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Volumn 5, Issue 4, 2013, Pages 516-530

A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes

Author keywords

IL 10; Inflammatory monocytes; Klebsiella; Mikulicz cell; Rhinoscleroma

Indexed keywords

CHEMOKINE RECEPTOR CCR2; INTERLEUKIN 10;

EID: 84875793179     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201202023     Document Type: Article
Times cited : (13)

References (60)
  • 2
    • 0035253603 scopus 로고    scopus 로고
    • Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia
    • Blease K, Mehrad B, Lukacs NW, Kunkel SL, Standiford TJ, Hogaboam CM (2001) Antifungal and airway remodeling roles for murine monocyte chemoattractant protein-1/CCL2 during pulmonary exposure to Asperigillus fumigatus conidia. J Immunol 166: 1832-1842
    • (2001) J Immunol , vol.166 , pp. 1832-1842
    • Blease, K.1    Mehrad, B.2    Lukacs, N.W.3    Kunkel, S.L.4    Standiford, T.J.5    Hogaboam, C.M.6
  • 3
    • 0029372481 scopus 로고
    • Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis
    • Bonfield TL, Konstan MW, Burfeind P, Panuska JR, Hilliard JB, Berger M (1995) Normal bronchial epithelial cells constitutively produce the anti-inflammatory cytokine interleukin-10, which is downregulated in cystic fibrosis. Am J Respir Cell Mol Biol 13: 257-261
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 257-261
    • Bonfield, T.L.1    Konstan, M.W.2    Burfeind, P.3    Panuska, J.R.4    Hilliard, J.B.5    Berger, M.6
  • 4
    • 34547828316 scopus 로고    scopus 로고
    • Chronic nasal infection caused by Klebsiella rhinoscleromatis or Klebsiella ozaenae: two forgotten infectious diseases
    • Botelho-Nevers E, Gouriet F, Lepidi H, Couvret A, Amphoux B, Dessi P, Raoult D (2007) Chronic nasal infection caused by Klebsiella rhinoscleromatis or Klebsiella ozaenae: two forgotten infectious diseases. Int J Infect Dis 11: 423-429
    • (2007) Int J Infect Dis , vol.11 , pp. 423-429
    • Botelho-Nevers, E.1    Gouriet, F.2    Lepidi, H.3    Couvret, A.4    Amphoux, B.5    Dessi, P.6    Raoult, D.7
  • 5
    • 63449117143 scopus 로고    scopus 로고
    • Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization
    • Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, Grimont P (2009) Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS ONE 4: e4982
    • (2009) PLoS ONE , vol.4
    • Brisse, S.1    Fevre, C.2    Passet, V.3    Issenhuth-Jeanjean, S.4    Tournebize, R.5    Diancourt, L.6    Grimont, P.7
  • 6
    • 0035013747 scopus 로고    scopus 로고
    • An interpretation of the structural changes responsible for the chronicity of rhinoscleroma
    • Canalis RF, Zamboni L (2001) An interpretation of the structural changes responsible for the chronicity of rhinoscleroma. Laryngoscope 111: 1020-1026
    • (2001) Laryngoscope , vol.111 , pp. 1020-1026
    • Canalis, R.F.1    Zamboni, L.2
  • 7
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: the master regulator of immunity to infection
    • Couper KN, Blount DG, Riley EM (2008a) IL-10: the master regulator of immunity to infection. J Immunol 180: 5771-5777
    • (2008) J Immunol , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 9
    • 79961102157 scopus 로고    scopus 로고
    • Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens
    • Cyktor JC, Turner J (2011) Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens. Infect Immun 79: 2964-2973
    • (2011) Infect Immun , vol.79 , pp. 2964-2973
    • Cyktor, J.C.1    Turner, J.2
  • 13
    • 77954212828 scopus 로고    scopus 로고
