Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 1, 2009, Pages 255-258

  Rathish, I G ^a   Javed, Kalim ^a   Ahmad, Shamim ^a   Bano, Sameena ^a   Alam, M S ^a   Pillai, K K ^b   Singh, Surender ^c   Bagchi, Vivek ^d  

^a HAMDARD UNIVERSITY   (India)

^b HAMDARD UNIVERSITY   (India)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^d INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

Author keywords

2 Pyrazolines; Anti inflammatory activity; Celecoxib; COX 1; COX 2

Indexed keywords

4 HYDRAZINOBENZENESULFONAMIDE; BENZENESULFONAMIDE DERIVATIVE; CELECOXIB; CHALCONE DERIVATIVE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; EXPERIMENTAL MODEL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PAW EDEMA; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS; ULCEROGENESIS;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CHALCONES; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; EDEMA; MOLECULAR STRUCTURE; PYRAZOLES; RATS; SULFONAMIDES;

RATTUS;

EID: 57849134109     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.10.105     Document Type: Article

References (13)

1. Hamberg M., and Samuelsson B. Proc. Natl. Acad. Sci. U.S.A. 70 (1973) 899
2. Fu J.Y., Masferrer J.L., Seibert K., Raz A., and Needleman P. J. Biol. Chem. 265 (1990) 16737
3. Smith W.L., and DeWitt D.L. Adv. Immunol. 62 (1996) 167
4. Herschman H.R. Biochim. Biophys. Acta 1299 (1996) 125
5. Meade E.A., Smith W.L., and DeWitt D.L. J. Biol. Chem. 268 (1993) 6610
6. Allison M.C., Howatson A.G., Torrance C.J., Lee F.D., and Russell R.I.G. N. Engl. J. Med. 327 (1992) 749
7. De Gaetano G., Donati M.B., and Cerletti C. Trends Pharmacol. Sci. 24 (2003) 245
8. Ahluwalia V.K., Bhagat P., Aggarwal R., and Chandra R. Intermediates in Organic Synthesis (2005), I.K. International Pvt. Ltd., New Delhi, Bangalore, Mumbai pp. 116-117
9. Khan M.S.Y., and Sharma P. Indian J. Chem. 32B (1993) 374
10. Andotra C.S., Khajuria J., Singh G.B., and Singh S. J. Indian Chem. Soc. 70 (1993) 266
11. 2), 6.49 (1H, dd, J = 1.8 Hz, J = 8.6 Hz, Ar-H), 6.58 (1H, s, Ar-H), 6.86 (2H, d, J = 7.8 Hz, Ar-H), 7.10-7.49 (5H, m, Ar-H), 7.74 (2H, d, J = 7.7 Hz, Ar-H)
12. Winter C.A., Risely E.A., and Nus G.N. Proc. Soc. Exp. Biol. 111 (1962) 544
13. Gierse J.K., Koboldt C.M., Walker M.C., Siebert K., and Isakson P.C. Biochem. J. 339 (1999) 607