Synthesis of novel pyrazole and dihydropyrazoles derivatives as potential anti-inflammatory and analgesic agents

Archives of Pharmacal Research

Volumn 35, Issue 5, 2012, Pages 807-821

  Abd El Gawad, Nagwa M ^a   Georgey, Hanan H ^a   Ibrahim, Nashwa A ^b,c   Amin, Noha H ^b   Abdelsalam, Rania M ^a  

^a CAIRO UNIVERSITY   (Egypt)

^b Beni Suef University   (Egypt)

^c UMM AL QURA UNIVERSITY   (Saudi Arabia)

Author keywords

Analgesic; Anti inflammatory; Dihydropyrazole; Pyrazole

Indexed keywords

(4 CHLOROPHENYL)[4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL]METHANONE; (4 CHLOROPHENYL)[4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL]METHANONE; 1 (4 CHLOROBENZYL) 4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 1 (4 CHLOROBENZYL) 4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 1 (4 CHLOROPHENYL) 2 [4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 (4 CHLOROPHENYL) 2 [4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL]ETHANONE; 1 [(4 CHLOROPHENYL)SULFONYL] 4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 1 [(4 CHLOROPHENYL)SULFONYL] 4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 1 BENZYL 4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 1 BENZYL 4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 2 [4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL] 1 PHENYLETHANONE; 2 [4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL] 1 PHENYLETHANONE; 4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOXIMIDAMIDE; 4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE; 4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOLE 1 CARBOXIMIDAMIDE; [4 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL](PHENYL)METHANONE; [4 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 4,5 DIHYDRO 1H PYRAZOL 1 YL](PHENYL)METHANONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; CELECOXIB; ETHYL 1 (4 METHOXYPHENYL) 4 METHYL 5 [4 (METHYLSULFANYLPHENYL] 1H PYRAZOLE 3 CARBOXYLATE; ETHYL 1 (4 METHOXYPHENYL) 4 METHYL 5 [4 (METHYLSULFONYL)PHENYL] 1H PYRAZOLE 3 CARBOXYLATE; ETHYL 2 METHYL 3 [4 (METHYLSULFANYL)PHENYL] 3 OXOPROPANOATE; ETHYL 2 METHYL 3 [4 (METHYLSULFONYL)PHENYL] 3 OXOPROPANOATE; ETHYL 4 METHYL 5 [4 (METHYLSULFANYL)PHENYL] 1 PHENYL 1H PYRAZOLE 3 CARBOXYLATE; ETHYL 4 METHYL 5 [4 (METHYLSULFONYL)PHENYL] 1 PHENYL 1H PYRAZOLE 3 CARBOXYLATE; INDOMETACIN; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; MOUSE; NONHUMAN; RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; EDEMA; FEMALE; MALE; MICE; PAIN MEASUREMENT; PYRAZOLES; RATS; RATS, WISTAR;

EID: 84862853678     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-012-0507-y     Document Type: Article

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