The miR-17-92 cluster expands multipotent hematopoietic progenitors whereas imbalanced expression of its individual oncogenic miRNAs promotes leukemia in mice

Blood

Volumn 119, Issue 19, 2012, Pages 4486-4498

  Li, Yanmei ^a,b   Vecchiarelli Federico, Laura M ^a,b   Li, You Jun ^a,b   Egan, Sean E ^a,c   Spaner, David ^a,b   Hough, Margaret R ^a,b   Ben David, Yaacov ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 17; MICRORNA 17 5P; MICRORNA 17 92; MICRORNA 19A; MICRORNA 92A; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL CHRONIC LYMPHATIC LEUKEMIA; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; ERYTHROID CELL; ERYTHROLEUKEMIA; FEMALE; GENE AMPLIFICATION; GENE CLUSTER; GENE CONTROL; GENE LOCUS; GENE OVEREXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LEUKEMOGENESIS; LYMPHOID CELL; MALE; MOUSE; MULTIPOTENT STEM CELL; NEWBORN; NONHUMAN; NONOBESE DIABETIC MOUSE; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCID MOUSE;

EID: 84861048490     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-09-378687     Document Type: Article

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