-
1
-
-
33751213587
-
The asthma epidemic
-
DOI 10.1056/NEJMra054308
-
Eder, W., Ege, M. J. & von Mutius, E. The asthma epidemic. N Engl J Med. 355, 2226-2235 (2006). (Pubitemid 44791164)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.21
, pp. 2226-2235
-
-
Eder, W.1
Ege, M.J.2
Von Mutius, E.3
-
2
-
-
15944410345
-
Cytokines allergy, and asthma
-
Ngoc, P. L., Gold, D. R., Tzianabos, A. O.,Weiss, S. T. & Celedón, J. C. Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol. 5, 161-166 (2005).
-
(2005)
Curr Opin Allergy Clin Immunol
, vol.5
, pp. 161-166
-
-
Ngoc, P.L.1
Gold, D.R.2
Tzianabos, A.O.3
Weiss, S.T.4
Celedón, J.C.5
-
3
-
-
0035719975
-
Th2 cytokines and asthma. Interleukin-4: Its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
-
DOI 10.1186/rr40
-
Steinke, J. W. & Borish, L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res. 2, 66-70 (2001). (Pubitemid 34187909)
-
(2001)
Respiratory Research
, vol.2
, Issue.2
, pp. 66-70
-
-
Steinke, J.W.1
Borish, L.2
-
4
-
-
84866534540
-
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma
-
Suzukawa, M. et al. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 189, 2641-2652 (2012).
-
(2012)
J Immunol
, vol.189
, pp. 2641-2652
-
-
Suzukawa, M.1
-
5
-
-
79551556034
-
Interleukin-33 in asthma: How big of a role does it play? Curr
-
Borish, L. & Steinke, J. W. Interleukin-33 in asthma: how big of a role does it play? Curr. Allergy Asthma Rep. 11, 7-11 (2011).
-
(2011)
Allergy Asthma Rep
, vol.11
, pp. 7-11
-
-
Borish, L.1
Steinke, J.W.2
-
6
-
-
75749149721
-
Thymic stromal lymphopoietin
-
He, R. & Geha, R. S. Thymic stromal lymphopoietin. Ann N Y Acad Sci. 1183, 13-24 (2010).
-
(2010)
Ann N y Acad Sci
, vol.1183
, pp. 13-24
-
-
He, R.1
Geha, R.S.2
-
7
-
-
40949121542
-
The airway epithelium is central to the pathogenesis of asthma
-
DOI 10.2332/allergolint.R-07-154
-
Holgate, S. T. The airway epithelium is central to the pathogenesis of asthma. Allergol Int. 57, 1-10 (2008). (Pubitemid 351413241)
-
(2008)
Allergology International
, vol.57
, Issue.1
, pp. 1-10
-
-
Holgate, S.T.1
-
8
-
-
84860691114
-
The airway epithelium in asthma
-
Lambrecht, B. N. & Hammad, H. The airway epithelium in asthma. Nat Med. 18, 684-692 (2012).
-
(2012)
Nat Med
, vol.18
, pp. 684-692
-
-
Lambrecht, B.N.1
Hammad, H.2
-
9
-
-
77954943215
-
Epithelial decision makers: In search of the 'epimmunome'
-
Swamy, M., Jamora, C., Havran, W. & Hayday, A. Epithelial decision makers: in search of the 'epimmunome'. Nat Immunol 11, 656-665 (2010).
-
(2010)
Nat Immunol
, vol.11
, pp. 656-665
-
-
Swamy, M.1
Jamora, C.2
Havran, W.3
Hayday, A.4
-
10
-
-
51549106954
-
Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma
-
Mabalirajan, U. et al. Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. J Immunol 181, 3540-3548 (2008).
-
(2008)
J Immunol
, vol.181
, pp. 3540-3548
-
-
Mabalirajan, U.1
-
11
-
-
77954105455
-
Mitochondrial dysfunction increases allergic airway inflammation
-
Aguilera-Aguirre, L. et al. Mitochondrial dysfunction increases allergic airway inflammation. J Immunol 183, 5379-5387 (2009).
