Effect of growth factors on the proliferation and gene expression of human meibomian gland epithelial cells

Investigative Ophthalmology and Visual Science

Volumn 54, Issue 4, 2013, Pages 2541-2550

  Liu, Shaohui ^a,b   Kam, Wendy R ^a,b,c   Ding, Juan ^a,b,c   Hatton, Mark P ^a,b,c,d   Sullivan, David A ^a,b,c  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

^d OPHTHALMIC CONSULTANTS OF BOSTON   (United States)

Author keywords

Gene expression; Growth factors; Meibomian gland

Indexed keywords

CALGRANULIN A; CALGRANULIN B; CCAAT ENHANCER BINDING PROTEIN ALPHA; CYCLIN A2; CYCLIN B2; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN E; CYCLIN G1; CYCLIN G2; CYTOKERATIN 16; CYTOKERATIN 6; DNA TOPOISOMERASE; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR; FATTY ACID BINDING PROTEIN; HYPOPHYSIS EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; REPLICATION FACTOR C; RETINOL DEHYDROGENASE; THROMBOSPONDIN 1;

ARTICLE; CELL COUNT; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; DNA REPLICATION; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPOGENESIS; MEIBOMIAN GLAND; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RIBOSOME; UPREGULATION;

CELL COUNT; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CONJUNCTIVA; EPIDERMAL GROWTH FACTOR; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; MEIBOMIAN GLANDS; PITUITARY GLAND; REAL-TIME POLYMERASE CHAIN REACTION; TIME FACTORS; TISSUE EXTRACTS;

EID: 84875972507     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-11221     Document Type: Article

References (52)