    • IFN-gamma triggers CCR2-independent monocyte entry into the brain during systemic infection by virulent Listeria monocytogenes
    • Drevets DA, Dillon MJ, Schawang JE, Stoner JA, Leenen PJM (2010) IFN-gamma triggers CCR2-independent monocyte entry into the brain during systemic infection by virulent Listeria monocytogenes. Brain Behav Immun 24: 919-929
    • (2010) Brain Behav Immun , vol.24 , pp. 919-929
    • Drevets, D.A.1    Dillon, M.J.2    Schawang, J.E.3    Stoner, J.A.4    Leenen, P.J.M.5
  • 14
    • 48749107414 scopus 로고    scopus 로고
    • Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii
    • Dunay IR, Damatta RA, Fux B, Presti R, Greco S, Colonna M, Sibley LD (2008) Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. Immunity 29: 306-317
    • (2008) Immunity , vol.29 , pp. 306-317
    • Dunay, I.R.1    Damatta, R.A.2    Fux, B.3    Presti, R.4    Greco, S.5    Colonna, M.6    Sibley, L.D.7
  • 15
    • 0018676669 scopus 로고
    • Transmission and scanning electron microscopic studies of rhinoscleroma
    • Gaafar H, El-Ghazzawi E, Awaad A, Harada Y (1979) Transmission and scanning electron microscopic studies of rhinoscleroma. J Laryngol Otol 93: 983-989
    • (1979) J Laryngol Otol , vol.93 , pp. 983-989
    • Gaafar, H.1    El-Ghazzawi, E.2    Awaad, A.3    Harada, Y.4
  • 16
    • 0034157615 scopus 로고    scopus 로고
    • Experimental intravenous inoculation of Klebsiella rhinoscleromatis bacilli in albino rats: a histopathological and bacteriological study
    • Gaafar HA, Bassiouny M, Mofty El M, Badour NM, Nour YA (2000) Experimental intravenous inoculation of Klebsiella rhinoscleromatis bacilli in albino rats: a histopathological and bacteriological study. Acta Otolaryngol 120: 279-285
    • (2000) Acta Otolaryngol , vol.120 , pp. 279-285
    • Gaafar, H.A.1    Bassiouny, M.2    Mofty El, M.3    Badour, N.M.4    Nour, Y.A.5
  • 17
    • 79952689605 scopus 로고    scopus 로고
    • Rhinoscleroma: an updated experience through the last 10 years
    • Gaafar HA, Gaafar AH, Nour YA (2011) Rhinoscleroma: an updated experience through the last 10 years. Acta Otolaryngol 131: 440-446
    • (2011) Acta Otolaryngol , vol.131 , pp. 440-446
    • Gaafar, H.A.1    Gaafar, A.H.2    Nour, Y.A.3
  • 18
    • 0029959459 scopus 로고    scopus 로고
    • In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha
    • Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kühn R, Muller W, Trinchieri G, Sher A (1996) In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. J Immunol 157: 798-805
    • (1996) J Immunol , vol.157 , pp. 798-805
    • Gazzinelli, R.T.1    Wysocka, M.2    Hieny, S.3    Scharton-Kersten, T.4    Cheever, A.5    Kühn, R.6    Muller, W.7    Trinchieri, G.8    Sher, A.9
  • 19
    • 0037963473 scopus 로고    scopus 로고
    • Blood monocytes consist of two principal subsets with distinct migratory properties
    • Geissmann F, Jung S, Littman DR (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19: 71-82
    • (2003) Immunity , vol.19 , pp. 71-82
    • Geissmann, F.1    Jung, S.2    Littman, D.R.3
  • 20
    • 77949315237 scopus 로고    scopus 로고
    • Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection
    • Goodyear A, Jones A, Troyer R, Bielefeldt-Ohmann H, Dow S (2010) Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection. J Immunol 184: 1445-1454
    • (2010) J Immunol , vol.184 , pp. 1445-1454
    • Goodyear, A.1    Jones, A.2    Troyer, R.3    Bielefeldt-Ohmann, H.4    Dow, S.5
  • 22
    • 35548976126 scopus 로고    scopus 로고
