Food-derived peptides stimulate mucin secretion and gene expression in intestinal cells

Journal of Agricultural and Food Chemistry

Volumn 60, Issue 35, 2012, Pages 8600-8605

  Martínez Maqueda, Daniel ^a   Miralles, Beatriz ^a   De Pascual Teresa, Sonia ^b   Reverón, Inés ^b   Muñoz, Rosario ^b   Recio, Isidra ^a  

^a INSTITUTE OF FOOD SCIENCE RESEARCH CIAL   (Spain)

^b INSTITUTE OF FOOD SCIENCE   (Spain)

Author keywords

gene expression; intestinal goblet cells; milk; mucins; opioid peptides

Indexed keywords

BASAL LEVELS; CELL TREATMENT; HUMAN MILK; INTESTINAL CELLS; MILK; MILK WHEY; MUCINS; OPIOID RECEPTORS;

CELL CULTURE; CELLS; DAIRY PRODUCTS; PEPTIDES; PHYSIOLOGY;

GENE EXPRESSION;

BETA CASOMORPHINE DERIVATIVE; BETA-CASOMORPHINS; ENDORPHIN; MESSENGER RNA; MUC5AC PROTEIN, HUMAN; MUCIN; MUCIN 5AC;

ARTICLE; CELL STRAIN HT29; DRUG EFFECT; GENE EXPRESSION; GENETICS; HUMAN; INTESTINE; METABOLISM; PROTEIN INTAKE; SECRETION (PROCESS);

DIETARY PROTEINS; ENDORPHINS; GENE EXPRESSION; HT29 CELLS; HUMANS; INTESTINES; MUCIN 5AC; MUCINS; RNA, MESSENGER;

TRITICUM AESTIVUM;

EID: 84865853755     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf301279k     Document Type: Article

References (31)

