Linoleic acid metabolite drives severe asthma by causing airway epithelial injury

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Mabalirajan, Ulaganathan ^a   Rehman, Rakhshinda ^a   Ahmad, Tanveer ^a   Kumar, Sarvesh ^b   Singh, Suchita ^a   Leishangthem, Geeta D ^c   Aich, Jyotirmoi ^a   Kumar, Manish ^a   Khanna, Kritika ^a   Singh, Vijay P ^a   Dinda, Amit K ^c   Biswal, Shyam ^b   Agrawal, Anurag ^a   Ghosh, Balaram ^a  

^a CSIR Institute of Genomics and Integrative Biology Delhi   (India)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; LINOLEIC ACID; UNSATURATED FATTY ACID; VANILLOID RECEPTOR;

ANIMAL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; DISEASE MODEL; EXTRACELLULAR SPACE; GENE SILENCING; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; MITOCHONDRION; MOUSE; NEUTROPHIL; PATHOLOGY; RESPIRATORY TRACT MUCOSA; SPECIES DIFFERENCE; ULTRASTRUCTURE;

ANIMALS; ASTHMA; CALCIUM; DISEASE MODELS, ANIMAL; EXTRACELLULAR SPACE; FATTY ACIDS, UNSATURATED; GENE KNOCKDOWN TECHNIQUES; HUMANS; LINOLEIC ACID; MICE; MICE, INBRED BALB C; MITOCHONDRIA; NEUTROPHILS; RESPIRATORY MUCOSA; SPECIES SPECIFICITY; TRPV CATION CHANNELS;

EID: 84874586013     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01349     Document Type: Article

References (47)

