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Volumn 9, Issue 1, 2013, Pages 57-66

Copper induces the accumulation of amyloid-beta in the brain

Author keywords

Amyloid beta protein; Amyloid precursor protein (APP); Beta site APP cleaving enzyme 1 (BACE1); Blood brain barrier (BBB); Blood CSF barrier (BCB); Copper; Low density lipoprotein receptor related protein 1 (LRP1); Neprilysin (NEP); Receptor for advanced glycation end products (RAGE)

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; COPPER; COPPER SULFATE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA;

EID: 84875836926     PISSN: 1738642X     EISSN: 20928467     Source Type: Journal    
DOI: 10.1007/s13273-013-0009-0     Document Type: Article
Times cited : (10)

References (48)
  • 1
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • 15295589 10.1038/nature02621 1:CAS:528:DC%2BD2cXmt1Gis7o%3D
    • Mattson, M. P. Pathways towards and away from Alzheimer's disease. Nature 430:631-639 (2004).
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 2
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • 16541076 10.1038/nature04533 1:CAS:528:DC%2BD28XitlKgurg%3D
    • Lesne, S. et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-357 (2006).
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1
  • 3
    • 0141594627 scopus 로고    scopus 로고
    • Copper, betaamyloid, and Alzheimer's disease: Tapping a sensitive connection
    • 14506299 10.1073/pnas.2135061100 1:CAS:528:DC%2BD3sXotFKnurw%3D
    • Bush, A. I., Masters, C. L. & Tanzi, R. E. Copper, betaamyloid, and Alzheimer's disease: tapping a sensitive connection. Proc Natl Acad Sci USA 100:11193-11194 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11193-11194
    • Bush, A.I.1    Masters, C.L.2    Tanzi, R.E.3
  • 4
    • 12144282992 scopus 로고    scopus 로고
    • Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides
    • 15578276 10.1007/s00775-004-0602-8 1:CAS:528:DC%2BD2cXhtVejurjI
    • Huang, X. et al. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. J Biol Inorg Chem 9:954-960 (2004).
    • (2004) J Biol Inorg Chem , vol.9 , pp. 954-960
    • Huang, X.1
  • 5
    • 0141719852 scopus 로고    scopus 로고
    • Gene-diet interactions in brain aging and neurodegenerative disorders
    • 12965973 1:CAS:528:DC%2BD3sXns1Kmtb0%3D
    • Mattson, M. P. Gene-diet interactions in brain aging and neurodegenerative disorders. Ann Intern Med 139:441-444 (2003).
    • (2003) Ann Intern Med , vol.139 , pp. 441-444
    • Mattson, M.P.1
  • 6
    • 18144374793 scopus 로고    scopus 로고
    • Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide
    • 15718230 10.1074/jbc.M500309200 1:CAS:528:DC%2BD2MXjtleitL0%3D
    • Raman, B. et al. Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide. J Biol Chem 280:16157-16162 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 16157-16162
    • Raman, B.1
  • 7
    • 84863430000 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of Abeta42 relationship with cholinergic cortical activity in Alzheimer's disease patients
    • Martorana, A. et al. Cerebrospinal fluid levels of Abeta42 relationship with cholinergic cortical activity in Alzheimer's disease patients. J Neural Transm. http://link.springer.com/content/pdf/10.1007%2Fs00702-012-0780-4 (2012).
    • (2012) J Neural Transm
    • Martorana, A.1
  • 8
    • 0024601426 scopus 로고
    • Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease
    • 2464938 1:STN:280:DyaL1M7jt1Ogtw%3D%3D
    • Ogomori, K. et al. Beta-protein amyloid is widely distributed in the central nervous system of patients with Alzheimer's disease. Am J Pathol 134:243-251 (1989).
    • (1989) Am J Pathol , vol.134 , pp. 243-251
    • Ogomori, K.1
  • 9
    • 0032211830 scopus 로고    scopus 로고
    • The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease
    • 9854312 10.1016/S0962-8924(98)01363-4 1:CAS:528:DyaK1MXmsV2m
    • Selkoe, D. J. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol 8:447-453 (1998).
    • (1998) Trends Cell Biol , vol.8 , pp. 447-453
    • Selkoe, D.J.1
  • 10
    • 65649105035 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptide across the bloodbrain barrier: Implication for therapies in Alzheimer's disease
    • 19275634 10.2174/187152709787601867 1:CAS:528:DC%2BD1MXktlanur8%3D
    • Deane, R., Bell, R. D., Sagare, A. & Zlokovic, B. V. Clearance of amyloid-beta peptide across the bloodbrain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets 8:16-30 (2009).
