Synthesis of novel indolyl-pyrimidine antiinflammatory, antioxidant and antibacterial agents

Indian Journal of Pharmaceutical Sciences

Volumn 70, Issue 2, 2008, Pages 208-215

  Panda, S ^a   Chowdary, P V R ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

Antibacterial; Antiinflammatory; Antioxidant; Indole; Pyrimidine

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETOPHENONE; ALCOHOL; ALDEHYDE DERIVATIVE; CARRAGEENAN; CHALCONE DERIVATIVE; GUANIDINE; HETEROCYCLIC COMPOUND; HYDROCHLORIC ACID; IBUPROFEN; INDOLE 3 ALDEHYDE; PYRIMIDINE DERIVATIVE; SODIUM HYDROXIDE; THIOUREA; UREA;

AGAR MEDIUM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; MALE; NONHUMAN; PAW EDEMA; PSEUDOMONAS AERUGINOSA; RAT; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS;

EID: 46349092661     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.41457     Document Type: Article

References (11)

1. Patel DH, Mistry BD, Desai KR. Synthesis and antimicrobial activity of pyrazolo[3,4-d]pyrimidines. Indian J Hetero Chem 2003;13:179-80.
2. Kreutzberger A, Sellheim M. Antimycotics. XIX. 4,6-Disubstituted 2-(cyanamino)pyrimidines Indian J Hetero Chem 1985;22:721-3.
3. Shanker K, Gupta GP, Singh S. Synthesis of novel pyrimidinediones and thiazolidinones as cardiovascular agents. Indian J Chem 1985;24:1094-7.
4. Lather V, Chowdary PV. Synthesis and antimicrobial activity of N1(arylidine hydrazidomethyl)-indoles,2-(substituted aryl)-3-(N1-indolyl acetamidyl)-4-oxo-thiazolidines and 5-benzylidine derivatives of thiazolidinones. Indian J Pharm Sci 2003;65:576-9.
5. Gadaginamath GS, Shyadligeri AS, Kavali RR. Chemoselectivity of indoledicarboxylates towards hydrazine hydrate: Part III-synthesis and antimicrobial activity of novel 4-thiazolidinonylindoles. Indian J Chem 1999:38:156-9.
6. Renukadevi P, Biradar JS. Synthesis and antimicrobial activity of 3,5-disubstituted-2-[1′-phenyl-5′-thioalkyl-s-triazol-2′-yl] indoles and 3,5-disubstituted-2-[1′-substituted aminomethyl-4′- phenyl-5′,4′-phenyl-5′(4′H)-thion-s-triazol-3-yl] indoles. Indian J Hetero Chem 1999;9:107-12.
7. Klohr SE, Cassady MJ. An intramolecular photocyclization to form the azepino[3,4,5-cd]indole system. Synthetic Communication 1988;18:671-4.
8. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol 1962;111:544-7.
9. Newbould BB. Chemotherapy of arthritis induced in rats by mycobacterial adjuvant. Brit J Pharmacol 1963;21:127-36.
10. Seeley HW, Van Denmark PJ. Microbes in action: A laboratory manual of microbiology. Mumbai: D B Taraporevala Sons and Co Pvt Ltd; 1975.
11. Kavanagh F. Analytical microbiology. New York: 1963. p. 313-46.