    • Expression of the immunomodulator IL-10 in type I pneumocytes of the rat: alterations of IL-10 expression in radiation-induced lung damage
    • Haase MG, Klawitter A, Geyer P, Baretton GB (2007) Expression of the immunomodulator IL-10 in type I pneumocytes of the rat: alterations of IL-10 expression in radiation-induced lung damage. J Histochem Cytochem 55: 1167-1172
    • (2007) J Histochem Cytochem , vol.55 , pp. 1167-1172
    • Haase, M.G.1    Klawitter, A.2    Geyer, P.3    Baretton, G.B.4
  • 23
    • 0034102994 scopus 로고    scopus 로고
    • Rhinoscleroma (editorial)
    • Hart C, Rao S (2000) Rhinoscleroma (editorial). J Med Microbiol 49: 395-396
    • (2000) J Med Microbiol , vol.49 , pp. 395-396
    • Hart, C.1    Rao, S.2
  • 25
    • 0015909781 scopus 로고
    • The Mikulicz cell in rhinoscleroma. Light, fluorescent and electron microscopic studies
    • Hoffmann EO, Loose LD, Harkin JC (1973) The Mikulicz cell in rhinoscleroma. Light, fluorescent and electron microscopic studies. Am J Pathol 73: 47-58
    • (1973) Am J Pathol , vol.73 , pp. 47-58
    • Hoffmann, E.O.1    Loose, L.D.2    Harkin, J.C.3
  • 27
    • 0030699387 scopus 로고    scopus 로고
    • Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor
    • Kurihara T, Warr G, Loy J, Bravo R (1997) Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptor. J Exp Med 186: 1757-1762
    • (1997) J Exp Med , vol.186 , pp. 1757-1762
    • Kurihara, T.1    Warr, G.2    Loy, J.3    Bravo, R.4
  • 28
    • 0030691025 scopus 로고    scopus 로고
    • Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
    • Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O, Ley K, Maeda N (1997) Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proc Natl Acad Sci USA 94: 12053-12058
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12053-12058
    • Kuziel, W.A.1    Morgan, S.J.2    Dawson, T.C.3    Griffin, S.4    Smithies, O.5    Ley, K.6    Maeda, N.7
  • 29
    • 0032797911 scopus 로고    scopus 로고
    • A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice
    • Li C, Corraliza I, Langhorne J (1999) A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice. Infect Immun 67: 4435-4442
    • (1999) Infect Immun , vol.67 , pp. 4435-4442
    • Li, C.1    Corraliza, I.2    Langhorne, J.3
  • 30
    • 42149083307 scopus 로고    scopus 로고
    • CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality
    • Lin KL, Suzuki Y, Nakano H, Ramsburg E, Gunn MD (2008) CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. J Immunol 180: 2562-2572
    • (2008) J Immunol , vol.180 , pp. 2562-2572
    • Lin, K.L.1    Suzuki, Y.2    Nakano, H.3    Ramsburg, E.4    Gunn, M.D.5
  • 33
    • 0023000757 scopus 로고
    • Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin
    • Nassif X, Sansonetti PJ (1986) Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin. Infect Immun 54: 603-608
    • (1986) Infect Immun , vol.54 , pp. 603-608
    • Nassif, X.1    Sansonetti, P.J.2
  • 34
    • 0024497512 scopus 로고
    • Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor
    • Nassif X, Fournier JM, Arondel J, Sansonetti PJ (1989) Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect Immun 57: 546-552
    • (1989) Infect Immun , vol.57 , pp. 546-552
    • Nassif, X.1    Fournier, J.M.2    Arondel, J.3    Sansonetti, P.J.4
  • 35
    • 24744458165 scopus 로고    scopus 로고
    • Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family
    • Ordway D, Henao-Tamayo M, Orme IM, Gonzalez-Juarrero M (2005) Foamy macrophages within lung granulomas of mice infected with Mycobacterium tuberculosis express molecules characteristic of dendritic cells and antiapoptotic markers of the TNF receptor-associated factor family. J Immunol 175: 3873-3881
