Subchronic supplementation of lithium carbonate induces reproductive system toxicity in male rat

Reproductive Toxicology

Volumn 17, Issue 6, 2003, Pages 683-690

  Thakur, Sonu Chand ^a,b   Thakur, Sarjeet Singh ^b   Chaube, Shail K ^c   Singh, Shiv P ^a  

^a DBS Post Graduate College Dehradun   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c NATIONAL INSTITUTE OF HEALTH AND FAMILY WELFARE   (India)

Author keywords

Epididymis; Fertility; Lithium carbonate; Prostate; Reproductive system toxicity; Seminal vesicle; Testis; Testosterone

Indexed keywords

LITHIUM CARBONATE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; CYTOPLASM; DEGENERATION; DIET; EPIDIDYMIS; FERTILITY; GENITAL SYSTEM; HISTOLOGY; INTERSTITIAL FLUID; MALE; MATING; MORPHOLOGY; NONHUMAN; ORGAN WEIGHT; PROSTATE; PROSTATE SECRETION; RAT; RAT STRAIN; REPRODUCTIVE TOXICITY; SEMINAL VESICLE; SERTOLI CELL; SPERM; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON ABNORMALITY; SPERMATOZOON MIGRATION; STATISTICAL SIGNIFICANCE; TESTIS WEIGHT;

EID: 0345307587     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(03)00107-2     Document Type: Article

References (35)

