Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents

European Journal of Medicinal Chemistry

Volumn 63, Issue , 2013, Pages 645-654

  Ragab, Fatma A ^a   Abdel Gawad, Nagwa M ^a   Georgey, Hanan H ^a   Said, Mona F ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Analgesic; Anti inflammatory; COX inhibition; Pyrazole; Pyrrole; Schiff's base

Indexed keywords

4 (4 (5 (4 CHLOROPHENYL) 2 (4 FLUOROPHENYL) 1H PYRROL 3 YL) 3 P TOLYL 1H PYRAZOL 1 YL)BENZENESULFONAMIDE; 4 CHLORO N ((1 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL) 1H PYRAZOL 4 YL)METHYLENE)ANILINE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; INDOMETACIN; N ((1 (4 CHLOROPHENYL) 3 (4 METHOXYPHENYL) 1H PYRAZOL 4 YL)METHYLENE) 4 METHOXYANILINE; PHENYLBUTAZONE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TOLERANCE; ENZYME INHIBITION; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOQUINONES; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; EDEMA; MALE; MICE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PAIN; PYRAZOLES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84875959593     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.03.005     Document Type: Article

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