    • (2005) J Immunol , vol.175 , pp. 3873-3881
    • Ordway, D.1    Henao-Tamayo, M.2    Orme, I.M.3    Gonzalez-Juarrero, M.4
  • 36
    • 76249117469 scopus 로고    scopus 로고
    • Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes
    • Osterholzer JJ, Chen G.-H, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB (2009) Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes. J Immunol 183: 8044-8053
    • (2009) J Immunol , vol.183 , pp. 8044-8053
    • Osterholzer, J.J.1    Chen, G.-H.2    Olszewski, M.A.3    Curtis, J.L.4    Huffnagle, G.B.5    Toews, G.B.6
  • 37
    • 0035158575 scopus 로고    scopus 로고
    • Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues
    • Palframan RT, Jung S, Cheng G, Weninger W, Luo Y, Dorf M, Littman DR, Rollins BJ, Zweerink H, Rot A, et al (2001) Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med 194: 1361-1373
    • (2001) J Exp Med , vol.194 , pp. 1361-1373
    • Palframan, R.T.1    Jung, S.2    Cheng, G.3    Weninger, W.4    Luo, Y.5    Dorf, M.6    Littman, D.R.7    Rollins, B.J.8    Zweerink, H.9    Rot, A.10
  • 38
    • 2942614999 scopus 로고    scopus 로고
    • CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis
    • Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF (2004) CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. J Immunol 172: 7647-7653
    • (2004) J Immunol , vol.172 , pp. 7647-7653
    • Peters, W.1    Cyster, J.G.2    Mack, M.3    Schlöndorff, D.4    Wolf, A.J.5    Ernst, J.D.6    Charo, I.F.7
  • 39
    • 0031792165 scopus 로고    scopus 로고
    • Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors
    • Podschun R, Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11: 589-603
    • (1998) Clin Microbiol Rev , vol.11 , pp. 589-603
    • Podschun, R.1    Ullmann, U.2
  • 40
    • 0019476256 scopus 로고
    • Direct evidence for the involvement of capsular polysaccharide in the immunoprotective activity of Klebsiella pneumoniae ribosomal preparations
    • Riottot MM, Fournier JM, Jouin H (1981) Direct evidence for the involvement of capsular polysaccharide in the immunoprotective activity of Klebsiella pneumoniae ribosomal preparations. Infect Immun 31: 71-77
    • (1981) Infect Immun , vol.31 , pp. 71-77
    • Riottot, M.M.1    Fournier, J.M.2    Jouin, H.3
  • 41
    • 22344454821 scopus 로고    scopus 로고
    • Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis
    • Robben PM, LaRegina M, Kuziel WA, Sibley LD (2005) Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis. J Exp Med 201: 1761-1769
    • (2005) J Exp Med , vol.201 , pp. 1761-1769
    • Robben, P.M.1    LaRegina, M.2    Kuziel, W.A.3    Sibley, L.D.4
  • 42
    • 69049108875 scopus 로고    scopus 로고
    • Foamy macrophages and the progression of the human tuberculosis granuloma
    • Russell DG, Cardona P.-J, Kim M.-J, Allain S, Altare F (2009) Foamy macrophages and the progression of the human tuberculosis granuloma. Nat Immunol 10: 943-948
    • (2009) Nat Immunol , vol.10 , pp. 943-948
    • Russell, D.G.1    Cardona, P.-J.2    Kim, M.-J.3    Allain, S.4    Altare, F.5
  • 43
    • 34247561732 scopus 로고    scopus 로고
    • Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection
    • Rydström A, Wick MJ (2007) Monocyte recruitment, activation, and function in the gut-associated lymphoid tissue during oral Salmonella infection. J Immunol 178: 5789-5801
    • (2007) J Immunol , vol.178 , pp. 5789-5801