    • (2009) CNS Neurol Disord Drug Targets , vol.8 , pp. 16-30
    • Deane, R.1    Bell, R.D.2    Sagare, A.3    Zlokovic, B.V.4
  • 11
    • 34047276442 scopus 로고    scopus 로고
    • Copper and Alzheimer's disease
    • 17300982 10.1016/j.cbpa.2007.01.678 1:CAS:528:DC%2BD2sXjvFegtbo%3D
    • Donnelly, P. S., Xiao, Z. & Wedd, A. G. Copper and Alzheimer's disease. Curr Opin Chem Biol 11:128-133 (2007).
    • (2007) Curr Opin Chem Biol , vol.11 , pp. 128-133
    • Donnelly, P.S.1    Xiao, Z.2    Wedd, A.G.3
  • 12
    • 72049102879 scopus 로고    scopus 로고
    • Copper in the brain and Alzheimer's disease
    • 19862561 10.1007/s00775-009-0600-y 1:CAS:528:DC%2BD1MXhtlamsr%2FN
    • Hung, Y. H., Bush, A. I. & Cherny, R. A. Copper in the brain and Alzheimer's disease. J Biol Inorg Chem 15:61-76 (2010).
    • (2010) J Biol Inorg Chem , vol.15 , pp. 61-76
    • Hung, Y.H.1    Bush, A.I.2    Cherny, R.A.3
  • 13
    • 0032507975 scopus 로고    scopus 로고
    • Copper, iron and zinc in Alzheimer's disease senile plaques
    • 9667777 10.1016/S0022-510X(98)00092-6 1:CAS:528:DyaK1cXjsVentbo%3D
    • Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L. & Markesbery, M. R. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 158:47-52 (1998).
    • (1998) J Neurol Sci , vol.158 , pp. 47-52
    • Lovell, M.A.1    Robertson, J.D.2    Teesdale, W.J.3    Campbell, J.L.4    Markesbery, M.R.5
  • 14
    • 1842504323 scopus 로고    scopus 로고
    • Redox-active metals, oxidative stress, and Alzheimer's disease pathology
    • 15105262 10.1196/annals.1306.012 1:CAS:528:DC%2BD2cXjvVOmsrw%3D
    • Huang, X., Moir, R. D., Tanzi, R. E., Bush, A. I. & Rogers, J. T. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci 1012:153-163 (2004).
    • (2004) Ann N y Acad Sci , vol.1012 , pp. 153-163
    • Huang, X.1    Moir, R.D.2    Tanzi, R.E.3    Bush, A.I.4    Rogers, J.T.5
  • 15
    • 24044479679 scopus 로고    scopus 로고
    • BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper
    • 15722349 10.1074/jbc.M412034200 1:CAS:528:DC%2BD2MXjsl2hsrY%3D
    • Angeletti, B. et al. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. J Biol Chem 280:17930-17937 (2005).
    • (2005) J Biol Chem , vol.280 , pp. 17930-17937
    • Angeletti, B.1
  • 16
    • 9144235443 scopus 로고    scopus 로고
    • Copper mediates dityrosine crosslinking of Alzheimer's amyloid-beta
    • 14717612 10.1021/bi0358824 1:CAS:528:DC%2BD3sXpvFSju7c%3D
    • Atwood, C. S. et al. Copper mediates dityrosine crosslinking of Alzheimer's amyloid-beta. Biochemistry 43:560-568 (2004).
    • (2004) Biochemistry , vol.43 , pp. 560-568
    • Atwood, C.S.1
  • 17
    • 0028177269 scopus 로고
    • The beta A4 amyloid precursor protein binding to copper
    • 7913895 10.1016/0014-5793(94)00658-X 1:CAS:528:DyaK2cXlvFyrsrw%3D
    • Hesse, L., Beher, D., Masters, C. L. & Multhaup, G. The beta A4 amyloid precursor protein binding to copper. FEBS Lett 349:109-116 (1994).
    • (1994) FEBS Lett , vol.349 , pp. 109-116
    • Hesse, L.1    Beher, D.2    Masters, C.L.3    Multhaup, G.4
  • 18
    • 0029935396 scopus 로고    scopus 로고
    • The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I)
    • 8596911 10.1126/science.271.5254.1406 1:CAS:528:DyaK28XhsFegtbw%3D
    • Multhaup, G. et al. The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I). Science 271:1406-1409 (1996).