-
(2009)
J Immunol
, vol.183
, pp. 5379-5387
-
-
Aguilera-Aguirre, L.1
-
12
-
-
77957769295
-
Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma
-
Thomas, B. et al.Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. J Allergy Clin Immunol 126, 722-729 (2010).
-
(2010)
J Allergy Clin Immunol
, vol.126
, pp. 722-729
-
-
Thomas, B.1
-
13
-
-
84860654915
-
Mitochondrial transfer from bone-marrow derived stromal cells to pulmonary alveoli protects against acute lung injury
-
Islam,M.N. et al.Mitochondrial transfer from bone-marrow derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat Med 18, 759-765 (2012).
-
(2012)
Nat Med
, vol.18
, pp. 759-765
-
-
Islam, M.N.1
-
14
-
-
78650405313
-
Tralokinumab an anti-IL-13 mAb for the potential treatment of asthma and COPD
-
Walsh, G. M. Tralokinumab, an anti-IL-13 mAb for the potential treatment of asthma and COPD. Curr Opin Investig Drugs. 11, 1305-1312 (2010).
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 1305-1312
-
-
Walsh, G.M.1
-
15
-
-
32444436464
-
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals
-
DOI 10.1172/JCI25167
-
Tyner, J. W. et al. Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals. J Clin Invest 116, 309-321 (2010). (Pubitemid 43228348)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.2
, pp. 309-321
-
-
Tyner, J.W.1
Kim, E.Y.2
Ide, K.3
Pelletier, M.R.4
Roswit, W.T.5
Morton, J.D.6
Battaile, J.T.7
Patel, A.C.8
Patterson, G.A.9
Castro, M.10
Spoor, M.S.11
You, Y.12
Brody, S.L.13
Holtzman, M.J.14
-
16
-
-
54349114505
-
Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: Effect of pro-inflammatory interleukin-13 on epithelial cell function
-
Heller, F., Fromm, A., Gitter, A. H., Mankertz, J. & Schulzke, J. D. Epithelial apoptosis is a prominent feature of the epithelial barrier disturbance in intestinal inflammation: effect of pro-inflammatory interleukin-13 on epithelial cell function. Mucosal Immunol. S58-S61 (2008).
-
(2008)
Mucosal Immunol
-
-
Heller, F.1
Fromm, A.2
Gitter, A.H.3
Mankertz, J.4
Schulzke, J.D.5
-
17
-
-
23244457836
-
Dissecting asthma using focused transgenic modeling and functional genomics
-
DOI 10.1016/j.jaci.2005.03.024, PII S0091674905005981
-
Kuperman, D. A. et al. Dissecting asthma using focused transgenic modeling and functional genomics. J Allergy Clin Immunol 116, 305-311 (2005). (Pubitemid 41096536)
-
(2005)
Journal of Allergy and Clinical Immunology
, vol.116
, Issue.2
, pp. 305-311
-
-
Kuperman, D.A.1
Lewis, C.C.2
Woodruff, P.G.3
Rodriguez, M.W.4
Yee, H.Y.5
Dolganov, G.M.6
Fahy, J.V.7
Erle, D.J.8
-
18
-
-
0025021123
-
Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells
-
Kühn, H. & Brash, A. R. Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells. J Biol Chem. 265, 1454-1458 (1990).
-
(1990)
J Biol Chem
, vol.265
, pp. 1454-1458
-
-
Kühn, H.1
Brash, A.R.2
-
19
-
-
50649110931
-
12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels
-
Hajek, A. R., Lindley, A. R., Favoreto, S., Jr, Carter, R., Schleimer, R. P. et al. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. J Allergy Clin Immunol 122, 633-639 (2008).
-
(2008)
J Allergy Clin Immunol
, vol.122
, pp. 633-639
-
-
Hajek, A.R.1
Lindley, A.R.2
Favoreto Jr. S3
Carter, R.4
Schleimer, R.P.5
-
20
-
-
70350117108
-
Effects of vitamin e on mitochondrial dysfunction and asthma features in an experimental allergic murine model
-
Mabalirajan, U., Aich, J., Leishangthem, G. D., Sharma, S. K., Dinda, A. K. et al. Effects of vitamin E on mitochondrial dysfunction and asthma features in an experimental allergic murine model. J Appl Physiol 107, 1285-1292 (2009).
