Anti-inflammatory effect of soyasaponins through suppressing nitric oxide production in LPS-stimulated RAW 264.7 cells by attenuation of NF-κB-mediated nitric oxide synthase expression

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2415-2418

  Zha, Long Ying ^a   Mao, Li Mei ^a   Lu, Xiao Cui ^a   Deng, Hong ^a   Ye, Ju Feng ^a   Chu, Xin Wei ^a   Sun, Su Xia ^a   Luo, Hai Ji ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Anti inflammatory; Inducible nitric oxide synthase; Nitric oxide; Nuclear factor kappa B; Soyasaponins

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SOYASAPOGENOL A; SOYASAPOGENOL B; SOYASAPONIN A1; SOYASAPONIN A2; SOYASAPONIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN RAW 264.7; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; MACROPHAGE; NONHUMAN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OLEANOLIC ACID; SAPONINS; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 79953279333     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.071     Document Type: Article

References (29)

1. J. Hu, M.B. Reddy, S. Hendrich, and P.A. Murphy J. Nutr. 134 2004 1867
2. Ö. Gülü-üstünda, and G. Mazza Crit. Rev. Food Sci. Nutr. 47 2007 231
3. D.M. Gurfinkel, and A.V. Rao Nutr. Cancer 47 2003 24
4. W. Zhang, and D.G. Popovich J. Agric. Food. Chem. 56 2008 2603
5. J.X. Xiao, G.Q. Huang, and S.H. Zhang Exp. Toxicol. Pathol. 59 2007 35
6. S. Lee, A.L. Simons, P.A. Murphy, and S. Hendrich Exp. Biol. Med. 230 2005 472
7. D.G. Oakenfull, and G.S. Sidhu Eur. J. Clin. Nutr. 44 1990 79
8. K. Hayashi, H. Hayashi, N. Hiraoka, and Y. Ikeshiro Planta Med. 63 1997 102
9. H. Nakashima, K. Okubo, Y. Honda, T. Tamura, S. Matsuda, and N. Yamamoto AIDS 3 1989 655
10. J. Kinjo, M. Imagire, M. Udayama, T. Arao, and T. Nohara Planta Med. 64 1998 233
11. J. Kinjo, T. Hirakawa, R. Tsuchihashi, T. Nagao, M. Okawa, T. Nohara, and H. Okabe Biol. Pharm. Bull. 26 2003 1357
12. Y. Ishii, and H. Tanizawa Biol. Pharm. Bull. 29 2006 1759
13. M.A. Berhow, E.D. Wagner, and S.F. Vaughn Mutat. Res. 448 2000 11
14. H. Jun, S. Kim, and M. Sung J. Med. Food 5 2002 235
15. E.M. Shin, H.Y. Zhou, L.Y. Guo, J.A. Kim, S.H. Lee, I. Merfort, S.S. Kang, H.K. Kim, S. Kim, and Y.S. Kim Int. Immunopharmacol. 8 2008 1524
16. L.M. Coussens, and Z. Werb Nature 420 2002 860
17. B.B. Aggarwal, S. Shishodia, S.K. Sandur, M.K. Pandey, and G. Sethi Biochem. Pharmacol. 72 2006 1605
18. K.H. Jung, E. Ha, M.J. Kim, H.J. Won, L.T. Zheng, H.K. Kim, S.J. Hong, J.H. Chung, and S.V. Yim Food Chem. Toxicol. 45 2007 1545
19. F. Aktan, S. Henness, B.D. Roufogalis, and A.J. Ammit Nitric Oxide 8 2003 235
20. K.S. Ahn, E.J. Noh, H.L. Zhao, S.H. Jung, S.S. Kang, and Y.S. Kim Life Sci. 76 2005 2315
21. J. Kang, M. Sung, T. Kawada, H. Yoo, Y. Kim, J. Kim, and R. Yu Cancer Lett. 230 2005 219
22. J.Y. Lee, J.W. Shin, K.S. Chun, K.K. Park, W.Y. Chung, Y.J. Bang, J.H. Sung, and Y.J. Surh Carcinogenesis 26 2005 359
23. A.A. Ellington, M. Berhow, and K.W. Singletary Carcinogenesis 26 2005 159
24. W.W. Chang, C.Y. Yu, T.W. Lin, P.H. Wang, and Y.C. Tsai Biochem. Biophys. Res. Commun. 341 2006 614
25. K. Oda, H. Matsuda, T. Murakami, S. Katayama, T. Ohgitani, and M. Yoshikawa Vaccine 21 2003 2145
26. D. Kiefer, and T. Pantuso Am. Fam. Physician 68 2003 1539
27. B.H. Jeon, C.S. Kim, H.S. Kim, J.B. Park, K.Y. Nam, and S.J. Chang Acta Pharmacol. Sin. 21 2000 1095
28. K.R. Kim, E.W. Son, D.K. Rhee, and S. Pyo Toxicol. In Vitro 16 2002 517
29. W.J. Zhang, J. Wojta, and B.R. Binder Arterioscler. Thromb. Vasc. Biol. 17 1997 465