Anti-inflammatory properties of potato glycoalkaloids in stimulated Jurkat and Raw 264.7 mouse macrophages

Life Sciences

Volumn 92, Issue 13, 2013, Pages 775-782

  Kenny, Olivia M ^a   McCarthy, Catherine M ^a   Brunton, Nigel P ^b   Hossain, Mohammad B ^b   Rai, Dilip K ^b   Collins, Stuart G ^a   Jones, Peter W ^a   Maguire, Anita R ^a   O'Brien, Nora M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b TEAGASC FOOD RESEARCH CENTRE   (Ireland)

Author keywords

Glycoalkaloids; Inflammation; Interleukin 2 production; Interleukin 8 production; Jurkat cells; Nitric oxide production; Raw 264.7 mouse macrophages

Indexed keywords

ALKALOID; ALPHA CHACONINE; ALPHA SOLANINE; ANTIINFLAMMATORY AGENT; CONCANAVALIN A; INTERLEUKIN 2; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PLANT EXTRACT; POTATO EXTRACT; SOLANIDINE; SOLANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; POTATO; SOLVENT EXTRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CONCANAVALIN A; DIOSGENIN; HUMANS; INTERLEUKIN-2; INTERLEUKIN-8; JURKAT CELLS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; PLANT EXTRACTS; SOLANINE; SOLANUM TUBEROSUM;

SOLANUM TUBEROSUM;

EID: 84875714036     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.02.006     Document Type: Article

References (29)

1. S.A. Aherne, and N.M. O'Brien Modulation of cytokine production by plant sterols in stimulated human Jurkat T cells Mol Nutr Food Res 52 2008 664 673
2. V. Bhatia, S.O. Kim, J.F. Aronson, C. Chao, M.R. Hellmich, and M. Falzon Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis Regul Pept 175 2012 49 60
3. F.L. Chiu, and J.K. Lin Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages FEBS Lett 582 2008 2407 2412
4. E. Choi, and S. Koo Anti-nociceptive and anti-inflammatory effects of the ethanolic extract of potato (Solanum tuberlosum) Food Agric Immunol 16 2005 29 39
5. K.S. Choi, E.K. Song, and C.Y. Yim Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages J Leukoc Biol 83 2008 1440 1450
6. J.C. Crispín, and G.C. Tsokos Transcriptional regulation of IL-2 in health and autoimmunity Autoimmun Rev 8 2009 190 195
7. V.M. Dirsch, A.K. Kiemer, H. Wagner, and A.M. Vollmar The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages Eur J Pharmacol 336 1997 211 217
8. C.A. Feghali, and T.M. Wright Cytokines in acute and chronic inflammation Front Biosci 2 1997 12 26
9. R.B. Filderman, and B.A. Kovacs Anti-inflammatory activity of steroid alkaloid glycoside, tomatine Br J Pharmacol 37 1969 748 755
10. K.G. Heal, N.A. Sheikh, M.R. Hollingdale, W.J. Morrow, and A.W. Taylor-Robinson Potentiation by a novel alkaloid glycoside adjuvant of a protective cytotoxic T cell immune response specific for a pre-erythrocytic malaria vaccine candidate antigen Vaccine 19 2001 4153 4161
11. B. Hernández-Ledesma, C.C. Hsieh, and B.O. de Lumen Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages Biochem Biophys Res Commun 390 2009 803 808
12. N. Huang, L. Rizshsky, C. Hauck, B.J. Nikolau, P.A. Murphy, and D.F. Birt Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages Phytochemistry 72 2011 2015 2023
13. V. Iablokov, B.C. Sydora, R. Foshaug, J. Meddings, D. Driedger, and T. Churchill Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease Dig Dis Sci 55 2010 3078 3085
14. T. Ishiko, K. Sakamoto, S. Yamashita, Y. Masuda, H. Kamohara, and S. Mita Carcinoma cells express IL-8 and IL-8 receptor: their inhibition attenuates the growth of carcinoma cells Int J Oncol 6 1995 119 122
15. V.B. Konkimalla, M. Blunder, R. Bauer, and T. Efferth Inhibition of inducible nitric oxide synthase by bis(helenalinyl)glutarate in RAW 264.7 macrophages Biochem Pharmacol 79 2010 1573 1580
16. R. Korhonen, A. Lahti, H. Kankaanranta, and E. Moilanen Nitric oxide production and signaling in inflammation Curr Drug Targets Inflamm Allergy 4 2005 471 479
17. J.K. Kunda, and Y.J. Surh Emerging avenues linking inflammation and cancer Free Radic Biol Med 52 2012 2013 2037
18. A. Marrelli, P. Cipriani, V. Liakouli, F. Carubbi, C. Perricone, and R. Perricone Angiogenesis in rheumatoid arthritis: a disease specific process or a common response to chronic inflammation? Autoimmun Rev 10 2011 595 598
19. A.L. McCarthy, Y.C. O'Callaghan, A. Connolly, C.O. Piggott, R.J. FitzGerald, and N.M. O'Brien In vitro antioxidant and anti-inflammatory effects of brewers' spent grain protein rich isolate and its associated hydrolysates Food Res Int 50 2013 205 212
20. S.E. Milner, N.P. Brunton, P.W. Jones, N.M. O'Brien, S.G. Collins, and A.R. Maguire Bioactivities of glycoalkaloids and their aglycones from Solanum species J Agric Food Chem 59 2011 3454 3484
21. W.J. Morrow, Y.W. Yang, and N.A. Sheikh Immunobiology of the tomatine adjuvant Vaccine 22 2004 2380 2384
22. M.G. Neuman Immune dysfunction in inflammatory bowel disease Transl Res 149 2007 173 186
23. S. Okamoto, N. Mukaida, K. Yasumoto, N. Rice, Y. Ishikawa, and H. Horiguchi The interleukin-8 AP-1 and κB-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization J Biol Chem 269 1994 8582 8589
24. B. Patel, R. Schutte, P. Sporns, J. Doyle, L. Jewel, and R.N. Fedorak Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease Inflamm Bowel Dis 8 2002 340 346
25. J.N. Sharma, A. Al-Omran, and S.S. Parvathy Role of nitric oxide in inflammatory diseases Inflammopharmacology 15 2007 252 259
26. J.S. Shin, Y.M. Park, J.H. Choi, H.J. Park, M.C. Shin, and Y.S. Lee Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-κB in RAW 264.7 murine macrophage cells Int Immunopharmacol 10 2010 943 950
27. R. Verlengia, R. Gorjão, C.C. Kanunfre, S. Bordin, T. Martins De Lima, and E.F. Martins Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells J Nutr Biochem 15 2004 657 665
28. L.Y. Zha, L.M. Mao, X.C. Lu, H. Deng, J.F. Ye, and X.W. Chu Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW 264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression Bioorg Med Chem Lett 21 2011 2415 2418
29. L. Zhang, and V. Sharma Human T-cell lymphotropic virus type-I tax gene induces Interleukin-8 secretion by autocrine mechanism and has no effect on interleukin-16 in transfected Jurkat cells Biochem Biophys Res Commun 273 2000 865 869