    • (1996) Science , vol.271 , pp. 1406-1409
    • Multhaup, G.1
  • 19
    • 0032546577 scopus 로고    scopus 로고
    • Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide
    • 9585534 10.1021/bi980022m 1:CAS:528:DyaK1cXislGgt7Y%3D
    • Multhaup, G. et al. Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide. Biochemistry 37:7224-7230 (1998).
    • (1998) Biochemistry , vol.37 , pp. 7224-7230
    • Multhaup, G.1
  • 20
    • 0032830357 scopus 로고    scopus 로고
    • Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice
    • 10526140 10.1016/S0006-8993(99)01861-2 1:CAS:528:DyaK1MXmsVWns7w%3D
    • White, A. R. et al. Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice. Brain Res 842:439-444 (1999).
    • (1999) Brain Res , vol.842 , pp. 439-444
    • White, A.R.1
  • 21
    • 79953137657 scopus 로고    scopus 로고
    • Copper promotes the trafficking of the amyloid precursor protein
    • 21177866 10.1074/jbc.M110.128512 1:CAS:528:DC%2BC3MXislyltLs%3D
    • Acevedo, K. M. et al. Copper promotes the trafficking of the amyloid precursor protein. J Biol Chem 286:8252-8262 (2011).
    • (2011) J Biol Chem , vol.286 , pp. 8252-8262
    • Acevedo, K.M.1
  • 22
    • 0035877747 scopus 로고    scopus 로고
    • Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases
    • 11278416 10.1074/jbc.M008511200 1:CAS:528:DC%2BD3MXksFGksbY%3D
    • Shirotani, K. et al. Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon- sensitive endopeptidases. J Biol Chem 276:21895-21901 (2001).
    • (2001) J Biol Chem , vol.276 , pp. 21895-21901
    • Shirotani, K.1
  • 23
    • 20444426464 scopus 로고    scopus 로고
    • Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease
    • 15929037 10.1002/ana.20494 1:CAS:528:DC%2BD2MXlslKks78%3D
    • Maruyama, M. et al. Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease. Ann Neurol 57:832-842 (2005).
    • (2005) Ann Neurol , vol.57 , pp. 832-842
    • Maruyama, M.1
  • 24
    • 0035846826 scopus 로고    scopus 로고
    • Reduced neprilysin in high plaque areas of Alzheimer brain: A possible relationship to deficient degradation of beta-amyloid peptide
    • 11121879 10.1016/S0304-3940(00)01675-X 1:CAS:528:DC%2BD3cXovFGrtb8%3D
    • Yasojima, K., Akiyama, H., McGeer, E. G. & McGeer, P. L. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide. Neurosci Lett 297:97-100 (2001).
    • (2001) Neurosci Lett , vol.297 , pp. 97-100
    • Yasojima, K.1    Akiyama, H.2    McGeer, E.G.3    McGeer, P.L.4
  • 25
    • 75149129707 scopus 로고    scopus 로고
    • Copper downregulates neprilysin activity through modulation of neprilysin degradation
    • 20061635 1:CAS:528:DC%2BC3MXjtV2ru70%3D
    • Li, M. et al. Copper downregulates neprilysin activity through modulation of neprilysin degradation. J Alzheimers Dis 19:161-169 (2010).
    • (2010) J Alzheimers Dis , vol.19 , pp. 161-169
    • Li, M.1
  • 26
    • 57649158930 scopus 로고    scopus 로고
    • Copper transport to the brain by the blood-brain barrier and blood-CSF barrier
    • 19014916 10.1016/j.brainres.2008.10.056 1:CAS:528:DC%2BD1cXhsFansrvF
    • Choi, B. S. & Zheng, W. Copper transport to the brain by the blood-brain barrier and blood-CSF barrier. Brain Res 1248:14-21 (2009).
    • (2009) Brain Res , vol.1248 , pp. 14-21
    • Choi, B.S.1    Zheng, W.2
  • 27
    • 0027769596 scopus 로고
    • Blood-brain barrier transport of circulating Alzheimer's amyloid beta
    • 8280117 10.1006/bbrc.1993.2582 1:CAS:528:DyaK2cXhtVeqsLk%3D
    • Zlokovic, B. V. et al. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun 197:1034-1040 (1993).