1. Pérez-Vilar, J. Gastrointestinal mucus gel barrier. In Oral Delivery of Macromolecular Drugs, 1st ed.; Bernkop-Schnürch, A., Ed.; Springer: New York, 2009; pp 21-47.
2. Otte, J.-M.; Ilka, W.; Stephan, B.; Ansgar, M. C.; Frank, S.; Michael, K.; Wolfgang, E. S. Human β defensin 2 promotes intestinal wound healing in vitro J. Cell. Biochem. 2008, 104, 2286-2297
3. Velcich, A.; Yang, W.; Heyer, J.; Fragale, A.; Nicholas, C.; Viani, S.; Kucherlapati, R.; Lipkin, M.; Yang, K.; Augenlicht, L. Colorectal cancer in mice genetically deficient in the mucin Muc2 Science 2002, 295, 1726-1729 (Pubitemid 34202910)
4. Lundin, E.; Zhang, J. X.; Huang, C. B.; Reuterving, C. O.; Hallmans, G.; Nygren, C.; Stenling, R. Oat bran, rye bran, and soybean hull increase goblet cell-volume density in the small-intestine of the golden-hamster. A histochemical and stereologic light-microscopy study Scand. J. Gastroenterol. 1993, 28, 15-22 (Pubitemid 23022378)
5. Shimotoyodome, A.; Meguro, S.; Hase, T.; Tokimitsu, I.; Sakata, T. Short chain fatty acids but not lactate or succinate stimulate mucus release in the rat colon Comp. Biochem. Phys. A 2000, 125, 525-531 (Pubitemid 30330771)
6. Gaudier, E.; Jarry, A.; Blottiere, H. M.; De Coppet, P.; Buisine, M. P.; Aubert, J. P.; Laboisse, C.; Cherbut, C.; Hoebler, C. Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 287, 1168-1174
7. Burger van Paassen, N.; Vincent, A.; Puiman, P. J.; Van der Sluis, M.; Bouma, J.; Boehm, G.; Van Goudoever, J. B.; Van Seuningen, I.; Renes, I. B. The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection Biochem. J. 2009, 420, 211-219
8. Dykstra, N. S.; Hyde, L.; Adawi, D.; Kulik, D.; Ahrne, S. I. V.; Molin, G.; Jeppsson, B.; Mackenzie, A.; Mack, D. R. Pulse probiotic administration induces repeated small intestinal muc3 expression in rats Pediatr. Res. 2011, 69, 206-211
9. Claustre, J.; Toumi, F.; Trompette, A.; Jourdan, G.; Guignard, H.; Chayvialle, J. A.; Plaisancié, P. Effects of peptides derived from dietary proteins on mucus secretion in rat jejunum Am. J. Physiol. Gastrointest. Liver Physiol. 2002, 283, 521-528
10. Trompette, A.; Claustre, J.; Caillon, F.; Jourdan, G.; Chayvialle, J. A.; Plaisancié, P. Milk bioactive peptides and β-casomorphins induce mucus release in rat jejunum J. Nutr. 2003, 133, 3499-3503 (Pubitemid 37409478)
11. Zoghbi, S.; Trompette, A.; Claustre, J.; Homsi, M. E.; Garzon, J.; Jourdan, G.; Scoazec, J.-Y.; Plaisancié, P. β-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway Am. J. Physiol. Gastrointest. Liver Physiol. 2006, 290, 1105-1113
12. Lesuffleur, T.; Porchet, N.; Aubert, J. P.; Swallow, D.; Gum, J. R.; Kim, Y. S.; Real, F. X.; Zweibaum, A. Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations J. Cell Sci. 1993, 106, 771-783 (Pubitemid 23346790)
13. Trompette, A.; Blanchard, C.; Zoghbi, S.; Bara, J.; Claustre, J.; Jourdan, G.; Chayvialle, J. A.; Plaisancié, P. The DHE cell line as a model for studying rat gastro-intestinal mucin expression: effects of dexamethasone Eur. J. Cell Biol. 2004, 83, 347-358 (Pubitemid 39307172)
14. Lesuffleur, T.; Barbat, A.; Dussaulx, E.; Zweibaum, A. Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells Cancer Res. 1990, 50, 6334-6343 (Pubitemid 20323697)
15. Contreras, M. d. M.; Carrón, R.; Montero, M. J.; Ramos, M.; Recio, I. Novel casein-derived peptides with antihypertensive activity Int. Dairy J. 2009, 19, 566-573
16. Linden, S. K.; Sutton, P.; Karlsson, N. G.; Korolik, V.; McGuckin, M. A. Mucins in the mucosal barrier to infection Mucosal Immunol. 2008, 1, 183-197 (Pubitemid 351541304)
17. Brantl, V.; Teschemacher, H.; Henschen, A.; Lottspeich, F. Novel opioid peptides derived from casein (β-casomorphins). I. Isolation from bovine casein peptone Hoppe-Seyler's Z. Physiol. Chem. 1979, 360, 1211-1216 (Pubitemid 10231176)
18. Yoshikawa, M.; Tani, F.; Yoshimura, T.; Chiba, H. Opioid peptides from milk proteins Agric. Biol. Chem. 1986, 50, 2419-2421 (Pubitemid 17189403)
19. Webb, G. C.; Akbar, M. S.; Zhao, C.; Steiner, D. F. Expression profiling of pancreatic β cells: glucose regulation of secretory and metabolic pathway genes Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 5773-5778 (Pubitemid 30367474)
20. Koch, G.; Wiedemann, K.; Teschemacher, H. Opioid activities of human β-casomorphins Naunyn Schmiedebergs Arch. Pharmacol. 1985, 331, 351-354
21. Loukas, S.; Varoucha, D.; Zioudrou, C.; Streaty, R. A.; Klee, W. A. Opioid activities and structures of α-casein-derived exorphins Biochemistry 1983, 22, 4567-4573 (Pubitemid 13010155)
22. Meisel, H. Overview on milk protein-derived peptides Int. Dairy J. 1998, 8, 363-373 (Pubitemid 28504135)
23. Fukudome, S.; Jinsmaa, Y.; Matsukawa, T.; Sasaki, R.; Yoshikawa, M. Release of opioid peptides, gluten exorphins by the action of pancreatic elastase FEBS Lett. 1997, 412, 475-479 (Pubitemid 27337092)
24. Jinsmaa, Y.; Yoshikawa, M. Enzymatic release of neocasomorphin and β-casomorphin from bovine β-casein Peptides 1999, 20, 957-962 (Pubitemid 29418031)
25. Howell, S.; Kenny, A. J.; Turner, A. J. A survey of membrane peptidases in two human colonic cell lines, Caco-2 and HT-29 Biochem. J. 1992, 284, 595-601
26. Han, K.-S.; Deglaire, A.; Sengupta, R.; Moughan, P. J. Hydrolyzed casein influences intestinal mucin gene expression in the rat J. Agric. Food Chem. 2008, 56, 5572-5576
27. Ushida, Y.; Shimokawa, Y.; Matsumoto, H.; Toida, T.; Hayasawa, H. Effects of bovine α-lactalbumin on gastric defense mechanisms in naive rats Biosci., Biotechnol., Biochem. 2003, 67, 577-583 (Pubitemid 39251954)
28. Ushida, Y.; Shimokawa, Y.; Toida, T.; Matsui, H.; Takase, M. Bovine α-lactalbumin stimulates mucus metabolism in gastric mucosa J. Dairy Sci. 2007, 90, 541-546 (Pubitemid 350049702)
29. Mezzaroba, L. F. H.; Carvalho, J. E.; Ponezi, A. N.; Antônio, M. A.; Monteiro, K. M.; Possenti, A.; Sgarbieri, V. C. Antiulcerative properties of bovine α-lactalbumin Int. Dairy J. 2006, 16, 1005-1012
30. Sprong, R. C.; Schonewille, A. J.; Van der Meer, R. Dietary cheese whey protein protects rats against mild dextran sulfate sodium-induced colitis: role of mucin and microbiota J. Dairy Sci. 2010, 93, 1364-1371
31. Tai, E. K.; Wong, H. P.; Lam, E. K.; Wu, W. K.; Yu, L.; Koo, M. W.; Cho, C. H. Cathelicidin stimulates colonic mucus synthesis by up-regulating MUC1 and MUC2 expression through a mitogen-activated protein kinase pathway J. Cell. Biochem. 2008, 104, 251-258