    • Rydström, A.1    Wick, M.J.2
  • 44
    • 41649107036 scopus 로고    scopus 로고
    • Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis
    • Saederup N, Chan L, Lira SA, Charo IF (2008) Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation 117: 1642-1648
    • (2008) Circulation , vol.117 , pp. 1642-1648
    • Saederup, N.1    Chan, L.2    Lira, S.A.3    Charo, I.F.4
  • 45
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M, O'Garra A (2010) The regulation of IL-10 production by immune cells. Nat Rev Immunol 10: 170-181
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 46
    • 33645902493 scopus 로고    scopus 로고
    • Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
    • Serbina NV, Pamer EG (2006) Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol 7: 311-317
    • (2006) Nat Immunol , vol.7 , pp. 311-317
    • Serbina, N.V.1    Pamer, E.G.2
  • 47
  • 48
    • 80355146868 scopus 로고    scopus 로고
    • Monocyte recruitment during infection and inflammation
    • Shi C, Pamer EG (2011) Monocyte recruitment during infection and inflammation. Nat Rev Immunol
    • (2011) Nat Rev Immunol
    • Shi, C.1    Pamer, E.G.2
  • 49
    • 77953399156 scopus 로고    scopus 로고
    • Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression
    • Shi C, Velázquez P, Hohl TM, Leiner I, Dustin ML, Pamer EG (2010) Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J Immunol 184: 6266-6274
    • (2010) J Immunol , vol.184 , pp. 6266-6274
    • Shi, C.1    Velázquez, P.2    Hohl, T.M.3    Leiner, I.4    Dustin, M.L.5    Pamer, E.G.6
  • 50
    • 84874209547 scopus 로고    scopus 로고
    • Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed
    • Shon AS, Bajwa RPS, Russo TA (2013) Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed. Virulence 4: 107-118
    • (2013) Virulence , vol.4 , pp. 107-118
    • Shon, A.S.1    Bajwa, R.P.S.2    Russo, T.A.3
  • 51
    • 15844430883 scopus 로고
    • Scleroma. Klebsiella rhinoscleromatis and its effect on mice
    • Steffen TN, Smith IM (1961) Scleroma. Klebsiella rhinoscleromatis and its effect on mice. Ann Otol Rhinol Laryngol 70: 935-952
    • (1961) Ann Otol Rhinol Laryngol , vol.70 , pp. 935-952
    • Steffen, T.N.1    Smith, I.M.2
  • 56
  • 58
    • 65249141836 scopus 로고    scopus 로고
    • Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae
    • Winter C, Herbold W, Maus R, Länger F, Briles DE, Paton JC, Welte T, Maus UA (2009) Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J Immunol 182: 4931-4937
    • (2009) J Immunol , vol.182 , pp. 4931-4937
    • Winter, C.1    Herbold, W.2    Maus, R.3    Länger, F.4    Briles, D.E.5    Paton, J.C.6    Welte, T.7    Maus, U.A.8
  • 59
    • 79251518588 scopus 로고    scopus 로고
    • Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague
    • Ye Z, Uittenbogaard AM, Cohen DA, Kaplan AM, Ambati J, Straley SC (2011) Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague. Infect Immun 79: 674-687
    • (2011) Infect Immun , vol.79 , pp. 674-687
    • Ye, Z.1    Uittenbogaard, A.M.2    Cohen, D.A.3    Kaplan, A.M.4    Ambati, J.5    Straley, S.C.6
  • 60
    • 18244395596 scopus 로고    scopus 로고
    • Cytokine profiles and inflammatory cells during HSV-1-induced acute retinal necrosis
    • Zheng M, Atherton SS (2005) Cytokine profiles and inflammatory cells during HSV-1-induced acute retinal necrosis. Invest Ophthalmol Vis Sci 46: 1356-1363
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 1356-1363
    • Zheng, M.1    Atherton, S.S.2


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