Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types

Planta Medica

Volumn 78, Issue 2, 2012, Pages 115-121

  Yung, Lisa Y ^a   Lam, Wing See ^a   Ho, Maurice K C ^a   Hu, Yueqing ^a   Ip, Fanny C F ^a   Pang, Haihong ^a   Chin, Allison C ^a   Harley, Calvin B ^a   Ip, Nancy Y ^a   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Astragalus membranaceus; cycloartane triterpenoid saponin; Fabaceae; mitogen activated protein kinase; telomerase activation

Indexed keywords

ASTRAGALOSIDE IV; CYCLOASTRAGENOL; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; CELL ACTIVITY; CELL STRAIN HEK293; CELL TYPE; DOSE RESPONSE; ENDOTHELIUM; FIBROBLAST; HUMAN; KERATINOCYTE; LUNG; MAMMARY GLAND; NONHUMAN; PROTEIN PHOSPHORYLATION; SRC HOMOLOGY DOMAIN;

ASTRAGALUS PLANT; BRAIN; BREAST; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; HUMANS; LUNG; PHOSPHORYLATION; PLANT EXTRACTS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SAPOGENINS; SAPONINS; SRC-FAMILY KINASES; TELOMERASE; TRITERPENES;

ASTRAGALUS MEMBRANACEUS; FABACEAE;

EID: 84856285216     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1280346     Document Type: Article

References (39)

