Naturally occurring glycoalkaloids in potatoes aggravate intestinal inflammation in two mouse models of inflammatory bowel disease

Digestive Diseases and Sciences

Volumn 55, Issue 11, 2010, Pages 3078-3085

  Iablokov, Vadim ^a   Sydora, Beate C ^a   Foshaug, Rae ^a   Meddings, Jon ^a   Driedger, Darcy ^b   Churchill, Tom ^a   Fedorak, Richard N ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b ALBERTA AGRICULTURE AND RURAL DEVELOPMENT   (Canada)

Author keywords

Crohn's disease; Glycoalkaloid; Inflammatory bowel disease; Intestinal permeability; Mucosal inflammation; Ulcerative colitis

Indexed keywords

ALPHA CHACONINE; CYTOKINE; DEXTRAN SULFATE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; MYELOPEROXIDASE; SODIUM SULFATE; SOLANINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENTERITIS; ENZYME BLOOD LEVEL; GENE; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; MALE; MOUSE; NONHUMAN; POTATO; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

ANIMALS; COLITIS, ULCERATIVE; COOKERY; CROHN DISEASE; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; MICE; PEROXIDASE; SOLANACEOUS ALKALOIDS; SOLANINE; SOLANUM TUBEROSUM;

EID: 78149358942     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1158-9     Document Type: Article

References (23)

