Protection against Fas-induced fulminant hepatic failure in liver specific integrin linked kinase knockout mice

Comparative Hepatology

Volumn 10, Issue , 2011, Pages

  Donthamsetty, Shashikiran ^a   Mars, Wendy M ^a   Orr, Anne ^a   Wu, Chuanyue ^a   Michalopoulos, George K ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Ecm signaling; Integrin linked kinase; Jo 2

Indexed keywords

ANTIBODY; FOCAL ADHESION KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN LINKED KINASE; JO 2 ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; FULMINANT HEPATIC FAILURE; LIVER CELL; LIVER INJURY; LIVER PROTECTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 81355147079     PISSN: None     EISSN: 14765926     Source Type: Journal    
DOI: 10.1186/1476-5926-10-11     Document Type: Article

References (33)

1. Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004, 39(2):273-278. 10.1002/hep.20051, 14767974.
2. Ibrahim SH, Kohli R, Gores GJ. Mechanisms of Lipotoxicity in NAFLD and Clinical Implications. J Pediatr Gastroenterol Nutr 2011, 53(2):131-140.
3. St-Pierre MV, Dufour JF. Biomarkers for Hepatocellular Apoptosis in the Management of Liver Diseases. Curr Pharm Biotechnol
4. Guicciardi ME, Gores GJ. Apoptosis as a mechanism for liver disease progression. Semin Liver Dis 2010, 30(4):402-410. 10.1055/s-0030-1267540, 3071245, 20960379.
5. Ogasawara J, Watanabe-Fukunaga R, Adachi M, Matsuzawa A, Kasugai T, Kitamura Y, Itoh N, Suda T, Nagata S. Lethal effect of the anti-Fas antibody in mice. Nature 1993, 364(6440):806-809. 10.1038/364806a0, 7689176.
6. Legate KR, Montanez E, Kudlacek O, Fassler R. ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 2006, 7(1):20-31. 10.1038/nrm1789, 16493410.
7. Wu C. The PINCH-ILK-parvin complexes: assembly, functions and regulation. Biochim Biophys Acta 2004, 1692(2-3):55-62. 10.1016/j.bbamcr.2004.01.006, 15246679.
8. Zhang Y, Chen K, Tu Y, Velyvis A, Yang Y, Qin J, Wu C. Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites. J Cell Sci 2002, 115(Pt 24):4777-4786.
9. Gkretsi V, Mars WM, Bowen WC, Barua L, Yang Y, Guo L, St-Arnaud R, Dedhar S, Wu C, Michalopoulos GK. Loss of integrin linked kinase from mouse hepatocytes in vitro and in vivo results in apoptosis and hepatitis. Hepatology 2007, 45(4):1025-1034. 10.1002/hep.21540, 17385211.
10. Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology 2008, 48(6):1932-1941. 10.1002/hep.22537, 2597430, 18846549.
11. Terpstra L, Prud'homme J, Arabian A, Takeda S, Karsenty G, Dedhar S, St-Arnaud R. Reduced chondrocyte proliferation and chondrodysplasia in mice lacking the integrin-linked kinase in chondrocytes. J Cell Biol 2003, 162(1):139-148. 10.1083/jcb.200302066, 2172728, 12835312.
12. Berasain C, Garcia-Trevijano ER, Castillo J, Erroba E, Santamaria M, Lee DC, Prieto J, Avila MA. Novel role for amphiregulin in protection from liver injury. J Biol Chem 2005, 280(19):19012-19020. 10.1074/jbc.M413344200, 15753092.
13. Gomez-Quiroz LE, Factor VM, Kaposi-Novak P, Coulouarn C, Conner EA, Thorgeirsson SS. Hepatocyte-specific c-Met deletion disrupts redox homeostasis and sensitizes to Fas-mediated apoptosis. J Biol Chem 2008, 283(21):14581-14589. 10.1074/jbc.M707733200, 2386934,2386934, 18348981.
14. Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG. Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. Adv Exp Med Biol 1996, 406:99-112.
15. Zhai D, Ke N, Zhang H, Ladror U, Joseph M, Eichinger A, Godzik A, Ng SC, Reed JC. Characterization of the anti-apoptotic mechanism of Bcl-B. Biochem J 2003, 376(Pt 1):229-236. 1223753, 12921534.
