The future of heavy ion radiotherapy

Medical Physics

Volumn 35, Issue 12, 2008, Pages 5653-5663

  Jäkel, Oliver ^a,b   Karger, Christian P ^a   Debus, Jürgen ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Heavy charged particles; Heavy ions; High LET; Radiotherapy; Relative biological effectiveness (RBE)

Indexed keywords

CLINICAL RESEARCH; COST EFFECTIVENESS; ENERGY TRANSFER; ION BEAMS; RADIOTHERAPY;

HEAVY CHARGED PARTICLES; HEAVY ION RADIOTHERAPY; HIGH LINEAR ENERGY TRANSFERS; HIGH-LET; INTENSITY-MODULATED; PRECISE MEASUREMENTS; RELATIVE BIOLOGICAL EFFECTIVENESS; THREE DIMENSIONAL BEAM;

HEAVY IONS;

HEAVY ION;

ARTICLE; COST EFFECTIVENESS ANALYSIS; DOSIMETRY; HUMAN; ION THERAPY; LINEAR ENERGY TRANSFER; PRESCRIPTION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION ENERGY; RADIOBIOLOGY; TREATMENT PLANNING;

EID: 56749169685     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3002307     Document Type: Article

References (63)

1. O. Jäkel, D. Schulz-Ertner, C. P. Karger, A. Nikoghosyan, and J. Debus, " Heavy ion therapy: Status and perspectives.," Technol. Cancer Res. Treat. 2, 377-387 (2003).
2. D. Schulz-Ertner, O. Jäkel, and W. Schlegel, " Radiation therapy with charged particles.," Semin. Radiat. Oncol. 16, 249-259 (2006).
3. O. Jäkel, M. Krämer, D. Schulz-Ertner, P. Heeg, C. P. Karger, B. Didinger, A. Nikoghosyan, and J. Debus, " Treatment planning for carbon ion radiotherapy in Germany: Review of clinical trials and treatment planning studies.," Radiother. Oncol. 73, S86-S91 (2004).
4. C. P. Karger and O. Jäkel, " Current status and new developments in ion therapy.," Strahlenther. Onkol. 183, 295-300 (2007).
5. G. Kraft, " Tumor therapy with heavy charged particles.," Prog. Part. Nucl. Phys. 45, S473-S544 (2000).
6. J. R. Castro, D. E. Linstadt, J. P. Bahary, P. L. Petti, I. Daftari, J. M. Collier, P. H. Gutin, G. Gauger, and T. L. Phillips, " Experience in charged particle irradiation of tumors of the skull base: 1977-1992.," Int. J. Radiat. Oncol., Biol., Phys. 29, 647-655 (1994).
7. Particle Newsletter 36, edited by, J. Sisterson, (Harvard Cyclotron Laboratory, Harvard University, Boston, 2005), www.ptcog.com.
8. J. R. Castro, " Results of heavy ion radiotherapy.," Radiat. Environ. Biophys. 34, 45-48 (1995).
9. H. Tsujii, " Clinical results of carbon ion radiotherapy at NIRS.," J. Radiat. Res. (Tokyo) 48 Suppl A, A1-A13 (2007).
10. M. Torikoshi, S. Minohara, N. Kanematsu, M. Komori, M. Kanazawa, K. Noda, N. Miyahara, H. Itoh, M. Endo, and T. Kanai, " Irradiation System for HIMAC.," J. Radiat. Res. (Tokyo) 48 Suppl A, A15-A25 (2007).
11. Y. Hishikawa, Y. Oda, H. Mayahara, A. Kawaguchi, K. Kagawa, M. Murakami, and M. Abe, " Status of the clinical work at Hyogo.," Radiother. Oncol. 73 Suppl 2, S38-S40 (2004).
12. P. Heeg, H. Eickhoff, and T. Haberer, " [Conception of heavy ion beam therapy at Heidelberg University (HICAT)].," Z. Med. Phys. 14, 17-24 (2004).
13. T. Haberer, J. Debus, H. Eickhoff, O. Jäkel, D. Schulz-Ertner, and U. Weber, " The Heidelberg Ion Therapy Center.," Radiother. Oncol. 73 Suppl 2, S186-S190 (2004).
14. U. Amaldi, " CNAO-The Italian Centre for Light-Ion Therapy.," Radiother. Oncol. 73 Suppl 2, S191-S201 (2004).