1. Bensky D, Gamble A, Kaptchuk T J. Chinese herbal medicine: materia medica. Revised edition. Seattle Eastland Press 1993 581
2. Chen G, Huang W. Progress in pharmacological effects of compositions of Astragalus membranaceu s. Chin J New Drugs 2008 17 1482-1485
3. Ma X Q., Shi Q, Duan J A., Dong T T., Tsim K W. Chemical analysis of Radix Astragali (Huangqi) in China: a comparison with its adulterants and seasonal variations. J Agric Food Chem 2002 50 4861-4866 (Pubitemid 34856156)
4. Li Z, Cao Q. Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats. Acta Pharmacol Sin 2002 23 898-904
5. Zhang W, Chen H, Zhang C, Liu R, Li H, Chen H. Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med 2006 72 4-8 (Pubitemid 43241585)
6. Luo Y, Qin Z, Hong Z, Zhang X, Ding D, Fu J, Zhang W, Chen J. Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett 2004 363 218-223 (Pubitemid 38746516)
7. Yu Q, Zhu T, Zhang Y. Effect of astrgaloside IV on the long-term consequences of renal ischemia-reperfusion injury in rat. Zhonghua Yi Xue Za Zhi 2004 84 1412-1415
8. Xu X, Chen X, Ji H, Li P, Bian Y, Yang D, Xu J, Bian Z, Zhang J. Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase. Pharmacology 2008 81 325-332 (Pubitemid 351666921)
9. Zhang W, Hufnagl P, Binder B, Wojta J. Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-B activation and adhesion molecule expression. Thromb Haemost 2003 90 904-914 (Pubitemid 37427861)
10. Zhang Y, Zhu H, Huang C, Cui X, Gao Y, Huang Y, Gong W, Zhao Y, Guo S. Astragaloside IV exerts antiviral effects against coxsackievirus B3 by upregulating interferon-gamma. J Cardiovasc Pharmacol 2006 47 190-195 (Pubitemid 44384056)
11. Wang Y, Li X, Song C, Hu Z. Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice. Acta Pharmacol Sin 2002 23 263-266 (Pubitemid 34194395)
12. Xu H, You C, Zhang R, Gao P, Wang Z. Effects of Astragalus polysaccharides and astragalosides on the phagocytosis of Mycobacterium tuberculosis by macrophages. J Int Med Res 2007 35 84-90 (Pubitemid 46477531)
13. Fauce S R., Jamieson B D., Chin A C., Mitsuyasu R T., Parish S T., Ng H L., Kitchen C M., Yang O O., Harley C B., Effros R B. Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol 2008 181 7400-7406
14. Bosc D G., Goueli B S., Janknecht R. HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene 2001 20 6215-6224 (Pubitemid 32964434)
15. Breitschopf K, Zeiher A M., Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett 2001 493 21-25 (Pubitemid 32241169)
16. Maida Y, Kyo S, Kanaya T, Wang Z, Yatabe N, Tanaka M, Nakamura M, Ohmichi M, Gotoh N, Murakami S, Inoue M. Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway. Oncogene 2002 21 4071-4079 (Pubitemid 34712874)
17. Kam A Y., Liu A M., Wong Y H. Formyl peptide-receptor like-1 requires lipid raft and extracellular signal-regulated protein kinase to activate inhibitor-B kinase in human U87 astrocytoma cells. J Neurochem 2007 103 1553-1566 (Pubitemid 47631825)
18. s distinctively requires protein kinase A, JNK, and phosphatidylinositol 3-kinase. J Biol Chem 2006 281 35812-35825 (Pubitemid 46041313)
19. New D C., Wu K, Kwok A W., Wong Y H. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J 2007 274 6025-6036 (Pubitemid 350135324)
20. Zakian V A. Structure and function of telomeres. Annu Rev Genet 1989 23 579-604 (Pubitemid 20033416)
21. Goueli B S., Janknecht R. Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol 2004 24 25-35 (Pubitemid 38010032)
22. Wang Z, Kyo S, Takakura M, Tanaka M, Yatabe N, Maida Y, Fujiwara M, Hayakawa J, Ohmichi M, Koike K, Inoue M. Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway. Cancer Res 2000 60 5376-5381
23. Li H, Pinto A R., Duan W, Li J, Toh B H., Liu J P. Telomerase down-regulation does not mediate PC12 pheochromocytoma cell differentiation induced by NGF, but requires MAP kinase signalling. J Neurochem 2005 95 891-901 (Pubitemid 41567179)
24. 14 and multiple signaling components: a mechanism requiring protein kinase C, calmodulin-dependent kinase II, ERK, and c-Src. J Biol Chem 2005 280 34617-34625 (Pubitemid 41504592)
25. Tsu R C., Chan J S., Wong Y H. Regulation of multiple effectors by the cloned -opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase. J Neurochem 1995 64 2700-2707
26. Zhu J, Lee S, Ho M K., Hu Y, Pang H, Ip F C., Chin A C., Harley C B., Ip N Y., Wong Y H. In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator. Drug Metab Pharmacokinet 2010 25 477-486
27. Zhu F, Li W, Yin Y, Li W. Effect of astragalosides on activation of extracellular signal regulated kinase in hippocampal neuron after injury induced by hypoxia/reoxygenation. Acta Univ Med Anhui 2009 44 471-474
28. Nguyen T T., Scimeca J C., Filloux C, Peraldi P, Carpentier J L., Van Obberghen E. Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor. J Biol Chem 1993 268 9803-9810 (Pubitemid 23146043)
29. Lowes V L., Ip N Y., Wong Y H. Integration of signals from receptor tyrosine kinases and G protein-coupled receptors. Neurosignals 2002 11 5-19 (Pubitemid 37499845)
30. Traverse S, Seedorf K, Paterson H, Marshall C J., Cohen P, Ullrich A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol 1994 4 694-701
31. Ramos J W. The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol 2008 40 2707-2719
32. Werry T D., Christopoulos A, Sexton P M. Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors. Curr Pharm Des 2006 12 1683-1702
33. Illario M, Cavallo A L., Bayer K U., Di Matola T, Fenzi G, Rossi G, Vitale M. Calcium/calmodulin-dependent protein kinase II binds to Raf-1 and modulates integrin-stimulated ERK activation. J Biol Chem 2003 278 45101-45108 (Pubitemid 37432642)
34. Choe E S., Wang J Q. Group I metabotropic glutamate receptors control phosphorylation of CREB, Elk-1 and ERK via a CaMKII-dependent pathway in rat striatum. Neurosci Lett 2001 313 129-132 (Pubitemid 33022587)
35. Qiu L, Wang Q, Di W, Jiang Q, Schefeller E, Derby S, Wanebo H, Yan B, Wan Y. Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. Int J Oncol 2005 27 823-830
36. Poeckel D, Tausch L, Altmann A, Feisst C, Klinkhardt U, Graff J, Harder S, Werz O. Induction of central signalling pathways and select functional effects in human platelets by beta-boswellic acid. Br J Pharmacol 2005 146 514-524 (Pubitemid 41487067)
37. 1101 is associated with modulation of receptor function. J Biol Chem 1999 274 8335-8343
38. Yarden Y. The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001 37 S3-S8 (Pubitemid 32938123)
39. Xu D, Dwyer J, Li H, Duan W, Liu J P. Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc. J Biol Chem 2008 283 23567-23580