Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent AKt, GSK-3β, and HSF-1 in mesenchymal stem cells

Cell Death and Disease

Volumn 4, Issue 3, 2013, Pages

  Son, T W ^a   Yun, S P ^a   Yong, M S ^a   Seo, B N ^a   Ryu, J M ^a   Youn, H Y ^a   Oh, Y M ^b   Han, H J ^a  

^a Seoul National University   (South Korea)

^b University of Ulsan   (South Korea)

Author keywords

Apoptosis; Cytoprotection; Heat Shock Protein; Hypoxic Injury; Netrin 1; Umbilical Cord Blood Derived Mesenchymal Stem Cell

Indexed keywords

ALPHA6BETA4 INTEGRIN; ANNEXIN; BLOCKING ANTIBODY; CASPASE 3; CASPASE 9; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 27; HEAT SHOCK TRANSCRIPTION FACTOR 1; LIPOCORTIN 5; NEOGENIN; NETRIN 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE B BETA; SMALL INTERFERING RNA; CELL SURFACE RECEPTOR; DCC PROTEIN, HUMAN; DNA BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HEAT SHOCK TRANSCRIPTION FACTOR; HSPB1 PROTEIN, HUMAN; NERVE GROWTH FACTOR; NETRIN-1; OXYGEN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

APOPTOSIS; ARTICLE; CELL COUNT; CELL HYPOXIA; CELL LYSATE; CELL PROTECTION; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DNA SYNTHESIS; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; GENE DELETION; HUMAN; HUMAN CELL; LIPID RAFT; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUCROSE DENSITY GRADIENT CENTRIFUGATION; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; MITOCHONDRION; PATHOLOGY; UMBILICAL CORD;

APOPTOSIS; CELL HYPOXIA; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; HSP27 HEAT-SHOCK PROTEINS; HUMANS; INTEGRIN ALPHA6BETA4; MESENCHYMAL STROMAL CELLS; MITOCHONDRIA; NERVE GROWTH FACTORS; OXYGEN; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UMBILICAL CORD;

EID: 84875907873     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.94     Document Type: Article

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