15. U. Amaldi and G. Kraft, " European developments in radiotherapy with beams of large radiobiological effectiveness.," J. Radiat. Res. (Tokyo) 48 Suppl A, A27-A41 (2007).
16. Q. Li, Z. Dai, Z. Yan, X. Jin, X. Liu, and G. Xiao, " Heavy-ion conformal irradiation in the shallow-seated tumor therapy terminal at HIRFL.," Med. Biol. Eng. Comput. 45 (11), 1037-1043 (2007).
17. P. Andreo, D. T. Burns, K. Hohlfeld, M. S. Huq, T. Kanai, F. Laitano, V. Smyth, and S. Vynckier, " Absorbed dose determination in external beam radiotherapy.," Technical Report Series No. 398 (2000).
18. S. Minohara, T. Kanai, M. Endo, K. Noda, and M. Kanazawa, " Respiratory gated irradiation system for heavy-ion radiotherapy.," Int. J. Radiat. Oncol., Biol., Phys. 47, 1097-1103 (2000).
19. C. Bert, N. Saito, A. Schmidt, N. Chaudhri, D. Schardt, and E. Rietzel, " Target motion tracking with a scanned particle beam.," Med. Phys. 34, 4768-4771 (2007).
20. D. Schulz-Ertner, A. Nikoghosyan, H. Hof, B. Didinger, S. E. Combs, O. Jäkel, C. P. Karger, L. Edler, and J. Debus, " Carbon ion radiotherapy of skull base chondrosarcomas.," Int. J. Radiat. Oncol., Biol., Phys. 67, 171-177 (2007).
21. D. Schulz-Ertner, C. P. Karger, A. Feuerhake, A. Nikoghosyan, S. E. Combs, O. Jäkel, L. Edler, M. Scholz, and J. Debus, " Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas.," Int. J. Radiat. Oncol., Biol., Phys. 68, 449-457 (2007).
22. D. Schulz-Ertner and H. Tsujii, " Particle radiation therapy using proton and heavier ion beams.," J. Clin. Oncol. 25, 953-964 (2007).
23. D. Schulz-Ertner, A. Nikoghosyan, B. Didinger, M. Munter, O. Jäkel, C. P. Karger, and J. Debus, " Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques.," Cancer 104, 338-344 (2005).
24. K. W. Ledingham, W. Galster, and R. Sauerbrey, " Laser-driven proton oncology-A unique new cancer therapy?," Br. J. Radiol. 80, 855-858 (2007).
25. G. J. Caporaso, 1994 US-CERN-Japan Joint Accelerator School: Topical Course: Frontiers Of Accelerator Technology, 3-9 Nov 1994, Maui, Hawaii, edited by, M. M. S. T. S. I. Kurokawa, (World Scientific, New Jersey, 1996), pp. 594-615.
26. S. E. Sampayan, G. J. Caporaso, D. M. Sanders, R. D. Stoddard, D. O. Trimble, J. Elizondo, M. L. Krogh, and T. F. Wieskamp, Particle Accelerator Conference, 1997. Proceedings of the 1997 (IEEE, Lawrence Livermore Nat. Lab., 1997), pp. 1308-1310.
27. Y.-J. Chen and A. C. Paul, Proceedings of PAC07, Albuquerque, New Mexico, USA, edited by, S. Hardage, and, C. Petit-Jean-Genaz, (IEEE, Piscataway, NJ, 2007), pp. 1787-1789.
28. D. Trbojevic, D. Parker, E. Keil, and A. M. Sessler, " Carbon/proton therapy: A novel gantry design.," Phys. Rev. ST Accel. Beams 2007, 053503-1-053503-6 (2007).
29. Y. Jongen, Design Studies of the Compact Superconducting Cyclotron for Hadron Therapy, Abstract TUPLS078, Proceedings of EPAC, Edinburgh, Scotland, 1678-1680 (2006).
30. H. Palmans, J. Seuntjens, F. Verhaegen, J. M. Denis, S. Vynckier, and H. Thierens, " Water calorimetry and ionization chamber dosimetry in an 85-MeV clinical proton beam.," Med. Phys. 23, 643-650 (1996).
31. H. J. Brede, K. D. Greif, O. Hecker, P. Heeg, J. Heese, D. T. Jones, H. Kluge, and D. Schardt, " Absorbed dose to water determination with ionization chamber dosimetry and calorimetry in restricted neutron, photon, proton and heavy-ion radiation fields.," Phys. Med. Biol. 51, 3667-3682 (2006).
