Role of parathyroid hormone-related protein in the pro-inflammatory and pro-fibrogenic response associated with acute pancreatitis

Regulatory Peptides

Volumn 175, Issue 1-3, 2012, Pages 49-60

  Bhatia, Vandanajay ^a   Kim, Sung O K ^a   Aronson, Judith F ^a   Chao, Celia ^a,b   Hellmich, Mark R ^a,b   Falzon, Miriam ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Acinar cells; Acute pancreatitis; Fibrosis; Inflammation; Parathyroid hormone related protein; Stellate cells

Indexed keywords

ALCOHOL; CERULETIDE; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; FIBRONECTIN; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MESSENGER RNA; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN[1-36]; PARATHYROID HORMONE RELATED PROTEIN[7-34]; PROCOLLAGEN; PROCOLLAGEN TYPE 1; UNCLASSIFIED DRUG;

ACINAR CELL; ACUTE PANCREATITIS; ALCOHOLIC PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL IMMORTALIZATION; CONTROLLED STUDY; CYSTIC FIBROSIS; FIBROGENESIS; INFLAMMATION; MOUSE; NONHUMAN; PANCREATIC STELLATE CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT;

ACINAR CELLS; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BONE NEOPLASMS; CAERULEIN; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COLLAGEN TYPE I; ETHANOL; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOENZYME TECHNIQUES; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; OSTEOSARCOMA; PANCREATIC STELLATE CELLS; PANCREATITIS; PARATHYROID HORMONE-RELATED PROTEIN; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84862786895     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2012.01.006     Document Type: Article

References (57)

