Differential gene expression in human fibroblasts after alpha-particle emitter 211At compared with 60Co irradiation

International Journal of Radiation Biology

Volumn 89, Issue 4, 2013, Pages 250-258

  Danielsson, Anna ^a   Claesson, Kristina ^a   Parris, Toshima Z ^a   Helou, Khalil ^a   Nemes, Szilárd ^a   Elmroth, Kecke ^a   Elgqvist, Jörgen ^a   Jensen, Holger ^b   Hultborn, Ragnar ^a  

^a SAHLGRENSKA ACADEMY AT UNIVERSITY OF GOTHENBURG   (Sweden)

^b Rigshospitalet   (Denmark)

Author keywords

Alpha emitters; Gene expression; High LET; Human fibroblast; Molecular radiobiology

Indexed keywords

ASTATINE 211; COBALT 60;

ALPHA RADIATION; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CENTROMERE; CHROMOSOME CONDENSATION; DOWN REGULATION; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IRRADIATION; MITOSIS; PRIORITY JOURNAL; RADIATION DOSE; UPREGULATION;

ALPHA PARTICLES; ASTATINE; CELL LINE; COBALT RADIOISOTOPES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HUMANS; LINEAR ENERGY TRANSFER; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTOME;

EID: 84875849377     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2013.746751     Document Type: Article

References (42)