32. F. Sauli, " GEM: A new concept for electron amplification in gas detectors.," Nucl. Instrum. Methods Phys. Res. A 386, 531-534 (1997).
33. G. T. Y. Chen, S. Mori, A. Chu, and M. Folkert, Uncertainties in image guided radiotherapy of lung tumors, Proceedings of NIRS-CNAO Joint Symposium on Carbon Ion Radiotherapy, Milan, Italy, 2006, pp. 192-193 (2006).
34. C. Zhang, P. Lechner, G. Lutz, M. Porroe, R. Richter, J. Treisa, L. Strüder, and S. N. Hang, " Development of DEPFET Macropixel detectors.," Nucl. Instrum. Methods Phys. Res. A 568, 207-216 (2008).
35. J. Jakubek, T. Holy, E. Lehmann, S. Pospisil, J. Uher, D. Vacik, and D. Vavrik, " Spatial resolution of Medipix-2 device as neutron pixel detector.," Nucl. Instrum. Methods Phys. Res. A 546, 164-169 (2005).
36. J. Jakubek, " Neutron imaging and tomography with Medipix2 and dental micro-roentgenography.," Nucl. Instrum. Methods Phys. Res. A 569, 205-209 (2006).
37. M. Rebisz, B. Voss, A. Heinz, E. Usenko, and M. Pomorski, " CVD diamond dosimeters for heavy ion beams.," Diamond Relat. Mater. 16, 1070-1073 (2007).
38. A. Wambersie, J. H. Hendry, P. Andreo, P. M. DeLuca, R. Gahbauer, H. Menzel, and G. Whitmore, " The RBE issues in ion-beam therapy: Conclusions of a joint IAEA/ICRU working group regarding quantities and units.," Radiat. Prot. Dosim. 122, 463-470 (2006).
39. M. Krämer and M. Scholz, " Rapid calculation of biological effects in ion radiotherapy.," Phys. Med. Biol. 51, 1959-1970 (2006).
40. M. Ellerbrock, O. Jäkel, M. Krämer, A. Nikoghosyan, and D. Schulz-Ertner, " Clinical implementation of intensity modulated heavy ion therapy.," Radiother. Oncol. 84, 129 (2007).
41. M. Ellerbrock, O. Jäkel, M. Krämer, A. Nikoghosyan, and D. Schulz-Ertner, " Multiple field optimization in heavy ion treatment planning-clinical aspects.," in Abstracts der Frühjahrstagung in Heidelberg (Deutsche Physikalische Gesellschaft (DPG) ST 6.4, Heidelberg, 2006).
42. M. Engelsman, E. Rietzel, and H. M. Kooy, " Four-dimensional proton treatment planning for lung tumors.," Int. J. Radiat. Oncol., Biol., Phys. 64, 1589-1595 (2006).
43. E. Rietzel, S. J. Rosenthal, D. P. Gierga, C. G. Willet, and G. T. Chen, " Moving targets: Detection and tracking of internal organ motion for treatment planning and patient set-up.," Radiother. Oncol. 73 Suppl 2, S68-S72 (2004).
44. S. Mori, G. T. Chen, and M. Endo, " Effects of intrafractional motion on water equivalent pathlength in respiratory-gated heavy charged particle beam radiotherapy.," Int. J. Radiat. Oncol., Biol., Phys. 69, 308-317 (2007).
45. P. Kupelian, T. Willoughby, A. Mahadevan, T. Djemil, G. Weinstein, S. Jani, C. Enke, T. Solberg, N. Flores, D. Liu, D. Beyer, and L. Levine, " Multi-institutional clinical experience with the Calypso System in localization and continuous, real-time monitoring of the prostate gland during external radiotherapy.," Int. J. Radiat. Oncol., Biol., Phys. 67, 1088-1098 (2007).
46. D. W. Litzenberg, J. M. Balter, S. W. Hadley, H. M. Sandler, T. R. Willoughby, P. A. Kupelian, and L. Levine, " Influence of intrafraction motion on margins for prostate radiotherapy.," Int. J. Radiat. Oncol., Biol., Phys. 65, 548-553 (2006).