-
(2009)
J Appl Physiol
, vol.107
, pp. 1285-1292
-
-
Mabalirajan, U.1
Aich, J.2
Leishangthem, G.D.3
Sharma, S.K.4
Dinda, A.K.5
-
21
-
-
68149138511
-
Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model
-
Mabalirajan, U., Dinda, A. K., Sharma, S. K. & Ghosh, B. Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model. J Immunol 183, 2059-2067 (2009).
-
(2009)
J Immunol
, vol.183
, pp. 2059-2067
-
-
Mabalirajan, U.1
Dinda, A.K.2
Sharma, S.K.3
Ghosh, B.4
-
22
-
-
47149104279
-
IL-13 induces a bronchial epithelial phenotype that is profibrotic
-
Malavia, N. K.,Mih, J. D., Raub, C. B., Dinh, B. T. & George, S. C. IL-13 induces a bronchial epithelial phenotype that is profibrotic. Respir Res. 9, 27 (2008).
-
(2008)
Respir Res
, vol.9
, pp. 27
-
-
Malavia, N.K.1
Mih, J.D.2
Raub, C.B.3
Dinh, B.T.4
George, S.C.5
-
23
-
-
79959369140
-
The sentinel role of the airway epithelium in asthma pathogenesis
-
Holgate, S. T. The sentinel role of the airway epithelium in asthma pathogenesis. Immunol Rev. 242, 205-219 (2011).
-
(2011)
Immunol Rev
, vol.242
, pp. 205-219
-
-
Holgate, S.T.1
-
24
-
-
0037477790
-
Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice
-
DOI 10.1074/jbc.M301175200
-
Hatley,M. E., Srinivasan, S., Reilly, K. B., Bolick, D. T. & Hedrick, C. C. Increased production of 12/15 lipoxygenase eicosanoids accelerates monocyte/endothelial interactions in diabetic db/db mice. J. Biol. Chem. 278, 25369-25375 (2003). (Pubitemid 36835286)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.28
, pp. 25369-25375
-
-
Hatley, M.E.1
Srinivasan, S.2
Reilly, K.B.3
Bolick, D.T.4
Hedrick, C.C.5
-
25
-
-
1942501585
-
12/15-Lipoxygenase Is Increased in Alzheimer's Disease: Possible Involvement in Brain Oxidative Stress
-
Praticò, D. et al. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am. J. Pathol. 164, 1655-1662 (2004). (Pubitemid 38529768)
-
(2004)
American Journal of Pathology
, vol.164
, Issue.5
, pp. 1655-1662
-
-
Pratico, D.1
Zhukareva, V.2
Yao, Y.3
Uryu, K.4
Funk, C.D.5
Lawson, J.A.6
Trojanowski, J.Q.7
Lee, V.M.-Y.8
-
26
-
-
0032189017
-
Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: Evidence for the involvement of transcription factor STAT6
-
Heydeck, D. et al. Interleukin-4 and-13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6. Blood 92, 2503-2510 (1998). (Pubitemid 28452994)
-
(1998)
Blood
, vol.92
, Issue.7
, pp. 2503-2510
-
-
Heydeck, D.1
Thomas, L.2
Schnurr, K.3
Trebus, F.4
Thierfelder, W.E.5
Ihle, J.N.6
Kuhn, H.7
-
27
-
-
0026565597
-
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase
-
Conrad, D. J., Kuhn, H., Mulkins, M., Highland, E. & Sigal, E. Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc. Natl. Acad. Sci. USA 89, 217-221 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 217-221
-
-
Conrad, D.J.1
Kuhn, H.2
Mulkins, M.3
Highland, E.4
Sigal, E.5
-
28
-
-
0028127310
-
Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes
-
Nassar, G. M.,Morrow, J. D., Roberts, II L. J., Lakkis, F. G. & Badr, K. F. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J. Biol. Chem. 269, 27631-27634 (1994). (Pubitemid 24346597)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.44
, pp. 27631-27634
-
-
Nassar, G.M.1
Morrow, J.D.2
Roberts II, L.J.3
Lakkis, F.G.4
Badr, K.F.5
-
29
-
-
0036042235
-
Reticulocyte maturation: Mitoptosis and exosome release
-
Géminard, C., de Gassart, A. & Vidal, M. Reticulocyte maturation: mitoptosis and exosome release. Biocell 26, 205-215 (2002). (Pubitemid 35012805)
-
(2002)
Biocell
, vol.26
, Issue.2
, pp. 205-215
-
-
Geminard, C.1
De Gassart, A.2
Vidal, M.3
-
30
-
-
80053084755
-
Lebrikizumab treatment in adults with asthma
-
Corren, J. et al. Lebrikizumab treatment in adults with asthma. N Engl J Med. 365, 1088-1098 (2011).
