Early gene expression in human lymphocytes after γ-irradiation - A genetic pattern with potential for biodosimetry

International Journal of Radiation Biology

Volumn 84, Issue 5, 2008, Pages 375-387

  Turtoi, A ^a   Brown, I ^b   Oskamp, D ^a   Schneeweiss, F H A ^a  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b UNIVERSITY HOSPITAL COVENTRY   (United Kingdom)

Author keywords

radiation; Biodosimetry; Early gene expression; Lymphocytes

Indexed keywords

CD69 ANTIGEN; CESIUM 137; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EARLY GROWTH RESPONSE FACTOR; EARLY GROWTH RESPONSE FACTOR 1; GAMMA INTERFERON; MUCIN 5B; POLO LIKE KINASE 2; PROTEIN MDM2; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE;

ADULT; ARTICLE; DNA MICROARRAY; DOSIMETRY; FEMALE; GAMMA IRRADIATION; GENE EXPRESSION PROFILING; GENE INDUCTION; GENE REPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTES; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIATION, IONIZING; RADIOMETRY; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION FACTORS;

EID: 45849130600     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000802029886     Document Type: Article

References (29)

1. Adachi Y, Tokuda N, Sawada T, Fukumto T. 2005. Semi-quantitative detection of cytokine messages in X-irradiated and regenerating rat thymus. Radiation Research 163: 400-407.
2. Ahmed MM, Venkatasubbarao K, Fruitwala SM, Muthukkumar S, Wood DPJ, Sells SF, Mohiuddin M, Rangnekar VM. 1996. EGR-1 induction is required for maximal radio-sensitivity in A375-C6 melanoma cells. Journal of Biological Chemistry 271:29231-29237.
3. Alexander JS, Elrod JW, Park JH. 2001. Roles of leukocyte and immune cell junction proteins. Microcirculation 8:169-179.
4. Amundson SA, Bittner M, Chen Y, Trent J, Meltzer P, Fornace AJ. 1999a. Fluorescent cDNA-microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18:3666-3672.
5. Amundson SA, Do KT, Fornace AJ. 1999b. Induction of stress genes by low doses of gamma rays. Radiation Research 152:225-231.
6. Amundson SA, Do KT, Shahab S, Bittner M, Meltzer P, Trent J, Fornace AJ. 2000. Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to IR. Radiation Research 154:342-346.
7. Amundson SA, Fornace AJ. 2003. Monitoring human radiation exposure by gene expression profiling: possibilities and pitfalls. Health Physics 85:36-42.
8. Amundson SA, Grace MB, Mcleland CB, Epperly MW, Yeager A, Zhan Q, Greenberger JS, Fornace AJ. 2004. Human in vivo radiation-induced biomarkers: Gene expression changes in radiotherapy patients. Cancer Research 64:6368-6371.
9. Anno GH, Young RW, Bloom RM, Mercier JR. 2003. Dose response relationships for acute IR lethality. Health Physics 84:565-575.
10. Anno GH, Baum SJ, Withers HR, Young RW. 1989. Symptomatology of acute radiation effects in humans after exposure to doses of 0.5-30 Gy. Health Physics 56:821-838.
11. BAE I, Fan S, Bhatia K, Kohn KW, Fornace AJ, O'Connor PM. 1995. Relationship between G1 arrest and stability of the p53 and P21Cip1/Waf1 proteins following g-irradiation of human lymphoma cells. Cancer Research 55:2387-2393.
12. Barenco M, Tomescu D, Brewer D, Callard R, Stark J, Hubank M. 2006. Ranked prediction of p53 targets using hidden variable dynamic modelling. Genome Biology 7:25.1-25.18.
13. Chen C, Boylan MT, Evans CA, Whetton AD, Wright EG. 2005. Application of two-dimensional difference gel electrophoresis to studying bone marrow macrophages and their in vivo responses to IR. Journal of Proteome Research 4:1371-1380.
14. Dressman HK, Muramoto GG, Chao NJ, Meadows S, Marshall D, Ginsburg GS, Nevins JR, Chute JP. 2007. Gene expression signatures that predict radiation exposure in mice and humans. PLOS Medicine 4:1-12.
15. Franken NP, Cate RT, Bree CV, Haveman J. 2004. Induction of the early response protein EGR-1 in human tumour cells after ionising radiation is correlated with a reduction of repair of lethal lesions and an increase of repair of sublethal lesions. International Journal of Oncology 24:1027-1031.
16. Franco N, Lamartine J, Frouin V, Le Minter P, Petat C, Leplat JJ, Libert F, Gidrol X, Martin MT. 2005. Low-dose exposure to γ-rays induces specific gene regulations in normal human keratinocytes. Radiation Research 163:623-635.
17. Gentleman RC, Carey V, Bates D, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JYH, Zhang J. 2004. Bioconductor: Open software development for computational biology and bioinformatics. Genome Biology 5:R80-80.15.
18. Guo WF, Lin RX, Huang J, Zhou Z, Yang J, Guo GZ, Wang SQ. 2005. Identification of differentially expressed genes contributing to radioresistance in lung cancer cells using microarray analysis. Radiation Research 164:27-35.
19. Hallahan DE, Dunphy E, Virudachalam S, Sukhatme VP, Kufe DW, Weichselbaum RR. 1995. c-JUN and EGR-1 participate in DNA synthesis and cell survival in response to IR exposure. Journal of Biological Chemistry 270:30303-30309.
20. Jen KY, Cheung VG. 2007. Transcriptional response of lymphoblastoid cells to IR. Genome Research 13:2092-2100.
21. Kanda R. 2000. Improvement of accuracy of chromosome aberration analysis for biological radiation dosimetry. Journal of Radiation Research 41:1-8.
22. Kang CM, Park KP, Song JE, Jeoung DI, Cho CK, Kim TH, Sangwoo B, Lee SJ, Lee YS. 2003. Possible biomarkers for IR exposure in human peripheral blood lymphocytes. Radiation Research 159:312-319.
23. Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, Perry ME. 2003. MDM2 is critical for inhibition of p53 during lymphopoiesis and the response to IR. Molecular and Cellular Biology 23:462-473.
24. Nobes CD, Lauritzen I, Mattei MG, Paris S, Hall A, Chardin P. 1998. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structure and loss of cell adhesion. Journal of Cell Biology 141:187-197.
25. Otomo T, Hishii M, Arai H, Sato K, Sasai K. 2004. Microarray analysis of temporal gene responses to IR in two glioblastoma cell lines: Up-regulation of DNA repair genes. Journal of Radiation Research 45:53-60.
26. Rieger KE, Chu G. 2004. Portrait of transcriptional responses to ultraviolet and IR in human cells. Nucleic Acids Research 32:4786-4803.
27. Szkanderova S, Vavrova J, Hernychova L, Neubauerova V, Lenco J, Stulik J. 2005. Proteome alterations in gamma-irradiated human T-lymphocyte leukemia cells. Radiation Research 163:307-315.
28. Turtoi A, Srivastava A, Sharan RN, Oskamp D, Hille R, Schneeweiss FHA. 2007. Early response of lymphocyte proteins after g-radiation. Journal of Radioanalytical and Nuclear Chemistry 274:435-439.
29. Zhang B, Su YP, Ai GP, Liu XH, Wang FC, Cheng TM. 2003. Differentially expressed proteins of gamma-ray irradiated mouse intestinal epithelial cells by two-dimensional electrophoresis and MALDI-TOF mass spectrometry. World Journal of Gastroenterology 9:2726-2731.