Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism

Journal of Biological Chemistry

Volumn 283, Issue 18, 2008, Pages 12305-12313

  Havasi, Andrea ^a   Li, Zhijian ^b   Wang, Zhiyong ^a   Martin, Jody L ^c   Botla, Venugopal ^a   Ruchalski, Kathleen ^a   Schwartz, John H ^a   Borkan, Steven C ^a  

^a BOSTON MEDICAL CENTER   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BIOELECTRIC POTENTIALS; FLOW INTERACTIONS; NUCLEIC ACIDS; OLIGOMERIZATION; RNA;

AKT ACTIVATIONS; APOPTOSIS; BAX ACTIVATIONS; CANCER CELLS; CELL SURVIVALS; CYTOCHROME C; IMMUNOPRECIPITATION; KINASE INHIBITORS; METABOLIC STRESSES; PHOSPHATIDYLINOSITOL; PROTECTIVE EFFECTS; RENAL EPITHELIAL CELLS;

CELL DEATH;

APOPTOSIS INDUCING FACTOR; CASPASE 3; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK PROTEIN 27; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN KINASE B; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HEAT SHOCK PROTEIN; HSPB1 PROTEIN, HUMAN; PHOSPHOSERINE; SMALL INTERFERING RNA; TUMOR PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; KIDNEY TUBULE CELL; MEMBRANE DAMAGE; METABOLIC STRESS; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RNA INTERFERENCE; UPREGULATION; ADENOVIRUS; ANIMAL; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE; CELL SURVIVAL; CYTOPROTECTION; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HEAT-SHOCK PROTEINS; HUMANS; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NEOPLASM PROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING;

EID: 45549088083     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801291200     Document Type: Article

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