1. Thody AJ, Shuster S. Control and function of sebaceous glands. Physiol Rev. 1989;69:383-416.
2. Knop E, Knop N, Millar T, Obata H, Sullivan DA. The International Workshop on Meibomian Gland Dysfunction: report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland. Invest Ophthalmol Vis Sci. 2011;52:1938-1978.
3. Maskin SL, Tseng SC. Clonal growth and differentiation of rabbit meibomian gland epithelium in serum-free culture: differential modulation by EGF and FGF. Invest Ophthalmol Vis Sci. 1992;33:205-217.
4. Matias JR, Orentreich N. Stimulation of hamster sebaceous glands by epidermal growth factor. J Invest Dermatol. 1983; 80:516-519.
5. Akimoto N, Sato T, Sakiguchi T, Kitamura K, Kohno Y, Ito A. Cell proliferation and lipid formation in hamster sebaceous gland cells. Dermatology. 2002;204:118-123.
6. Fatimah SS, Tan GC, Chua KH, Tan AE, Hayati AR. Effects of epidermal growth factor on the proliferation and cell cycle regulation of cultured human amnion epithelial cells. J Biosci Bioeng. 2012;114:220-227.
7. Hammond SL, Ham RG, Stampfer MR. Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract. Proc Natl Acad Sci U S A. 1984;81:5435-5439.
8. Galy A, Jolivet M, Jolivet-Reynaud C, Hadden J. Fibroblast growth factor (FGF) and an FGF-like molecule in pituitary extracts stimulate thymic epithelial cell proliferation. Thymus. 1990;15:199-211.
9. Wille JJ, Park J, Elgavish A. Effects of growth factors, hormones, bacterial lipopolysaccharides, and lipotechoic acids on the clonal growth of normal ureteral epithelial cells in serum-free culture. J Cell Physiol. 1992;150:52-58.
10. Ang LP, Tan DT, Seah CJ, Beuerman RW. The use of human serum in supporting the in vitro and in vivo proliferation of human conjunctival epithelial cells. Br J Ophthalmol. 2005; 89:748-752.
11. Creek KE, Geslani G, Batova A, Pirisi L. Progressive loss of sensitivity to growth control by retinoic acid and transforming growth factor-beta at late stages of human papillomavirus type 16-initiated transformation of human keratinocytes. Adv Exp Med Biol. 1995;375:117-135.
12. Liu S, Khandelwal P, Hatton M, Sullivan DA. Culture, immortalization and characterization of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci. 2010;51: 3993-4005.
13. Liu S, Richards SM, Lo K, Hatton M, Fay AM, Sullivan DA. Changes in gene expression in meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011;52:2727-2740.
14. Shi L, Reid LH, Jones WD, et al. The MicroArray Quality Control (MAQC) project shows inter and intraplatform reproducibility of gene expression measurements. Nature Biotechnol. 2006;24:1151-1161.
15. Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genetics. 2000;25:25-29.
16. Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol. 2003;4:R7.
17. Lu S, Gough AW, Bobrowski WF, Stewart BH. Transport properties are not altered across Caco-2 cells with heightened TEER despite underlying physiological and ultrastructural changes. J Pharm Sci. 1996;85:270-273.
18. Hughes P, Marshall D, Reid Y, Parkes H, Gelber C. The costs of using unauthenticated, over-passaged cell lines: how much more data do we need? BioTechniques. 2007;43:575, 577-578, 581-582 passim.
19. Buolamwini JK. Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Des. 2000;6:379-392.
20. Yu Q, Wu J. Involvement of cyclins in mammalian spermato genesis. Mol Cell Biochem. 2008;315:17-24.
21. Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J Cell Biochem. 2005; 96:906-913.
22. Sherr CJ. Mammalian G1 cyclins. Cell. 1993;73:1059-1065.
23. Dirks PB, Rutka JT. Current concepts in neuro-oncology: the cell cycle-a review. Neurosurgery. 1997;40:1000-1013, discussion 1013-1005.
24. Besson A, Yong VW. Mitogenic signaling and the relationship to cell cycle regulation in astrocytomas. J Neuro-Oncol. 2001; 51:245-264.
25. Schmidt EV. The role of c-myc in cellular growth control. Oncogene. 1999;18:2988-2996.
26. Thomas G. An encore for ribosome biogenesis in the control of cell proliferation. Nat Cell Biol. 2000;2:E71-E72.
27. Hohl D, de Viragh PA, Amiguet-Barras F, Gibbs S, Backendorf C, Huber M. The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins. J Invest Dermatol. 1995;104: 902-909.
28. Tesfaigzi J, Carlson DM. Expression, regulation, and function of the SPR family of proteins. A review. Cell Biochem Biophys. 1999;30:243-265.
29. Fischer DF, Sark MW, Lehtola MM, Gibbs S, van de Putte P, Backendorf C. Structure and evolution of the human SPRR3 gene: implications for function and regulation. Genomics. 1999;55:88-99.
30. Song HJ, Poy G, Darwiche N, et al. Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. Genomics. 1999;55:28-42.
31. Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nature Rev. 2005;6:328-340.
32. Mischke D, Korge BP, Marenholz I, Volz A, Ziegler A. Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex (epidermal differentiation complex") on human chromosome 1q21. J Invest Dermatol. 1996;106:989-999.2.
33. Kawasaki S, Kawamoto S, Yokoi N, et al. Up-regulated gene expression in the conjunctival epithelium of patients with Sjögren's syndrome. Exp Eye Res. 2003;77:17-26.
34. Li S, Gallup M, Chen YT, McNamara NA. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:2466-2475.
35. Iizuka H, Takahashi H, Honma M, Ishida-Yamamoto A. Unique keratinization process in psoriasis: late differentiation markers are abolished because of the premature cell death. J Dermatol. 2004;31:271-276.
36. Ishida-Yamamoto A, Iizuka H, Manabe M, et al. Altered distribution of keratinization markers in epidermolytic hyperkeratosis. Arch Dermatol Res. 1995;287:705-711.
37. Jester JV, Nicolaides N, Kiss-Palvolgyi I, Smith RE. Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Invest Ophthalmol Vis Sci. 1989;30: 936-945.
38. Ito A, Sakiguchi T, Kitamura K, Akamatsu H, Horio T. Establishment of a tissue culture system for hamster sebaceous gland cells. Dermatology. 1998;197:238-244.
39. Berger J, Moller DE. The mechanisms of action of PPARs. Ann Rev Med. 2002;53:409-435.
40. Fajas L, Debril MB, Uwerx J. Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis. J Mol Endocrinol. 2001;27:1-9.
41. Qi C, Zhu Y, Reddy JK. Peroxisome proliferator-activated receptors, coactivators, and downstream targets. Cell Biochem Biophys. 2000;32:187-204.
42. Ferre P. The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. Diabetes. 2004;53(suppl 1):S43-S50.
43. Zouboulis CC, Schagen S, Alestas T. The sebocyte culture: a model to study the pathophysiology of the sebaceous gland in sebostasis, seborrhoea and acne. Arch Dermatol Res. 2008; 300:397-413.
44. Desvergne B, Michalik L, Wahli W. Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol. 2004;18:1321-1332.
45. van Raalte DH, Li M, Pritchard PH, Wasan KM. Peroxisome proliferator-activated receptor (PPAR)-alpha: a pharmacological target with a promising future. Pharm Res. 2004;21:1531-1538.
46. Wang YX, Lee CH, Tiep S, et al. Peroxisome-proliferator activated receptor delta activates fat metabolism to prevent obesity. Cell. 2003;113:159-170.
47. Barish GD, Narkar VA, Evans RM. PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest. 2006;116:590-597.
48. Di-Poi N, Michalik L, Desvergne B, Wahli W. Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis. Lipids. 2004;39:1093-1099.
49. Thorner MO, Vance ML, Laws ER Jr, Horvath E, Kovacs K. The anterior pituitary. In: Wilson JD, Foster DW, Kronenberg HM, Larsen PR, eds. Williams Textbook of Endocrinology, 9th ed. Philadelphia: WB Saunders; 1998:249-340.
50. Halper J, Parnell PG, Carter BJ, Ren P, Scheithauer BW. Presence of growth factors in human pituitary. Lab Invest. 1992;66:639-645.
51. Zouboulis CC, Bohm M. Neuroendocrine regulation of sebocytes a pathogenetic link between stress and acne. Exp Dermatol. 2004;13(suppl 4):31-35.
52. Xia LQ, Zouboulis C, Detmar M, Mayer-da-Silva A, Stadler R, Orfanos CE. Isolation of human sebaceous glands and cultivation of sebaceous gland-derived cells as an in vitro model. J Invest Dermatol. 1989;93:315-321.