Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: A model for the development of novel antiparasitic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 718-723

  Balliano, Gianni ^a   Dehmlow, Henrietta ^b   Oliaro Bosso, Simonetta ^a   Scaldaferri, Matilde ^a   Taramino, Silvia ^a   Viola, Franca ^a   Caron, Giulia ^a   Aebi, Johannes ^b   Ackermann, Jean ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antiparasitic agents; Inhibitors; Lanosterol synthase; Oxidosqualene cyclase

Indexed keywords

ANTIFUNGAL AGENT; ANTIPARASITIC AGENT; ANTITRYPANOSOMAL AGENT; CYCLOHEXYLAMINE DERIVATIVE; FUNGAL ENZYME; HETEROCYCLIC COMPOUND; OXIDOSQUALENE CYCLASE; RO 488071; UNCLASSIFIED DRUG;

ARABIDOPSIS; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; FUNGAL STRAIN; IC 50; NONHUMAN; PNEUMOCYSTIS CARINII; SACCHAROMYCES CEREVISIAE; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPARASITIC AGENTS; ARABIDOPSIS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, THIN LAYER; DRUG DESIGN; HUMANS; INTRAMOLECULAR TRANSFERASES; MICROSOMES, LIVER; MODELS, CHEMICAL; PNEUMOCYSTIS CARINII; SACCHAROMYCES CEREVISIAE; STEROLS; TRYPANOSOMA CRUZI;

ARABIDOPSIS THALIANA; PNEUMOCYSTIS; PNEUMOCYSTIS CARINII; SACCHAROMYCES CEREVISIAE; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 58549106546     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.040     Document Type: Article

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