1. Gupta AK, Knowles SR, Gupta MA, Jaunkalns R, Shear NH. Lithium therapy associated with hidradenitis suppurativa: case report and a review of the dermatologic side effects of lithium. J Am Dermatol 1995;32:382-6.
2. Shaldubina A, Agam G, Belmaker RH. The mechanism of lithium action: state of the art, ten years later. Prog Neuropsychopharmacol Biol Psychiatry 2001;25:855-66.
3. Bowden CL. Key treatment studies of lithium in manic-depressive illness - efficacy and side effects. J Clin Psychiatry 1998;59: 13-9.
4. Singer I, Rotenberg D, Duschett JB. Lithium induced nephrogenic diabetes insipidus-in vivo and in vitro studies. J Clin Invest 1972;51:1081-91.
5. Lazarus JH, Bennie EH. Effect of lithium on thyroid function in man. Acta Endocrinol (Copenh) 1972;70:277.
6. Gosselin RE, Smith RP, Hodge HC. Clinical toxicology of commercial products. 5th ed. Baltimore, MD: Williams and Wilkins; 1994.
7. Blay SL, Ferraz MP, Calil HM. Lithium induced male sexual impairment: two case reports. J Clin Psychiatry 1982;43(12):497-8.
8. Boulos BM, Carnow B, Naik N, Bederkx JP, Kauffman RF, Azarnoff DL. Placental transfer of lithium and environmental toxicants and their effects on the newborn. Fed Proc 1973;32:745.
9. Trautner EM, Pennycuik PR, Morris JH, Gershon S, Shankly KH. The effects of prolonged sub-toxic lithium ingestion on preganancy in rats. Aust J Exp Biol Med Sci 1958;36:305.
10. Szabo KT. Teratogenic effect of lithium carbonate in the fetal rat. Nature 1970;225:73.
11. Marathe MR, Thomas GP, Embryotoxicity and teratogenicity of lithium carbonate in wistar rats. Toxicol Lett 1986;34:115-20.
12. Sechzer JA, Alexander GJ, Lieberman KW. Maternal neglect and delayed development: effects of lithium intake in rats. Anat Rec 1992;232:79A-80A.
13. Jana D, Nandi D, Maiti RK, Ghosh D. Effect of human chorionic gonadotrophin coadministration on the activities of ovarian delta5-3beta-hydroxysteroid dehydrogenase, and 17beta-hydroxysteroid dehydrogenase, and uterine histology in lithium chloride-treated albino rats. Reprod Toxicol 2001;15:215-9.
14. Ng TB, Liu WK. Toxic effect of heavy metals on cells isolated from the rat adrenal and testis. In Vitro Cell Dev Biol 1990;26: 24-8.
15. Ghosh D, Biswas NM, Chaudhuri A, Ghosh PK. Direct effect of lithium chloride on testicular delta 5-3 beta and 17 beta-hydroxysteroid dehydrogenase activities in the rat-in vitro study. Acta Physiol Hung 1990;76(4):287-90.
16. Ghosh D, Chowdhury A, Biswas NM, Ghosh PK. Effect of lithium chloride on testicular steroidogenesis and gametogenesis in immature male rats. Acta Endocrinol (Copenh) 1991;124:76-82.
17. Aizenberg D, Sinler M, Zemishlay Z, Weizman A. Lithium and male sexual function in affective patients. Clin Neuropharmacol 1996;19:515-9.
18. Uma R, Chattopadhyay SM. The effects of lithium on reproductive physiology and maternal behaviour in rats. Ind J Pharmacol 1999;31:309-10.
19. Banerji TK, Parkening TA, Collins TJ, Rassoli A. Lithum-induced changes in the plasma and pituitary levels of luteinising hormone, follicle stimulating hormone and prolactin in rats. Life Sci 1983;33:1621-7.
20. Chatterjee S, Roden K, Banerjee TK. Morphological changes in some endocrine organs in rats following chronic lithium treatment. Anat Anz 1990;170:31-7.
21. Singh B, Dhawan D, Mangal PC, Chand B, Singh N, Trehan PN. Combined action of lead and lithium on essential and nonessential elements in rat blood. Biol Trace Elem Res 1994;46(1/2):15-28.
22. Sharpe RM, Cooper I. Testicular interstitial fluid as a monitor for changes in the intratesticular environment in the rat. J Reprod Fertil 1983;69:125-35.
23. Widmark A, Damber JE, Bergh A. Relationship between human chorionic gonadotrophin induced changes in testicular microcirculation and the formation of testicular interstitial fluid. J Endocrinol 1986;109:419-25.
24. Robb GW, Amann RP, Killian GJ. Daily sperm production and epididymal reserves of pubertal and adult rats. J Reprod Fertil 1978;54:103-7.
25. Amann RP, Johnson L, Thompson DL, Pickett BW. Daily spermatozoal production and epididymal spermatozoal reserves of the human male. J Urol 1976;124:211-5.
26. Seed J, Chapin RE, Clegg ED, Dostal LE, Foote RH, Hurtt ME, et al. Methods for assessing sperm motility, morphology, and counts in the rat, rabbit and dog: a consensus report. Reprod Toxicol 1996;10(3):237-44.
27. Garcia Aseff S, Fuentes LB, Villegas O, Guzman J. Distribution of lithium in different CNS areas and other tissues of adult male and female viscacha (Lagostmus maximus maximus). J Trace Elem Med Biol 1999;12(4):217-20.
28. Perez Romera E, Munoz E, Mohamed F, Dominguez S, Scardapane L, Villegas O, et al. Lithium effect on testicular tissue and spermatozoa of viscacha (Lagostomus maximus maximus). A comparative study with rats. J Trace Elem Med Biol 2000;14:81-3.
29. Paul HE, Paul MF, Kopko F, Bender RC, Everett G. Carbohydrate metabolism studies on the testis of rat for certain nitro furans. Endocrinology 1953;53:585-8.
30. U.S. Environmental Protection Agency. Guidelines for mutagenicity risk assessment. Fed Reg 1986;51:34006-12.
31. RTECS (Registry of Toxic Effects of Chemical Substances). Lithium chloride (online file retrieved 4/5/95). National Institute of Occupational Safety and Health, Cincinnati, OH; 1995.
32. Fawcett DW, editor. Bloom and Fawcett: a textbook of histology. Philadelphia: W.B. Saunders; 1986. p. 796-850.
33. Orth JM, Gunsalvs GL, Lamperti AA. Evidence from sertoli cell depleted rats indicates that spermatid number in adults depends on number of sertoli cells produced during perinatal development. Endocrinology 1988;122:787-94.
34. Berndtson WE. Age related changes in the number of sertoli cells in male rats and their relationship to spermatogenesis. Biol Reprod 1989;40:80.
35. Johnson L, Zane RS, Petty CS. Quantification of the human sertoli cell population: its distribution, relation to germ cell numbers and age related decline. Biol Reprod 1984;31:785-95.