47. ICRU Report 62, Prescribing, Recording and Reporting Photon Beam Therapy (supplement to ICRU report 50) (International Commission on Radiation Units and Measurements, Washington, DC, 1999).
48. S. Minohara, M. Endo, T. Kanai, H. Kato, and H. Tsujii, " Estimating uncertainties of the geometrical range of particle radiotherapy during respiration.," Int. J. Radiat. Oncol., Biol., Phys. 56, 121-125 (2003).
49. C. Bert, S. O. Grozinger, and E. Rietzel, " Quantification of interplay effects of scanned particle beams and moving targets.," Phys. Med. Biol. 53, 2253-2265 (2008).
50. T. Furukawa, T. Inaniwa, S. Sato, T. Tomitani, S. Minohara, K. Noda, and T. Kanai, " Design study of a raster scanning system for moving target irradiation in heavy-ion radiotherapy.," Med. Phys. 34, 1085-1097 (2007).
51. C. Bert and E. Rietzel, " 4D treatment planning for scanned ion beams.," Radiother. Oncol. 2, 24 (2007).
52. S. O. Grozinger, E. Rietzel, Q. Li, C. Bert, T. Haberer, and G. Kraft, " Simulations to design an online motion compensation system for scanned particle beams.," Phys. Med. Biol. 51, 3517-3531 (2006).
53. C. Bert, K. G. Metheany, K. P. Doppke, A. G. Taghian, S. N. Powell, and G. T. Chen, " Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients.," Int. J. Radiat. Oncol., Biol., Phys. 64, 1265-1274 (2006).
54. J. D. Hoisak, K. E. Sixel, R. Tirona, P. C. Cheung, and J. P. Pignol, " Prediction of lung tumour position based on spirometry and on abdominal displacement: accuracy and reproducibility.," Radiother. Oncol. 78, 339-346 (2006).
55. J. D. Hoisak, K. E. Sixel, R. Tirona, P. C. Cheung, and J. P. Pignol, " Correlation of lung tumor motion with external surrogate indicators of respiration.," Int. J. Radiat. Oncol., Biol., Phys. 60, 1298-1306 (2004).
56. T. Nakano, Y. Suzuki, T. Ohno, S. Kato, M. Suzuki, S. Morita, S. Sato, K. Oka, and H. Tsujii, " Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia.," Clin. Cancer Res. 12, 2185-2190 (2006).
57. K. Gunzert-Marx, D. Schardt, and R. S. Simon, " The fast neutron component in treatment irradiations with 12C beam.," Radiother. Oncol. 73 Suppl 2, S92-S95 (2004).
58. M. Goitein and M. Jermann, " The relative costs of proton and X-ray radiation therapy.," Clin. Oncol. (R Coll. Radiol) 15, S37-S50 (2003).
59. O. Jäkel, B. Land, S. E. Combs, D. Schulz-Ertner, and J. Debus, " On the cost-effectiveness of carbon ion radiation therapy for skull base chordoma.," Radiother. Oncol. 83, 133-138 (2007).
60. J. Lundkvist, M. Ekman, S. R. Ericsson, B. Jonsson, and B. Glimelius, " Proton therapy of cancer: Potential clinical advantages and cost-effectiveness.," Acta Oncol. 44, 850-861 (2005).
61. M. Lodge, M. Pijls-Johannesma, L. Stirk, A. J. Munro, R. D. De, and T. Jefferson, " A systematic literature review of the clinical and cost-effectiveness of hadron therapy in cancer.," Radiother. Oncol. 83, 110-122 (2007).
62. C. P. Karger, P. Peschke, R. Sanchez-Brandelik, M. Scholz, and J. Debus, " Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: Experimental results and clinical implications.," Int. J. Radiat. Oncol., Biol., Phys. 66, 1488-1497 (2006).
63. Y. Furusawa, K. Fukutsu, M. Aoki, H. Itsukaichi, K. Eguchi-Kasai, H. Ohara, F. Yatagai, T. Kanai, and K. Ando, " Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C-, and (20)Ne-ion beams.," Radiat. Res. 154, 485-496 (2000).