-
(2011)
N Engl J Med
, vol.365
, pp. 1088-1098
-
-
Corren, J.1
-
31
-
-
84874586013
-
Linoleic acid metabolite drives severe asthma by causing airway epithelial injury
-
Mabalirajan, U. et al. Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. Sci. Rep. 3, 1349 (2013).
-
Sci. Rep
, vol.3
, Issue.1349
, pp. 2013
-
-
Mabalirajan, U.1
-
32
-
-
65549141587
-
Interleukin-13 induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
-
Zhao, J. et al. Interleukin-13 induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells. Am J Respir Crit Care Med. 179, 782-790 (2009).
-
(2009)
Am J Respir Crit Care Med
, vol.179
, pp. 782-790
-
-
Zhao, J.1
-
33
-
-
36048930552
-
12(S)-Hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium
-
DOI 10.1016/j.abb.2007.09.018, PII S0003986107004857
-
Nazarewicz, R. R. et al. 12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide byincreasing intramitochondrial calcium. Arch Biochem Biophys. 468, 114-120 (2007). (Pubitemid 350087854)
-
(2007)
Archives of Biochemistry and Biophysics
, vol.468
, Issue.1
, pp. 114-120
-
-
Nazarewicz, R.R.1
Zenebe, W.J.2
Parihar, A.3
Parihar, M.S.4
Vaccaro, M.5
Rink, C.6
Sen, C.K.7
Ghafourifar, P.8
-
34
-
-
0029068291
-
13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo
-
Henricks, P. A., Engels, F., van der Linde, H. J., Garssen, J. & Nijkamp, F. P. 13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo. J Allergy Clin Immunol. 96, 36-43 (1995).
-
(1995)
J Allergy Clin Immunol
, vol.96
, pp. 36-43
-
-
Henricks, P.A.1
Engels, F.2
Van Der Linde, H.J.3
Garssen, J.4
Nijkamp, F.P.5
-
35
-
-
77951787575
-
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
-
Patwardhan, A. M. et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J. Clin. Invest. 120, 1617-1626 (2010).
-
(2010)
J. Clin. Invest
, vol.120
, pp. 1617-1626
-
-
Patwardhan, A.M.1
-
36
-
-
0042692791
-
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-δ to induce apoptosis in colorectal cancer cells
-
DOI 10.1073/pnas.1631086100
-
Shureiqi, I. et al. The 15-lipoxygenase-1 product 13-S- hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci USA 100, 9968-9973 (2003). (Pubitemid 37087052)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.17
, pp. 9968-9973
-
-
Shureiqi, I.1
Jiang, W.2
Zuo, X.3
Wu, Y.4
Stimmel, J.B.5
Leesnitzer, L.M.6
Morris, J.S.7
Fan, H.-Z.8
Fischer, S.M.9
Lippman, S.M.10
-
37
-
-
84856013252
-
15-Lipoxygenase eicosanoids are the putative ligands for vanilloid receptors and peroxisome proliferator-activated receptors (PPARs
-
Mabalirajan, U., Agrawal, A. & Ghosh, B. 15-Lipoxygenase eicosanoids are the putative ligands for vanilloid receptors and peroxisome proliferator-activated receptors (PPARs). Proc Natl Acad Sci USA. 109, E1 (2012).
