Adverse events following infusion of T cells for adoptive immunotherapy: A 10-year experience

Cytotherapy

Volumn 12, Issue 6, 2010, Pages 743-749

  Cruz, Conrad Russell ^a   Hanley, Patrick J ^a   Liu, Hao ^a   Torrano, Vicky ^a   Lin, Yu Feng ^a   Arce, James A ^a   Gottschalk, Stephen ^a   Savoldo, Barbara ^a   Dotti, Gianpietro ^a   Louis, Chrystal U ^a   Leen, Ann M ^a   Gee, Adrian P ^a   Rooney, Cliona M ^a   Brenner, Malcolm K ^a   Bollard, Catherine M ^a   Heslop, Helen E ^a  

^a HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Adverse events; Cytotoxic T lymphocytes; EpsteinBarr virus; Infusion reaction; T cells

Indexed keywords

ALANINE AMINOTRANSFERASE; DIMETHYL SULFOXIDE; DIPHENHYDRAMINE; GAMMA GLUTAMYLTRANSFERASE; PARACETAMOL;

ACUTE BIPHENOTYPIC LEUKEMIA; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADENOVIRUS INFECTION; ADOLESCENT; ADOPTIVE IMMUNOTHERAPY; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALLERGY; ALLODEPLETED T LYMPHOCYTE; ALLOTRANSPLANTATION; ANTIGEN SPECIFIC CYTOTOXIC T LYMPHOCYTE; ANTIGEN SPECIFICITY; APLASTIC ANEMIA; ARTICLE; AUTOTRANSPLANTATION; BETA THALASSEMIA; CELL EXPANSION; CELL MANIPULATION; CHILD; CHILL; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CONFIDENCE INTERVAL; CYTOMEGALOVIRUS INFECTION; CYTOTOXIC T LYMPHOCYTE; DIAPHORESIS; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DYSPNEA; EDEMA; EPITHELIUM TUMOR; EPSTEIN BARR VIRUS INFECTION; EX VIVO STUDY; FANCONI ANEMIA; FEMALE; FEVER; FOLLOW UP; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GRAFT RECIPIENT; HEADACHE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMOPHAGOCYTIC SYNDROME; HODGKIN DISEASE; HUMAN; HYPOTENSION; HYPOXIA; INFLAMMATION; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NASOPHARYNX CARCINOMA; NAUSEA; NAUSEA AND VOMITING; NEUROBLASTOMA; NONHODGKIN LYMPHOMA; ORGAN TRANSPLANTATION; OXYGEN SATURATION; PAIN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SEVERE COMBINED IMMUNODEFICIENCY; SWELLING; T CELL DEPLETION; T LYMPHOCYTE; TACHYCARDIA; TASTE DISORDER;

EID: 77957305203     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.3109/14653241003709686     Document Type: Article

References (31)

1. Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME. Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer. 2008;8:299-308.
2. Disis ML, Bernhard H, Jaffee EM. Use of tumour-responsive T cells as cancer treatment. Lancet. 2009;373:673-83.
3. June CH. Adoptive T cell therapy for cancer in the clinic. J Clin Invest. 2007;117:1466-76.
4. Leen AM, Rooney CM, Foster AE. Improving T cell therapy for cancer. Annu Rev Immunol. 2007;25:243-65.
5. Fujita Y, Rooney CM, Heslop HE. Adoptive cellular immunotherapy for viral diseases. Bone Marrow Transplant. 2008;41:193-8.
6. Beck O, Topp MS, Koehl U, Roilides E, Simitsopoulou M, Hanisch M, et al. Generation of highly purified and functionally active human TH1 cells against Aspergillus fumigatus. Blood. 2006;107:2562-9.
7. Nicolson KS, Wraith DC. Natural and induced regulatory T cells: targets for immunotherapy of autoimmune disease and allergy. Inflamm Allergy Drug Targets. 2006;5:141-8.
8. Leen AM, Heslop HE. Cytotoxic T lymphocytes as immunetherapy in haematological practice. Br J Haematol. 2008;143:169-79.
9. Falkenburg JH, Heslop HE, Barrett AJ. T cell therapy in allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2008;14(Suppl 1):136-41.
10. National Institutes of Health. ClinicalTrials. Gov. Accessed June 5, 2009. Bethesda: National Institutes of Health; http://www.clinicaltrials.gov/ ct2/results?term=t+cell+immunotherapy
11. Alessandrino P, Bernasconi P, Caldera D, Colombo A, Bonfichi M, Malcovati L, et al. Adverse events occurring during bone marrow or peripheral blood progenitor cell infusion: analysis of 126 cases. Bone Marrow Transplant. 1999;23:533-7.
12. Cordoba R, Arrieta R, Kerguelen A, Hernandez-Navarro F. The occurrence of adverse events during the infusion of autologous peripheral blood stem cells is related to the number of granulocytes in the leukapheresis product. Bone Marrow Transplant. 2007;40:1063-7.
13. Food and Drug Administration. Proposed Approach to Regulation of Cellular and Tissue-Based Products. Rockville, Maryland: Food and Drug Administration; 1997.
14. Brentjens R, Yeh R, Bernal Y, Riviere I, Sadelain M. Treatment of chronic lymphocytic leukemia with genetically targeted autologous T cells: case report of an unforeseen adverse event on a phase I clinical trial. Molecular Therapy. In press.
15. Morgan RA, Yang JC, Kitano M, Dudley ME, Laurencot CM, Rosenberg SA. Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2. Mol Ther. 2010 epub.
16. Savoldo B, Huls MH, Liu Z, Okamura T, Volk HD, Reinke P, et al. Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood. 2002;100:4059-66.
17. Bollard CM, Aguilar L, Straathof KC, Gahn B, Huls MH, Rousseau A, et al. Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease. J Exp Med. 2004;200:1623-33.
18. Straathof KC, Bollard CM, Popat U, Huls MH, Lopez T, Morriss MC, et al. Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes. Blood. 2005;105:1898-904.
19. Amrolia PJ, Muccioli-Casadei G, Huls H, Adams S, Durett A, Gee A, et al. Adoptive immunotherapy with allodepleted donor T cells improves immune reconstitution after haploidentical stem cell transplantation. Blood. 2006;108:1797-808.
20. Leen AM, Myers GD, Sili U, Huls MH, Weiss H, Leung KS, et al. Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals. Nat Med. 2006;12:1160-6.
21. Savoldo B, Goss JA, Hammer MM, Zhang L, Lopez T, Gee AP, et al. Treatment of solid organ transplant recipients with autologous Epstein Barr virus-specific cytotoxic T lymphocytes (CTLs). Blood. 2006;108:2942-9.
22. Bollard CM, Gottschalk S, Leen AM, Weiss H, Straathof KC, Carrum G, et al. Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer. Blood. 2007;110:2838-45.
23. Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 2008;14:1264-70.
24. Louis CU, Straathof K, Bollard CM, Gerken C, Huls MH, Gresik MV, et al. Enhancing the in vivo expansion of adoptively transferred EBV-specific CTL with lymphodepleting CD45 monoclonal antibodies in NPC patients. Blood. 2009;113:2442-50.
25. Leen AM, Christin A, Myers GD, Liu H, Cruz CR, Hanley PJ, et al. Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplant. Blood. 2009;114:4283-92
26. Heslop HE, Slobod KS, Pule MA, Hale GA, Rousseau A, Smith CA, et al. Long term outcome of EBV specific T cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients. Blood. 2010;115:3670-9.
27. Burger SR. Current regulatory issues in cell and tissue therapy. Cytotherapy. 2003;5:289-98.
28. Gastineau DA. Will regulation be the death of cell therapy in the United States? Bone Marrow Transplant. 2004;33:777-80.
29. Higano CS, Schellhammer PF, Small EJ, Burch PA, Nemunaitis J, Yuh L, et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer. 2009;115:3670-9
30. Martino M, Morabito F, Messina G, Irrera G, Pucci G, Iacopino P. Fractionated infusions of cryopreserved stem cells may prevent DMSO-induced major cardiac complications in graft recipients. Haematologica. 1996;81:59-61.
31. Ozdemir E, Akgedik K, Akdogan S, Kansu E. The lollipop with strawberry aroma may be promising in reduction of infusion-related nausea and vomiting during the infusion of cryopreserved peripheral blood stem cells. Biol Blood Marrow Transplant. 2008;14:1425-8.