1. Yadav D., Whitcomb D.C. The role of alcohol and smoking in pancreatitis. Nat Rev Gastroenterol Hepatol 2010, 7:131-145.
2. Cappell M.S. Acute pancreatitis: etiology, clinical presentation, diagnosis, and therapy. Med Clin North Am 2008, 92:889-923.
3. Leung P.S., Ip S.P. Pancreatic acinar cells: its role in acute pancreatitis. Int J Biochem Cell Biol 2006, 38:1024-1030.
4. Ramnath R.D., Sun J., Bhatia M. Involvement of SRC family kinases in substance P-induced chemokine production in mouse pancreatic acinar cells and its significance in acute pancreatitis. J Pharmacol Exp Ther 2009, 329:418-428.
5. Gukovsky L., Gukovskaya A.S., Blinman T.A., Zaninovic V., Pandol S.J. Early NF-κB activation is associated with hormone-induced pancreatitis. Am J Physiol 1998, 275:G1402-G1414.
6. Ramudo L., Yubero S., Manso M.A., Vicente S., De Dios I. Signal transduction of MCP-1 expression induced by pancreatitis-associated ascitic fluid in pancreatic acinar cells. J Cell Mol Med 2009, 13:1314-1320.
7. Omary M.B., Lugea A.L., Lowe A.W., Pandol S.J. The pancreatic stellate cell: a star on the rise in pancreatic disease. J Clin Invest 2007, 117:50-59.
8. Strewler G.I. Mechanisms of disease: the physiology of parathyroid hormone-related protein. N Engl J Med 2000, 342:177-185.
9. Mannstadt M., Jüppner H., Gardella T.J. Receptors for PTH and PTHrP. Am J Physiol 1999, 277:F665-F675.
10. Clemens T.L., Cormier S., Eichinger A., Endlich K., Fiaschi-Taesch E., Frieman P.A., Karaplis A.C., Massfelder T., Roosert J., Schluter K.D., Silve C., Stewart A.F., Takane K., Helwig J.J. Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. Br J Phamacol 2001, 134:1113-1136.
11. Vasavada R.C., Cavaliere C., D'Ercole A.J., Dann P., Burtis W.J., Madlener A.L., Zawalich K., Zawalich W., Philbrick W., Stewart A.F. Overexpression of parathyroid hormone-related protein in the pancreatic islet of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia. J Biol Chem 1996, 271:1200-1208.
12. Cebrian A., Garcia-Ocano A., Takane K.K., Sipula D., Stewart A.F., Vasavada R.C. Overexpression of parathyroid hormone-related protein inhibits pancreatic β-cell death in vivo and in vitro. Diabetes 2002, 51:3003-3013.
13. Rámila D., Ardura J.A., Esteban V., Ortega A., Ruiz-Ortega M., Bosch R.J., Esbrit P. Parathyroid hormone-related protein promotes inflammation in the kidney with an obstructed ureter. Kidney Int 2008, 73:835-847.
14. Yoshida T., Sakamotoa H., Horiuchi T., Yamamoto S., Suematsu A., Oda H., Koshihara Y. Involvement of prostaglandin E2 in interleukin-1a-induced parathyroid hormone-related peptide production in synovial fibroblasts of patients with rheumatoid arthritis. J Clin Endocrinol Metab 2001, 86:3272-3278.
15. Martin-Ventura J.L., Ortego M., Esbrit P., Hernandez-Presa M.A., Ortega L., Egido J. Possible role of parathyroid hormone-related protein as a proinflammatory cytokine in atherosclerosis. Stroke 2003, 34:1783-1789.
16. Funk J.L. A role for parathyroid hormone-related protein in the pathogenesis of inflammatory/autoimmune disease. Immunopharmacology 2001, 1:1101-1121.
17. Funk J.L., Wei H., Downey K.J., Yocum D., Benjamin J.B., Carley W. Expression of PTHrP and its cognate receptor in the rheumatoid synovial microcirculation. Biochem Biophys Res Commun 2002, 297:890-897.
18. Ortega A., Rámila D., Ardura J.A., Esteban V., Ruiz-Ortega M., Barat A., Gazapo R., Bosch R.J., Esbrit P. Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic-acid-induced nephrotoxicity. Am Soc Nephrol 2006, 17:1594-1603.
19. Charrier A.L., Brigstock D.R. Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis. Lab Invest 2010, 90:1179-1188.
20. Frossard J.L., Lenglet S., Montecucco F., Steffens S., Galan K., Pelli G., Spahr L., Mach F., Hadengue A. Role of CCL-2, CCR-2 and CCR-4 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. J Clin Pathol 2011, 64:387-393.
21. Kruse M.L., Hildebrand P.B., Timke C., Fölsch U.R., Schäfer H., Schmidt W.E. Isolation, long-term culture, and characterization of rat pancreatic fibroblastoid/stellate cells. Pancreas 2001, 23:49-54.
22. Bachem M.G., Schneider E., Groβ H., Weidenbach H., Schmid R.M., Menke A., Siech M., Beger H., Grunert A., Adler G. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998, 115:421-432.
23. Mathison A., Liebl A., Bharucha J., Mukhopadhyay D., Lomberk G., Shah V., Urrutia R. Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes. Pancreatology 2010, 10:505-516.
24. Talon I., Lindner V., Sourbier C., Schordan E., Rothhut S., Barthelmebs M., Lang H., Helwig J.-J., Massfelder T. Antitumor effect of parathyroid hormone-related protein neutralizing antibody in human renal cell carcinoma in vitro and in vivo. Carcinogenesis 2006, 27:73-83.
25. Tancred T.M., Belch A.R., Reiman T., Pilarski L.M., Kirshner J. Altered expression of fibronectin and collagens I and IV in multiple myeloma and monoclonal gammopathy of undetermined significance. J Histochem Cytochem 2009, 57:239-247.
26. Diveti P., Lanske B., Kronenberg H.M., Bringhurst F.R. Conditionally immortalized murine osteoblasts lacking the type 1 PTH/PTHrP receptor. J Bone Miner Res 1998, 13:1835-1845.
27. Bai X.-H., Wang D.-W., Kong L., Zhang Y., Luan Y., Kobayashi T. ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor. Mol Cell Biol 2009, 29:4201-4219.
28. Wang G., Petzke M.M., Iyer R., Wu H., Schwartz I. Pattern of proinflammatory cytokine induction in RAW264.7 mouse macrophages is identical for virulent and attenuated Borrelia burgdorferi. J Immunol 2008, 180:8306-8315.
29. Okamoto Yoshida Y., Umemura M., Yahagi A., O'Brien R.L., Ikuta K., Kishihara K., Hara H., Nakae S., Iwakura Y., Matsuzaki G. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol 2010, 184:4414-4422.
