A Drosophila approach to thyroid cancer therapeutics

Drug Discovery Today: Technologies

Volumn 10, Issue 1, 2013, Pages

  Das, Tirtha K ^a   Cagan, Ross L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [4 (4 CHLOROPHENYLSULFAMOYL)PHENYLACETYL] 3,5 DIMETHYLPYRAZOLE; AD 57; PROTEIN RET; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAF PROTEIN; TRANSCRIPTION FACTOR SIN3A; UNCLASSIFIED DRUG; VANDETANIB;

ANTINEOPLASTIC ACTIVITY; CANCER INVASION; CANCER THERAPY; CARCINOGENESIS; CELL POLARITY; CELL PROLIFERATION; DNA MODIFICATION; DROSOPHILA; DRUG EFFICACY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; GENE LOCUS; HUMAN; INSECT CELL; MULTIPLE ENDOCRINE NEOPLASIA; NONHUMAN; REVIEW; THYROID CANCER; THYROID MEDULLARY CARCINOMA; TUMOR GENE;

ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE MODELS, ANIMAL; DROSOPHILA; DRUG EVALUATION, PRECLINICAL; HUMANS; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-RET; QUINAZOLINES; THYROID NEOPLASMS;

EID: 84875721552     PISSN: None     EISSN: 17406749     Source Type: Journal    
DOI: 10.1016/j.ddtec.2012.09.004     Document Type: Review

References (24)

1. V.A. Rudrapatna Drosophila cancer models Dev. Dyn. 241 2012 107 118
2. K. Tumaneng Organ size control by hippo and TOR pathways Curr. Biol. 22 2012 R368 R379
3. C. de la Cova Drosophila myc regulates organ size by inducing cell competition Cell 117 2004 107 116
4. J.R. Huh Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role Curr. Biol. 14 2004 1262 1266
5. H.D. Ryoo Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways Dev. Cell 7 2004 491 501
6. Q. Huang Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy Nat. Med. 17 2011 860 866
7. R.D. Read A drosophila model for EGFR-Ras and PI3K-dependent human glioma PLoS Genet. 5 2009 e1000374
8. R.A. Pagliarini, and T. Xu A genetic screen in Drosophila for metastatic behavior Science 302 2003 1227 1231
9. M. Vidal Differing Src signaling levels have distinct outcomes in Drosophila Cancer Res. 67 2007 10278 10285
10. M. Vidal Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis Dev. Cell 10 2006 33 44
11. M. Wu Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion Nature 463 2010 545 548
12. J.B. Cordero Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter Dev. Cell 18 2010 999 1011
13. R.D. Read A Drosophila model of multiple endocrine neoplasia type 2 Genetics 171 2005 1057 1081
14. T.K. Das Sin3a acts through a multi-gene module to regulate invasion in drosophila and human tumors Oncogene 2012 10.1038/onc.2012.326
15. F. Carlomagno ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases Cancer Res. 62 2002 7284 7290
16. M. Vidal ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma Cancer Res. 65 2005 3538 3541
17. S.A. Wells Jr. Vandetanib for the treatment of patients with locally advanced or metastatic hereditary medullary thyroid cancer J. Clin. Oncol. 28 2010 767 772
18. S.A. Wells Jr. Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial J. Clin. Oncol. 30 2012 134 141
19. A.C. Dar Chemical genetic discovery of targets and anti-targets for cancer polypharmacology Nature 486 2012 80 84
20. B. Apsel Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases Nat. Chem. Biol. 4 2008 691 699
21. A.C. Dar Small molecule recognition of c-Src via the Imatinib-binding conformation Chem. Biol. 15 2008 1015 1022
22. R. Gedaly PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathways Anticancer Res. 30 2010 4951 4958
23. A. Carracedo Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer J. Clin. Invest. 118 2008 3065 3074
24. T. Das, and R. Cagan Drosophila as a novel therapeutic discovery tool for thyroid cancer Thyroid 20 2010 689 695