1. Amundson SA, Fornace AJ Jr. 2003. Monitoring human radiation exposure by gene expression profiling: Possibilities and pitfalls. Health Physics 85: 36-42. (Pubitemid 36706038)
2. Amundson SA, Do KT, Vinikoor LC, Lee RA, Koch-Paiz CA, Ahn J, Reimers M, Chen Y, Scudiero DA, Weinstein JN, et al. 2008. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Research 68: 415-424. (Pubitemid 351380067)
3. Azzam EI, de Toledo SM, Waker AJ, Little JB. 2000. High and low fluences of alpha-particles induce a G1 checkpoint in human diploid fibroblasts. Cancer Research 60: 2623-2631. (Pubitemid 30318236)
4. Benjamini Y, Drai D, Elmer G, KafkafiN, Golani I. 2001. Controlling the false discovery rate in behavior genetics research. Behavioural Brain Research 125: 279-284. (Pubitemid 33000466)
5. Brechbiel MW. 2007. Targeted alpha-therapy: Past, present, future? Dalton Transactions 43: 4918-4928.
6. Claesson AK, Stenerlow B, Jacobsson L, Elmroth K. 2007. Relative biological effectiveness of the alpha-particle emitter (211)At for double-strand break induction in human fibroblasts. Radiation Research 167: 312-318. (Pubitemid 351292543)
7. Crosby ME, Jacobberger J, Gupta D, Macklis RM, Almasan A. 2007. E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma. Oncogene 26: 1897-1909. (Pubitemid 46474643)
8. Deng X, Gao F, May WS Jr. 2003. Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS. Blood 102: 3179-3185. (Pubitemid 37314754)
9. Elgqvist J, Bernhardt P, Hultborn R, Jensen H, Karlsson B, Lindegren S, Warnhammar E, Jacobsson L. 2005. Myelotoxicity and RBE of 211Atconjugated monoclonal antibodies compared with 99mTc-conjugated monoclonal antibodies and 60Co irradiation in nude mice. Journal of Nuclear Medicine 46: 464-471. (Pubitemid 43093156)
10. Fletcher L, Cerniglia GJ, Nigg EA, Yend TJ, Muschel RJ. 2004. Inhibition of centrosome separation after DNA damage: A role for Nek2. Radiation Research 162: 128-135. (Pubitemid 39100011)
11. Franken NA, ten Cate R, Krawczyk PM, Stap J, Haveman J, Aten J, Barendsen GW. 2011. Comparison of RBE values of high-LET alpha-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death. Radiation Oncology 6: 64.
12. Ghandhi SA, Yaghoubian B, Amundson SA. 2008. Global gene expression analyses of bystander and alpha particle irradiated normal human lung fibroblasts: Synchronous and differential responses. BMC Medical Genomics 1: 63.
13. Goodhead DT. 2010. New radiobiological, radiation risk and radiation protection paradigms. Mutation Research 687: 13-16.
14. Guillou E, Ibarra A, Coulon V, Casado-Vela J, Rico D, Casal I, Schwob E, Losada A, Mendez J. 2010. Cohesin organizes chromatin loops at DNA replication factories. Genes and Development 24: 2812-2822.
15. Hada M, Georgakilas AG. 2008. Formation of clustered DNA damage after high-LET irradiation: A review. Journal of Radiation Research 49: 203-210. (Pubitemid 351744272)
16. Harper JW, Elledge SJ. 2007. The DNA damage response: Ten years after. Molecular Cell 28: 739-745. (Pubitemid 350217064)
17. Harrison J, Day P. 2008. Radiation doses and risks from internal emitters. Journal of Radiological Protection 28: 137-159. (Pubitemid 351813634)
18. Jakel O, Karger CP, Debus J. 2008. The future of heavy ion radiotherapy. Medical Physics 35: 5653-5663.
19. Jakob B, Scholz M, Taucher-Scholz G. 2000. Immediate localized CDKN1A (p21) radiation response after damage produced by heavyion tracks. Radiation Research 154: 398-405.
20. Karlsson KH, Stenerlow B. 2004. Focus formation of DNA repair proteins in normal and repair-deficient cells irradiated with high-LET ions. Radiation Research 161: 517-527. (Pubitemid 40754220)
21. Kis E, Szatmari T, Keszei M, Farkas R, Esik O, Lumniczky K, Falus A, Safrany G. 2006. Microarray analysis of radiation response genes in primary human fibroblasts. International Journal of Radiation Oncology, Biology, Physics 66: 1506-1514.
22. Kurpinski K, Jang DJ, Bhattacharya S, Rydberg B, Chu J, So J, Wyrobek A, Li S, Wang D. 2009. Differential effects of x-rays and highenergy 56Fe ions on human mesenchymal stem cells. International Journal of Radiation Oncology, Biology, Physics 73: 869-877.
23. Lindegren S, Back T, Jensen HJ. 2001. Dry-distillation of astatine-211 from irradiated bismuth targets: A time-saving procedure wiThhigh recovery yields. Applied Radiation and Isotopes 55: 157-160. (Pubitemid 32241030)
24. Lindegren S, Frost S, Back T, Haglund E, Elgqvist J, Jensen H. 2008. Direct procedure for the production of 211At-labeled antibodies with an epsilon-lysyl-3-(trimethylstannyl)benzamide immunoconjugate. Journal of Nuclear Medicine 49: 1537-1545.
25. Ljungman M, Lane DP. 2004. Transcription - guarding the genome by sensing DNA damage. Nature Reviews. Cancer 4: 727-737. (Pubitemid 39215071)
26. Meador JA, Ghandhi SA, Amundson SA. 2011. p53-independent downregulation of histone gene expression in human cell lines by high- and low-let radiation. Radiation Research 175: 689-699.
27. Meadows SK, Dressman HK, Muramoto GG, Himburg H, Salter A, Wei Z, Ginsburg GS, Chao NJ, Nevins JR, Chute JP. 2008. Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS ONE 3: e1912.
28. Milenic DE, Garmestani K, Brady ED, Albert PS, Ma D, Abdulla A, Brechbiel MW. 2004. Targeting of HER2 antigen for the treatment of disseminated peritoneal disease. Clinical Cancer Research 10: 7834-7841. (Pubitemid 39587521)
29. Parris TZ, Danielsson A, Nemes S, Kovacs A, Delle U, Fallenius G, Mollerstrom E, Karlsson P, Helou K. 2010. Clinical implications of gene dosage and gene expression patterns in diploid breast carcinoma. Clinical Cancer Research 16: 3860-3874.
30. Pires IM, Bencokova Z, Milani M, Folkes LK, Li JL, Stratford MR, Harris AL, Hammond EM. 2011. Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability. Cancer Research 70: 925-935.
31. Ross HJ, Canada AL, Antoniono RJ, Redpath JL. 1997. High and low dose rate irradiation have opposing effects on cytokine gene expression in human glioblastoma cell lines. European Journal of Cancer 33: 144-152. (Pubitemid 27099582)
32. Schmid TE, Dollinger G, Beisker W, Hable V, Greubel C, Auer S, Mittag A, Tarnok A, Friedl AA, Molls M, et al. 2010. Differences in the kinetics of gamma-H2AX fluorescence decay after exposure to low and high LET radiation. International Journal of Radiation Biology 86: 682-691.
33. Seidl C, Port M, Apostolidis C, Bruchertseifer F, Schwaiger M, Senekowitsch-Schmidtke R, Abend M. 2010. Differential gene expression triggered by highly cytotoxic alpha-emitter-immunoconjugates in gastric cancer cells. Investigational New Drugs 28: 49-60.
34. Sgouros G, Roeske JC, McDevitt MR, Palm S, Allen BJ, Fisher DR, Brill AB, Song H, Howell RW, Akabani G, et al. 2010. MIRD pamphlet No. 22 (abridged): Radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy. Journal of Nuclear Medicine 51: 311-328.
35. Snyder AR, Morgan WF. 2004. Gene expression profiling after irradiation: Clues to understanding acute and persistent responses? Cancer Metastasis Reviews 23: 259-268. (Pubitemid 38881810)
36. Sokolov MV, Smirnova NA, Camerini-Otero RD, Neumann RD, Panyutin IG. 2006. Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclide. Gene 382: 47-56. (Pubitemid 44550245)
37. Sorensen BS, Overgaard J, Bassler N. 2011. In vitro RBE-LET dependence for multiple particle types. Acta Oncologica 50: 757-762.
38. Taguchi M, Kimura A, Watanabe R, Hirota K. 2009. Estimation of yields of hydroxyl radicals in water under various energy heavy ions. Radiation Research 171: 254-263.
39. Turtoi A. 2010. Gene expression profiles of human lymphocytes exposed to 211At alfa particles. Radiation Research 174: 125-136.
40. Turtoi A, Brown I, Oskamp D, Schneeweiss FH. 2008. Early gene expression in human lymphocytes after gamma-irradiation - a genetic pattern with potential for biodosimetry. International Journal of Radiation Biology 84: 375-387. (Pubitemid 351878841)
41. Vilborg A, Bersani C, Wilhelm MT, Wiman KG. 2011. The p53 target Wig-1: A regulator of mRNA stability and stem cell fate? Cell Death and Differentiation 18: 1434-1440.
42. Zhou T, Chou J, Mullen TE, Elkon R, Zhou Y, Simpson DA, Bushel PR, Paules RS, Lobenhofer EK, Hurban P, et al. 2007. Identification of primary transcriptional regulation of cell cycle-regulated genes upon DNA damage. Cell Cycle 6: 972-981. (Pubitemid 46658752)