30. Robert K., Nehmé J., Bourbon E., Pivert G., Friguet B., Delcayre C., Delabar J.-M., Janel N. Cystathionine β synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver. Gastroenterology 2005, 128:1405-1415.
31. Fujimoto M., Maezawa Y., Yokote K., Joh K., Kobayashi K., Kawamura H., Nishimura M., Roberts A.B., Saito Y., Moria S. Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy. Biochem Biophys Res Commun 2003, 305:1002-1007.
32. Wang L., Raikwar N., Deng L., Yang M., Liang L., Shao C., Evan A.P., Stambrook P.J., Sahota A., Tischfield J.A. Altered gene expression in kidneys of mice with 2,8-dihydroxyadenine nephrolithiasis. Kidney Int 2000, 58:528-536.
33. Clerc P., Coll Constans M.G., Lulka H., Broussaud S., Guigné C., Leung-Theung-Long S., Perrin C., Knauf C., Carpéné C., Pénicaud L., Seva C., Burcelin R., Valet P., Fourmy D., Dufresne M. Involvement of cholecystokinin 2 receptor in food intake regulation: hyperphagia and increased fat deposition in cholecystokinin 2 receptor-deficient mice. Endocrinology 2007, 148:1039-1049.
34. Okano K., Wu S., Huang X., Pirola C.J., Jüppner H., Abou-Samra A.B., Segre G.V., Iwasaki K., Fagin J.A., Clemens T.L. Parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast-like cells: cell-specific regulation by angiotensin-II and PTHrP. Endocrinology 1994, 135:1093-1099.
35. Peinnequin A., Mouret C., Birot O., Alonso A., Mathieu J., Clarençon D., Agay D., Chancerelle Y., Multon E. Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC Immunol 2004, 5:3. 10.1186/1471-2172-5-3.
36. Perrone L., Devi T.S., Hosoya K.-I., Terasaki T., Singh L.P. Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. J Cell Physiol 2009, 221:262-272.
37. Ohno T., Hirano S., Rousseau B. Age-associated changes in the expression and deposition of vocal fold collagen and hyaluronan. Ann Otol Rhinol Laryngol 2009, 118:735-741.
38. Wu D., Hong Q., Chen X., Fu B., Li A., Liu H., Bai X., Wang J. Effective suppression of fibronectin synthesis by retrovirus delivered shRNA in rat cardiac fibroblasts. Sci China C Life Sci 2004, 47:368-375.
39. Nelovkov A., Areda T., Innos J., Kõks S., Vasar E. Rats displaying distinct exploratory activity also have different expression patterns of γ-aminobutyric acid- and cholecystokinin-related genes in brain regions. Brain Res 2006, 1100:21-31.
40. Bragado M.J., Dabrowski A., Groblewski G.E., Williams J.A. CCK activates p90rsk in rat pancreatic acini through protein kinase C. Am J Physiol 1997, 273:C1472-C1479.
41. Shen X., Rychahou P.G., Evers B.M., Falzon M. PTHrP increases xenograft growth and promotes integrin α6β4 expression and Akt activation in colon cancer. Cancer Lett 2007, 258:241-252.
42. Williams J.A., Blevins G.T. Cholecystokinin and regulation of pancreatic acinar cell function. Physiol Rev 1993, 73:701-723.
43. Singh P., Owlia A., Espeijo R., Dai B. Novel gastrin receptors mediate mitogenic effects of gastrin and processing intermediates of gastrin on Swiss 3T3 fibroblasts. J Biol Chem 1995, 270:8429-8438.
44. Wang B., Yang Y., Abou-Samra A.B., Friedman P.A. NHERF1 regulates parathyroid hormone receptor desensitization: interference with β-arrestin binding. Mol Pharmacol 2009, 75:1189-1197.
45. Berna M.J., Seiz O., Nast J.F., Benten D., Bläker M., Koch J., Lohse A.W., Pace A. CCK1 and CCK2 receptors are expressed on pancreatic stellate cells and induce collagen production. J Biol Chem 2010, 285:38905-38914.
46. Comfort M.W., Gambill E.E., Baggenstoss A.H. Chronic relapsing pancreatitis. Gastroenterology 1946, 6:239-285.
47. Whitcomb D.C. Hereditary pancreatitis: new insights into acute and chronic pancreatitis. Gut 1999, 45:317-322.
48. Whitcomb D.C. Inflammation and cancer. V. Chronic pancreatitis and pancreatic cancer. Am J Physiol Gastrointest Liver Physiol 2004, 287:G315-G319.
49. Pandol S.J., Lugea A., Mareninova O.A., Smoot D., Gorelick F.S., Gukovskaya A.S., Gukovsky I. Investigating the pathobiology of alcoholic pancreatitis. Alcohol Clin Exp Res 2011, 35:1-8.
50. Batemen A.C., Turner S.M., Thomas K.S.A., McCrudden P.R., Fine D.R., Johnson P.A., Johnson C.D., Iredale J.P. Apoptosis and proliferation of acinar and islet cells in chronic pancreatitis: evidence for differential cell loss mediating preservation of islet function. Gut 2002, 50:542-548.
51. Bhatia V., Saini M.K., Falzon M. Nuclear PTHrP targeting regulates PTHrP secretion and enhances LoVo cell proliferation and survival. Reg Pept 2009, 158:149-155.
52. Ye Y., Wang C., Du P., Falzon M., Seitz P.K., Cooper C.W. Overexpression of parathyroid hormone-related protein enhances apoptosis in the rat intestinal cell lines, IEC-6. Endocrinology 2001, 142:1906-1914.
53. Fiaschi-Taesch N.M., Stewart A.F. Minireview: parathyroid hormone-related protein as an intracrine factor-trafficking mechanisms and functional consequences. Endocrinology 2003, 144:407-411.
54. Apte M.V., Haber P.S., Darby S.J., Rodgers S.C., McCaughan G.W., Korsten M.A., Pirola R.C., Wilson J.S. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 1999, 44:534-541.
55. Gress T.M., Menke A., Bachem M., Muller-Pillasch F., Ellenrieder V., Weidenbach H., Wagner M., Adler G. Role of extracellular matrix in pancreatic disease. Digestion 1998, 59:625-637.
56. Consolo M., Amoroso A., Spandidos D.A., Mazzarino M.C. Matrix metalloproteinases and their inhibitors as markers of inflammation and fibrosis in chronic liver disease. Int J Mol Med 2009, 24:143-152.n.
57. Detlefsen S., Sipos B., Feyerabend B., Klöoppel G. Fibrogenesis in alcoholic chronic pancreatitis: the role of tissue necrosis, macrophages, myofibroblasts and cytokines. Mod Pathol 2006, 19:1019-1026.