16. Huh CG, Factor VM, Sanchez A, Uchida K, Conner EA, Thorgeirsson SS. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci USA 2004, 101(13):4477-4482. 10.1073/pnas.0306068101, 384772, 15070743.
17. Marques JM, Belza I, Holtmann B, Pennica D, Prieto J, Bustos M. Cardiotrophin-1 is an essential factor in the natural defense of the liver against apoptosis. Hepatology 2007, 45(3):639-648. 10.1002/hep.21508, 17326158.
18. Boudreau NJ, Jones PL. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 1999, 339(Pt 3):481-488. 1220180, 10215583.
19. Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 2005, 6(1):56-68. 10.1038/nrm1549, 15688067.
20. Hao H, Naomoto Y, Bao X, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Wang ZG, Takaoka M. Focal adhesion kinase as potential target for cancer therapy (Review). Oncol Rep 2009, 22(5):973-979.
21. Sonoda Y, Matsumoto Y, Funakoshi M, Yamamoto D, Hanks SK, Kasahara T. Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60. J Biol Chem 2000, 275(21):16309-16315. 10.1074/jbc.275.21.16309, 10821872.
22. Sonoda Y, Watanabe S, Matsumoto Y, Aizu-Yokota E, Kasahara T. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line. J Biol Chem 1999, 274(15):10566-10570. 10.1074/jbc.274.15.10566, 10187851.
23. Dedhar S, Williams B, Hannigan G. Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling. Trends Cell Biol 1999, 9(8):319-323. 10.1016/S0962-8924(99)01612-8, 10407411.
24. Hannigan G, Troussard AA, Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 2005, 5(1):51-63. 10.1038/nrc1524, 15630415.
25. Hehlgans S, Haase M, Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 2007, 1775(1):163-180.
26. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J, Dedhar S. Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells. Proc Natl Acad Sci USA 2000, 97(7):3207-3212. 10.1073/pnas.060579697, 16217, 10716737.
27. Apte U, Gkretsi V, Bowen WC, Mars WM, Luo JH, Donthamsetty S, Orr A, Monga SP, Wu C, Michalopoulos GK. Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. Hepatology 2009, 50(3):844-851. 10.1002/hep.23059, 2914599, 19575460.
28. Donthamsetty S, Bhave VS, Kliment CS, Bowen WC, Mars WM, Bell AW, Stewart RE, Orr A, Wu C, Michalopoulos GK. Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene. Hepatology 2011, 53(2):587-595. 10.1002/hep.24040, 21274879.
29. Donthamsetty S, Bowen W, Mars W, Bhave V, Luo JH, Wu C, Hurd J, Orr A, Bell A, Michalopoulos G. Liver-specific ablation of integrin-linked kinase in mice results in enhanced and prolonged cell proliferation and hepatomegaly after phenobarbital administration. Toxicol Sci 2010, 113(2):358-366. 10.1093/toxsci/kfp281, 2807039, 19920070.
30. Paranjpe S, Bowen WC, Bell AW, Nejak-Bowen K, Luo JH, Michalopoulos GK. Cell cycle effects resulting from inhibition of hepatocyte growth factor and its receptor c-Met in regenerating rat livers by RNA interference. Hepatology 2007, 45(6):1471-1477. 10.1002/hep.21570, 2632963, 17427161.
31. Paranjpe S, Bowen WC, Tseng GC, Luo JH, Orr A, Michalopoulos GK. RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats. Am J Pathol 2010, 176(6):2669-2681. 10.2353/ajpath.2010.090605, 2877830, 20395437.
32. Hannigan GE, McDonald PC, Walsh MP, Dedhar S. Integrin-linked kinase: Not so 'pseudo' after all. Oncogene 2011, 30(43):4375-85. 10.1038/onc.2011.177, 21602880.
33. Persad S, Dedhar S. The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metastasis Rev 2003, 22(4):375-384. 10.1023/A:1023777013659, 12884912.