-
(2012)
Proc Natl Acad Sci USA
, vol.109
-
-
Mabalirajan, U.1
Agrawal, A.2
Ghosh, B.3
-
38
-
-
42649089790
-
Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
-
DOI 10.1038/nri2294, PII NRI2294
-
Serhan, C. N., Chiang, N. & Van Dyke, T. E. Resolving inflammation: dual antiinflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 8, 349-361 (2008). (Pubitemid 351595216)
-
(2008)
Nature Reviews Immunology
, vol.8
, Issue.5
, pp. 349-361
-
-
Serhan, C.N.1
Chiang, N.2
Van Dyke, T.E.3
-
39
-
-
51849153327
-
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma
-
Planaguma, A. et al. Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med. 178, 574-582 (2008).
-
(2008)
Am J Respir Crit Care Med
, vol.178
, pp. 574-582
-
-
Planaguma, A.1
-
40
-
-
77649275723
-
Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma
-
Mabalirajan, U. et al. Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. J Allergy Clin Immunol 125, 626-635 (2010).
-
(2010)
J Allergy Clin Immunol
, vol.125
, pp. 626-635
-
-
Mabalirajan, U.1
-
41
-
-
80052502658
-
Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation
-
Kumar, M. et al. Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation. J Allergy Clin Immunol 128, 1077-1085 (2011).
-
(2011)
J Allergy Clin Immunol
, vol.128
, pp. 1077-1085
-
-
Kumar, M.1
-
42
-
-
84863323038
-
Loss of function of inositol polyphosphate 4 phosphatase reversibly increases the severity of allergic airway inflammation
-
Aich, J., Mabalirajan, U., Ahmad, T., Agrawal, A. & Ghosh, B. Loss of function of inositol polyphosphate 4 phosphatase reversibly increases the severity of allergic airway inflammation. Nat Commun 3, 877 (2012).
-
(2012)
Nat Commun
, vol.3
, pp. 877
-
-
Aich, J.1
Mabalirajan, U.2
Ahmad, T.3
Agrawal, A.4
Ghosh, B.5
-
43
-
-
78650016927
-
L-arginine reduces mitochondrial dysfunction and epithelial injury in murine allergic airway inflammation
-
Mabalirajan, U. et al. L-arginine reduces mitochondrial dysfunction and epithelial injury in murine allergic airway inflammation. Int. Immunopharmacol. 10, 1514-1519 (2010).
-
(2010)
Int. Immunopharmacol
, vol.10
, pp. 1514-1519
-
-
Mabalirajan, U.1
-
44
-
-
41749102195
-
A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma
-
DOI 10.1164/rccm.200705-781OC
-
Sharma, M. et al. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. Am J Respir Crit Care Med. 177, 712-719 (2008). (Pubitemid 351490558)
-
(2008)
American Journal of Respiratory and Critical Care Medicine
, vol.177
, Issue.7
, pp. 712-719
-
-
Sharma, M.1
Batra, J.2
Mabalirajan, U.3
Sharma, S.4
Nagarkatti, R.5
Aich, J.6
Sharma, S.K.7
Niphadkar, P.V.8
Ghosh, B.9
-
45
-
-
44849088072
-
A single nucleotide polymorphism (A → G) in intron 3 of IFNγ gene is associated with asthma
-
DOI 10.1038/gene.2008.17, PII GENE200817
-
Kumar, A.&Ghosh, B.Asingle nucleotide polymorphism (A-.G) in intron 3 of IFN gamma gene is associated with asthma. Genes Immun. 9, 294-301 (2008). (Pubitemid 351791484)
-
(2008)
Genes and Immunity
, vol.9
, Issue.4
, pp. 294-301
-
-
Kumar, A.1
Ghosh, B.2
-
46
-
-
0033033949
-
Assessment of hazardous dust exposure by BAL and induced sputum
-
Fireman, E. Assessment of hazardous dust exposure by BAL and induced sputum. Chest 115, 1720-1728 (2009).
-
(2009)
Chest
, vol.115
, pp. 1720-1728
-
-
Fireman, E.1
|