628
    • Blackwell, T.K.1    Bowerman, B.2    Priess, J.R.3    Weintraub, H.4
  • 50
    • 37649008205 scopus 로고    scopus 로고
    • Protons act as a transmitter for muscle contraction in C. elegans
    • Beg AA, Ernstrom GG, Nix P, Davis MW, Jorgensen EM, (2008) Protons act as a transmitter for muscle contraction in C. elegans. Cell 132: 149-160.
    • (2008) Cell , vol.132 , pp. 149-160
    • Beg, A.A.1    Ernstrom, G.G.2    Nix, P.3    Davis, M.W.4    Jorgensen, E.M.5
  • 51
    • 42649130014 scopus 로고    scopus 로고
    • PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
    • Lo SC, Hannink M, (2008) PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res 314: 1789-1803.
    • (2008) Exp Cell Res , vol.314 , pp. 1789-1803
    • Lo, S.C.1    Hannink, M.2
  • 52
    • 33845981493 scopus 로고    scopus 로고
    • PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex
    • Lo SC, Hannink M, (2006) PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. J Biol Chem 281: 37893-37903.
    • (2006) J Biol Chem , vol.281 , pp. 37893-37903
    • Lo, S.C.1    Hannink, M.2
  • 53
    • 3543008924 scopus 로고    scopus 로고
    • Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
    • Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, et al. (2004) Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24: 7130-7139.
    • (2004) Mol Cell Biol , vol.24 , pp. 7130-7139
    • Kobayashi, A.1    Kang, M.I.2    Okawa, H.3    Ohtsuji, M.4    Zenke, Y.5
  • 54
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, et al. (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13: 76-86.
    • (1999) Genes Dev , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5
  • 55
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, et al. (2011) Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 331: 456-461.
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5
  • 56
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M, (2009) RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10: 57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 57
  • 58
    • 0028356773 scopus 로고
    • The GTPase Rab3a negatively controls calcium-dependent exocytosis in neuroendocrine cells
    • Johannes L, Lledo PM, Roa M, Vincent JD, Henry JP, et al. (1994) The GTPase Rab3a negatively controls calcium-dependent exocytosis in neuroendocrine cells. EMBO J 13: 2029-2037.
    • (1994) EMBO J , vol.13 , pp. 2029-2037
    • Johannes, L.1    Lledo, P.M.2    Roa, M.3    Vincent, J.D.4    Henry, J.P.5
  • 59
    • 1642366742 scopus 로고    scopus 로고
    • Rab3A negatively regulates activity-dependent modulation of exocytosis in bovine adrenal chromaffin cells
    • Thiagarajan R, Tewolde T, Li Y, Becker PL, Rich MM, et al. (2004) Rab3A negatively regulates activity-dependent modulation of exocytosis in bovine adrenal chromaffin cells. J Physiol 555: 439-457.
    • (2004) J Physiol , vol.555 , pp. 439-457
    • Thiagarajan, R.1    Tewolde, T.2    Li, Y.3    Becker, P.L.4    Rich, M.M.5
  • 60
    • 0025942107 scopus 로고
    • Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences
    • Mello CC, Kramer JM, Stinchcomb D, Ambros V, (1991) Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10: 3959-3970.
    • (1991) EMBO J , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 61
    • 0038725897 scopus 로고    scopus 로고
    • Genome-wide RNAi screening in Caenorhabditis elegans
    • Kamath RS, Ahringer J, (2003) Genome-wide RNAi screening in Caenorhabditis elegans. Methods 30: 313-321.
    • (2003) Methods , vol.30 , pp. 313-321
    • Kamath, R.S.1    Ahringer, J.2
  • 63
    • 68349104949 scopus 로고    scopus 로고
    • MAQGene: software to facilitate C. elegans mutant genome sequence analysis
    • Bigelow H, Doitsidou M, Sarin S, Hobert O, (2009) MAQGene: software to facilitate C. elegans mutant genome sequence analysis. Nat Methods 6: 549.
    • (2009) Nat Methods , vol.6 , pp. 549
    • Bigelow, H.1    Doitsidou, M.2    Sarin, S.3    Hobert, O.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.