1. Ngoc, P. L., Gold, D. R., Tzianabos, A. O., Weiss, S. T. & Celedón, J. C. Cytokines, allergy, and asthma. Curr. Opin. Allergy Clin. Immunol. 5, 161-166 (2005) (Pubitemid 40434466)
2. Lambrecht, B. N. & Hammad, H. The airway epithelium in asthma. Nat. Med. 18, 684-692 (2012)
3. Swamy, M., Jamora, C., Havran, W. & Hayday, A. Epithelial decision makers: in search of the 'epiimmunome. ' Nat. Immunol. 11, 656-665 (2010)
4. He, R. & Geha, R. S. Thymic stromal lymphopoietin. Ann. N. Y. Acad. Sci. 1183, 13-24 (2010)
5. Borish, L. & Steinke, J. W. Interleukin-33 in asthma: how big of a role does it play? Curr. Allergy Asthma Rep. 11, 7-11 (2011)
6. Suzukawa, M. et al. Epithelial Cell-Derived IL-25, but Not Th17 Cell-Derived IL-17 or IL-17F, Is Crucial for MurineAsthma. J. Immunol. In Press (2012)
7. Mabalirajan, U. et al. Mitochondrial structural changes and dysfunction are associated with experimental allergic asthma. J. Immunol. 181, 3540-3548 (2008)
8. Aguilera-Aguirre, L. et al. Mitochondrial dysfunction increases allergic airway inflammation. J. Immunol. 183, 5379-5387 (2009)
9. Thomas, B. et al. Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma. J. Allergy Clin. Immunol. 126, 722-729 (2010)
10. Rabinovich, R. A. et al. Mitochondrial dysfunction in COPD patients with low body mass index. Eur. Respir. J. 29, 643-650 (2012) (Pubitemid 46554612)
11. Wang, D. & Dubois, R. N. Eicosanoids and cancer. Nat. Rev. Cancer 10, 181-193 (2010)
12. Peters-Golden, M. & Peters-Golden, M. & Henderson, W. R., Jr. Leukotrienes. N. Engl. J. Med. 357, 1841-1854 (2007)
13. Camacho, M., Godessart, N., Antón, R., García, M. & Vila L. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J. Biol. Chem. 270, 17279-17286 (1995)
14. Baer, A. N., Costello, P. B. & Green, F. A. Free and esterified 13(R, S)-hydroxyoctadecadienoic acids: principal oxygenase products inpsoriatic skin scales. J. Lipid. Res. 31, 125-130 (1990) (Pubitemid 20038153)
15. Ogawa, E. et al. Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-kB signaling pathway. J. Invest. Dermatol. 131, 604-612 (2011)
16. Kühn, H. & Brash, A. R. Occurrence of lipoxygenase products in membranes of rabbit reticulocytes. Evidence for a role of the reticulocyte lipoxygenase in the maturation of red cells. J. Biol. Chem. 265, 1454-1458 (1990)
17. Henricks, P. A., Engels, F., van der Linde, H. J., Garssen, J. & Nijkamp, F. P. 13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo. J. Allergy Clin. Immunol. 96, 36-43 (1995)
18. Islam, M. N. et al. Mitochondrial transfer from bone-marrow derived stromal cells to pulmonary alveoli protects against acute lung injury. Nat. Med. 18, 759-765 (2012)
19. Arrington, D. D., Van Vleet, T. R. & Schnellmann, R. G. Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction. Am. J. Physiol. Cell Physiol. 291, C1159-1171 (2006) (Pubitemid 44878586)
20. Wenzel, S. Severe asthma in adults. Am. J. Respir. Crit. Care Med. 172, 149-160 (2005) (Pubitemid 40981187)
21. Seow, C. Y., Schellenberg, R. R. & Paré, P. D. Structural and functional changes in the airway smooth muscle of asthmatic subjects. Am. J. Respir. Crit. Care Med. 158, S179-S186 (1998) (Pubitemid 28536588)
22. Bramley, A. M., Thomson, R. J., Roberts, C. R. & Schellenberg, R. R. Hypothesis: excessive bronchoconstriction in asthma is due to decreased airway elastance. Eur. Respir. J. 7, 337-341 (1994) (Pubitemid 24138002)
23. Patwardhan, A. M. et al. Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J. Clin. Invest. 120, 1617-1626 (2010)
24. Shureiqi, I. et al. The 15-lipoxygenase-1 product 13-S- hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc. Natl. Acad. Sci. U S A 100, 9968-9973 (2003) (Pubitemid 37087052)
25. Gees, M., Colsoul, B. & Nilius, B. The role of transient receptor potential cation channels in Ca21 signaling. Cold Spring Harb. Perspect. Biol. 2, a003962 (2010)
26. Kim, S. R., Kim, S. U., Oh, U. & Jin, B. K. Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitrovia Ca21-mediated mitochondrial damage and cytochrome c release. J. Immunol. 177, 4322-4329 (2006) (Pubitemid 44469760)
27. Geppetti, P., Materazzi, S. & Nicoletti P. The transient receptor potential vanilloid 1: role in airway inflammation and disease. Eur. J. Pharmacol. 533, 207-214 (2006) (Pubitemid 43348347)
28. Bessac, B. F. & Jordt, S. E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda). 23, 360-370 (2008)
29. McLeod, R. L., Correll, C. C., Jia, Y. &Anthes, J. C. TRPV1 antagonists as potential antitussive agents. Lung 186 Suppl 1, S59-65 (2008) (Pubitemid 351327286)
30. Xu, W., Comhair, S. A. A., Janocha, A. J., Mavrakis, L. A. & Erzurum, S. C. Alteration of nitric oxide synthesis related to abnormal cellular bioenergetics in asthmatic airway epithelium. Am. J. Respir. Crit. Care Med. 181, A1436 (2010)
31. Hong, S., Agresta, L., Guo, C. & Wiley, J. W. The TRPV1 receptor is associated with preferential stress in large dorsal ganglion neurons in early diabetic sensory neuropathy. J Neurochem 105, 1212-1222 (2008) (Pubitemid 351590783)
32. Alcorn, J. F., Crowe, C. R. & Kolls, J. K. TH17 cells in asthma and COPD. Annu. Rev. Physiol. 72, 495-516 (2010)
33. Caceres, A. I. et al. A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. Proc. Natl. Acad. Sci. U S A 106, 9099-9104 (2009)
34. Veronesi, B. et al. Vanilloid (capsaicin) receptors influence inflammatory sensitivity in response to particulate matter. Toxicol. Appl. Pharmacol. 169, 66-76 (2000)
35. Zhang, X., Huang, J. & McNaughton, P. A. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. EMBO J. 24, 4211-4223 (2005) (Pubitemid 41828897)
36. Bonini, S. et al. Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc. Natl. Acad. Sci. U S A 93, 10955-10960 (1996) (Pubitemid 26333099)
37. Mabalirajan, U. et al. Beneficial effects of high dose of L-arginine on airway hyperresponsiveness and airway inflammation in a murine model of asthma. J. Allergy Clin. Immunol. 125, 626-635 (2010)
38. Kumar, M. et al. Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation. J. Allergy Clin. Immunol. 128, 1077-1085 (2011)
39. Aich, J., Mabalirajan, U., Ahmad, T., Agrawal, A. & Ghosh, B. Loss of function of inositol polyphosphate 4 phosphatase reversibly increases the severity of allergic airway inflammation. Nat. Commun. 3, 877 (2012)
40. Khan-Merchant, N., Penumetcha, M., Meilhac, O. & Parthasarathy, S. Oxidized fatty acids promote atherosclerosis only in the presence of dietary cholesterol in low-density lipoprotein receptor knockout mice. J. Nutr. 132, 3256-3262 (2002) (Pubitemid 35304230)
41. Zhang, X. et al. Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis. J. Biol. Chem. 279, 10677-10684 (2004) (Pubitemid 38372680)
42. Kuperman, D. A. et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat. Med. 8, 885-889 (2002)
43. Mabalirajan, U. et al. L-arginine reduces mitochondrial dysfunction and epithelial injury in murine allergic airway inflammation. Int. Immunopharmacol. 10, 1514-1519 (2010)
44. Sharma, M. et al. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. Am. J. Respir. Crit. Care Med. 177, 712-719 (2008) (Pubitemid 351490558)
45. Kumar, A., B. Asingle nucleotide polymorphism (A-. G) in intron 3 of IFN gamma gene is associated with asthma. Genes Immun. 9, 294-301 (2008) (Pubitemid 351791484)
46. Fireman, E. Assessment of hazardous dust exposure by BAL and induced sputum. Chest 115, 1720-1728 (2009)
47. Nagai, T., Sawano, A., Park, E. S. & Miyawaki, A. Circularly permuted green fluorescent proteins engineered to sense Ca21. Proc. Natl. Acad. Sci. U. S. A. 98, 3197-3202 (2001). (Pubitemid 32220822)