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 1034-1040
    • Zlokovic, B.V.1
  • 28
    • 70349229285 scopus 로고    scopus 로고
    • Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1
    • 19501112 10.1016/j.taap.2009.05.024 1:CAS:528:DC%2BD1MXhtFyqsLvK
    • Behl, M., Zhang, Y., Monnot, A. D., Jiang, W. & Zheng, W. Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1. Toxicol Appl Pharmacol 240:245-254 (2009).
    • (2009) Toxicol Appl Pharmacol , vol.240 , pp. 245-254
    • Behl, M.1    Zhang, Y.2    Monnot, A.D.3    Jiang, W.4    Zheng, W.5
  • 29
    • 0032561995 scopus 로고    scopus 로고
    • Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged
    • 9457114 10.1016/S0140-6736(97)09234-9 1:STN:280:DyaK1c7hvVaqtQ%3D%3D
    • Rubenstein, E. Relationship of senescence of cerebrospinal fluid circulatory system to dementias of the aged. Lancet 351:283-285 (1998).
    • (1998) Lancet , vol.351 , pp. 283-285
    • Rubenstein, E.1
  • 30
    • 0034516988 scopus 로고    scopus 로고
    • Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein
    • 11193794 10.1111/j.1749-6632.2000.tb05554.x 1:CAS:528: DC%2BD3MXntVaqtQ%3D%3D
    • Selkoe, D. J. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Ann N Y Acad Sci 924:17-25 (2000).
    • (2000) Ann N y Acad Sci , vol.924 , pp. 17-25
    • Selkoe, D.J.1
  • 31
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloidss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • 11120756 10.1172/JCI10498 1:CAS:528:DC%2BD3cXovFagtbs%3D
    • Shibata, M. et al. Clearance of Alzheimer's amyloidss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 106:1489-1499 (2000).
    • (2000) J Clin Invest , vol.106 , pp. 1489-1499
    • Shibata, M.1
  • 32
    • 33749157416 scopus 로고    scopus 로고
    • RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
    • 16865397 10.1007/s00401-006-0115-3 1:CAS:528:DC%2BD28XhtVagsrzN
    • Donahue, J. E. et al. RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease. Acta Neuropathol 112:405-415 (2006).
    • (2006) Acta Neuropathol , vol.112 , pp. 405-415
    • Donahue, J.E.1
  • 33
    • 54049094343 scopus 로고    scopus 로고
    • Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    • 18657529 10.1016/j.brainres.2008.06.124 1:CAS:528:DC%2BD1cXhtVKmu7vF
    • Miller, M. C. et al. Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease. Brain Res 1230:273-280 (2008).
    • (2008) Brain Res , vol.1230 , pp. 273-280
    • Miller, M.C.1
  • 34
    • 0013615899 scopus 로고    scopus 로고
    • RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
    • 8751438 10.1038/382685a0 1:CAS:528:DyaK28Xlt1yltr0%3D
    • Yan, S. D. et al. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382:685-691 (1996).
    • (1996) Nature , vol.382 , pp. 685-691
    • Yan, S.D.1
  • 35
    • 0141702360 scopus 로고    scopus 로고
    • Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
    • 12920183 10.1073/pnas.1832769100 1:CAS:528:DC%2BD3sXnslynu7s%3D
    • Sparks, D. L. & Schreurs, B. G. Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease. Proc Natl Acad Sci USA 100:11065-11069 (2003).
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 11065-11069
    • Sparks, D.L.1    Schreurs, B.G.2
  • 36
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • 12415125 10.1146/annurev.pharmtox.43.100901.140248 1:CAS:528: DC%2BD3sXitFWqt74%3D
    • Selkoe, D. J. & Schenk, D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43:545-584 (2003).
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 37
    • 0035950225 scopus 로고    scopus 로고
    • Clearing the brain's amyloid cobwebs
    • 11683988 10.1016/S0896-6273(01)00475-5 1:CAS:528:DC%2BD3MXosVKmtLg%3D
    • Selkoe, D. J. Clearing the brain's amyloid cobwebs. Neuron 32:177-180 (2001).
    • (2001) Neuron , vol.32 , pp. 177-180
    • Selkoe, D.J.1
  • 38
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • 18215617 10.1016/j.neuron.2008.01.003 1:CAS:528:DC%2BD1cXhvVSrtrc%3D
    • Zlokovic, B. V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57:178-201 (2008).
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1
  • 39
    • 0023914178 scopus 로고
    • Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type
    • 3281669 10.1016/S0006-291X(88)80486-8 1:CAS:528:DyaL1cXksFalurk%3D
    • Prelli, F. et al. Different processing of Alzheimer's beta-protein precursor in the vessel wall of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Biochem Biophys Res Commun 151:1150-1155 (1988).