1. M Chichlowski LP Hale 2008 Bacterial-mucosal interactions in inflammatory bowel disease-an alliance gone bad Am J Physiol Gastrointest Liver Physiol 295 G1139 G1149 1:CAS:528:DC%2BD1cXhsFWgtbzO 10.1152/ajpgi.90516.2008 18927210
2. KL Madsen D Malfair D Gray, et al. 1999 Interleukin-10 gene-deficient mice develop a primary intestinal permeability defect in response to enteric microflora Inflamm Bowel Dis 5 4 262 270 1:STN:280:DC%2BD3c%2Fks1Srsw%3D%3D 10.1002/ibd.3780050405 10579119
3. DJ Berg J Zhang JV Weinstock, et al. 2002 Rapid development of colitis in NSAID-treated IL-10-deficient mice Gastroenterology 123 1527 1542 1:CAS:528:DC%2BD38XptVGjsLg%3D 10.1053/gast.2002.1231527 12404228
4. W Strober I Fuss P Mannon 2007 The fundamental basis of inflammatory bowel disease J Clin Invest 117 3 514 521 1:CAS:528:DC%2BD2sXis12hsbk%3D 10.1172/JCI30587 17332878 (Pubitemid 46348505)
5. DB Smith GJ Roddick JL Jones 1996 Potato glycoalkaloids: some unanswered questions Trends Food Sci Technol 7 126 131 1:CAS:528:DyaK28XjtVejsL4%3D 10.1016/0924-2244(96)10013-3
6. JG Roddick M Weissenberg AL Leonard 2001 Membrane disruption and enzyme inhibition by naturally-occurring and modified chacotriose-containing solanum steroidal glycoalkaloids Phytochemistry 56 6 603 610 1:CAS:528: DC%2BD3MXhvFKisb4%3D 10.1016/S0031-9422(00)00420-9 11281138 (Pubitemid 32216499)
7. T Mandimika H Baykus Y Vissers, et al. 2007 Differential gene expression in intestinal epithelial cells induced by single and mixtures of potato glycoalkaloids J Agric Food Chem 55 24 10055 10066 1:CAS:528:DC%2BD2sXht1CmtrvF 10.1021/jf0724320 17973450 (Pubitemid 350305196)
8. EA Keukens T de Vrije C van den Boom, et al. 1995 Molecular basis of glycoalkaloid induced membrane disruption Biochim Biophys Acta 1240 2 216 228 10.1016/0005-2736(95)00186-7 8541293 (Pubitemid 26005549)
9. B Patel R Schutte P Sporns, et al. 2002 Potato glycoalkaloids adversely affect intestinal permeability and aggravate inflammatory bowel disease Inflamm Bowel Dis 8 5 340 346 10.1097/00054725-200209000-00005 12479649
10. B Egger M Bajaj-Elliott TT MacDonald, et al. 2000 Characterization of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency Digestion 62 4 240 248 1:CAS:528:DC%2BD3cXoslWju70%3D 10.1159/000007822 11070407
11. LA Dieleman MJ Palmen H Akol, et al. 1998 Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines Clin Exp Immunol 114 3 p385 p391 10.1046/j.1365-2249.1998.00728.x (Pubitemid 28539597)
12. R Kühn J Löhler D Rennick, et al. 1993 Interleukin-10-deficient mice develop chronic enterocolitis Cell 75 263 274 10.1016/0092-8674(93)80068-P 8402911 (Pubitemid 23320290)
13. M Friedman 2006 Potato glycoalkaloids and metabolites: roles in the plant and in the diet J Agric Food Chem 54 23 8655 8681 1:CAS:528:DC%2BD28XhtV2gtLjJ 10.1021/jf061471t 17090106 (Pubitemid 44797509)
14. AOAC International. AOAC official methods of analysis. AOAC official method 997.13. Glycoalkaloids (α-solanine and α-chaconine) in potato tubers. In: Trucksess MW, ed. Natural Toxins. Gaithersburg: AOAC; 1997:63-65.
15. JB Meddings I Gibbons 1998 Discrimination of site-specific alterations in gastrointestinal permeability in the rat Gastroenterology 114 1 83 92 1:CAS:528:DyaK1cXksF2mtw%3D%3D 10.1016/S0016-5085(98)70636-5 9428222 (Pubitemid 28020958)
16. BC Sydora MM Tavernini JS Doyle, et al. 2005 Association with selected bacteria does not cause enterocolitis in IL-10 gene-deficient mice despite a systemic immune response Dig Dis Sci 50 905 913 1:CAS:528:DC%2BD2MXjvVCnu7w%3D 10.1007/s10620-005-2663-0 15906767 (Pubitemid 40684910)
17. EA Keukens T de Vrije CH Fabrie, et al. 1992 Dual specificity of sterol-mediated glycoalkaloid induced membrane disruption Biochim Biophys Acta 1110 2 127 136 1:CAS:528:DyaK38XmsVKrtLc%3D 10.1016/0005-2736(92)90349-Q 1390841
18. SL Sinden RE Webb 1972 Effect of variety and location on the glycoalkaloid content of potatoes Am J Potato Res 49 9 334 338 1:CAS:528:DyaE3sXis1ChtQ%3D%3D 10.1007/BF02861777
19. SA Yang SH Paek N Kozukue, et al. 2006 Alpha-chaconine, a potato glycoalkaloid, induces apoptosis of HT-29 human colon cancer cells through caspase-3 activation and inhibition of ERK 1/2 phosphorylation Food Chem Toxicol 44 6 839 846 1:CAS:528:DC%2BD28Xjs1aitbY%3D 10.1016/j.fct.2005.11.007 16387404
20. T Mandimika H Baykus Y Vissers, et al. 2007 Differential gene expression in intestinal epithelial cells induced by single and mixtures of potato glycoalkaloids J Agric Food Chem 55 24 10055 10066 1:CAS:528:DC%2BD2sXht1CmtrvF 10.1021/jf0724320 17973450 (Pubitemid 350305196)
21. RA Ribeiro FQ Cunha SH Ferreira 1990 Recombinant gamma interferon causes neutrophil migration mediated by the release of a macrophage neutrophil chemotactic factor Int J Exp Pathol 71 5 717 725 1:STN:280: DyaK3M%2Fgt1CjtQ%3D%3D 2119790
22. N Kozukue KS Yoon GI Byun, et al. 2008 Distribution of glycoalkaloids in potato tubers of 59 accessions of two wild and five cultivated solanum species J Agric Food Chem 56 24 11920 11928 1:CAS:528:DC%2BD1cXhsVWrur3I 10.1021/jf802631t 19053181
23. TT Mensinga AJ Sips CJ Rompelberg, et al. 2005 Potato glycoalkaloids and adverse effects in humans: an ascending dose study Regul Toxicol Pharmacol 41 1 66 72 1:CAS:528:DC%2BD2MXis1Sjsw%3D%3D 10.1016/j.yrtph.2004.09.004 15649828 (Pubitemid 40092652)