    • (1988) Biochem Biophys Res Commun , vol.151 , pp. 1150-1155
    • Prelli, F.1
  • 40
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
    • 1406936 10.1038/359325a0 1:CAS:528:DyaK38XmtFSisrc%3D
    • Seubert, P. et al. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 359:325-327 (1992).
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1
  • 41
    • 77953541514 scopus 로고    scopus 로고
    • The transition metals copper and iron in neurodegenerative diseases
    • 20399203 10.1016/j.cbi.2010.04.010 1:CAS:528:DC%2BC3cXntVeltbY%3D
    • Rivera-Mancia, S. et al. The transition metals copper and iron in neurodegenerative diseases. Chem Biol Interact 186:184-199 (2010).
    • (2010) Chem Biol Interact , vol.186 , pp. 184-199
    • Rivera-Mancia, S.1
  • 42
    • 46849101764 scopus 로고    scopus 로고
    • Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease
    • 18463412 10.1159/000129365 1:CAS:528:DC%2BD1cXotF2ktbw%3D
    • Gerhardsson, L., Lundh, T., Minthon, L. & Londos, E. Metal concentrations in plasma and cerebrospinal fluid in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 25:508-515 (2008).
    • (2008) Dement Geriatr Cogn Disord , vol.25 , pp. 508-515
    • Gerhardsson, L.1    Lundh, T.2    Minthon, L.3    Londos, E.4
  • 43
    • 0032507975 scopus 로고    scopus 로고
    • Copper, iron and zinc in Alzheimer's disease senile plaques
    • 9667777 10.1016/S0022-510X(98)00092-6 1:CAS:528:DyaK1cXjsVentbo%3D
    • Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L. & Markesbery, W. R. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 158:47-52 (1998).
    • (1998) J Neurol Sci , vol.158 , pp. 47-52
    • Lovell, M.A.1    Robertson, J.D.2    Teesdale, W.J.3    Campbell, J.L.4    Markesbery, W.R.5
  • 44
    • 45849148467 scopus 로고    scopus 로고
    • Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin
    • 18583042 10.1016/j.neulet.2008.05.070 1:CAS:528:DC%2BD1cXnvVOgtbg%3D
    • Lin, R. et al. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci Lett 440:344-347 (2008).
    • (2008) Neurosci Lett , vol.440 , pp. 344-347
    • Lin, R.1
  • 45
    • 33644832483 scopus 로고    scopus 로고
    • Induction of cellular prion protein gene expression by copper in neurons
    • 16148034 10.1152/ajpcell.00160.2005 1:CAS:528:DC%2BD28XhsVSisr8%3D
    • Varela-Nallar, L. et al. Induction of cellular prion protein gene expression by copper in neurons. Am J Physiol Cell Physiol 290:C271-281 (2006).
    • (2006) Am J Physiol Cell Physiol , vol.290 , pp. 271-281
    • Varela-Nallar, L.1
  • 46
    • 45849148467 scopus 로고    scopus 로고
    • Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: Blockage by curcumin
    • 18583042 10.1016/j.neulet.2008.05.070 1:CAS:528:DC%2BD1cXnvVOgtbg%3D
    • Lin, R. et al. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci Lett 440:344-347 (2008).
    • (2008) Neurosci Lett , vol.440 , pp. 344-347
    • Lin, R.1
  • 47
    • 3442876969 scopus 로고    scopus 로고
    • Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets
    • 15289330 10.1158/0008-5472.CAN-04-0496 1:CAS:528:DC%2BD2cXmtF2mtbg%3D
    • Andersen, C. L., Jensen, J. L. & Orntoft, T. F. Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64:5245-5250 (2004).
    • (2004) Cancer Res , vol.64 , pp. 5245-5250
    • Andersen, C.L.1    Jensen, J.L.2    Orntoft, T.F.3
  • 48
    • 1842483281 scopus 로고    scopus 로고
    • Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations
    • 15127793 10.1023/B:BILE.0000019559.84305.47 1:CAS:528: DC%2BD2cXhvF2mtLk%3D
    • Pfaffl, M. W., Tichopad, A., Prgomet, C. & Neuvians, T. P. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper-Excel-based tool using pair-wise correlations. Biotechnol Lett 26:509-515 (2004).
    • (2004) Biotechnol Lett , vol.26 , pp. 509-515
    • Pfaffl, M.W.1    Tichopad, A.2    Prgomet, C.3    Neuvians, T.P.4


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